Page last updated: 2024-09-28

Carcinoma, Basosquamous

A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)

Synonyms(1)

Synonym
Carcinoma, Basosquamous

Research Excerpts

Overview

ExcerptReference
"Basosquamous carcinoma is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma."( Cawte, TG; Edwards, MJ; Martin, RC; McMasters, KM; Sewell, CL, 2000)
"Basosquamous carcinoma is an aggressive epithelial neoplasm with a propensity for local recurrence and potential for distant metastatic spread."( Cawte, TG; Edwards, MJ; Martin, RC; McMasters, KM; Sewell, CL, 2000)
"Identification of basosquamous carcinoma is also facilitated with this method."( Beer, TW; Shepherd, P; Theaker, JM, 2000)
"Basosquamous carcinoma is a rare cutaneous neoplasm that has caused considerable controversy as to its classification, pathogenesis, and management."( Rieger, KE; Sarin, KY; Tan, CZ, 2017)

Research

Studies (82)

TimeframeStudies, This Condition (%)All Conditions %
pre-199038 (46.34)23.3326
1990's9 (10.98)12.5806
2000's19 (23.17)18.1394
2010's10 (12.20)28.8240
2020's6 (7.32)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low10
chlorine0low20
salicylic acid0low90
histamine0low10
urea0low20
azathioprine0low10
fluorouracil0medium71
ibuprofen0low10
protoporphyrin ix0low10
mitomycin0low10
prednisone0low10
uridine0low10
bromodeoxyuridine0low10
galactose0low10
citrulline0low10
c.i. 425100low10
deoxyuridine0low10
fucose0low10
mannose0low10
silver0low10
silver nitrate0low10
propiconazole0low20
fluorodeoxyglucose f180low10
methotrexate0low10
glucosamine0low10
inositol 3-phosphate0low20
bromochloroacetic acid0low160
phenylephrine hydrochloride0low50
antimony0low10
radium0low40
involucrin0low10
acid phosphatase0low30
bucladesine0low10
sodium ethylxanthate0low10
lde2250low30
gdc 04490low30
epidermal growth factor0low10
angiogenin0low10
amido black0low10

Protein Targets (480)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Luciferase5005
pregnane X receptor6006
phosphopantetheinyl transferase6006
RAR-related orphan receptor gamma110011
SMAD family member 23003
SMAD family member 33003
TDP1 protein110011
Microtubule-associated protein tau6006
AR protein160016
caspase 7, apoptosis-related cysteine protease3003
aldehyde dehydrogenase 1 family, member A18008
nuclear receptor subfamily 1, group I, member 3120012
retinoic acid nuclear receptor alpha variant 1110011
estrogen-related nuclear receptor alpha150015
farnesoid X nuclear receptor7007
pregnane X nuclear receptor9009
estrogen nuclear receptor alpha140014
peroxisome proliferator-activated receptor delta9009
peroxisome proliferator activated receptor gamma110011
caspase-33003
euchromatic histone-lysine N-methyltransferase 29009
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
thyroid hormone receptor beta isoform a3003
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 1130013
Voltage-dependent calcium channel gamma-2 subunit8008
Cellular tumor antigen p53120012
Cytochrome P450 1A20202
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Aldo-keto reductase family 1 member B10202
Adenosine receptor A30202
Alpha-1B adrenergic receptor0202
Glutamate receptor 29009
Acetylcholinesterase0303
Sodium-dependent noradrenaline transporter 0213
Aryl hydrocarbon receptor0011
Alpha-1A adrenergic receptor0202
Chain A, Beta-lactamase3003
bromodomain adjacent to zinc finger domain 2B3003
geminin120012
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Ferritin light chain4004
interleukin 83003
acetylcholinesterase2002
thioredoxin reductase7007
ATAD5 protein, partial5005
Fumarate hydratase2002
GLI family zinc finger 3100010
thioredoxin glutathione reductase2002
EWS/FLI fusion protein7007
glucocorticoid receptor [Homo sapiens]8008
retinoid X nuclear receptor alpha120012
G1001
polyprotein2002
P531001
arylsulfatase A5005
IDH17007
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x7007
Bloom syndrome protein isoform 13003
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 2120012
DNA polymerase iota isoform a (long)8008
peripheral myelin protein 225005
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 15005
muscarinic acetylcholine receptor M12002
lamin isoform A-delta108008
Gamma-aminobutyric acid receptor subunit pi1001
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40304
Bile salt export pump0404
Bile salt export pump0606
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Nuclear receptor ROR-gamma4004
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
GABA theta subunit1001
Inositol hexakisphosphate kinase 11001
Canalicular multispecific organic anion transporter 10303
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Gamma-aminobutyric acid receptor subunit epsilon1001
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial1001
estrogen receptor 2 (ER beta)7007
progesterone receptor9009
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
histone deacetylase 9 isoform 31001
nuclear receptor subfamily 1, group I, member 23003
Nuclear hormone receptor family member daf-120011
chromobox protein homolog 1100010
nuclear factor erythroid 2-related factor 2 isoform 25005
serine/threonine-protein kinase mTOR isoform 12002
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
Thymidine kinase, cytosolic0102
Thymidine phosphorylase0002
Thymidylate kinase0101
Spike glycoprotein5005
Thymidine kinase0001
Thymidylate kinase0101
glp-1 receptor, partial4004
vasopressin V1b receptor1001
cAMP-dependent protein kinase type I-alpha regulatory subunit0011
cAMP-dependent protein kinase type II-beta regulatory subunit0011
cAMP-dependent protein kinase catalytic subunit beta isoform 10011
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
neuropeptide S receptor isoform A2002
cAMP-dependent protein kinase catalytic subunit beta isoform 30011
Carbonic anhydrase 10304
Carbonic anhydrase 20316
Carbonic anhydrase 40203
Carbonic anhydrase0102
Carbonic anhydrase 150203
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
General amino-acid permease GAP10001
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Chain A, Dutpase0011
Chain A, Dutpase0011
Chain B, Dutpase0011
Chain A, Dutpase0011
Chain B, Dutpase0011
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV1001
Skn7p0001
hypoxia-inducible factor 1 alpha subunit3003
Thrombopoietin1001
thyroid stimulating hormone receptor2002
nonstructural protein 14004
67.9K protein4004
huntingtin isoform 21001
flap endonuclease 13003
Vpr2002
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Amyloid-beta precursor protein1001
Thymidylate synthase0303
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
ATP-dependent phosphofructokinase3003
Fucose-binding lectin PA-IIL0202
CD209 antigen0303
USP1 protein, partial5005
importin subunit beta-1 isoform 14004
snurportin-14004
DNA polymerase kappa isoform 15005
histone acetyltransferase KAT2A isoform 13003
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
Albumin0224
Albumin0022
Cytochrome P450 3A40203
Cytochrome P450 2D60101
Cytochrome P450 2C9 0304
Sodium-dependent dopamine transporter0101
Sodium-dependent serotonin transporter0101
Cytochrome P450 2C190101
Smoothened homolog0112
Glutamate receptor ionotropic, NMDA 2B0002
Potassium voltage-gated channel subfamily H member 20101
Sonic hedgehog protein0102
Sonic hedgehog protein0202
Smoothened homolog0325
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
GLS protein3003
apical membrane antigen 1, AMA12002
regulator of G-protein signaling 42002
potassium voltage-gated channel subfamily H member 2 isoform d1001
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Carbonic anhydrase 120102
Solute carrier family 22 member 30102
Plasma kallikrein0001
Carbonic anhydrase 30102
Macrophage migration inhibitory factor0202
Carbonic anhydrase 60102
Histamine H2 receptor0123
Adenosine receptor A10102
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0102
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0102
Histamine H1 receptor0224
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase 70102
Histamine H2 receptor2013
Carbonic anhydrase0002
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90102
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0001
Solute carrier family 22 member 10102
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 130102
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
Histamine H3 receptor0123
NFKB1 protein, partial2002
transcriptional regulator ERG isoform 33003
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40101
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Dihydrofolate reductase0304
Fatty acid-binding protein, liver0101
Albumin0101
Prostaglandin G/H synthase 10202
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0102
UDP-glucuronosyltransferase 2B70001
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10202
Caspase-10101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Prostaglandin G/H synthase 2 0102
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30101
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Cytochrome P450 2J20101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Prostaglandin G/H synthase 20202
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20101
TAR DNA-binding protein 433003
Solute carrier family 22 member 60203
Prostaglandin G/H synthase 1 0102
Solute carrier family 22 member 200303
Solute carrier family 22 member 80203
Solute carrier family 22 member 60303
Dehydrogenase/reductase SDR family member 90101
Alpha-mannosidase 2C10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase3003
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial2002
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
vitamin D3 receptor isoform VDRA4004
DNA polymerase beta2002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
cytochrome P450 family 3 subfamily A polypeptide 41001
cytochrome P450 2D61001
Indoleamine 2,3-dioxygenase 10101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
nuclear receptor ROR-gamma isoform 13003
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, RNA-directed RNA polymerase NS50101
Chain A, Cruzipain1001
SUMO-10101
WRN1001
Smad31001
isocitrate dehydrogenase 1, partial1001
pyruvate kinase1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
mitogen-activated protein kinase 11001
atrial natriuretic peptide receptor 2 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase PLK11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
tumor susceptibility gene 101 protein1001
POsterior Segregation0011
chaperonin GroEL1001
60 kDa chaperonin0101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
60 kDa heat shock protein, mitochondrial0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
10 kDa heat shock protein, mitochondrial0101
Exoribonuclease H 0101
Thiosulfate sulfurtransferase0101
Coproheme decarboxylase0011
60 kDa chaperonin 0101
Protease 0101
10 kDa chaperonin 0101
Single-stranded DNA cytosine deaminase1001
Zinc finger protein mex-50011
phosphoglycerate kinase1001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Caspase-71001
caspase-31001
lethal factor (plasmid)1001
Rap guanine nucleotide exchange factor 32002
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Chain A, Cytidine Deaminase0101
Sodium/nucleoside cotransporter 10202
Sodium/nucleoside cotransporter 20202
Cytidine deaminase0101
Equilibrative nucleoside transporter 20202
Protein cereblon0202
Equilibrative nucleoside transporter 10202
Uridine-cytidine kinase 1 0001
Solute carrier family 28 member 30202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]