Page last updated: 2024-12-06

2-(aminomethyl)pyridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-(Aminomethyl)pyridine is a heterocyclic compound with a pyridine ring and an aminomethyl group attached to the 2-position. It is an important building block in organic synthesis and has been used to synthesize various pharmaceuticals and other useful molecules. 2-(Aminomethyl)pyridine can be synthesized via a number of methods, including the reduction of 2-cyanopyridine or the reaction of 2-chloromethylpyridine with ammonia. The compound has been shown to exhibit a range of biological activities, including anti-inflammatory, antioxidant, and antimicrobial effects. Its importance in research stems from its versatility as a starting material for the synthesis of other compounds, its potential therapeutic applications, and its ability to serve as a model system for studying the properties of pyridine derivatives. Research on 2-(Aminomethyl)pyridine continues to focus on exploring its biological activities, developing new synthetic methods for its preparation, and investigating its potential use in drug discovery.'

Cross-References

ID SourceID
PubMed CID19509
CHEMBL ID32189
CHEBI ID81387
SCHEMBL ID40328
SCHEMBL ID2086329
MeSH IDM000610296

Synonyms (94)

Synonym
2-picolylamine
nsc-59705
2-pyridinemethanamine
2-picolinamine
2-(aminomethyl)pyridine ,
3731-51-9
pyridine, 2-(aminomethyl)-
nsc59705
wln: t6nj b1z
2-pyridinemethylamine
.beta.-picolylamine
brn 0108054
2-pyridylmethylamine
nsc 59705
(2-pyridylmethyl)amine
einecs 223-090-5
pyridine, 2-aminomethyl-
inchi=1/c6h8n2/c7-5-6-3-1-2-4-8-6/h1-4h,5,7h
2-picolylamine, 99%
2-aminomethyl-pyridine
A1161
CHEMBL32189
pyridin-2-ylmethanamine
2-pyridyl-methylamine
chebi:81387 ,
2-aminomethylpyridine
AKOS000118825
C17926
1-(pyridin-2-yl)methanamine
STK802385
pyridylmethylamine
pyridin-2-yl-methanamine
c-pyridin-2-yl-methylamine
BCP9000115
2-(aminomethyl)pyridine;2-picolylamine
AM803799
5-22-09-00232 (beilstein handbook reference)
xk7252m2pa ,
unii-xk7252m2pa
BP-12086
FT-0608727
AB00731
SCHEMBL40328
picolylamine
2-pyridinylmethylamine
pyridin-2-ylmethylamine
2-amino methyl pyridine
2(aminomethyl)pyridine
2-(amino methyl)pyridine
1-pyridin-2-ylmethaneamine
c-pyridine-2-yl-methylamine
2-(aminomethyl)-pyridine
pyridin-2-ylmethyl amine
2-aminomethyl pyrdine
aminomethylpyridine
2-pyridinylmethanamine
pyridine-2-ylmethanamine
(pyridin-2-ylmethyl)amine
(pyridin-2-yl)methylamine
1-pyridin-2-ylmethanamine
2-(amino methyl) pyridine
pyridine-2-ylmethylamine
picolinamine
(2-pyridyl)methanamine
(pyridin-2-yl)methanamine
2-picolyl amine
aminomethyl pyridine
2-aminomethyl pyridine
2-(aminomethyl)pryidine
2-aminomethylpryidine
(2-pyridinylmethyl)amine
pyridine-2-methylamine
2-amino methylpyridine
(pyridin-2-ylmethyl)-amine
2-(aminomethyl) pyridine
2-pyridylmethanamine
2-(amino)methylpyridine
DTXSID5063152
SCHEMBL2086329
.alpha.-picolylamine
W-106551
PS-9292
mfcd00006360
pyridinemethanamine
CS-W007488
F2190-0394
2-picolylamine, for hplc derivatization, >=98.0% (gc)
Q27155325
2-(aminomethyl)pyridine 2-pyridinemethaneamine
F11236
EN300-19584
o-picolylamine
alpha-(aminomethyl)pyridine
Z104474352
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyridinesAny organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (30)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)KA41.50000.24000.81921.6700AID318346
Carbonic anhydrase 1Homo sapiens (human)KA26.00000.02001.72197.4000AID1331203; AID1397319; AID268620; AID291061; AID307896; AID318343; AID365827; AID409984; AID462829; AID691713; AID725228
Carbonic anhydrase 2Homo sapiens (human)Ka34.00000.01101.42737.8000AID1331204; AID1397320; AID268621; AID291063; AID307897; AID318344; AID365828; AID409986; AID414329; AID462830; AID464319; AID691714; AID725229
Plasma kallikreinHomo sapiens (human)KA0.24000.04401.39744.3800AID305777
Carbonic anhydrase 3Homo sapiens (human)Ka1.03000.09100.72851.1200AID365829; AID409993
Carbonic anhydrase 4Homo sapiens (human)KA5.19000.07904.45607.3000AID365830; AID375786
Carbonic anhydrase 6Homo sapiens (human)KA14.00001.20005.82769.5400AID307898; AID462831
Adenosine receptor A1Rattus norvegicus (Norway rat)KA34.00000.01101.32337.8000AID691714
Adenosine receptor A2aRattus norvegicus (Norway rat)KA34.00000.01101.32337.8000AID691714
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)KA23.56000.01002.79269.8100AID305776
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Carbonic anhydrase 7Homo sapiens (human)KA43.70000.71003.875610.0000AID291065
Carbonic anhydraseSaccharomyces cerevisiae S288CKa16.20000.95005.12509.3000AID414331; AID464321
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Carbonic anhydrase 9Homo sapiens (human)KA1.07000.00904.24939.7100AID318345
Carbonic anhydrase-like protein, putativeTrypanosoma cruzi strain CL BrenerKA100.00000.14002.80507.5400AID1397322
Carbonic anhydraseCandida albicans SC5314KA29.10000.96003.95338.4000AID458784
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka15.00007.10008.30009.5000AID464322
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Carbonic anhydrase 15Mus musculus (house mouse)KA11.60004.00007.68579.5000AID375787
Carbonic anhydrase 13Mus musculus (house mouse)KA3.80000.01301.51404.6000AID268622
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA43.70000.71003.79009.7400AID291065
Carbonic anhydrase 14Homo sapiens (human)KA21.70000.01002.28947.2100AID291067
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)KA0.24000.04402.120510.0000AID305777
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
Factor XII activationPlasma kallikreinHomo sapiens (human)
proteolysisPlasma kallikreinHomo sapiens (human)
blood coagulationPlasma kallikreinHomo sapiens (human)
zymogen activationPlasma kallikreinHomo sapiens (human)
plasminogen activationPlasma kallikreinHomo sapiens (human)
fibrinolysisPlasma kallikreinHomo sapiens (human)
positive regulation of fibrinolysisPlasma kallikreinHomo sapiens (human)
response to bacteriumCarbonic anhydrase 3Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 3Homo sapiens (human)
bicarbonate transportCarbonic anhydrase 4Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 4Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter tasteCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 7Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 7Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 7Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 7Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 7Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 14Homo sapiens (human)
response to bacteriumCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
serine-type endopeptidase activityPlasma kallikreinHomo sapiens (human)
protein bindingPlasma kallikreinHomo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 3Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 3Homo sapiens (human)
nickel cation bindingCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 4Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 6Homo sapiens (human)
G protein-coupled adenosine receptor activityAdenosine receptor A2aRattus norvegicus (Norway rat)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular regionPlasma kallikreinHomo sapiens (human)
extracellular spacePlasma kallikreinHomo sapiens (human)
plasma membranePlasma kallikreinHomo sapiens (human)
extracellular exosomePlasma kallikreinHomo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytoplasmCarbonic anhydrase 3Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 4Homo sapiens (human)
rough endoplasmic reticulumCarbonic anhydrase 4Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentCarbonic anhydrase 4Homo sapiens (human)
Golgi apparatusCarbonic anhydrase 4Homo sapiens (human)
trans-Golgi networkCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
external side of plasma membraneCarbonic anhydrase 4Homo sapiens (human)
cell surfaceCarbonic anhydrase 4Homo sapiens (human)
membraneCarbonic anhydrase 4Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 4Homo sapiens (human)
transport vesicle membraneCarbonic anhydrase 4Homo sapiens (human)
secretory granule membraneCarbonic anhydrase 4Homo sapiens (human)
brush border membraneCarbonic anhydrase 4Homo sapiens (human)
perinuclear region of cytoplasmCarbonic anhydrase 4Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
extracellular regionCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
cytosolCarbonic anhydrase 6Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
Golgi membraneAdenosine receptor A2aRattus norvegicus (Norway rat)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
cytosolCarbonic anhydrase 7Homo sapiens (human)
cytoplasmCarbonic anhydrase 7Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
membraneCarbonic anhydrase 14Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 14Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 14Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (65)

Assay IDTitleYearJournalArticle
AID318346Activation of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID1281543Activation of Malassezia globosa beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped flow CO2 hydrase method2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids.
AID1397321Activation of Leishmania donovani chagasi CA preincubated for 15 mins followed by CO2 addition by stopped-flow assay
AID409984Activation of human recombinant CA1 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID318344Activation of human recombinant CA2 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID365829Activation of human recombinant CA3 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID409993Activation of human recombinant CA3 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID268620Activation of human recombinant CA1 by CO2 hydrase assay2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID409986Activation of human recombinant CA2 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID461089Inhibition of hydratase-activity of human erythrocytes CA2 by CO2-hydration method2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.
AID691713Activity of human recombinant CA1 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID1331206Activation of Burkholderia pseudomallei gamma carbonic anhydrase at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID458787Activation of Cryptococcus neoformans beta-carbonic anhydrase Can2 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID1397320Activation of human CA2 by stopped-flow CO2 hydration assay
AID1331204Activation of recombinant human carbonic anhydrase 2 at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID409992Activation of Methanosarcina thermophila cobalt(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID318345Activation of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID1331205Activation of recombinant Methanosarcina thermophila gamma carbonic anhydrase at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID74488Inhibitory activity against murine gelatinase B at 5 mM was determined2002Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16
Design and synthesis of novel inhibitors of gelatinase B.
AID365830Activation of human recombinant truncated CA4 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID365827Activation of human recombinant CA1 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID464322Activation of Candida glabrata recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID307898Activation of human recombinant CA6 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID318343Activation of human recombinant CA1 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID462832Activation of Stylophora pistillata carbonic anhydrase STPCA by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID375787Activation of membrane associated mouse recombinant carbonic anhydrase 15 isoform by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID725229Activation of human recombinant CA2 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID462830Activation of human recombinant CA2by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID414329Activation of human recombinant CA2 by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID462831Activation of human full length CA6 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID464319Activation of human recombinant carbonic anhydrase isoenzyme 2 by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID725226Activation of Sulfurihydrogenibium azorense recombinant alpha carbonic anhydrase by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID409990Activation of Methanosarcina thermophila Zinc(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID268622Activation of mouse recombinant CA13 by CO2 hydrase method2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID1331210Activation of Burkholderia pseudomallei gamma carbonic anhydrase assessed as Kcat at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID464321Activation of Saccharomyces cerevisiae recombinant Nce103p by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID307896Activation of human recombinant CA1 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID464320Activation of archaea Methanobacterium thermoautotrophicum recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID461323Inhibition of esterase-activity of human erythrocytes CA2 by spectrophotometry2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.
AID268621Activation of human recombinant CA2 by CO2 hydrase assay2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID291067Activation of of human recombinant CA14 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID691714Activity of human recombinant CA2 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID307897Activation of human recombinant CA2 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID305776Activation of human recombinant carbonic anhydrase 5A by stopped-flow CO2 hydrase method2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
AID725227Activation of Sulfurihydrogenibium yellowstonense recombinant CA by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID461088Inhibition of hydratase-activity of CA1 from human erythrocytes by CO2-hydration method2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.
AID291061Activation of human recombinant CA1 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID409988Activation of Methanobacterium thermoautotrophicum beta-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID414330Activation of Methanothermobacter thermautotrophicus recombinant Cab by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID1397319Activation of human CA1 by stopped-flow CO2 hydration assay
AID461322Inhibition of esterase-activity of CA1 from human erythrocytes by spectrophotometry2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.
AID291063Activation of human recombinant CA2 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID461324Inhibition of CA1 from human erythrocytes by Lineweaver-Burke analysis2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.
AID725228Activation of human recombinant CA1 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID305777Activation of human recombinant carbonic anhydrase 5B by stopped-flow CO2 hydrase method2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
AID414331Activation of yeast recombinant CA by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID1397322Activation of Trypanosoma cruzi CA preincubated for 15 mins followed by CO2 addition by stopped-flow assay
AID458784Activation of Candida albicans beta-carbonic anhydrase Nce103 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID375786Activation of human recombinant carbonic anhydrase 4 lacking 20 amino terminal residues by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID691715Activity of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant CA expressed in Escherichia coli BL21(DE3) after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID291065Activation of human recombinant CA7 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID462829Activation of human recombinant CA1 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID461325Inhibition of human erythrocytes CA2 by Lineweaver-Burke analysis2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.
AID365828Activation of human recombinant CA2 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID1331203Activation of recombinant human carbonic anhydrase 1 at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (52.63)29.6817
2010's9 (47.37)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.13 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index40.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]