Autosomal Dominant Optic Atrophy

Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.

Synonym
Optic Atrophy, Juvenile
Optic Atrophy Type 1
Dominant Optic Atrophy
Autosomal Dominant Optic Atrophy
Kjer's Optic Atrophy
Kjer-Type Optic Atrophy
Autosomal Dominant Optic Atrophy Kjer Type
Kjer Type Optic Atrophy
Optic Atrophy, Hereditary, Autosomal Dominant
Optic Atrophy, Kjer Type
Optic Atrophy 1
Optic Atrophy, Autosomal Dominant

Excerpt	Reference
"Dominant optic atrophy is a rare inherited optic nerve degeneration caused by mutations in the mitochondrial fusion gene OPA1."	( Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J, 2012)
"Autosomal dominant optic atrophy is the most common hereditary optic atrophy disease and is characterized by central vision loss and degeneration of RGCs."	( Chen, J; Guan, MX; Huang, T; Riazifar, H, 2016)

Excerpt	Reference
"Dominant optic atrophy has been associated with mutations in the OPA1 gene, which encodes for a dynamin-related GTPase, a mitochondrial protein implicated in the formation and maintenance of mitochondrial network and morphology."	( Barbiroli, B; Barboni, P; Baruzzi, A; Carelli, V; Clementi, V; Iotti, S; Lodi, R; Longanesi, L; Malucelli, E; Schimpf, S; Tonon, C; Valentino, ML; Wissinger, B, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (2.56)	23.3326
1990's	0 (0.00)	12.5806
2000's	9 (23.08)	18.1394
2010's	23 (58.97)	28.8240
2020's	6 (15.38)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
creatine	low	1	0
lactic acid	low	1	0
histamine	low	1	0
carbonyl cyanide m-chlorophenyl hydrazone	low	1	0
idebenone	medium	3	1
miconazole	low	1	0
aspartic acid	low	2	0
histidine	low	1	0
arginine	low	2	0
pregnenolone	low	1	0
d-alpha tocopherol	low	1	0
paraquat	low	1	0
glutamic acid	low	3	0
n-acetylaspartic acid	low	1	0
brinzolamide	low	1	0
bradykinin	low	1	0
ginsenoside rg1	low	1	0
3-methylglutaconic acid	low	1	0
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone	low	2	0
6,7-dihydroxyflavone	low	1	0
cysteine	low	1	0
staurosporine	low	2	0
phosphocreatine	low	1	0
nad	low	1	0
cytochrome c-t	low	2	0
ubiquinone	medium	3	1
eye	low	2	0

Protein Targets (488)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Ferritin light chain	6	0	0	6
glp-1 receptor, partial	4	0	0	4
thioredoxin reductase	5	0	0	5
TDP1 protein	8	0	0	8
Smad3	2	0	0	2
nonstructural protein 1	1	0	0	1
67.9K protein	2	0	0	2
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
geminin	5	0	0	5
neuropeptide S receptor isoform A	2	0	0	2
TAR DNA-binding protein 43	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Microtubule-associated protein tau	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
Aromatase	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Histamine H2 receptor	3	0	1	4
Caspase-7	1	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	5	0	0	5
NFKB1 protein, partial	1	0	0	1
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	3	0	0	3
flap endonuclease 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Cytochrome P450 3A4	0	2	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
arylsulfatase A	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
lamin isoform A-delta10	6	0	0	6
Metabotropic glutamate receptor 6	0	2	2	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	1	0	7
Carbonic anhydrase 2	0	2	1	10
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	3	1	6
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	1	6
Glutamate receptor ionotropic, NMDA 2B	0	3	1	6
Glutamate receptor ionotropic, NMDA 2C	0	3	1	6
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	3	1	6
Glutamate receptor ionotropic, NMDA 3B	0	3	1	6
Carbonic anhydrase 4	0	1	0	4
Glutamate receptor ionotropic, NMDA 3A	0	3	1	6
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, CARBONIC ANHYDRASE IV	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
RAR-related orphan receptor gamma	5	0	0	5
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
cytochrome P450 2D6	4	0	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Carbonic anhydrase	0	1	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 12	0	1	0	4
Bile salt export pump	0	3	0	3
Carbonic anhydrase 3	0	1	0	3
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Carbonic anhydrase 4	0	2	0	5
Carbonic anhydrase 6	0	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 9	0	1	0	4
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 13	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	3
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
Chain A, PAPAIN	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
Luciferase	2	0	0	2
acetylcholinesterase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
GLI family zinc finger 3	3	0	0	3
AR protein	8	0	0	8
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
progesterone receptor	3	0	0	3
glucocorticoid receptor [Homo sapiens]	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	1	0	0	1
estrogen nuclear receptor alpha	7	0	0	7
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	2	0	0	2
thyroid hormone receptor beta isoform 2	5	0	0	5
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	2	0	5
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Cellular tumor antigen p53	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit delta	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	3	2	1	6
Glutamate receptor 2	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit beta-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit beta-2	3	2	1	6
Inositol monophosphatase 1	1	0	0	1
GABA theta subunit	3	2	0	5
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	3	2	0	5
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
USP1 protein, partial	3	0	0	3
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Pantothenate synthetase	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
ATAD5 protein, partial	2	0	0	2
Hsf1 protein	0	0	1	1
regulator of G-protein signaling 4	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peripheral myelin protein 22	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
EWS/FLI fusion protein	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	3	2	5
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase	0	0	0	3
Solute carrier family 22 member 1	0	1	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Histamine H3 receptor	0	1	2	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
G	2	0	0	2
vitamin D3 receptor isoform VDRA	2	0	0	2
huntingtin isoform 2	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	2	1	3
Cytochrome P450 2C19	0	2	0	2
Spike glycoprotein	1	0	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
NAD-dependent protein deacetylase	0	1	0	1
thyroid stimulating hormone receptor	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
pregnane X nuclear receptor	2	0	0	2
polyprotein	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
Acetylcholinesterase	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Androgen receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Aromatase	0	0	1	1
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sodium-dependent dopamine transporter	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
heat shock protein 90, putative	0	0	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Photosystem I iron-sulfur center	0	0	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Autosomal Dominant Optic Atrophy

Synonyms(12)

Research Excerpts

Overview

Context

Research

Studies (39)

Protein Targets (488)

Autosomal Dominant Optic Atrophy

Synonyms(12)

Research Excerpts

Overview

Context

Research

Studies (39)

Drugs Studied (34)

Protein Targets (488)