Page last updated: 2024-09-28

Kelly's Syndrome

A syndrome of DYSPHAGIA with IRON-DEFICIENCY ANEMIA that is due to congenital anomalies in the ESOPHAGUS (such as cervical esophageal webs). It is known as Patterson-Kelly syndrome in the United Kingdom.

Synonyms(6)

Synonym
Kelly's Syndrome
Patterson's Syndrome
Patterson-Brown-Kelly Syndrome
Plummer-Vinson Syndrome
Syndrome, Plummer-Vinson
Patterson-Kelly Syndrome

Research

Studies (41)

TimeframeStudies, This Condition (%)All Conditions %
pre-199015 (36.59)23.3326
1990's5 (12.20)12.5806
2000's10 (24.39)18.1394
2010's7 (17.07)28.8240
2020's4 (9.76)9.53
DrugIndicatedRelationship StrengthStudiesTrials
citric acid, anhydrous0low10
histamine0low10
pyridoxine0low10
thiamine0low10
fentanyl0low10
fluorouracil0low10
propofol0low10
argon0low10
barium sulfate0low50
carboplatin0low10
riboflavin0low20
digoxin0low10
barium0low10
ferrous fumarate0low10
nystatin a10low10
ferrous citrate0low10
vitamin b 120low30
folic acid0low10

Protein Targets (386)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
acetylcholinesterase3003
phosphopantetheinyl transferase2002
RAR-related orphan receptor gamma4004
estrogen receptor 2 (ER beta)4004
G2002
cytochrome P450 2D62002
euchromatic histone-lysine N-methyltransferase 25005
vitamin D3 receptor isoform VDRA1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 15005
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 11001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase2002
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
GLI family zinc finger 35005
aldehyde dehydrogenase 1 family, member A15005
nuclear receptor subfamily 1, group I, member 34004
glucocorticoid receptor [Homo sapiens]4004
farnesoid X nuclear receptor5005
estrogen nuclear receptor alpha7007
peroxisome proliferator activated receptor gamma4004
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
thyroid hormone receptor beta isoform a3003
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Beta-lactamase0101
Proto-oncogene tyrosine-protein kinase Src0101
3-dehydroquinate dehydratase0011
ATP-citrate synthase 0001
Ribonuclease T0001
Cell death-related nuclease 40001
3-dehydroquinate dehydratase0011
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Beta-lactamase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain1001
interleukin 82002
PAX80001
SMAD family member 22002
ATAD5 protein, partial2002
PPM1D protein1001
SMAD family member 32002
TDP1 protein4004
AR protein7007
STAT3, partial0101
thioredoxin glutathione reductase1001
Smad31001
progesterone receptor4004
regulator of G-protein signaling 42002
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor5005
67.9K protein2002
peroxisome proliferator-activated receptor delta3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
alpha-galactosidase2002
IDH12002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
thyroid stimulating hormone receptor2002
activating transcription factor 65005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)4004
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
tumor necrosis factor2002
nuclear factor erythroid 2-related factor 2 isoform 23003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
thyroid hormone receptor beta isoform 24004
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
nuclear receptor ROR-gamma isoform 11001
geminin2002
lethal factor (plasmid)2002
lamin isoform A-delta104004
Solute carrier organic anion transporter family member 1A40102
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump0505
Cellular tumor antigen p535005
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Integrin beta-31001
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB10203
Integrin alpha-IIb1001
Cytochrome P450 3A40101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Glutamate receptor 22002
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Nuclear receptor ROR-gamma1113
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10101
Luciferase2002
cytochrome P450 family 3 subfamily A polypeptide 44004
potassium voltage-gated channel subfamily H member 2 isoform d2002
Solute carrier family 22 member 1 0204
Nuclear receptor subfamily 1 group I member 20011
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Histamine H1 receptor0325
Mu-type opioid receptor0213
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20101
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV1001
glp-1 receptor, partial2002
Skn7p0001
thioredoxin reductase2002
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit2002
Microtubule-associated protein tau1001
Thrombopoietin1001
thyroid stimulating hormone receptor4004
EWS/FLI fusion protein2002
nonstructural protein 11001
arylsulfatase A1001
Histone H2A.x2002
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
chromobox protein homolog 11001
huntingtin isoform 21001
flap endonuclease 11001
serine/threonine-protein kinase mTOR isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
peripheral myelin protein 221001
survival motor neuron protein isoform d1001
muscleblind-like protein 1 isoform 11001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40102
Solute carrier family 22 member 80001
Epidermal growth factor receptor0101
Amyloid-beta precursor protein1001
Thymidylate synthase0202
Aromatase0101
Canalicular multispecific organic anion transporter 10101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Dihydrofolate reductase0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
USP1 protein, partial3003
glucocerebrosidase1001
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
DNA polymerase beta1001
Thymidylate synthase0202
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein1001
GLS protein2002
apical membrane antigen 1, AMA11001
bromodomain adjacent to zinc finger domain 2B1001
transforming acidic coiled-coil-containing protein 30001
DNA polymerase iota isoform a (long)2002
Solute carrier family 22 member 20001
Carbonic anhydrase 120001
Solute carrier family 22 member 30102
Carbonic anhydrase 10203
Carbonic anhydrase 20204
Plasma kallikrein0001
Carbonic anhydrase 30001
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40001
Carbonic anhydrase 60102
Histamine H2 receptor0123
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Histamine H2 receptor0011
Carbonic anhydrase0002
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0001
Solute carrier family 22 member 10203
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20203
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Histamine H3 receptor0123
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
caspase-31001
Bloom syndrome protein isoform 11001
D(1A) dopamine receptor1001
heat shock protein beta-12002
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M11001
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit pi2114
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-22114
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-32114
Gamma-aminobutyric acid receptor subunit alpha-62114
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit alpha-12114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
GABA theta subunit2114
Gamma-aminobutyric acid receptor subunit epsilon2114
UDP-glucuronosyltransferase 1A80001
Pyridoxal kinase0001
Bile salt export pump0101
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
15-lipoxygenase, partial1001
NPYLR7B0011
aryl hydrocarbon receptor1001
thyrotropin-releasing hormone receptor1001
mitogen-activated protein kinase 11001
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor1001
Riboflavin-binding protein0112
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Caspase-71001
Spike glycoprotein1001
10 kDa heat shock protein, mitochondrial0101
Inositol monophosphatase 11001
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]