Compounds > galegine
Page last updated: 2024-11-05

galegine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Galegine is an alkaloid found in the seeds of the plant Galega officinalis, commonly known as goat's rue. It is a potent hypoglycemic agent, meaning it lowers blood sugar levels. Galegine has been studied for its potential therapeutic applications in managing diabetes, particularly type 2 diabetes. It works by stimulating the release of insulin from pancreatic beta cells. However, its clinical use is limited due to its toxicity and potential side effects. Research continues to explore its potential therapeutic value, particularly in combination with other agents. Its synthesis involves complex organic chemistry methods, starting from naturally derived precursors.'

galegine: structure given in first source; from Verbesina encelioides and Gelega oficinalis plants; toxic to livestock [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
VerbesinagenusA plant genus of the family ASTERACEAE. Members contain galegine (GUANIDINES).[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Verbesina encelioidesspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID10983
CHEMBL ID111469
CHEBI ID5265
SCHEMBL ID868430
SCHEMBL ID8342952
MeSH IDM0200693

Synonyms (34)

Synonym
NCI60_041670
n-3,3-dimethylallylguanidine
galegin
guanidine, (3-methyl-2-butenyl)-
brn 1754651
(3-methylbut-2-enyl)guanidine
isopentenyl guanidine
galegine
C08303 ,
543-83-9
AKOS000276789
2-(3-methylbut-2-enyl)guanidine
chebi:5265 ,
CHEMBL111469
3-04-00-00465 (beilstein handbook reference)
dimethylallylguanidine
r469kqg1ef ,
isoamylene guanidine
unii-r469kqg1ef
guanidine, n-(3-methyl-2-buten-1-yl)-
3-methyl-2-butenylguanidine
n-(3-methyl-2-buten-1-yl)guanidine
galegine [mi]
1-guanidino-3-methyl-butene-2
isoamyleneguanidine
SCHEMBL868430
SCHEMBL8342952
DTXSID10202659 ,
n-3,3-dimethylallylguanidin
1-(3-methylbut-2-en-1-yl)guanidine
Q27106696
n-(3-methylbut-2-en-1-yl)guanidine
EN300-317748
dtxcid90125150

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The minimum toxic dose of 5-6 g/kg indicates a high toxicity when compared to other poisonous plants of the southeastern area of Buenos Aires province, Argentina."( Experimental toxicity of verbesina encelioides in sheep and isolation of galegine.
Campero, CM; Caracino, M; Chayer, R; Cosentino, B; Lopez, TA, 1996)		0.53

Dosage Studied

ExcerptRelevanceReference
" The higher dosed sheep became recumbent a few hours later and died 60 h after dosing without showing further signs."( Experimental toxicity of verbesina encelioides in sheep and isolation of galegine.
Campero, CM; Caracino, M; Chayer, R; Cosentino, B; Lopez, TA, 1996)		0.53
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
guanidinesAny organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID193687Percent change in diastolic blood pressure (mmHg)in anesthetized rats by i.v. administration1999Bioorganic & medicinal chemistry letters, Nov-15, Volume: 9, Issue:22
Further hypotensive metabolites from Verbesina caracasana.
AID352979Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.5 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352975Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.60 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID421872Cytotoxicity against human SF295 cells after 3 days by MTT assay2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Cytotoxic guanidine alkaloids from Pterogyne nitens.
AID352977Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.54 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID374700Antiobesity activity in high fat diet-induced obese BALB/c mouse model assessed as change in average daily body weight at 0.38 mmol/kg/day administered through diet for 28 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID193703Percent change in tidal volume expressed in microL in anesthetized rats by i.v. administration1999Bioorganic & medicinal chemistry letters, Nov-15, Volume: 9, Issue:22
Further hypotensive metabolites from Verbesina caracasana.
AID374697Hypoglycemic activity in ob/ob mouse model assessed as blood glucose level at 0.26 mmol/kg/day administered through diet for 28 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352938Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.57 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID1177547Antimicrobial activity against methicillin-resistant Staphylococcus aureus EMRSA-16 assessed as absence of growth after 18 hrs by MTT assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID352984Antiobesity activity in ob/ob mouse model assessed as change in average daily weight at 0.26 mmol/kg/day administered through diet for 28 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352939Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.70 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352978Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.62 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID193699Percent change in systolic blood pressure (mmHg)in anesthetized rats by i.v. administration1999Bioorganic & medicinal chemistry letters, Nov-15, Volume: 9, Issue:22
Further hypotensive metabolites from Verbesina caracasana.
AID1177546Antimicrobial activity against methicillin-resistant Staphylococcus aureus EMRSA-15 assessed as absence of growth after 18 hrs by MTT assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID352940Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.59 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352937Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.51 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID374704Antiobesity activity in high fat diet-induced obese BALB/c mouse model assessed as change in average daily food intake at 0.38 mmol/kg/day administered through diet for 28 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID193681Maximum rate of rise of the left ventricular isovolumetric pressure in anesthetized rats by i.v. administration1999Bioorganic & medicinal chemistry letters, Nov-15, Volume: 9, Issue:22
Further hypotensive metabolites from Verbesina caracasana.
AID352974Antiobesity activity in lean normal BALB/c mouse assessed as change in average daily weight at 0.5 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID1177548Bactericidal activity against multi-drug-resistant Staphylococcus aureus SA-1199B expressing NorA efflux pump incubated for 18 hrs followed by transfer to Petri dishes and measured after 24 hrs2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID352963Antiobesity activity in lean normal BALB/c mouse assessed as change in average daily food intake at 0.5 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID421869Cytotoxicity against human HL60 cells after 3 days by MTT assay2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Cytotoxic guanidine alkaloids from Pterogyne nitens.
AID352941Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.52 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID1177542Antimicrobial activity against multi-drug-resistant Staphylococcus aureus SA-1199B expressing NorA efflux pump assessed as absence of growth after 18 hrs by MTT assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID352976Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.72 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352936Toxicity in lean normal BALB/c mouse assessed as overt signs of behavioural changes at equimolar dose of 0.5 mmol/kg galegine administered daily through diet for 7 days2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID352942Hypoglycemic activity in lean normal BALB/c mouse assessed as blood glucose level at 0.5 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID1177544Antimicrobial activity against methicillin-resistant Staphylococcus aureus XU212 assessed as absence of growth after 18 hrs by MTT assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID421870Cytotoxicity against human HCT8 cells after 3 days by MTT assay2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Cytotoxic guanidine alkaloids from Pterogyne nitens.
AID193688Percent change in heart rate expressed in beats / min in anesthetized rats by i.v. administration1999Bioorganic & medicinal chemistry letters, Nov-15, Volume: 9, Issue:22
Further hypotensive metabolites from Verbesina caracasana.
AID1177543Antimicrobial activity against methicillin-resistant Staphylococcus aureus RN4220 assessed as absence of growth after 18 hrs by MTT assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID421871Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Cytotoxic guanidine alkaloids from Pterogyne nitens.
AID352948Antidiabetic activity in lean normal BALB/c mouse assessed as effect on blood lactate level at 0.40 mmol/kg/day administered through diet for 7 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID374708Hypoglycemic activity in high fat diet-induced obese BALB/c mouse model assessed as blood glucose level at 0.38 mmol/kg/day administered through diet for 28 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
AID193697Percent change in respiratory frequency (RF) expressed in beats / min in anesthetized rats by i.v. administration1999Bioorganic & medicinal chemistry letters, Nov-15, Volume: 9, Issue:22
Further hypotensive metabolites from Verbesina caracasana.
AID1177545Antimicrobial activity against Staphylococcus aureus ATCC25943 assessed as absence of growth after 18 hrs by MTT assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.
AID352987Antiobesity activity in ob/ob mouse model assessed as change in average daily food intake at 0.26 mmol/kg/day administered through diet for 28 days relative to time-matched control2009Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
Benzylguanidines and other galegine analogues inducing weight loss in mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (14.29)18.7374
1990's4 (28.57)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's3 (21.43)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 53.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index53.11 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.20 (4.65)
Search Engine Demand Index79.73 (26.88)
Search Engine Supply Index2.03 (0.95)

This Compound (53.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
agmatine
Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.		210guanidines;
primary amino compound		Escherichia coli metabolite;
mouse metabolite
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		7.4110alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
histamine
[no description available]		210aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
arcaine
arcaine: RN given refers to parent cpd; structure. 1,4-diguanidinobutane : A guanidine derivative consisting of butane having guanidino groups at the 1- and 4-positions.		2.0510guanidines
clonidine
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.		210clonidine;
imidazoline
debrisoquin
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.		2.0510carboxamidine;
isoquinolines		adrenergic agent;
antihypertensive agent;
human metabolite;
sympatholytic agent
dimaprit
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.		2.3110imidothiocarbamic ester
guanethidine
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.. guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.. guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.		210azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent
metformin
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.		7.4110guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
norfloxacin
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.		2.110fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		210benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		210alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		6.9310arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
phenformin
Phenformin: A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290). phenformin : A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis.		7.5220biguanidesantineoplastic agent;
geroprotector;
hypoglycemic agent
benzylguanidine
[no description available]		7.0510
hexamethonium chloride
[no description available]		210
piericidin a
piericidin A: pyridine-substituted fatty alcohol antibiotic; minor descriptor (75-85); on-line & Index Medicus search ANTIBIOTICS (75-85); RN given refers to (S-(R*,R*-(all-E)))-isomer. piericidin A : A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase		2.4110aromatic ether;
methylpyridines;
monohydroxypyridine;
secondary allylic alcohol		antimicrobial agent;
bacterial metabolite;
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor;
mitochondrial respiratory-chain inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Weight Reduction
[description not available]		02.4520
Weight Loss
Decrease in existing BODY WEIGHT.		02.4520
Blood Pressure, High
[description not available]		02.3110
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		02.3110
Disease, Pulmonary
[description not available]		01.9810
Ovine Diseases
[description not available]		01.9810
Lung Diseases
Pathological processes involving any part of the LUNG.		01.9810
Chronic Lung Injury
[description not available]		01.9910
Bright Disease
A historical classification which is no longer used. It described acute glomerulonephritis, acute nephritic syndrome, or acute nephritis. Named for Richard Bright.		01.9910
Bleeding
[description not available]		01.9910
Plant Poisoning
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.		01.9910
Glomerulonephritis
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.		01.9910
Hemorrhage
Bleeding or escape of blood from a vessel.		01.9910