Somatostatinoma

A SOMATOSTATIN-secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). It is also found in the INTESTINE. Somatostatinomas are associated with DIABETES MELLITUS; CHOLELITHIASIS; STEATORRHEA; and HYPOCHLORHYDRIA. The majority of somatostatinomas have the potential for METASTASIS.

Synonyms(1)

Synonym
Somatostatinoma

Research Excerpts

Overview

Excerpt	Reference
"A case of duodenal somatostatinoma is described in a patient with Von Recklinghausen neurofibromatosis."	( Gooszen, HG; Hagen, EC; Houben, GM; Jansen, JB; Lamers, CB; Meinders, AE; Nikkels, RE; van Duinen, SG, 1992)
"Five cases of somatostatinoma are reported, four being primarily located in the pancreas and one in the duodenum."	( Couturier, E; Gepts, W; Pipeleers, D; Reynders, J; Somers, G, 1983)
"A duodenal somatostatinoma is described in a patient suffering from a tumoral obstruction of the bile duct."	( Gepts, W; Pipeleers, D; Pipeleers-Marichal, M; Somers, G, 1983)
"Somatostatinoma is a rare neuroendocrine tumor which especially develops in the pancreas."	( Achim, F; Bacanu, F; Cociu, L; Constantin, A; Constantinoiu, S; Hoara, P; Iosif, C; Predescu, D; Surugiu, P, 2012)
"Somatostatinoma is one of the pNETs associated with tumors of pancreatic δ cells, which produce and secrete somatostatin."	( Chikazawa, K; Imaizumi, Y; Noda, S; Suzuki, Y; Yamamura, H, 2020)

Treatment

Excerpt	Reference
"The results of SRS and octreotide treatment in three somatostatinoma patients were examined."	( Angeletti, S; Annibale, B; Basso, N; Bordi, C; Corleto, VD; Delle Fave, G; Marignani, M; Moretti, A; Schillaci, O; Scopinaro, F; Silecchia, G, 1998)

Research

Studies (48)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	22 (45.83)	23.3326
1990's	13 (27.08)	12.5806
2000's	6 (12.50)	18.1394
2010's	6 (12.50)	28.8240
2020's	1 (2.08)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	1	1
histamine	low	1	0
niacinamide	low	1	0
theophylline	low	1	0
pentetic acid	medium	3	1
valproic acid	medium	1	1
fluorouracil	low	1	0
ag 1879	low	1	0
tolbutamide	low	2	0
tyrosine	low	1	0
arginine	low	1	0
barium sulfate	low	1	0
zidovudine	low	1	0
paxilline	low	1	0
xylose	low	1	0
bilirubin	low	1	0
pentagastrin	low	2	0
losartan potassium	low	1	0
cholecystokinin	low	2	0
(dtpa-phe(1))-octreotide	low	2	0
xenin 25	low	1	0
gastrins	low	5	0
glucagon	low	10	0
somatostatin-28	low	2	0
neuropeptide y	low	1	0
c-peptide	medium	4	1
neurotensin	low	5	0
vasoactive intestinal peptide	low	7	0
epidermal growth factor	low	1	0
transforming growth factor alpha	low	1	0
gallium ga 68 dotatate	low	1	0
dacarbazine	low	1	0

Protein Targets (460)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Lck Kinase	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	0	1
Chain A, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Tyrosine-protein kinase Lyn	0	1	0	1
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	2
TDP1 protein	6	0	0	6
Smad3	3	0	0	3
regulator of G-protein signaling 4	3	0	0	3
nonstructural protein 1	3	0	0	3
67.9K protein	3	0	0	3
LAP4	0	0	1	1
RPL19A	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
amino acid transporter AGP1	0	0	1	1
geminin	10	0	0	10
survival motor neuron protein isoform d	3	0	0	3
Receptor-interacting serine/threonine-protein kinase 2	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Epidermal growth factor receptor	0	3	0	3
Tyrosine-protein kinase Lck	0	2	0	2
Proto-oncogene tyrosine-protein kinase LCK	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Tyrosine-protein kinase Lyn	0	1	0	1
Tyrosine-protein kinase HCK	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-B receptor 2	0	1	1	2
Alpha-synuclein	1	0	0	1
Tyrosine-protein kinase CSK	0	1	0	1
Tyrosine-protein kinase ZAP-70	0	1	0	1
Casein kinase I isoform delta	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Mitogen-activated protein kinase 14	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	5	0	0	5
NFKB1 protein, partial	1	0	0	1
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	7	0	0	7
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	3	0	0	3
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	3	0	0	3
Cytochrome P450 3A4	0	0	0	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, Cruzipain	1	0	0	1
USP1 protein, partial	4	0	0	4
Microtubule-associated protein tau	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
vitamin D3 receptor isoform VDRA	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	7	0	0	7
Caspase-7	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
interleukin 8	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
AR protein	6	0	0	6
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
estrogen-related nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	8	0	0	8
cytochrome P450 2D6	2	0	0	2
peroxisome proliferator activated receptor gamma	4	0	0	4
thyroid stimulating hormone receptor	1	0	0	1
activating transcription factor 6	2	0	0	2
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Bile salt export pump	0	8	0	8
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	3	0	0	3
endonuclease IV	2	0	0	2
acetylcholinesterase	2	0	0	2
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	2	0	0	2
GLI family zinc finger 3	6	0	0	6
Thrombopoietin	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
progesterone receptor	1	0	0	1
EWS/FLI fusion protein	3	0	0	3
retinoid X nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	4	0	0	4
peroxisome proliferator-activated receptor delta	2	0	0	2
arylsulfatase A	4	0	0	4
IDH1	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
thyroid hormone receptor beta isoform 2	5	0	0	5
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
peripheral myelin protein 22	5	0	0	5
muscleblind-like protein 1 isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Cellular tumor antigen p53	3	0	0	3
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
Glutamate receptor 2	1	0	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Chain A, Ferritin light chain	1	0	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	3	0	3
GABA theta subunit	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	2	0	0	2
apical membrane antigen 1, AMA1	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Carbonic anhydrase 12	0	0	0	2
Solute carrier family 22 member 3	0	1	0	2
Carbonic anhydrase 1	0	0	0	2
Carbonic anhydrase 2	0	0	0	3
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	0	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	2
Carbonic anhydrase 6	0	0	0	2
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	2	0	5
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	5
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 7	0	0	0	2
Histamine H2 receptor	1	0	1	2
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Histamine H3 receptor	0	1	2	3
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
aryl hydrocarbon receptor	2	0	0	2
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
TPA: protein transporter TIM10	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
POsterior Segregation	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
BZLF2	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	0	1	1
Gastrin/cholecystokinin type B receptor	0	1	1	2
15-lipoxygenase, partial	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Spike glycoprotein	2	0	0	2
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium channel subfamily K member 2	0	0	2	2
Renin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
D(3) dopamine receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	2	5
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A1	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
G	1	0	0	1
Solute carrier family 22 member 6	0	1	0	2
Bile salt export pump	0	2	0	2
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Albumin	0	1	2	3
Albumin	0	0	1	1
Cytochrome P450 2C9	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	4
UDP-glucuronosyltransferase 1-6	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Aldo-keto reductase family 1 member B1	0	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Thymidine kinase, cytosolic	0	2	0	3
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Reverse transcriptase/RNaseH	0	1	2	6
Protease	0	1	1	2
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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