Page last updated: 2024-09-27

Somatostatinoma

A SOMATOSTATIN-secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). It is also found in the INTESTINE. Somatostatinomas are associated with DIABETES MELLITUS; CHOLELITHIASIS; STEATORRHEA; and HYPOCHLORHYDRIA. The majority of somatostatinomas have the potential for METASTASIS.

Synonyms(1)

Synonym
Somatostatinoma

Research Excerpts

Overview

ExcerptReference
"A case of duodenal somatostatinoma is described in a patient with Von Recklinghausen neurofibromatosis."( Gooszen, HG; Hagen, EC; Houben, GM; Jansen, JB; Lamers, CB; Meinders, AE; Nikkels, RE; van Duinen, SG, 1992)
"Five cases of somatostatinoma are reported, four being primarily located in the pancreas and one in the duodenum."( Couturier, E; Gepts, W; Pipeleers, D; Reynders, J; Somers, G, 1983)
"A duodenal somatostatinoma is described in a patient suffering from a tumoral obstruction of the bile duct."( Gepts, W; Pipeleers, D; Pipeleers-Marichal, M; Somers, G, 1983)
"Somatostatinoma is a rare neuroendocrine tumor which especially develops in the pancreas."( Achim, F; Bacanu, F; Cociu, L; Constantin, A; Constantinoiu, S; Hoara, P; Iosif, C; Predescu, D; Surugiu, P, 2012)
"Somatostatinoma is one of the pNETs associated with tumors of pancreatic δ cells, which produce and secrete somatostatin."( Chikazawa, K; Imaizumi, Y; Noda, S; Suzuki, Y; Yamamura, H, 2020)

Treatment

ExcerptReference
"The results of SRS and octreotide treatment in three somatostatinoma patients were examined."( Angeletti, S; Annibale, B; Basso, N; Bordi, C; Corleto, VD; Delle Fave, G; Marignani, M; Moretti, A; Schillaci, O; Scopinaro, F; Silecchia, G, 1998)

Research

Studies (48)

TimeframeStudies, This Condition (%)All Conditions %
pre-199022 (45.83)23.3326
1990's13 (27.08)12.5806
2000's6 (12.50)18.1394
2010's6 (12.50)28.8240
2020's1 (2.08)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium11
histamine0low10
niacinamide0low10
theophylline0low10
pentetic acid0medium31
valproic acid0medium11
fluorouracil0low10
ag 18790low10
tolbutamide0low20
tyrosine0low10
arginine0low10
barium sulfate0low10
zidovudine0low10
paxilline0low10
xylose0low10
bilirubin0low10
pentagastrin0low20
losartan potassium0low10
cholecystokinin0low20
(dtpa-phe(1))-octreotide0low20
xenin 250low10
gastrins0low50
glucagon0low100
somatostatin-280low20
neuropeptide y0low10
c-peptide0medium41
neurotensin0low50
vasoactive intestinal peptide0low70
epidermal growth factor0low10
transforming growth factor alpha0low10
gallium ga 68 dotatate0low10
dacarbazine0low10

Protein Targets (460)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Lck Kinase0101
Chain A, BCL-2-RELATED PROTEIN A10001
Chain A, Tyrosine-protein kinase Lyn0101
Chain A, Tyrosine-protein kinase Lyn0101
glp-1 receptor, partial3003
Skn7p0002
TDP1 protein6006
Smad33003
regulator of G-protein signaling 43003
nonstructural protein 13003
67.9K protein3003
LAP40011
RPL19A0011
nuclear factor erythroid 2-related factor 2 isoform 22002
amino acid transporter AGP10011
geminin100010
survival motor neuron protein isoform d3003
Receptor-interacting serine/threonine-protein kinase 20101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase ABL10101
Proto-oncogene tyrosine-protein kinase Src0112
Epidermal growth factor receptor0303
Tyrosine-protein kinase Lck0202
Proto-oncogene tyrosine-protein kinase LCK 0101
Tyrosine-protein kinase Fyn0101
Tyrosine-protein kinase Lyn0101
Tyrosine-protein kinase HCK0101
Proto-oncogene tyrosine-protein kinase Src0202
Ephrin type-A receptor 30011
Ephrin type-B receptor 20112
Alpha-synuclein1001
Tyrosine-protein kinase CSK0101
Tyrosine-protein kinase ZAP-700101
Casein kinase I isoform delta0101
TAR DNA-binding protein 434004
Mitogen-activated protein kinase 140101
HSP40, subfamily A [Plasmodium falciparum 3D7]0002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase5005
phosphopantetheinyl transferase5005
NFKB1 protein, partial1001
GLS protein3003
thyroid stimulating hormone receptor7007
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450 2C19 precursor2002
chromobox protein homolog 13003
flap endonuclease 13003
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)3003
Cytochrome P450 3A40001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Cruzipain1001
USP1 protein, partial4004
Microtubule-associated protein tau3003
aldehyde dehydrogenase 1 family, member A14004
vitamin D3 receptor isoform VDRA1001
DNA polymerase kappa isoform 11001
caspase-1 isoform alpha precursor1001
lamin isoform A-delta107007
Caspase-71001
Inositol monophosphatase 13003
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
interleukin 82002
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
AR protein6006
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha6006
estrogen nuclear receptor alpha8008
cytochrome P450 2D62002
peroxisome proliferator activated receptor gamma4004
thyroid stimulating hormone receptor1001
activating transcription factor 62002
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Bile salt export pump0808
Matrix metalloproteinase-90101
Isocitrate lyase0101
Canalicular multispecific organic anion transporter 10505
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase3003
endonuclease IV2002
acetylcholinesterase2002
pregnane X receptor2002
ATAD5 protein, partial2002
GLI family zinc finger 36006
Thrombopoietin1001
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor1001
EWS/FLI fusion protein3003
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor4004
pregnane X nuclear receptor4004
peroxisome proliferator-activated receptor delta2002
arylsulfatase A4004
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
thyroid hormone receptor beta isoform 25005
huntingtin isoform 22002
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 15005
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
peripheral myelin protein 225005
muscleblind-like protein 1 isoform 12002
Voltage-dependent calcium channel gamma-2 subunit1001
Solute carrier family 22 member 80001
Cellular tumor antigen p533003
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
Glutamate receptor 21001
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0022
bromodomain adjacent to zinc finger domain 2B4004
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a2002
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit alpha-20202
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit rho-20011
Gamma-aminobutyric acid receptor subunit alpha-60202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10303
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70303
GABA theta subunit0202
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit epsilon0202
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60303
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase2002
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
apical membrane antigen 1, AMA11001
potassium voltage-gated channel subfamily H member 2 isoform d3003
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Carbonic anhydrase 120002
Solute carrier family 22 member 30102
Carbonic anhydrase 10002
Carbonic anhydrase 20003
Plasma kallikrein0002
Carbonic anhydrase 30002
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40002
Carbonic anhydrase 60002
Histamine H2 receptor0123
Adenosine receptor A10205
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0105
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0002
Histamine H1 receptor0224
Glutamate receptor ionotropic, NMDA 1 0002
Carbonic anhydrase0002
Carbonic anhydrase 70002
Histamine H2 receptor1012
Carbonic anhydrase0003
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90002
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0003
Carbonic anhydrase0003
Glutamate receptor ionotropic, NMDA 2D0002
Solute carrier family 22 member 10102
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0002
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150002
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0002
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
Histamine H3 receptor0123
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
Neurotensin receptor type 10011
Neurotensin receptor type 20113
Myelin basic protein0011
Neurotensin receptor type 10112
Neurotensin receptor type 10225
Neurotensin receptor type 20213
Sortilin0101
Chain A, NAD-dependent deacetylase0101
aryl hydrocarbon receptor2002
Caspase-72002
caspase-32002
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Poly [ADP-ribose] polymerase 10101
Tissue factor0202
Cytochrome P450 3A50101
NAD-dependent protein deacetylase HST20101
Fatty-acid amide hydrolase 10101
Protein mono-ADP-ribosyltransferase PARP150101
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0202
NAD-dependent protein deacetylase 0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
TPA: protein transporter TIM100101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
tumor susceptibility gene 101 protein1001
POsterior Segregation0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20101
Sodium-dependent noradrenaline transporter 0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30101
Zinc finger protein mex-50011
BZLF20101
cytochrome P450 family 3 subfamily A polypeptide 42002
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0011
Gastrin/cholecystokinin type B receptor0112
15-lipoxygenase, partial1001
M-phase phosphoprotein 81001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Spike glycoprotein2002
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Phosphodiesterase 0202
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Potassium channel subfamily K member 20022
Renin0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
5-hydroxytryptamine receptor 1A0101
Intestinal-type alkaline phosphatase0101
Replicase polyprotein 1ab0101
Adenosine receptor A30101
Replicase polyprotein 1ab0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Thyroid hormone receptor beta0101
D(3) dopamine receptor0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A10202
Adenosine receptor A30101
Adenosine receptor A2a0225
Adenosine receptor A2b0102
Adenosine receptor A2b0102
Adenosine receptor A10215
Vasopressin V2 receptor0001
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Adenosine receptor A10101
Nuclear receptor ROR-gamma2002
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Guanine nucleotide-binding protein G1001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Adenylate cyclase type 10001
Chitotriosidase-10101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Sigma non-opioid intracellular receptor 10202
Adenosine receptor A2b0001
Palmitoleoyl-protein carboxylesterase NOTUM0011
Endochitinase B10101
Phospholipase A-2-activating protein0101
SMAD family member 22002
SMAD family member 32002
G1001
Solute carrier family 22 member 60102
Bile salt export pump0202
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Albumin0123
Albumin0011
Cytochrome P450 2C9 0202
UDP-glucuronosyltransferase 2B70204
UDP-glucuronosyltransferase 1-60102
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Lanosterol 14-alpha demethylase0101
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Aldo-keto reductase family 1 member B10001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
nuclear receptor subfamily 1, group I, member 21001
pyruvate kinase PKM isoform a1001
serine/threonine-protein kinase PLK11001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Thymidine kinase, cytosolic0203
Protein kinase C beta type0101
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Solute carrier organic anion transporter family member 1A30001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Solute carrier family 22 member 60001
Solute carrier family 22 member 70001
Reverse transcriptase/RNaseH 0126
Protease 0112
Solute carrier family 22 member 80001
Solute carrier family 22 member 110001
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
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