histamine has been researched along with jnj 7777120 in 46 studies
Timeframe | Studies, this research(%) | All Research% |
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pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 15 (32.61) | 29.6817 |
2010's | 30 (65.22) | 24.3611 |
2020's | 1 (2.17) | 2.80 |
Authors | Studies |
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Bakker, RA; De Esch, IJ; Leurs, R; Terzioglu, N; van Rijn, RM | 1 |
Bakker, RA; Leurs, R; Lim, HD; Ling, P; Thurmond, RL; van Rijn, RM | 1 |
Adami, M; Coruzzi, G; de Esch, IJ; Guaita, E; Hanzer, A; Leurs, R; Lim, HD; Smits, RA; Zuiderveld, OP | 1 |
Falus, A; Jelinek, I; Keseru, GM; Kiss, B; Kiss, R; Könczöl, A; László, V; Noszál, B; Szalai, F | 1 |
Adami, M; Broeker, J; Coruzzi, G; de Esch, IJ; Guaita, E; Haaksma, E; Leurs, R; Sansuk, K; Smits, RA; Zuiderveld, OP | 1 |
Kottke, T; Proschak, E; Sander, K; Schneider, EH; Schneider, G; Seifert, R; Stark, H; Tanrikulu, Y; Weizel, L | 1 |
Buschauer, A; Dove, S; Geyer, R; Igel, P; Seifert, R; Strasser, A | 1 |
de Esch, IJ; de Graaf, C; Istyastono, EP; Kooistra, AJ; Leurs, R; Lim, HD; Nijmeijer, S; Roumen, L; van de Stolpe, A; Vischer, HF | 1 |
Bessembinder, K; de Esch, IJ; Kuhne, S; Leurs, R; Lim, HD; Smits, RA; van der Meer, T; Wijtmans, M; Zuiderveld, OP | 1 |
Savall, BM; Thurmond, RL; Tichenor, MS; Venable, JD | 1 |
Elz, S; Gobleder, S; Hammer, SG; Heinrich, MR; Naporra, F; Strasser, A; Wittmann, HJ | 1 |
Buschauer, A; Geyer, R; Nordemann, U; Strasser, A; Wittmann, HJ | 1 |
Desai, PJ; Dunford, PJ; Karlsson, L; McQueen, D; Thurmond, RL; Williams, KN | 1 |
Chazot, P; Dijkstra, D; Gutzmer, R; Leurs, R; Shenton, FC; Stark, H; Werfel, T | 1 |
Eros, D; Falus, A; Keseru, GM; Kiss, R; Noszál, B; Rácz, A | 1 |
Jójárt, B; Keseru, GM; Kiss, R; Viskolcz, B | 1 |
Bakker, RA; de Esch, IJ; Haaksma, E; Jongejan, A; Leurs, R; Lim, HD | 1 |
Thurmond, RL; Tiligada, E; Zampeli, E | 1 |
Oda, M; Sato, H; Suwa, E; Suzuki, M; Ueno, K; Yamaura, K | 1 |
Kamitani, S; Kawasaki, S; Kohyama, T; Nagase, T; Takizawa, H; Yamauchi, Y | 1 |
Bäumer, W; Kietzmann, M; Leurs, R; Rossbach, K; Sander, K; Stark, H | 1 |
Beermann, S; Neumann, D; Seifert, R | 1 |
Gschwandtner, M; Gutzmer, R; Schäkel, K; Werfel, T | 1 |
Borrebaeck, CA; Broos, S; Greiff, L; Lindstedt, M; Lundberg, K | 1 |
Desai, P; Thurmond, RL | 1 |
Bäumer, W; Kietzmann, M; Olivry, T; Paps, J; Petersen, LJ; Sander, K; Stahl, J; Stark, H | 1 |
Bergoc, RM; Cricco, GP; Croci, M; Martinel Lamas, DJ; Massari, NA; Medina, VA; Rivera, ES; Sambuco, L | 1 |
Dartt, DA; Hayashi, C; Hayashi, D; Hodges, RR; Li, D; Shatos, M | 1 |
Hirasawa, N; Ohsawa, Y | 1 |
Jin, C; Karlstedt, K; Panula, P | 1 |
Gschwandtner, M; Gutzmer, R; Koether, B; Stark, H; Werfel, T | 1 |
Bäumer, W; Ehling, S; Glatzer, F; Gschwandtner, M; Gutzmer, R; Janik, K; Kietzmann, M; Klos, A; Rossbach, K; Werfel, T | 1 |
Sato, S; Suwa, E; Ueno, K; Yamaura, K | 1 |
De Man, JG; De Winter, BY; Deiteren, A; Moreels, TG; Pelckmans, PA; Ruyssers, NE | 1 |
Brown, V; Chazot, PL; Comer, D; Dib, K; Ennis, M; Jenei, V; Katebe, M; McFarlane, C; Perecko, T; Scheithauer, T; Thurmond, RL | 1 |
Kyriakidis, K; Palaiologou, M; Tiligada, E; Tiniakos, D; Zampeli, E | 1 |
Camussi, G; Chazot, PL; Grange, C; Lanzi, C; Moggio, A; Pini, A; Rosa, AC; Veglia, E | 1 |
Aromando, RF; Curotto, P; Farías, RO; Garabalino, MA; Gonzalez, SJ; Heber, EM; Itoiz, ME; Martinel Lamas, DJ; Medina, VA; Monti Hughes, A; Nigg, DW; Pozzi, E; Rivera, ES; Schwint, AE; Thorp, SI; Trivillin, VA | 1 |
Hong, SM; Lee, HM; Park, IH; Shin, JM; Um, JY | 1 |
Chlopicki, S; Grosicki, M; Kieć-Kononowicz, K; Wójcik, T | 1 |
Bäumer, W; Dunston, SM; Ehling, S; Roßbach, K; Stark, H | 1 |
Ahn, KJ; Choe, YB; Han, SH; Hur, MS; Kim, BM; Kim, HR; Kim, KW; Kim, MJ; Lee, YW | 1 |
Barbieri van Haaster, MM; Benítez, MB; Brandt, M; González, DA; Orman, B; Quinteros Villarruel, E; Stranieri, GM | 1 |
Ebenezer, AJ; Prasad, K; Rajan, S; Thangam, EB | 1 |
Fang, Q; Homberg, JR; Li, W; Liao, P; Liu, C; Luan, Y; Meng, X; Shan, L; Shen, J; Swaab, DF; Wang, J; Zhou, P | 1 |
Cremaschi, GA; Formoso, K; Herrero Ducloux, MV; Martinel Lamas, D; Massari, NA; Medina, VA; Nicoud, MB; Sterle, HA; Táquez Delgado, MA | 1 |
2 review(s) available for histamine and jnj 7777120
Article | Year |
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Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
Topics: Aminopyridines; Animals; Arthritis, Rheumatoid; Asthma; Dermatitis, Atopic; Drug Partial Agonism; Histamine Agonists; Histamine Antagonists; Humans; Hypersensitivity; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship | 2015 |
Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?
Topics: Animals; Asthma; Disease Models, Animal; Histamine; Humans; Indoles; Inflammation; Mice; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4 | 2010 |
44 other study(ies) available for histamine and jnj 7777120
Article | Year |
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Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
Topics: Benzimidazoles; Binding, Competitive; Cell Line; Histamine H1 Antagonists; Humans; Indoles; Ligands; Piperazines; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship | 2004 |
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
Topics: Cell Line; Histamine Agonists; Humans; Imidazoles; Indoles; Isothiuronium; Ligands; Methylhistamines; Piperazines; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Receptors, Histamine H4 | 2005 |
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Topics: Anti-Inflammatory Agents; Drug Design; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Receptors, Histamine; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2008 |
Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Topics: Binding, Competitive; Cell Line, Tumor; Databases, Factual; Histamine Antagonists; Humans; Ligands; Models, Molecular; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship | 2008 |
Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
Topics: Animals; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Drug Design; Histamine Agonists; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4 | 2008 |
2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization.
Topics: Ligands; Magnetic Resonance Spectroscopy; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2009 |
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
Topics: Animals; Drug Discovery; Guanidine; Guanidines; Guanosine Triphosphate; Histamine Agonists; Humans; Hydrolysis; Isotope Labeling; Mice; Models, Molecular; Protein Conformation; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship; Substrate Specificity | 2009 |
Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
Topics: Cell Line, Tumor; Histamine Antagonists; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Quantitative Structure-Activity Relationship; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Stereoisomerism; Thiourea | 2011 |
Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Topics: Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Design; Histamine Antagonists; Humans; Hypersensitivity; Inhibitory Concentration 50; Kinetics; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship; Time Factors | 2012 |
2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity.
Topics: Animals; Cell Line; Drug Inverse Agonism; Drug Partial Agonism; Histamine Agonists; Histamine Antagonists; Humans; Indoles; Ligands; Molecular Docking Simulation; Piperazines; Pyrimidines; Quinazolines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H4; Spodoptera | 2016 |
Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists.
Topics: Animals; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Histamine Agonists; Humans; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Protein Conformation; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Sf9 Cells; Spodoptera; Stereoisomerism; Structure-Activity Relationship | 2016 |
Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.
Topics: Animals; Disease Models, Animal; Edema; Female; Foot; Histamine; Histamine Agonists; Histamine Antagonists; Indoles; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Knockout; Piperazines; Pruritus; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H4 | 2007 |
Histamine downregulates monocyte CCL2 production through the histamine H4 receptor.
Topics: Calcium; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Down-Regulation; Histamine; Histamine Agonists; Humans; Imidazoles; Indoles; Interferon-gamma; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 8; Methylhistamines; Monocytes; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Thiourea; Up-Regulation | 2007 |
Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Crystallography, X-Ray; Histamine; Histamine Agonists; Histamine Antagonists; Humans; Indoles; Models, Molecular; Molecular Sequence Data; Piperazines; Protein Conformation; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Rhodopsin; Sequence Homology, Amino Acid | 2008 |
Activation mechanism of the human histamine H4 receptor--an explicit membrane molecular dynamics simulation study.
Topics: Binding Sites; Cell Membrane; Computer Simulation; Conserved Sequence; Drug Design; Extracellular Space; Histamine; Humans; Indoles; Intracellular Space; Ligands; Models, Molecular; Movement; Phosphatidylcholines; Piperazines; Protein Structure, Secondary; Protons; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Water | 2008 |
Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.
Topics: Amino Acid Sequence; Animals; Cell Line; Histamine; Humans; Indoles; Mice; Molecular Sequence Data; Phenylalanine; Piperazines; Receptors, Adrenergic, beta-2; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Species Specificity | 2008 |
The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva.
Topics: Animals; Conjunctiva; Conjunctivitis; Histamine; Histamine Antagonists; Indoles; Male; p-Methoxy-N-methylphenethylamine; Piperazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4 | 2009 |
Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist.
Topics: Animals; Disease Models, Animal; Epidermis; Histamine; Histamine Antagonists; Humans; Indoles; Keratinocytes; Male; Mice; Mice, Inbred ICR; Piperazines; Pruritus; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Substance P | 2009 |
Histamine stimulates human lung fibroblast migration.
Topics: Cell Migration Assays; Cell Movement; Cells, Cultured; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Fibroblasts; Fibronectins; Histamine; Histamine Antagonists; Humans; Indoles; Lung; Piperazines; Ranitidine; Receptors, Histamine; Wound Healing | 2010 |
The histamine H receptor as a new target for treatment of canine inflammatory skin diseases.
Topics: Animals; Calcium; Cell Line; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Female; Guanidines; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Indoles; Inflammation; Intercellular Signaling Peptides and Proteins; Male; Mastocytoma; Mice; Mice, Inbred BALB C; Peptides; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Skin Diseases; Thiourea; Wasp Venoms | 2009 |
Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity.
Topics: Amino Sugars; Cytokines; Dendritic Cells; Dermatitis, Atopic; Flow Cytometry; Histamine; Humans; Indoles; Inflammation; Interferon-gamma; Lipopolysaccharides; Methylhistamines; Piperazines; Psoriasis; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells.
Topics: Adult; Allergens; Case-Control Studies; Dendritic Cells; Female; Gene Expression Regulation; Histamine; Humans; Hypersensitivity; Indoles; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Piperazines; Pyrilamine; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H4; T-Lymphocytes; Transcription, Genetic; Young Adult | 2011 |
Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation.
Topics: Animals; Bone Marrow; Cells, Cultured; Enzyme Activation; Histamine; Indoles; Inflammation; Interleukin-6; Lipopolysaccharides; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Signal Transduction | 2011 |
Lack of preventing effect of systemically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of acute atopic dermatitis.
Topics: Aging; Animals; Antigens, Dermatophagoides; Cetirizine; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Dogs; Erythema; Female; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Hydroxyzine; Indoles; Male; Permeability; Piperazines; Skin; Skin Absorption; Triamcinolone | 2011 |
Role of H4 receptor in histamine-mediated responses in human melanoma.
Topics: Cell Differentiation; Cell Growth Processes; Cell Line, Tumor; Guanidines; Histamine; Humans; Imidazoles; Immunohistochemistry; Indoles; Melanoma; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; RNA, Messenger; Skin Neoplasms; Thiourea | 2011 |
Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion.
Topics: Animals; Blotting, Western; Cells, Cultured; Cimetidine; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Goblet Cells; Histamine; Histamine Agonists; Histamine Antagonists; Humans; Indoles; Male; Methylhistamines; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Histamine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles | 2012 |
The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Bone Marrow Cells; Chemokine CCL17; Chemokine CCL22; Cytokines; Dermatitis, Atopic; Dibenzoxepins; Disease Models, Animal; Down-Regulation; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine Release; Immunoglobulin E; Indoles; Male; Mast Cells; Mice; Olopatadine Hydrochloride; Picryl Chloride; Piperazines; Receptors, Histamine H1; Semaphorin-3A | 2012 |
Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Line; Dose-Response Relationship, Drug; Endothelial Cells; Histamine; Imidazoles; Indoles; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Profiling of histamine H4 receptor agonists in native human monocytes.
Topics: Cell Line; Dose-Response Relationship, Drug; Histamine; Histamine Agonists; Histamine Antagonists; Humans; Indoles; Interleukin-12; Ligands; Monocytes; Piperazines; Ranitidine; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H2; Receptors, Histamine H4; Transfection | 2013 |
Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor.
Topics: Animals; Cell Line; Cell Proliferation; Dermatitis, Atopic; Female; Gene Expression Regulation; Histamine; Histamine Antagonists; Humans; Indoles; Keratinocytes; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Peptidoglycan; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4 | 2013 |
Increased expression of the histamine H4 receptor following differentiation and mediation of the H4 receptor on interleukin-8 mRNA expression in HaCaT keratinocytes.
Topics: Cell Differentiation; Cell Line; Gene Expression Regulation; Histamine; Humans; Indoles; Interleukin-8; Keratinocytes; Piperazines; Protein Precursors; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; RNA, Messenger; Tumor Necrosis Factor-alpha | 2014 |
Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.
Topics: Animals; Cetirizine; Colitis; Colonoscopy; Convalescence; Disease Models, Animal; Histamine; Histamine H1 Antagonists, Non-Sedating; Histamine Release; Hypersensitivity; Indoles; Intestinal Mucosa; Male; Mast Cells; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H4; Regeneration; Trinitrobenzenesulfonic Acid | 2014 |
The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils.
Topics: Cell Adhesion; Cell Degranulation; Cell Line, Tumor; Cell Shape; Cells, Cultured; Cytochalasin B; Fibrinogen; Histamine; Humans; Indoles; Leukemia, Promyelocytic, Acute; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; MAP Kinase Signaling System; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oximes; p38 Mitogen-Activated Protein Kinases; Piperazines; Piperidines; Protein Conformation; Pyridines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; RNA, Messenger | 2014 |
Histamine H3 and H4 receptor ligands modify vascular histamine levels in normal and arthritic large blood vessels in vivo.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Arthritis, Experimental; Azepines; Dimethindene; Endothelium; Freund's Adjuvant; Histamine; Histamine H1 Antagonists; Histamine H3 Antagonists; Indoles; Inflammation; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Vena Cava, Inferior | 2015 |
Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation.
Topics: Benzazepines; Cell Line; Chlorpheniramine; Dose-Response Relationship, Drug; Epithelial Cells; Histamine; Histamine Antagonists; Humans; In Vitro Techniques; Indoles; Kidney Tubules; Niacinamide; Piperazines; Ranitidine; Receptors, Histamine; Second Messenger Systems | 2015 |
Histamine reduces boron neutron capture therapy-induced mucositis in an oral precancer model.
Topics: Animals; Boron Neutron Capture Therapy; Cricetinae; Disease Models, Animal; Histamine; Indoles; Mouth Neoplasms; Piperazines; Precancerous Conditions; Radiation Injuries, Experimental; Radiation-Protective Agents; Stomatitis | 2015 |
Stimulatory effects of histamine on migration of nasal fibroblasts.
Topics: Cell Adhesion; Cell Movement; Cells, Cultured; Cytoskeleton; Estrenes; Fibroblasts; Histamine; Humans; Immunization; Indoles; Pertussis Toxin; Piperazines; Pyrrolidinones; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Signal Transduction; Turbinates | 2015 |
In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium.
Topics: Cell Adhesion; Cell Communication; Cell Line; Cell Separation; Cell Survival; Drug Inverse Agonism; Endothelium; Eosinophils; Histamine; Histamine Agonists; Histamine H1 Antagonists; Humans; Indoles; Ligands; Methylhistamines; N-Formylmethionine Leucyl-Phenylalanine; Piperazines; Piperidines; Receptors, Histamine | 2016 |
Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo.
Topics: Animals; Chemokine CCL17; Chemotaxis; Coculture Techniques; Dendritic Cells; Dermatitis, Atopic; Disease Models, Animal; Female; Histamine; Humans; Indoles; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperazines; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Skin; Toluene 2,4-Diisocyanate | 2016 |
Preliminary study of histamine H
Topics: Cell Separation; Dermatitis, Seborrheic; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Histamine; Humans; Indoles; Interleukin-17; Interleukin-23; Piperazines; Psoriasis; Receptors, Histamine H4; Recombinant Proteins; Signal Transduction; Th17 Cells | 2017 |
Histamine stimulates secretion of extracellular vesicles with nucleotidase activity in rat submandibular gland.
Topics: Animals; Extracellular Vesicles; Histamine; In Vitro Techniques; Indoles; Male; Microscopy, Electron, Transmission; Nucleotidases; Piperazines; Rats; Rats, Wistar; Submandibular Gland | 2018 |
Silencing of H4R inhibits the production of IL-1β through SAPK/JNK signaling in human mast cells.
Topics: Calcium; Cell Line; Gene Expression Regulation; Gene Silencing; Histamine; Humans; Indoles; Interleukin-1beta; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mast Cells; Methylhistamines; Piperazines; Pyrilamine; Receptors, Histamine H4; RNA, Small Interfering | 2018 |
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopaminergic Neurons; Histamine; Indoles; Inflammation; Male; Microglia; Nerve Degeneration; Parkinson Disease; Parkinsonian Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H4; Rotenone | 2019 |
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Databases, Factual; Female; Histamine; Histamine Agonists; Histamine Antagonists; Histidine Decarboxylase; Humans; Indoles; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred BALB C; Mice, Knockout; Oximes; Piperazines; Prognosis; Receptors, Histamine H4; Triple Negative Breast Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |