histamine has been researched along with Pruritus in 552 studies
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation." | 9.69 | Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. ( Ammitzbøll, N; Arendt-Nielsen, L; Drewes, AM; Lo Vecchio, S; Okutani, H, 2023) |
| " The aim of this study was to investigate the anti-pruritic effect of capsaicin against histamine-induced pruritus compared with that of topical steroid or vehicle in 15 healthy beagles." | 9.27 | Anti-pruritic effect of topical capsaicin against histamine-induced pruritus on canine skin. ( Bae, S; Jeong, H; Oh, T; Yu, J, 2018) |
| "Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects." | 9.20 | Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. ( Forster, C; Handwerker, HO; Hartmann, EM, 2015) |
| " Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire." | 9.20 | A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. ( Bauer, M; Lang-Zwosta, I; Nishino, K; Scherzer, T; Schwameis, R; Zeitlinger, M, 2015) |
| "The histamine H4 receptor (H4R) is a promising target for the treatment of pruritus." | 9.19 | The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects. ( Chen, B; Dunford, PJ; Francke, K; Greenspan, AJ; Kollmeier, A; Thurmond, RL; Xia, Y; Xu, XL; Zhou, B, 2014) |
| "H1-antihistamines are the first-line treatment of chronic idiopathic urticaria (CIU), but CIU is occasionally refractory to the conventional treatment doses." | 9.17 | Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations. ( Kabashima, K; Miyachi, Y; Nakahigashi, K; Tanizaki, H, 2013) |
| "To investigate the mechanism(s) by which SCG relieves allergen- and histamine-induced dermal inflammation by assessing its effects on pruritus, flare, skin temperature and weal volume." | 9.14 | Topical sodium cromoglicate relieves allergen- and histamine-induced dermal pruritus. ( Church, MK; Escribano, L; Magerl, M; Martus, P; Maurer, M; Vieira Dos Santos, R; Zuberbier, T, 2010) |
| "To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally." | 9.14 | Responses to intradermal injections of substance P in psoriasis patients with pruritus. ( Amatya, B; Nordlind, K; Wahlgren, CF, 2010) |
| "Our data show a tendency to suppressive effect of montelukast on flare and itching but not on wheal which is basic for SPT interpretation." | 9.12 | The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests. ( Górski, P; Kuna, P; Kupczyk, M; Kupryś, I, 2007) |
| "Elevated plasma histamine levels are considered to play a part in the pathophysiology of hemodialysis-related pruritus." | 9.10 | Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy. ( Domröse, U; Dunker, N; Gollnick, H; Neumann, KH; Weisshaar, E, 2003) |
| "The present study examines the efficacy of second-generation antihistamines in relieving pruritus due to AD." | 9.10 | Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels. ( Imaizumi, A; Kawakami, T; Mizoguchi, M; Murakami, F; Soma, Y, 2003) |
| "Naltrexone 50 mg per day by mouth was given to 15 haemodialysis patients with severe resistant pruritus in a randomised, double-blind, placebo-controlled crossover trial." | 9.08 | Randomised crossover trial of naltrexone in uraemic pruritus. ( Agami, O; Blum, M; Fireman, E; Kivity, S; laina, A; Peer, G; Silverberg, D, 1996) |
| "The present data do not support the thesis that the increased plasma histamine concentration is causally related to pruritus in hemodialysis patients or that the antiallergic drug, azelastin HCL, alleviates the pruritus of dialysis patients by decreasing plasma histamine levels." | 9.07 | Effects of azelastin on pruritus and plasma histamine levels in hemodialysis patients. ( Hamada, M; Hasegawa, M; Ida, M; Matsui, C; Morohashi, M, 1994) |
| "We undertook a 10-week placebo-controlled, double-blind, crossover study in a group of patients receiving hemodialysis who had severe pruritus, to investigate the effects of recombinant human erythropoietin on their pruritus and plasma histamine levels." | 9.07 | Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. ( Bartoli, E; Cecchin, E; De Marchi, S; Santini, G; Sepiacci, G; Villalta, D, 1992) |
| "2 antipruritic ointments, when compared to placebo, were ineffective against histamine-induced itching applied in 2 volunteers after the intracutaneous injection of histamine." | 9.05 | Placebo-controlled study of the efficacy of topical antihistaminics against histamine-induced pruritus. ( Milsmann, E; Rohdewald, P, 1985) |
| "This study evaluates the ability of hydroxyzine and various neuroleptics to suppress histamine-induced pruritus in ten volunteer subjects with the use of a double-blind crossover protocol." | 9.04 | Suppression of histamine-induced pruritus by hydroxyzine and various neuroleptics. ( Ahmed, AR; Arnold, AJ; Jones, HE; Simpson, JG, 1979) |
| "A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects." | 9.04 | Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975) |
| " The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers." | 9.04 | The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. ( Davies, MG; Horton, RJ; Marks, R; Storari, FE, 1979) |
| " We aimed to compare the effects of cromolyn sodium and other medications on cholestatic pruritus, serum biochemistry, histamine, total bile acids, autotaxin, liver histopathology, and mast cell distribution in tissues in an experimental cholestasis model conducted by bile duct ligation." | 8.31 | The Investigation of Therapeutic Implications of Mast Cell Stabilizer Cromolyn Sodium on Cholestasis and Cholestatic Pruritus in Experimental Cholestasis. ( Barut, F; Can, M; Hussen, SU; Özbakış Dengiz, G; Üstündağ, Y; Yılmaz Ürün, Y; Yurdakul Ertan, H, 2023) |
| "Our results suggest that functional inhibition of histamine receptor 4 by adriforant reduces itch and inflammation in vivo." | 8.31 | Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. ( Bäumer, W; Bruno, S; Delucis-Bronn, C; Fehlmann, D; Goetschy, JF; Hauchard, A; Kaupmann, K; Kempf, D; Raulf, F; Röhn, TA; Roussel, E; Stark, H; Uluckan, Ö; Urban, B; Wack, N; Wang, Y; Wilzopolski, J; Zerwes, HG, 2023) |
| "Oxytocin (OXT) is secreted in a large amount during the middle and late pregnancy." | 8.31 | Oxytocin increases itch sensitivity of mice in late pregnancy and its peripheral receptor mechanism of itch-promoting effect. ( Chen, LY; Li, H; Wang, XD; Wu, ZY; Xi, EP; Yang, G, 2023) |
| "Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent." | 8.12 | Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain. ( Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J, 2022) |
| " Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine." | 7.96 | Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. ( Funahashi, H; Haruta-Tsukamoto, A; Ishida, Y; Miyahara, Y; Nishimori, T, 2020) |
| "This study compared the sensory qualities evoked by different models of experimentally induced pruritus including skin prick testing (SPT) with histamine or capsaicin and application of cowhage spicules." | 7.91 | Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage. ( Altrichter, S; Church, MK; Deuring, E; Hawro, T; Lehmann, S; Maurer, M; Metz, M; Weller, K, 2019) |
| " After the capsaicin-induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25-40 spicules)." | 7.85 | Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N, 2017) |
| "This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers." | 7.83 | Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Imai, Y; Koenig, J; Petersen, KK, 2016) |
| "To date, suggestions that endothelin-1 (ET-1) causes nociception and pruritus are based on results in preclinical models in which responses to pruritic and nociceptive stimuli cannot be distinguished." | 7.78 | Endothelin-1 induces itch and pain in the mouse cheek model. ( Gomes, LO; Hara, DB; Rae, GA, 2012) |
| "Six allergic conjunctivitis patients (12 eyes) and 4 healthy volunteers (8 eyes) were investigated in terms of the effect of cooling sheets on eye itching and tear histamine concentration, before and 5 min after cooling the eyelids with cooling sheets." | 7.76 | Relation between cooling sheet effect and tear histamine concenration in allergic conjunctivitis. ( Hirakawa, N; Yano, H; Yanoshita, R; Yoshii, M, 2010) |
| "We investigated the character of histamine H(1) receptor and H(4) receptor in allergic conjunctivitis." | 7.75 | Role of histamine H(4) receptor in allergic conjunctivitis in mice. ( Kagawa, Y; Kamei, C; Kurata, Y; Nakano, Y; Ono, R; Takahashi, Y, 2009) |
| "The contribution of the novel histamine H(4) receptor to histaminergic and allergic pruritus was investigated." | 7.74 | Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. ( Desai, PJ; Dunford, PJ; Karlsson, L; McQueen, D; Thurmond, RL; Williams, KN, 2007) |
| "Having observed altered itch and flare reactions after histamine application in patients with atopic eczema, we tried to determine these reactions in patients with urticaria and psoriasis." | 7.70 | Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria. ( Handwerker, HO; Heyer, G; Koppert, W; Martus, P, 1998) |
| "While histamine is the crucial mediator of pruritus in type 1 allergic reactions, its role in atopic dermatitis (AD) is unclear." | 7.70 | Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. ( Heyer, G; Lischetzki, G; McGlone, F; Rukwied, R; Schmelz, M, 2000) |
| "Pruritus is a common symptom in uraemic patients and its aetiology is poorly understood, although several factors have been implicated, including high histamine plasma levels." | 7.69 | Uraemic pruritus is not related to plasma histamine concentrations. ( De Filippi, C; Galli, F; Piazza, V; Pisati, P; Regazzini, R; Sacchi, S; Salvadeo, A, 1995) |
| "The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)." | 7.69 | Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996) |
| "The incidence of red man syndrome (RMS) and its relationship to histamine were investigated in patients receiving vancomycin or an aminoglycoside (control)." | 7.68 | Prospective evaluation of red man syndrome in patients receiving vancomycin. ( Lamp, KC; O'Sullivan, TL; Ruffing, MJ; Rybak, MJ; Warbasse, LH, 1993) |
| "Fifty-four uremic patients (26 patients were maintained on continuous ambulatory peritoneal dialysis [CAPD] and 28 on hemodialysis [HD]) were screened for pruritus and plasma histamine." | 7.68 | Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. ( Fritz, P; Hübel, E; Kuhlmann, U; Machleidt, C; Mettang, T; Weber, J, 1990) |
| "A role for histamine in the pathogenesis of uremic pruritus was investigated in maintenance hemodialysis patients." | 7.68 | Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. ( Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES, 1991) |
| "Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to glomerular capillaries and arterial endothelium." | 7.68 | Plasma histamine in patients with chronic renal failure and nephrotic syndrome. ( Balliod, R; Barradas, MA; Dandona, P; Fonseca, VA; Gill, DS; Moorhead, JF, 1991) |
| " We determined plasma levels of histamine in uraemic patients and examined their correlation with the presence of pruritus." | 7.68 | Increased plasma histamine levels in uraemic pruritus. ( Balcke, P; Grimm, G; Kurz, RW; Sertl, K; Stockenhuber, F, 1990) |
| "We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr." | 7.67 | Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. ( Farnam, J; Grant, JA; Guernsey, BG; Jorizzo, JL; Petrusa, ER, 1984) |
| "We have studied the influence of cold exposure on itch, erythema and wheal, in response to histamine scratch tests, in 14 volunteers." | 7.67 | The relevance of low skin temperature inhibiting histamine-induced itch to the location of contact urticarial symptoms in the fish processing industry. ( Halkier-Sørensen, L; Thestrup-Pedersen, K, 1989) |
| "We studied blood histamine activity (HA) and cutaneous fibrinolytic activity (CFA) in a patient with polycythaemia rubra vera (PRV) and water-induced pruritus, before and after water exposure." | 7.67 | Polycythaemia rubra vera and water-induced pruritus: blood histamine levels and cutaneous fibrinolytic activity before and after water challenge. ( Brunetti, L; Greaves, MW; Kobza-Black, A; Lotti, TM; Panconesi, E; Steinman, HK, 1987) |
| "The effects of topical treatment with capsaicin or mustard oil on histamine-induced pruritus, wheal formation and flare response were studied in the human skin." | 7.67 | Capsaicin prevents histamine-induced itching. ( Bognár, A; Husz, S; Jancsó, G; Obál, F; Tóth-Kása, I, 1986) |
| " Blood specimens were obtained from each arm serially over a one-hour interval, and serum speciments were assessed for histamine, eosinophil chemotactic factor of anaphylaxis, and complement components." | 7.65 | Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. ( Austen, KF; Soter, NA; Wasserman, SI, 1976) |
| "Deep muscle pain is often associated with sensory changes in the corresponding dermatome." | 6.71 | Interaction between histamine-induced itch and experimental muscle pain. ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004) |
| "Histamine-induced flare was quantified using laser-Doppler flowmetry." | 6.70 | Influence of vagus nerve stimulation on histamine-induced itching. ( Birklein, F; Haslbeck, KM; Kirchner, A; Schmelz, M; Stefan, H, 2002) |
| "Pruritus is a common, unpleasant symptom of uremic patients." | 6.69 | Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. ( Balaskas, EV; Bamihas, GI; Karamouzis, M; Tourkantonis, A; Voyiatzis, G, 1998) |
| "In control subjects, but not in atopic eczema (AE) patients, capsaicin pretreatment significantly reduced the flare area." | 6.69 | Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. ( Forster, C; Handwerker, HO; Heyer, G; Weisshaar, E, 1998) |
| "Histamine was applied iontophoretically to the forearm skin and the following parameters were assessed thereafter: weal and flare size, itch intensity and the extension of the area of alloknesis ('itchy skin') around the application site." | 6.68 | Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis. ( Diepgen, LT; Dotzer, M; Handwerker, OH; Heyer, G, 1997) |
| "Pruritus was evoked by intradermal injection of histamine and the histamine liberator compound 48/80." | 6.66 | Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80. ( Fjellner, B; Lengstam, I; Lindelöf, B; Wahlgren, CF, 1989) |
| "Pruritus was provoked by intradermal injection of histamine on the upper arm." | 6.65 | The influence of mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on experimental pruritus induced by histamine. ( Ekblom, A; Fjellner, B; Hansson, P, 1984) |
| "Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation." | 5.69 | Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. ( Ammitzbøll, N; Arendt-Nielsen, L; Drewes, AM; Lo Vecchio, S; Okutani, H, 2023) |
| "Because pain and pruritus are clearly distinct nociceptive sensory modalities in humans, the current study evaluates the potential of ET-1 to elicit scratching behavior in mice." | 5.33 | Endothelin-1 causes pruritus in mice. ( D'Orléans-Juste, P; Fernandes, MB; Rae, GA; Trentin, PG, 2006) |
| " The aim of this study was to investigate the anti-pruritic effect of capsaicin against histamine-induced pruritus compared with that of topical steroid or vehicle in 15 healthy beagles." | 5.27 | Anti-pruritic effect of topical capsaicin against histamine-induced pruritus on canine skin. ( Bae, S; Jeong, H; Oh, T; Yu, J, 2018) |
| "Persistent pruritus is one of the most common symptoms in hemodialysis patients." | 5.27 | [Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels]. ( Kuze, M; Sanada, S; Yoshida, O, 1987) |
| " A histamine-induced itch was evoked on the left dorsal forearms of healthy participants, who were asked to report the subjective sensation of itching every 30s for 23 min." | 5.22 | A transcranial direct current stimulation over the sensorimotor cortex modulates the itch sensation induced by histamine. ( Kakigi, R; Koyama, S; Mochizuki, H; Nakagawa, K; Sadato, N; Tanaka, S, 2016) |
| "Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects." | 5.20 | Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. ( Forster, C; Handwerker, HO; Hartmann, EM, 2015) |
| " Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire." | 5.20 | A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. ( Bauer, M; Lang-Zwosta, I; Nishino, K; Scherzer, T; Schwameis, R; Zeitlinger, M, 2015) |
| "The histamine H4 receptor (H4R) is a promising target for the treatment of pruritus." | 5.19 | The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects. ( Chen, B; Dunford, PJ; Francke, K; Greenspan, AJ; Kollmeier, A; Thurmond, RL; Xia, Y; Xu, XL; Zhou, B, 2014) |
| " This study has compared the antipruritic efficacy of topical polidocanol in histamine-induced itch and a histamine-independent, cowhage-induced model of pruritus." | 5.19 | Polidocanol inhibits cowhage - but not histamine-induced itch in humans. ( Church, MK; Fluhr, JW; Hawro, T; Maurer, M; Mengeaud, V; Metz, M; Redoulès, D, 2014) |
| "H1-antihistamines are the first-line treatment of chronic idiopathic urticaria (CIU), but CIU is occasionally refractory to the conventional treatment doses." | 5.17 | Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations. ( Kabashima, K; Miyachi, Y; Nakahigashi, K; Tanizaki, H, 2013) |
| "Red man syndrome (RMS) is a well-known adverse reaction that occurs in pediatric patients receiving vancomycin, yet reported prevalence is varied, and characteristics and risk factors are not well understood." | 5.16 | Defining risk factors for red man syndrome in children and adults. ( Dai, H; Gaedigk, A; James, LP; Jones, BL; Myers, AL; Neville, KA, 2012) |
| "To investigate the mechanism(s) by which SCG relieves allergen- and histamine-induced dermal inflammation by assessing its effects on pruritus, flare, skin temperature and weal volume." | 5.14 | Topical sodium cromoglicate relieves allergen- and histamine-induced dermal pruritus. ( Church, MK; Escribano, L; Magerl, M; Martus, P; Maurer, M; Vieira Dos Santos, R; Zuberbier, T, 2010) |
| "To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally." | 5.14 | Responses to intradermal injections of substance P in psoriasis patients with pruritus. ( Amatya, B; Nordlind, K; Wahlgren, CF, 2010) |
| " Overall, 51 healthy volunteers underwent a histamine skin prick test on both arms in order to trigger local pruritus." | 5.14 | Ethyl chloride as an antipruritic agent: a double-blind placebo-controlled prospective study. ( Gal-Oz, A; Kivity, S; Rogowski, O; Swartzon, M, 2010) |
| "Our data show a tendency to suppressive effect of montelukast on flare and itching but not on wheal which is basic for SPT interpretation." | 5.12 | The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests. ( Górski, P; Kuna, P; Kupczyk, M; Kupryś, I, 2007) |
| "This study was conducted to assess the pharmacodynamic effects (ie, inhibition of wheal response to cutaneous histamine challenge, and subjective assessments of itching, flare, and pain) and tolerability of the fast-dissolving 20-mg ebastine tablet formulation compared with desloratadine 5-mg capsule and placebo." | 5.12 | Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult ( Antonijoan, R; Barbanoj, MJ; Esbrí, R; Fortea, J; García-Gea, C; Pérez, J; Puntes, M; Serra, C, 2007) |
| "Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis." | 5.10 | Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses. ( Furue, M; Koga, T; Morita, K; Moroi, Y; Urabe, K, 2002) |
| "Elevated plasma histamine levels are considered to play a part in the pathophysiology of hemodialysis-related pruritus." | 5.10 | Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy. ( Domröse, U; Dunker, N; Gollnick, H; Neumann, KH; Weisshaar, E, 2003) |
| " Histamine always provoked itching and rarely pain, capsaicin always pain but never itching." | 5.10 | Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. ( Handwerker, HO; Hilliges, M; Schmelz, M; Schmidt, R; Torebjork, HE; Weidner, C, 2003) |
| "The present study examines the efficacy of second-generation antihistamines in relieving pruritus due to AD." | 5.10 | Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels. ( Imaizumi, A; Kawakami, T; Mizoguchi, M; Murakami, F; Soma, Y, 2003) |
| "We investigated the effects of tactile allodynia on the itch and mechanically evoked dysesthesiae produced by an intradermal injection of histamine in human volunteers." | 5.09 | Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. ( Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J, 1999) |
| "We have studied experimentally induced itch (using histamine iontophoresis) and pain (using topical mustard oil) in healthy human volunteers, measured using visual analogue scale (VAS) ratings." | 5.08 | A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain. ( McMahon, SB; Ward, L; Wright, E, 1996) |
| "Naltrexone 50 mg per day by mouth was given to 15 haemodialysis patients with severe resistant pruritus in a randomised, double-blind, placebo-controlled crossover trial." | 5.08 | Randomised crossover trial of naltrexone in uraemic pruritus. ( Agami, O; Blum, M; Fireman, E; Kivity, S; laina, A; Peer, G; Silverberg, D, 1996) |
| "5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroquine." | 5.07 | Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers. ( Abila, B; Ambakederemo, AW; Asomugha, L; Ezeamuzie, IC; Igbigbi, PS, 1994) |
| "The present data do not support the thesis that the increased plasma histamine concentration is causally related to pruritus in hemodialysis patients or that the antiallergic drug, azelastin HCL, alleviates the pruritus of dialysis patients by decreasing plasma histamine levels." | 5.07 | Effects of azelastin on pruritus and plasma histamine levels in hemodialysis patients. ( Hamada, M; Hasegawa, M; Ida, M; Matsui, C; Morohashi, M, 1994) |
| "We undertook a 10-week placebo-controlled, double-blind, crossover study in a group of patients receiving hemodialysis who had severe pruritus, to investigate the effects of recombinant human erythropoietin on their pruritus and plasma histamine levels." | 5.07 | Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. ( Bartoli, E; Cecchin, E; De Marchi, S; Santini, G; Sepiacci, G; Villalta, D, 1992) |
| "In order to investigate whether any regional difference in itch perception exists in experimentally induced pruritus, various concentrations of histamine (1, 3." | 5.07 | Perception of histamine-induced itch elicited in three different skin regions. ( Ekblom, A; Wahlgren, CF, 1991) |
| "The red man syndrome (RMS) is the most common toxicity of vancomycin therapy." | 5.07 | Red man syndrome: incidence, etiology, and prophylaxis. ( Mascola, JR; Oldfield, EC; Wallace, MR, 1991) |
| "The effectiveness of a eutectic mixture of the local anaesthetics lignocaine and prilocaine (EMLA cream) in relieving artificially induced pruritus was examined in 20 volunteers." | 5.06 | Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. ( Connelly, DM; Hill, S; Marks, R; Shuttleworth, D, 1988) |
| " Itching was induced by intradermal injections of histamine on the upper arm." | 5.06 | Effect of acupuncture on experimentally induced itch. ( Bondesson, L; Lundeberg, T; Thomas, M, 1987) |
| "2 antipruritic ointments, when compared to placebo, were ineffective against histamine-induced itching applied in 2 volunteers after the intracutaneous injection of histamine." | 5.05 | Placebo-controlled study of the efficacy of topical antihistaminics against histamine-induced pruritus. ( Milsmann, E; Rohdewald, P, 1985) |
| "This study evaluates the ability of hydroxyzine and various neuroleptics to suppress histamine-induced pruritus in ten volunteer subjects with the use of a double-blind crossover protocol." | 5.04 | Suppression of histamine-induced pruritus by hydroxyzine and various neuroleptics. ( Ahmed, AR; Arnold, AJ; Jones, HE; Simpson, JG, 1979) |
| "A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects." | 5.04 | Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975) |
| " The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers." | 5.04 | The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. ( Davies, MG; Horton, RJ; Marks, R; Storari, FE, 1979) |
| "We have found that pretreatment of human skin with prostaglandin E1 significantly lowers the threshold of human skin to itching evoked by both histamine and papain." | 5.04 | Prostaglandins and pruritus. ( Burton, JL; Burton, PA; Duncan, EH; Lovell, CR, 1976) |
| "Prostaglandin E(1) lowers the threshold of human skin to histamine-evoked itching." | 5.04 | Itch: role of prostaglandins. ( Greaves, MW; McDonald-Gibson, W, 1973) |
| " Various receptors (TRPA1, TRPV1, PAR2, gastrin-releasing peptide receptor (GRPR), Mas-related G proteins), secreted molecules (histamine, nerve growth factor (NGF), substance P (SP), proteases), and cytokines/chemokines (thymic stromal lymphopoietin (TSLP), IL-2, IL-4, IL-13, and IL-31) are implicated as mediators of chronic pruritus." | 4.93 | Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out? ( Mollanazar, NK; Smith, PK; Yosipovitch, G, 2016) |
| "In the elderly, H1-antihistamine therapy is commonly prescribed for treatment of rhinitis, conjunctivitis, pruritus, eczema, urticaria, and for prophylaxis of anaphylactoid reactions." | 4.81 | H1-antihistamines in the elderly. ( Kaliner, MA, 2002) |
| "Histamine is known to be a classical inducer of pruritus." | 4.78 | Histamine, antihistamines and atopic eczema. ( Behrendt, H; Ring, J, 1990) |
| " We aimed to compare the effects of cromolyn sodium and other medications on cholestatic pruritus, serum biochemistry, histamine, total bile acids, autotaxin, liver histopathology, and mast cell distribution in tissues in an experimental cholestasis model conducted by bile duct ligation." | 4.31 | The Investigation of Therapeutic Implications of Mast Cell Stabilizer Cromolyn Sodium on Cholestasis and Cholestatic Pruritus in Experimental Cholestasis. ( Barut, F; Can, M; Hussen, SU; Özbakış Dengiz, G; Üstündağ, Y; Yılmaz Ürün, Y; Yurdakul Ertan, H, 2023) |
| "Chronic itch is the most prominent feature of atopic dermatitis (AD), and antihistamine treatment is often less effective in reducing clinical pruritus severity in AD." | 4.31 | Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3. ( Deng, J; Liu, Y; Shao, H; Tang, Z; Wu, G; Yang, N; Yang, Y, 2023) |
| "Our results suggest that functional inhibition of histamine receptor 4 by adriforant reduces itch and inflammation in vivo." | 4.31 | Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. ( Bäumer, W; Bruno, S; Delucis-Bronn, C; Fehlmann, D; Goetschy, JF; Hauchard, A; Kaupmann, K; Kempf, D; Raulf, F; Röhn, TA; Roussel, E; Stark, H; Uluckan, Ö; Urban, B; Wack, N; Wang, Y; Wilzopolski, J; Zerwes, HG, 2023) |
| "Oxytocin (OXT) is secreted in a large amount during the middle and late pregnancy." | 4.31 | Oxytocin increases itch sensitivity of mice in late pregnancy and its peripheral receptor mechanism of itch-promoting effect. ( Chen, LY; Li, H; Wang, XD; Wu, ZY; Xi, EP; Yang, G, 2023) |
| "Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent." | 4.12 | Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain. ( Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J, 2022) |
| "Lysophosphatidic acid (LPA) is involved in the pathophysiology of cholestatic pruritus and neuropathic pain." | 4.12 | Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin. ( Düll, MM; Kremer, AE; Namer, B; Reeh, PW; Ries, V; Stengel, M; Strupf, M, 2022) |
| " In mice, while allergen-provoked acute itch is mediated by the mast cell-histamine axis in steady state, AD-associated inflammation renders this pathway dispensable." | 4.02 | A basophil-neuronal axis promotes itch. ( Ardeleanu, M; Baek, J; Chai, JN; Chen, Z; Dong, X; Hamilton, JD; Hsieh, CS; Hu, H; Kim, BS; Kim, S; Kubo, M; Li, F; Liu, Q; Mack, MR; Margolis, DJ; Miller, MJ; Morrison, SA; Trier, AM; Ver Heul, AM; Wang, F; Xie, Z; Xu, AZ; Yang, TB, 2021) |
| " Compared to the naïve mice, a significant increase in itch-related behaviors was observed in the CCD mice after the injection of pruritogens including histamine and BAM8-22, but not after the injection of capsaicin, although all the above agents evoked enhanced pain-related behaviors toward the injected site." | 4.02 | The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion. ( Fang, Y; Ma, C; Tao, J; Wang, T, 2021) |
| " Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine." | 3.96 | Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. ( Funahashi, H; Haruta-Tsukamoto, A; Ishida, Y; Miyahara, Y; Nishimori, T, 2020) |
| "This study compared the sensory qualities evoked by different models of experimentally induced pruritus including skin prick testing (SPT) with histamine or capsaicin and application of cowhage spicules." | 3.91 | Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage. ( Altrichter, S; Church, MK; Deuring, E; Hawro, T; Lehmann, S; Maurer, M; Metz, M; Weller, K, 2019) |
| "Scombroid poisoning is a poorly known type of food poisoning due to the presence of histamine in spoiled fish of the Scombridae family." | 3.88 | [Three cases of scombroid poisoning]. ( Del Giudice, P; Harmelin, Y; Hubiche, T; Pharaon, M, 2018) |
| " Itch responses were evoked by histamine, chloroquine, and dinitrochlorobenzene-induced contact dermatitis (CD)." | 3.88 | GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way. ( Han, MK; Im, SY; Im, YN; Kim, HK; Lee, HK; Lee, YD; Park, JS; Song, HR, 2018) |
| " After the capsaicin-induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25-40 spicules)." | 3.85 | Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N, 2017) |
| "We conclude that activation of mechano-insensitive nociceptors is sufficient to provoke itch by histamine- and acid-induced pain." | 3.83 | Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin. ( Benrath, J; Dusch, M; Ringkamp, M; Rukwied, R; Schmelz, M; van der Ham, J; Weinkauf, B, 2016) |
| "This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers." | 3.83 | Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Imai, Y; Koenig, J; Petersen, KK, 2016) |
| "To test whether the results of skin provocation with cowhage, an established model of histamine-independent pruritus, and histamine are different in AD patients and healthy subjects and whether these tests may be used as diagnostic markers of AD." | 3.83 | Skin provocation tests may help to diagnose atopic dermatitis. ( Altrichter, S; Church, MK; Fluhr, JW; Hawro, T; Lehmann, S; Maurer, M; Metz, M; Zuberbier, T, 2016) |
| "Acute pruritus was induced in ICR mice by a single intradermal injection of histamine, 4-methylhistamine, serotonin, compound 48/80, substance P (SP), or the proteinase-activated receptor-2 (PAR-2)-activating peptide SLIGRL-NH2." | 3.80 | Sex-related differences in SLIGRL-induced pruritus in mice. ( Suwa, E; Tomono, A; Ueno, K; Yamaura, K, 2014) |
| "Effects of chlorogenic acid on surfactant-induced itching were studied in mice." | 3.79 | Prevention of topical surfactant-induced itch-related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis. ( Andoh, T; Inami, Y; Kuraishi, Y, 2013) |
| "Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain." | 3.79 | Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. ( Giesler, GJ; Moser, HR, 2013) |
| " Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia." | 3.79 | Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013) |
| " We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1-containing kainate (KA) receptors are involved in scratching induced by histamine and non-histamine-dependent itching stimuli." | 3.79 | Cortical GluK1 kainate receptors modulate scratching in adult mice. ( Chen, T; Descalzi, G; Koga, K; Li, XY; Yamada, K; Zhuo, M, 2013) |
| "Itching guinea pig model caused by histamine, itching mice model, eczema guinea pig model caused by OVA, and inhibitory effect on pathogens in vitro were used to observe the itching threshold, symptoms and other related physiological index, as well as the inhibitory effect on the normal skin fungi by water extraction of Kochiae Fructus to evaluate the external therapeutic function of Kochiae Fructus." | 3.78 | [Normative research on bacteriostasis and relieving itching external therapeutic function of kochiae fructus]. ( Chen, SJ; Chi, HY; Liu, QY; Pin, G; Shao, LJ; She, YY; Song, LY; Wang, JN; Yao, CH, 2012) |
| "Urticaria is mainly caused by mast cell-derived histamine through the histamine H(1) receptor." | 3.78 | Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch. ( Fukuoka, M; Ikoma, A; Kabashima, K; Miyachi, Y; Tanizaki, H, 2012) |
| " Itch and pain were induced using the following somatosensory stimuli: electrical stimulation, histamine iontophoresis and the cold pressor test." | 3.78 | Role of induced negative and positive emotions in sensitivity to itch and pain in women. ( Evers, AW; Kraaimaat, FW; Kroeze, S; van de Kerkhof, PC; van Laarhoven, AI; van Riel, PL; Walker, AL; Wilder-Smith, OH, 2012) |
| "To date, suggestions that endothelin-1 (ET-1) causes nociception and pruritus are based on results in preclinical models in which responses to pruritic and nociceptive stimuli cannot be distinguished." | 3.78 | Endothelin-1 induces itch and pain in the mouse cheek model. ( Gomes, LO; Hara, DB; Rae, GA, 2012) |
| " In many diseases, pruritus is not effectively treated with antihistamines, indicating the involvement of nonhistaminergic mechanisms." | 3.77 | A role for nociceptive, myelinated nerve fibers in itch sensation. ( Borzan, J; Hartke, TV; Johanek, LM; LaMotte, RH; Meyer, RA; Ringkamp, M; Schepers, RJ; Shim, B; Shimada, SG, 2011) |
| " To this end, electrical stimuli were applied before and after histamine application (HPCS) to female patients with psoriasis and healthy female control subjects." | 3.76 | Heterotopic pruritic conditioning and itch--analogous to DNIC in pain? ( Evers, AWM; Kraaimaat, FW; van de Kerkhof, PCM; van Laarhoven, AIM; Wilder-Smith, OH, 2010) |
| "Six allergic conjunctivitis patients (12 eyes) and 4 healthy volunteers (8 eyes) were investigated in terms of the effect of cooling sheets on eye itching and tear histamine concentration, before and 5 min after cooling the eyelids with cooling sheets." | 3.76 | Relation between cooling sheet effect and tear histamine concenration in allergic conjunctivitis. ( Hirakawa, N; Yano, H; Yanoshita, R; Yoshii, M, 2010) |
| "There are numerous studies of the pruritus-producing effects of histamine, serotonin, tryptase, substance P and interleukin-2 in humans and mice, but very little reported in dogs even though a common reason dogs are presented to veterinarians is pruritus." | 3.75 | Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs. ( Carr, MN; Koch, SN; Reiter, LV; Torres, SM, 2009) |
| "We investigated the character of histamine H(1) receptor and H(4) receptor in allergic conjunctivitis." | 3.75 | Role of histamine H(4) receptor in allergic conjunctivitis in mice. ( Kagawa, Y; Kamei, C; Kurata, Y; Nakano, Y; Ono, R; Takahashi, Y, 2009) |
| " These mice showed profound scratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of their histamine dependence." | 3.75 | Cellular basis of itch sensation. ( Chen, ZF; Liu, XY; Meng, XL; Sun, YG; Yin, J; Zhao, ZQ, 2009) |
| "The contribution of the novel histamine H(4) receptor to histaminergic and allergic pruritus was investigated." | 3.74 | Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. ( Desai, PJ; Dunford, PJ; Karlsson, L; McQueen, D; Thurmond, RL; Williams, KN, 2007) |
| " This sensitization does not appear to be simply based on skin inflammation because histamine-induced itch was not augmented in lesional skin of psoriasis." | 3.72 | Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis. ( Ikoma, A; Miyachi, Y; Rukwied, R; Schmelz, M; Ständer, S; Steinhoff, M, 2003) |
| "Despite the high prevalence of pruritus, scalp skin is less sensitive to histamine-induced experimental itching." | 3.71 | Sensitivity of human scalp skin to pruritic stimuli investigated by intradermal microdialysis in vivo. ( McGlone, F; Rukwied, R; Schmelz, M; Zeck, S, 2002) |
| "Patients suffering from pruritus due to atopic dermatitis show, in asymptomatic skin, reduced itch and flare responses to histamine, the major pruritogenic mediator." | 3.71 | Interactions of histamine and bradykinin on polymodal C-fibres in isolated rat skin. ( Koppert, W; Martus, P; Reeh, PW, 2001) |
| "We investigated itch-associated responses (scratching) to mosquito bites and the role of histamine and mast cells in mosquito-induced itching in mice." | 3.71 | Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice. ( Ichikawa, T; Kamimura, K; Kawai, S; Kitagawa, K; Kuraishi, Y; Nojima, H; Ohtsuka, E; Shirai, Y, 2001) |
| "Having observed altered itch and flare reactions after histamine application in patients with atopic eczema, we tried to determine these reactions in patients with urticaria and psoriasis." | 3.70 | Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria. ( Handwerker, HO; Heyer, G; Koppert, W; Martus, P, 1998) |
| " The scratching induced by 5-HT (100 nmol site(-1), peak effective dose) was suppressed by capsaicin (repeated administration) and the opioid antagonist naloxone, features being similar to human itching." | 3.70 | Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. ( Kuraishi, Y; Nagasawa, T; Satoh, M; Yamaguchi, T, 1999) |
| "While histamine is the crucial mediator of pruritus in type 1 allergic reactions, its role in atopic dermatitis (AD) is unclear." | 3.70 | Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. ( Heyer, G; Lischetzki, G; McGlone, F; Rukwied, R; Schmelz, M, 2000) |
| "Pruritus is a common symptom in uraemic patients and its aetiology is poorly understood, although several factors have been implicated, including high histamine plasma levels." | 3.69 | Uraemic pruritus is not related to plasma histamine concentrations. ( De Filippi, C; Galli, F; Piazza, V; Pisati, P; Regazzini, R; Sacchi, S; Salvadeo, A, 1995) |
| "The etiology of atopic pruritus is unclear and seems mostly histamine-independent." | 3.69 | Pruritogenic effects of mitogen-stimulated peripheral blood mononuclear cells in atopic eczema. ( Cremer, B; Czarnetzki, BM; Dippel, E; Heimann, A, 1995) |
| " Histamine was iontophoretically applied to the skin of the forearm, and stimulus-induced itching and burning sensations were rated on visual analogue scales." | 3.69 | Atopic eczema and histamine-induced sensations. ( Handwerker, HO; Heyer, G; Koppert, W, 1996) |
| "The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)." | 3.69 | Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996) |
| "The effect of endoscopic thoracic sympathectomy on experimentally histamine-induced itch was studied in seven patients, all of whom were suffering from palmar hyperhidrosis; cutaneous warm, cold, and heat pain perception thresholds were also studied in five of these seven patients." | 3.69 | Sympathectomy does not influence experimental itch and cutaneous temperature perception thresholds. ( Ekblom, A; Lengstam, I; Lind, G; Meyerson, BA; Wahlgren, CF, 1996) |
| " The antipruritic effect of tropisetron reported in cholestatic and uremic pruritus could not be verified in healthy persons under experimental conditions." | 3.69 | Can a serotonin type 3 (5-HT3) receptor antagonist reduce experimentally-induced itch? ( Gollnick, H; Weisshaar, E; Ziethen, B, 1997) |
| "The incidence of red man syndrome (RMS) and its relationship to histamine were investigated in patients receiving vancomycin or an aminoglycoside (control)." | 3.68 | Prospective evaluation of red man syndrome in patients receiving vancomycin. ( Lamp, KC; O'Sullivan, TL; Ruffing, MJ; Rybak, MJ; Warbasse, LH, 1993) |
| "Fifty-four uremic patients (26 patients were maintained on continuous ambulatory peritoneal dialysis [CAPD] and 28 on hemodialysis [HD]) were screened for pruritus and plasma histamine." | 3.68 | Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. ( Fritz, P; Hübel, E; Kuhlmann, U; Machleidt, C; Mettang, T; Weber, J, 1990) |
| "A role for histamine in the pathogenesis of uremic pruritus was investigated in maintenance hemodialysis patients." | 3.68 | Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. ( Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES, 1991) |
| " Histamine was iontophoretically applied to the receptive fields of these units for 20 or 30 s and was found to provoke itching sensations lasting several minutes, together with wheal and flare responses." | 3.68 | Discharge patterns of human C-fibers induced by itching and burning stimuli. ( Forster, C; Handwerker, HO; Kirchhoff, C, 1991) |
| "Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to glomerular capillaries and arterial endothelium." | 3.68 | Plasma histamine in patients with chronic renal failure and nephrotic syndrome. ( Balliod, R; Barradas, MA; Dandona, P; Fonseca, VA; Gill, DS; Moorhead, JF, 1991) |
| " We determined plasma levels of histamine in uraemic patients and examined their correlation with the presence of pruritus." | 3.68 | Increased plasma histamine levels in uraemic pruritus. ( Balcke, P; Grimm, G; Kurz, RW; Sertl, K; Stockenhuber, F, 1990) |
| "We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr." | 3.67 | Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. ( Farnam, J; Grant, JA; Guernsey, BG; Jorizzo, JL; Petrusa, ER, 1984) |
| " Pruritus was elicited by intradermal injection of histamine." | 3.67 | Pruritus during standardized mental stress. Relationship to psychoneuroendocrine and metabolic parameters. ( Arnetz, BB; Eneroth, P; Fjellner, B; Kallner, A, 1985) |
| "Cutaneous reactions induced by intradermal histamine injection were studied in uremic patients with and without pruritus who were undergoing maintenance hemodialysis and also in healthy subjects." | 3.67 | The sensitivity of uremic and normal human skin to histamine. ( Hägermark, O; Lins, LE; Ståhle-Bäckdahl, M, 1988) |
| "We have studied the influence of cold exposure on itch, erythema and wheal, in response to histamine scratch tests, in 14 volunteers." | 3.67 | The relevance of low skin temperature inhibiting histamine-induced itch to the location of contact urticarial symptoms in the fish processing industry. ( Halkier-Sørensen, L; Thestrup-Pedersen, K, 1989) |
| "We studied blood histamine activity (HA) and cutaneous fibrinolytic activity (CFA) in a patient with polycythaemia rubra vera (PRV) and water-induced pruritus, before and after water exposure." | 3.67 | Polycythaemia rubra vera and water-induced pruritus: blood histamine levels and cutaneous fibrinolytic activity before and after water challenge. ( Brunetti, L; Greaves, MW; Kobza-Black, A; Lotti, TM; Panconesi, E; Steinman, HK, 1987) |
| "The effects of topical treatment with capsaicin or mustard oil on histamine-induced pruritus, wheal formation and flare response were studied in the human skin." | 3.67 | Capsaicin prevents histamine-induced itching. ( Bognár, A; Husz, S; Jancsó, G; Obál, F; Tóth-Kása, I, 1986) |
| "The effect of astemizole on the weal and flare response to intradermal histamine has been studied in normal volunteers after single dosing, and in patients with urticaria and pruritus after chronic dosing with the drug." | 3.66 | The effects of astemizole on histamine-induced weal and flare. ( Bateman, DN; Chapman, PH; Rawlins, MD, 1983) |
| " Blood specimens were obtained from each arm serially over a one-hour interval, and serum speciments were assessed for histamine, eosinophil chemotactic factor of anaphylaxis, and complement components." | 3.65 | Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. ( Austen, KF; Soter, NA; Wasserman, SI, 1976) |
| "The tissues affected by histamine and anaphylactic reactions are identical." | 3.63 | Histamine and the antihistaminic drugs. ( KEENEY, EL, 1950) |
| "Histaminergic itch was robustly inhibited by short-term homotopic noxious heat stimuli for up to 10 min." | 2.90 | Antipruritic effects of transient heat stimulation on histaminergic and nonhistaminergic itch. ( Andersen, HH; Arendt-Nielsen, L; Riccio, D, 2019) |
| "Histamine iontophoresis is a well-standardized in vivo model to quantitatively study the early stages of cutaneous inflammation with minimal impact on the skin barrier." | 2.84 | Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel. ( Falcone, D; Richters, R; Uzunbajakava, N; van de Kerkhof, PCM; van Erp, PEJ, 2017) |
| "Histamine 1% was applied to the volar forearms using skin prick-test lancets." | 2.84 | Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Hilborg, SD; Jerwiarz, A; Melholt, C; Randers, A; Simoni, A, 2017) |
| "Allergic conjunctivitis is highly prevalent and affects up to one third of the general population." | 2.82 | Neuropathic pain and itch: mechanisms in allergic conjunctivitis. ( Chisolm, S; Kalangara, JP; Kuruvilla, ME; Vanijcharoenkarn, K, 2022) |
| " First, the dose-response was investigated by assessing FBF throughout a dose-escalating histamine infusion." | 2.78 | Histamine-induced vasodilatation in the human forearm vasculature. ( Bateman, DN; Crowe, J; Cuthbert, H; Eddleston, M; Jenkins, PJ; Johnston, NR; Sandilands, EA; Webb, DJ, 2013) |
| " These results suggest that double-dosed levocetirizine treatment suppresses histamine-induced skin symptoms more rapidly, profoundly and sustainably than conventionally dosed levocetirizine treatment." | 2.78 | A double dose of levocetirizine leads to better control of histamine-induced flare, wheal and itch in healthy donors. ( Kabashima, K; Miyachi, Y; Nakahigashi, K; Nakamizo, S; Tanizaki, H, 2013) |
| "Levocetirizine was more inhibitory than fexofenadine on wheal, flare and pruritus (p < 0." | 2.78 | The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers. ( Church, MK; Maurer, M; Schoepke, N, 2013) |
| "Histamine levels were assessed in two groups of subjects with dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyrithione shampoo." | 2.76 | Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment. ( Fieno, A; Filloon, T; Kerr, K; Mills, KJ; Schwartz, JR; Szepietowski, JC; Wehmeyer, K, 2011) |
| "Histamine prick tests were performed four times at the treatment sites (before treatment, and days 1, 3 and 7 after treatment)." | 2.74 | Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin. ( Arendt-Nielsen, L; Drewes, AM; Gazerani, P; Pedersen, NS, 2009) |
| "Because pain has been more extensively studied, some extrapolations to itch can be proposed and verified by experiments." | 2.72 | Itch processing in the brain. ( Ben Salem, D; Carré, JL; Dufor, O; Misery, L; Najafi, P, 2021) |
| "Levocetirizine was used as a comparator." | 2.71 | Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin. ( Boutsiouki, P; Church, MK; Clough, GF; Denham, KJ, 2003) |
| "Deep muscle pain is often associated with sensory changes in the corresponding dermatome." | 2.71 | Interaction between histamine-induced itch and experimental muscle pain. ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004) |
| "Pruritus is the most distressing symptom in haemodialysis (HD) patients." | 2.71 | Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients. ( Dunker, N; Gollnick, H; Röhl, FW; Weisshaar, E, 2004) |
| "Itch and pain were scored on a visual analogue scale at regular intervals." | 2.70 | Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study. ( Benfeldt, E; Jensen, SB; Menné, T; Serup, J; Thomsen, JS, 2002) |
| "Histamine-induced flare was quantified using laser-Doppler flowmetry." | 2.70 | Influence of vagus nerve stimulation on histamine-induced itching. ( Birklein, F; Haslbeck, KM; Kirchner, A; Schmelz, M; Stefan, H, 2002) |
| "Pruritus is a common, unpleasant symptom of uremic patients." | 2.69 | Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. ( Balaskas, EV; Bamihas, GI; Karamouzis, M; Tourkantonis, A; Voyiatzis, G, 1998) |
| "In control subjects, but not in atopic eczema (AE) patients, capsaicin pretreatment significantly reduced the flare area." | 2.69 | Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. ( Forster, C; Handwerker, HO; Heyer, G; Weisshaar, E, 1998) |
| "Histamine 10 microl was injected into each bleb, and the resulting magnitude of itch estimated." | 2.69 | Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. ( Atanassoff, PG; Brull, SJ; Greenquist, K; Lamotte, RH; Silverman, DG; Zhang, J, 1999) |
| "Pruritus is a major clinical problem in patients with polycythaemia vera (PV)." | 2.68 | Long-term treatment with interferon-alpha 2b for severe pruritus in patients with polycythaemia vera. ( de Wolf, JT; Egger, R; Halie, MR; Huijgens, PC; Muller, EW; Vellenga, E; Wijermans, PW, 1995) |
| "Histamine was applied iontophoretically to the forearm skin and the following parameters were assessed thereafter: weal and flare size, itch intensity and the extension of the area of alloknesis ('itchy skin') around the application site." | 2.68 | Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis. ( Diepgen, LT; Dotzer, M; Handwerker, OH; Heyer, G, 1997) |
| " A linear dose-response relationship was shown with random injection order for all subjective variables studied (itch latency and duration, maximal itch intensity, 'total itch index') with the VAS, but only for itch duration and 'total itch index' with the FPNVS." | 2.66 | Some aspects of the experimental induction and measurement of itch. ( Ekblom, A; Hägermark, O; Wahlgren, CF, 1989) |
| "Pruritus was evoked by intradermal injection of histamine and the histamine liberator compound 48/80." | 2.66 | Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80. ( Fjellner, B; Lengstam, I; Lindelöf, B; Wahlgren, CF, 1989) |
| "Pruritus was provoked by intradermal injection of histamine on the upper arm." | 2.65 | The influence of mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on experimental pruritus induced by histamine. ( Ekblom, A; Fjellner, B; Hansson, P, 1984) |
| "Pruritus was not obtained with either 4-methyl histamine or dimaprit." | 2.65 | Sensory responses of human skin to synthetic histamine analogues and histamine. ( Davies, MG; Greaves, MW, 1980) |
| "Patients with atopic eczema show different activation patterns and kinetics compared to healthy volunteers." | 2.48 | Itch and the brain. ( Behrendt, H; Darsow, U; Napadow, V; Pfab, F; Ring, J; Tölle, TR; Valet, M, 2012) |
| "Pruritus is an integral part of the patient's symptoms in numerous dermatological and systemic diseases in humans and animals." | 2.47 | Pruritus: an overview of current concepts. ( Grundmann, S; Metz, M; Ständer, S, 2011) |
| "Itching (pruritus) is perhaps the most common symptom associated with inflammatory skin diseases and can be a lead symptom ofextracutaneous disease (e." | 2.46 | Histamine and antihistamines in atopic dermatitis. ( Buddenkotte, J; Maurer, M; Steinhoff, M, 2010) |
| "Itch (pruritus) is a sensory phenomenon characterized by a (usually) negative affective component and the initiation of a special behavioral act, i." | 2.44 | TRP channels as novel players in the pathogenesis and therapy of itch. ( Bíró, T; Dobrosi, N; Géczy, T; Marincsák, R; Paus, R; Tóth, BI, 2007) |
| "The phenomenon of itching has received surprisingly little scientific scrutiny despite its commonality--hence its designation as a kind of neglected, "orphan symptom." | 2.43 | Update for nurse anesthetists--pt 4. Itching, the "little" big problem as an orphan symptom. ( Biddle, C; Toomey, M, 2006) |
| "Pruritus is a common problem that can result from many conditions." | 2.38 | Pruritus. What to do when the itching won't stop. ( Phillips, WG, 1992) |
| "Atopic dermatitis is clearly characterized by altered cutaneous physiologic responses." | 2.37 | Pharmacophysiology of atopic dermatitis. ( Hanifin, JM, 1986) |
| "Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response." | 1.91 | Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways. ( Li, BM; Liu, Y; Liu, YU; Ma, CL; Mou, B; Pan, H; Peng, J; Xiong, MT; Yang, Y; Yun, X; Zhang, JY; Zhang, QR; Zhao, HX, 2023) |
| "Atopic dermatitis is often associated with increased pain." | 1.91 | Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis. ( Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R, 2023) |
| "Pruritus is one of the major symptoms of sensitive skin." | 1.62 | Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study. ( Gong, Q; Hua, W; Jiang, P; Li, L; Wan, R; Zuo, Y, 2021) |
| "The sensation of itching is generated by signals that travel from the skin to nerve cells in the spinal cord." | 1.62 | BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk. ( Barry, DM; Chen, ZF; Gao, F; Jin, H; Jin, JH; Kim, R; Liu, B; Liu, J; Liu, XT; Liu, XY; Meng, QT; Munanairi, A; Peng, J; Shen, KF; Sun, Y; Tao, A; Wan, L; Yang, Q; Yin, J, 2021) |
| "Pruritus is one of the leading symptoms of dermatitis herpetiformis (DH), however, studies on the pathogenesis of pruritus are scarce." | 1.56 | Mast cells and thymic stromal lymphopoietin (TSLP) expression positively correlates with pruritus intensity in dermatitis herpetiformis. ( Chen, X; Liu, H; Liu, T; Liu, Y; Lu, X; Sun, L; Sun, Y; Wang, J; Xia, Q; Zhang, F, 2020) |
| "In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density." | 1.51 | Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study. ( Agelopoulos, K; Conrad, H; Hatt, H; Hidding, J; Lotts, T; Osada, N; Pereira, MP; Pogatzki-Zahn, E; Schmelz, M; Ständer, S, 2019) |
| "This will promote the research and treatment of pruritus and depression." | 1.48 | The behavioral study on the interactive aggravation between pruritus and depression. ( Bai, Y; Feng, YP; Li, H; Wang, XD; Yang, G, 2018) |
| "Pruritus of end-stage renal disease (ESRD) is a multifactorial symptom of complex etiology not yet fully understood." | 1.40 | Voxel-based morphometry and arterial spin labeling fMRI reveal neuropathic and neuroplastic features of brain processing of itch in end-stage renal disease. ( Coghill, RC; Emerson, NM; Kraft, RA; Nattkemper, LA; Papoiu, AD; Patel, TS; Valdes-Rodriguez, R; Yosipovitch, G, 2014) |
| "Histamine was applied by iontophoresis (7." | 1.39 | Mechano-insensitive nociceptors are sufficient to induce histamine-induced itch. ( Benrath, J; Blunk, J; Dusch, M; Konrad, C; Menzer, C; Rukwied, R; Schley, M; Schmelz, M, 2013) |
| "Pruritus was recorded by the subjects, using a computerized visual analogue scale, while flare and wheal were recorded by the investigator." | 1.39 | Pruritic and vascular responses induced by serotonin in patients with atopic dermatitis and in healthy controls. ( Nordlind, K; Rausl, A; Wahlgren, CF, 2013) |
| "Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive hereditary disorder that is characterized by having both sensory neuropathy and anhidrosis." | 1.38 | Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation. ( Satoh, T; Tanaka, A; Tanaka, T; Yokozeki, H, 2012) |
| "Pruritus is a severe symptom that is difficult to treat in atopic dermatitis patients." | 1.38 | Red ginseng inhibits scratching behavior associated with atopic dermatitis in experimental animal models. ( Iwao, H; Izumi, Y; Miura, K; Nakao, T; Osada-Oka, M; Samukawa, K; Shiota, M, 2012) |
| "Ginsenoside Re was orally administered to the mice treated with antibiotics (cefadroxil, oxytetracycline and erythromycin mixture (COE), streptomycin or/and tetracycline) and then investigated the relationship between ginsenoside Re-metabolizing β-glucosidase and α-rhamnosidase activities of intestinal microflora and its antiscratching behavioral effect." | 1.38 | Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice. ( Han, MJ; Jang, SE; Joh, EH; Jung, IH; Kim, DH, 2012) |
| " Its inhibitory effect was dependent on the dosage and administration period." | 1.37 | Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from kimchi in mice. ( Han, MJ; Hyun, YJ; Jang, SE; Kim, DH; Trinh, HT, 2011) |
| "Imiquimod (IQ) is an agonist of Toll-like receptor 7 (TLR7) used to treat various infectious skin diseases such as genital warts, keratosis, and basal cell carcinoma." | 1.37 | Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. ( Han, SK; Kim, D; Kim, SJ; Lee, CJ; Lee, J; Lee, SJ; Min, H; Park, GH; Simon, MI; Wall, E, 2011) |
| "Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood." | 1.37 | Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. ( Dong, X; Liu, Q; Meeker, S; Patel, KN; Undem, BJ, 2011) |
| "Baicalin was anaerobically incubated with human fecal microflora, and its metabolites, baicalein and oroxylin A, were isolated." | 1.36 | Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice. ( Baek, NI; Joh, EH; Kim, DH; Kwak, HY; Trinh, HT, 2010) |
| "Atopic dermatitis is a stress-responsive disorder that involves the autonomic nervous system." | 1.36 | Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis. ( Chan, YH; Papoiu, AD; Patel, TS; Russoniello, CV; Tran, BW; Wang, H; Yosipovitch, G, 2010) |
| " Flares were induced before dosing and up to 96 h afterwards by intradermal PAF and histamine." | 1.36 | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. ( Church, MK, 2010) |
| "Its effects against pruritus are mainly attributed to its inhibition of mediator release from activated mast cells and direct antagonist effects on the released mediators which may act as local pruritogens." | 1.33 | Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice. ( Baolin, L; Ning, T; Weiwei, W, 2005) |
| " The dose-response curve of tryptase action was bell-shaped and the effect peaked at 0." | 1.33 | Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. ( Andoh, T; Kuraishi, Y; Lee, JB; Nojima, H; Ui, H, 2006) |
| " Multiple chloroquine drug doses were used, revealing the existence of inverted-U dose-response relationships in every strain, allowing us to determine strain-dependent peak scratching behavior over the entire dose range." | 1.33 | Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. ( Green, AD; Lehto, SG; Mogil, JS; Smith, SB; Young, KK, 2006) |
| "Because pain and pruritus are clearly distinct nociceptive sensory modalities in humans, the current study evaluates the potential of ET-1 to elicit scratching behavior in mice." | 1.33 | Endothelin-1 causes pruritus in mice. ( D'Orléans-Juste, P; Fernandes, MB; Rae, GA; Trentin, PG, 2006) |
| "Itching is one of the major clinical symptoms in atopic dermatitis (AD) and complicates the management of this pathological condition." | 1.33 | Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis. ( Arimura, A; Asakawa, M; Deguchi, M; Hikita, I; Hirasawa, T; Horikawa, T; Matsutani, T; Oku, H; Yoshioka, T, 2006) |
| "Substance P was also effective in causing scratching behaviour in both mast cell-deficient and wild-type mice." | 1.32 | Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice. ( Hossen, MA; Kamei, C; Kayasuga, R; Sugimoto, Y, 2003) |
| "morphine (1 mg/kg)." | 1.32 | The role of central mu opioid receptors in opioid-induced itch in primates. ( Edwards, T; Ko, MC; Lee, H; Naughton, NN; Song, MS, 2004) |
| "Pretreatment of arachidonic acid increased the skin prostaglandins (prostaglandin D2, prostaglandin E2, prostaglandin F2alpha and 6-keto-prostaglandin F1alpha) contents, but indomethacin decreased the prostaglandin D2 and prostaglandin E2 contents." | 1.32 | Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. ( Arai, I; Futaki, N; Hashimoto, Y; Inoue, T; Nakaike, S; Sugimoto, M; Takahashi, N; Takano, N, 2004) |
| "To assess the itch-associated response of primary afferents innervating the murine skin in vivo, dose-response curves and time-courses for itch-scratching and cutaneous nerve firing responses to intradermal injections of pruritogens (histamine and serotonin) were compared in ICR and ddY mice." | 1.31 | Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice. ( Kuraishi, Y; Maekawa, T; Nojima, H, 2000) |
| "Histamine was used as the reference stimulus for model development because it is firmly established as a pruritogen in both conjunctiva and skin." | 1.29 | Characterization of a behavioral model for peripherally evoked itch suggests platelet-activating factor as a potent pruritogen. ( Nieves, AL; Spada, CS; Tuckett, RP; Williams, LS; Woodward, DF, 1995) |
| "Compared to controls, atopic eczema patients showed significantly reduced alloknesis or total lack of it in the area around a skin site to which histamine had been iontophoretically applied, although histamine elicited itching in most patients." | 1.29 | Histamine-induced itch and alloknesis (itchy skin) in atopic eczema patients and controls. ( Handwerker, HO; Heyer, G; Schmitz, J; Ulmer, FJ, 1995) |
| "Despite advances in dialysis treatment, pruritus remains a common and distressing manifestation of chronic renal failure." | 1.28 | Pruritus in hemodialysis patients. ( Ståhle-Bäckdahl, M, 1992) |
| " Significant dose-response relationships were found between histamine concentration and each of ID, Imax, Tii and flare in both patients and controls." | 1.28 | Patients' perception of itch induced by histamine, compound 48/80 and wool fibres in atopic dermatitis. ( Bergström, R; Hägermark, O; Wahlgren, CF, 1991) |
| "Histamine and papain were given in doses of 0." | 1.28 | Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine. ( Alreja, M; LaMotte, RH; Simone, DA, 1991) |
| "Pruritus is a frequent symptom in chronic cholestatic liver disease." | 1.28 | Raised histamine concentrations in chronic cholestatic liver disease. ( Gittlen, SD; Maddrey, WC; Schulman, ES, 1990) |
| " Dose-response relationships were evaluated for SP and NT (10-320 pmols) in AD and healthy controls." | 1.28 | Skin reactivity to neuropeptides in atopic dermatitis. ( Giannetti, A; Girolomoni, G, 1989) |
| "Persistent pruritus is one of the most common symptoms in hemodialysis patients." | 1.27 | [Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels]. ( Kuze, M; Sanada, S; Yoshida, O, 1987) |
| "Itching was present in nine cases and correlated well with the numbers of skin mast cells but not with circulating basophils or whole blood histamine." | 1.27 | Skin mast cells in polycythaemia vera: relationship to the pathogenesis and treatment of pruritus. ( Boughton, B; Burt, D; Crocker, J; Jackson, N, 1987) |
| "Aquagenic pruritus is probably common, but it is generally unrecognised and may be misdiagnosed." | 1.26 | Aquagenic pruritus. ( Black, AK; Coutts, A; Eady, RA; Greaves, MW, 1981) |
| "Thus exercise-induced anaphylactoid reactions can appear with a variety of cutaneous manifestations, including angioedema only, giant urticaria, and cholinergic urticaria." | 1.26 | Exercise-induced urticaria, angioedema, and anaphylactoid episodes. ( Erffmeyer, J; Lewis, J; Lieberman, P; Treadwell, G, 1981) |
| "Histamine was released into the systemic circulation in both conditions in a similar time course; however, systemic symptoms occurred only after the 41 degree C bath." | 1.26 | Evaluation of a patient with both aquagenic and cholinergic urticaria. ( Bock, SA; Davis, RS; Remigio, LK; Schocket, AL, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 96 (17.39) | 18.7374 |
| 1990's | 77 (13.95) | 18.2507 |
| 2000's | 115 (20.83) | 29.6817 |
| 2010's | 201 (36.41) | 24.3611 |
| 2020's | 63 (11.41) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 2 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 2 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 3 |
| Nattkemper, LA | 3 |
| Zhi, K | 1 |
| Romero, KE | 1 |
| Shah, SM | 1 |
| Ju, T | 1 |
| Fourzali, K | 1 |
| Golpanian, RS | 1 |
| MacQuhae, F | 1 |
| Chan, YH | 4 |
| Lebo, DB | 1 |
| Yosipovitch, G | 21 |
| Zhang, Z | 2 |
| Pan, J | 1 |
| Zhu, T | 1 |
| Malewicz, N | 1 |
| Ye, K | 1 |
| Rong, J | 1 |
| Luo, Y | 1 |
| Situ, Y | 1 |
| Verkhratsky, A | 1 |
| Wang, Y | 5 |
| Zhao, J | 1 |
| Tang, D | 1 |
| Nie, H | 3 |
| Zuo, Y | 2 |
| Jiang, P | 2 |
| Wan, R | 2 |
| Li, L | 3 |
| Gong, Q | 1 |
| Hua, W | 2 |
| Toyama, S | 1 |
| Tominaga, M | 6 |
| Takamori, K | 3 |
| Meng, QT | 2 |
| Liu, XY | 5 |
| Liu, XT | 4 |
| Liu, J | 2 |
| Munanairi, A | 1 |
| Barry, DM | 5 |
| Liu, B | 2 |
| Jin, H | 2 |
| Sun, Y | 5 |
| Yang, Q | 2 |
| Gao, F | 2 |
| Wan, L | 3 |
| Peng, J | 2 |
| Jin, JH | 2 |
| Shen, KF | 2 |
| Kim, R | 2 |
| Yin, J | 4 |
| Tao, A | 3 |
| Chen, ZF | 8 |
| Weng, L | 1 |
| van Laarhoven, AIM | 8 |
| Peerdeman, KJ | 3 |
| Evers, AWM | 6 |
| Riccio, D | 2 |
| Andersen, HH | 13 |
| Arendt-Nielsen, L | 14 |
| Malewicz, NM | 3 |
| Ieong, HF | 2 |
| Oeck, S | 2 |
| Kumowski, N | 1 |
| Shimada, SG | 5 |
| LaMotte, RH | 16 |
| Rattray, Z | 1 |
| Jung, S | 1 |
| Escamilla-Rivera, V | 1 |
| Chen, Z | 3 |
| Tang, X | 1 |
| Zhou, J | 1 |
| Wang, B | 3 |
| Wu, H | 1 |
| Qi, H | 1 |
| Li, H | 4 |
| Pan, L | 1 |
| Zhang, K | 1 |
| Yuan, M | 1 |
| Qiu, HJ | 1 |
| Gao, Y | 1 |
| Ma, R | 2 |
| Weng, W | 1 |
| Zhang, H | 2 |
| Guo, R | 1 |
| Yang, Y | 5 |
| Yang, F | 1 |
| Zhou, A | 1 |
| Cheng, J | 1 |
| Chen, ZY | 1 |
| Zhu, MX | 2 |
| Li, Y | 3 |
| Fukasawa, T | 1 |
| Yoshizaki-Ogawa, A | 1 |
| Enomoto, A | 1 |
| Miyagawa, K | 1 |
| Sato, S | 1 |
| Yoshizaki, A | 1 |
| Kalangara, JP | 1 |
| Vanijcharoenkarn, K | 1 |
| Chisolm, S | 1 |
| Kuruvilla, ME | 1 |
| Seldeslachts, A | 1 |
| Peigneur, S | 1 |
| Mebs, D | 1 |
| Tytgat, J | 1 |
| Yurdakul Ertan, H | 1 |
| Özbakış Dengiz, G | 1 |
| Barut, F | 1 |
| Yılmaz Ürün, Y | 1 |
| Can, M | 1 |
| Hussen, SU | 1 |
| Üstündağ, Y | 1 |
| Katayama, Y | 1 |
| Miura, A | 1 |
| Sakamoto, T | 2 |
| Takanami, K | 2 |
| Sakamoto, H | 2 |
| Ryu, K | 3 |
| Heo, Y | 3 |
| Lee, Y | 3 |
| Jeon, H | 3 |
| Namkung, W | 3 |
| Yang, N | 2 |
| Shao, H | 2 |
| Deng, J | 2 |
| Tang, Z | 4 |
| Wu, G | 4 |
| Liu, Y | 4 |
| Jiang, B | 2 |
| Li, GW | 2 |
| Dong, F | 2 |
| Luo, Z | 2 |
| Cai, B | 2 |
| Wei, M | 2 |
| Huang, J | 4 |
| Wang, K | 2 |
| Feng, X | 2 |
| Tong, F | 2 |
| Wang, S | 2 |
| Wang, Q | 2 |
| Han, Q | 2 |
| Li, C | 2 |
| Zhang, X | 6 |
| Yang, L | 2 |
| Bao, L | 2 |
| Uluckan, Ö | 1 |
| Bruno, S | 1 |
| Wack, N | 1 |
| Wilzopolski, J | 2 |
| Goetschy, JF | 1 |
| Delucis-Bronn, C | 1 |
| Urban, B | 1 |
| Fehlmann, D | 1 |
| Stark, H | 2 |
| Hauchard, A | 1 |
| Roussel, E | 1 |
| Kempf, D | 1 |
| Kaupmann, K | 1 |
| Raulf, F | 1 |
| Bäumer, W | 3 |
| Röhn, TA | 1 |
| Zerwes, HG | 1 |
| Liang, Y | 1 |
| Fan, Z | 1 |
| Li, J | 3 |
| Zhang, Y | 3 |
| Shi, X | 1 |
| Zhu, Y | 1 |
| Xu, RQ | 1 |
| Ma, L | 1 |
| Chen, T | 3 |
| Zhang, WX | 1 |
| Chang, K | 1 |
| Wang, J | 5 |
| Lee, C | 1 |
| Oh, J | 1 |
| Lee, JH | 1 |
| Kaang, BK | 2 |
| Ko, HG | 2 |
| Chen, X | 2 |
| Chen, R | 1 |
| Xu, X | 1 |
| Wang, XY | 1 |
| Jia, WB | 1 |
| Zhao, DS | 1 |
| Liu, N | 1 |
| Pang, Z | 1 |
| Liu, XQ | 1 |
| Mou, B | 1 |
| Zhang, QR | 1 |
| Zhao, HX | 1 |
| Zhang, JY | 2 |
| Yun, X | 1 |
| Xiong, MT | 1 |
| Liu, YU | 1 |
| Pan, H | 1 |
| Ma, CL | 1 |
| Li, BM | 1 |
| Antoniadou, I | 1 |
| Georgiou, M | 1 |
| Dotsikas, Y | 1 |
| Lamprou, A | 1 |
| Lougiakis, N | 1 |
| Pouli, N | 1 |
| Karousis, N | 1 |
| Loukas, Y | 1 |
| Tseti, I | 1 |
| Marakos, P | 1 |
| Papapetropoulos, A | 1 |
| Haruta-Tsukamoto, A | 3 |
| Kanemaru-Kawazoe, A | 1 |
| Kogoh, Y | 1 |
| Miyahara, Y | 3 |
| Funahashi, H | 5 |
| Hirano, Y | 1 |
| Nishimori, T | 4 |
| Ishida, Y | 4 |
| Pavlenko, D | 2 |
| Todurga Seven, Z | 1 |
| Bystrom, L | 1 |
| Markan, A | 1 |
| Verpile, R | 1 |
| Ishida, H | 1 |
| Akiyama, T | 21 |
| Yang, G | 2 |
| Wang, XD | 2 |
| Chen, LY | 1 |
| Wu, ZY | 1 |
| Xi, EP | 1 |
| Okutani, H | 1 |
| Lo Vecchio, S | 4 |
| Ammitzbøll, N | 1 |
| Drewes, AM | 2 |
| Chen, WZ | 1 |
| Shen, TY | 1 |
| Wang, M | 1 |
| Yuan, L | 1 |
| Wang, LH | 1 |
| Ding, WQ | 1 |
| Shi, XX | 1 |
| Wang, XF | 1 |
| Bo, BS | 1 |
| Liang, ZF | 1 |
| Sun, YG | 2 |
| Yang, TB | 3 |
| Kim, BS | 4 |
| Mueller, SM | 1 |
| Mueller, F | 1 |
| Reinhardt, J | 1 |
| Itin, P | 1 |
| Navarini, A | 1 |
| Stippich, C | 1 |
| Borgwardt, S | 1 |
| Ganchingco, JRC | 1 |
| Fukuyama, T | 1 |
| Yoder, JA | 1 |
| Holle, H | 2 |
| Matsuo, T | 1 |
| Naono-Nakayama, R | 2 |
| Ebihara, K | 2 |
| Huang, Z | 1 |
| Zhou, X | 1 |
| Zhang, J | 3 |
| Mai, CL | 1 |
| Mai, JZ | 1 |
| Liu, C | 1 |
| Liu, XG | 1 |
| Kim, SH | 1 |
| Seong, GS | 1 |
| Choung, SY | 1 |
| Alvaro, CG | 1 |
| Braz, JM | 1 |
| Bernstein, M | 1 |
| Hamel, KA | 1 |
| Craik, V | 1 |
| Yamanaka, H | 1 |
| Basbaum, AI | 1 |
| Deng, YZ | 1 |
| Lu, YC | 2 |
| Wu, WW | 1 |
| Cheng, L | 1 |
| Zan, GY | 1 |
| Chai, JR | 1 |
| Wang, YJ | 2 |
| Liu, JG | 2 |
| Zeng, X | 1 |
| Wilhelm, S | 1 |
| Pecova, T | 1 |
| Kocan, I | 1 |
| Vysehradsky, R | 1 |
| Pecova, R | 1 |
| Wang, F | 3 |
| Gadotti, VM | 2 |
| Kreitinger, JM | 1 |
| Wageling, NB | 1 |
| Budke, D | 1 |
| Diaz, P | 1 |
| Zamponi, GW | 2 |
| Sakai, K | 4 |
| Hashimoto, T | 5 |
| Lozada, T | 1 |
| Tsagareli, MG | 1 |
| Nozadze, I | 1 |
| Tsiklauri, N | 1 |
| Carstens, MI | 15 |
| Gurtskaia, G | 1 |
| Carstens, E | 20 |
| Xia, Q | 1 |
| Liu, T | 3 |
| Sun, L | 1 |
| Lu, X | 1 |
| Liu, H | 2 |
| Zhang, F | 1 |
| Lehmann, S | 3 |
| Deuring, E | 2 |
| Weller, K | 2 |
| Scheffel, J | 1 |
| Metz, M | 6 |
| Maurer, M | 7 |
| Hawro, T | 4 |
| Kelemen, B | 1 |
| Pinto, S | 1 |
| Kim, N | 1 |
| Lisztes, E | 1 |
| Hanyicska, M | 1 |
| Vladár, A | 1 |
| Oláh, A | 1 |
| Pénzes, Z | 1 |
| Shu, B | 1 |
| Vriens, J | 1 |
| Bíró, T | 3 |
| Rohács, T | 1 |
| Voets, T | 1 |
| Tóth, BI | 3 |
| Najafi, P | 1 |
| Dufor, O | 1 |
| Ben Salem, D | 1 |
| Misery, L | 3 |
| Carré, JL | 1 |
| Hoffmann, S | 1 |
| Elberling, J | 9 |
| Setsu, T | 1 |
| Hamada, Y | 1 |
| Oikawa, D | 1 |
| Mori, T | 1 |
| Ishiuji, Y | 4 |
| Sato, D | 1 |
| Narita, M | 2 |
| Miyazaki, S | 1 |
| Furuta, E | 1 |
| Suda, Y | 1 |
| Sakai, H | 1 |
| Ochiya, T | 1 |
| Tezuka, H | 1 |
| Iseki, M | 1 |
| Inada, E | 1 |
| Yamanaka, A | 1 |
| Kuzumaki, N | 1 |
| Trier, AM | 1 |
| Li, F | 2 |
| Kim, S | 3 |
| Chai, JN | 1 |
| Mack, MR | 2 |
| Morrison, SA | 1 |
| Hamilton, JD | 1 |
| Baek, J | 2 |
| Ver Heul, AM | 1 |
| Xu, AZ | 1 |
| Xie, Z | 1 |
| Dong, X | 9 |
| Kubo, M | 2 |
| Hu, H | 1 |
| Hsieh, CS | 1 |
| Liu, Q | 6 |
| Margolis, DJ | 1 |
| Ardeleanu, M | 1 |
| Miller, MJ | 1 |
| Wang, T | 2 |
| Tao, J | 1 |
| Fang, Y | 1 |
| Ma, C | 4 |
| Klein, A | 1 |
| Sypek, EI | 1 |
| Hartke, TV | 2 |
| Wooten, M | 1 |
| Ringkamp, M | 6 |
| Sölle, A | 1 |
| Worm, M | 1 |
| Benedetti, F | 1 |
| Sabine Bartholomäus, T | 1 |
| Schwender-Groen, L | 1 |
| Klinger, R | 1 |
| Li, X | 1 |
| Yao, J | 1 |
| Hu, KH | 1 |
| Wu, B | 2 |
| Sui, JF | 1 |
| Gao, J | 1 |
| Wu, GY | 2 |
| Liu, SL | 1 |
| Düll, MM | 1 |
| Stengel, M | 1 |
| Ries, V | 1 |
| Strupf, M | 2 |
| Reeh, PW | 3 |
| Kremer, AE | 1 |
| Namer, B | 3 |
| Wong, LS | 1 |
| Yen, YT | 1 |
| Lee, CH | 1 |
| Uta, D | 1 |
| Matsuda, KI | 1 |
| Kawata, M | 1 |
| Kietzmann, M | 1 |
| Mishra, SK | 2 |
| Rossbach, K | 1 |
| Graceffa, RF | 1 |
| Boezio, AA | 1 |
| Able, J | 1 |
| Altmann, S | 3 |
| Berry, LM | 2 |
| Boezio, C | 1 |
| Butler, JR | 1 |
| Chu-Moyer, M | 3 |
| Cooke, M | 1 |
| DiMauro, EF | 3 |
| Dineen, TA | 2 |
| Feric Bojic, E | 2 |
| Foti, RS | 3 |
| Fremeau, RT | 2 |
| Guzman-Perez, A | 3 |
| Gao, H | 3 |
| Gunaydin, H | 3 |
| Huang, H | 3 |
| Huang, L | 2 |
| Ilch, C | 1 |
| Jarosh, M | 3 |
| Kornecook, T | 3 |
| Kreiman, CR | 2 |
| La, DS | 2 |
| Ligutti, J | 4 |
| Milgram, BC | 1 |
| Lin, MJ | 3 |
| Marx, IE | 2 |
| Nguyen, HN | 2 |
| Peterson, EA | 2 |
| Rescourio, G | 1 |
| Roberts, J | 1 |
| Schenkel, L | 1 |
| Shimanovich, R | 1 |
| Sparling, BA | 1 |
| Stellwagen, J | 1 |
| Taborn, K | 3 |
| Vaida, KR | 1 |
| Yeoman, J | 1 |
| Yu, V | 3 |
| Zhu, D | 1 |
| Moyer, BD | 4 |
| Weiss, MM | 3 |
| He, Z | 1 |
| Tian, X | 1 |
| Kamal, GM | 1 |
| Li, Z | 2 |
| Liu, Z | 3 |
| Xu, F | 1 |
| Xiang, H | 1 |
| Sølvsten, H | 1 |
| Liljencrantz, J | 1 |
| Pitcher, MH | 1 |
| Low, LA | 1 |
| Bauer, L | 1 |
| Bushnell, MC | 1 |
| Yu, YQ | 1 |
| Hao, Y | 1 |
| Falcone, D | 1 |
| Uzunbajakava, N | 1 |
| Richters, R | 1 |
| van de Kerkhof, PCM | 5 |
| van Erp, PEJ | 1 |
| Chomchai, S | 1 |
| Chomchai, C | 1 |
| Bartels, DJP | 2 |
| Stroo, M | 1 |
| Hijne, K | 1 |
| Donders, ART | 1 |
| Harmelin, Y | 1 |
| Hubiche, T | 1 |
| Pharaon, M | 1 |
| Del Giudice, P | 1 |
| Whalley, K | 1 |
| Reddy, VB | 1 |
| Azimi, E | 1 |
| Chu, L | 1 |
| Lerner, EA | 1 |
| Meeuwis, SH | 1 |
| van Middendorp, H | 1 |
| Veldhuijzen, DS | 1 |
| De Houwer, J | 1 |
| Lavrijsen, APM | 1 |
| Jeffry, J | 1 |
| Peng, JH | 1 |
| Mo, P | 1 |
| Bardoni, R | 1 |
| Palkar, R | 1 |
| Ongun, S | 1 |
| Catich, E | 1 |
| Li, N | 2 |
| Borad, N | 1 |
| Sarkisian, A | 1 |
| McKemy, DD | 1 |
| Justesen, FD | 1 |
| Pedersen, JB | 1 |
| Sørensen, LL | 1 |
| Jensen, LP | 1 |
| Ji, Y | 1 |
| Jang, Y | 1 |
| Lee, WJ | 1 |
| Yang, YD | 1 |
| Shim, WS | 3 |
| Im, YN | 1 |
| Lee, YD | 1 |
| Park, JS | 1 |
| Kim, HK | 1 |
| Im, SY | 1 |
| Song, HR | 1 |
| Lee, HK | 1 |
| Han, MK | 1 |
| Lu, B | 1 |
| Chen, M | 2 |
| Zheng, P | 1 |
| Lewis, DJ | 1 |
| Huang, S | 1 |
| Duvic, M | 1 |
| Hwang, BJ | 1 |
| Lough, K | 1 |
| Williams, SE | 1 |
| Chen, J | 1 |
| Burette, SW | 1 |
| Diaz, LA | 1 |
| Su, MA | 1 |
| Xiao, S | 1 |
| Lipshetz, B | 1 |
| Khasabov, SG | 4 |
| Truong, H | 1 |
| Netoff, TI | 1 |
| Simone, DA | 7 |
| Giesler, GJ | 7 |
| Cao, T | 1 |
| Tey, HL | 2 |
| Follansbee, T | 1 |
| Fujii, M | 2 |
| Davoodi, A | 5 |
| Nagamine, M | 6 |
| Iodi Carstens, M | 1 |
| Sanders, KM | 3 |
| Bai, Y | 2 |
| Feng, YP | 1 |
| Christensen, JD | 1 |
| Murray, JK | 1 |
| Andrews, KL | 1 |
| Sham, K | 1 |
| Long, J | 1 |
| Aral, J | 1 |
| Amagasu, S | 1 |
| Liu, D | 3 |
| Zou, A | 1 |
| Min, X | 1 |
| Wang, Z | 2 |
| Ilch, CP | 1 |
| Kornecook, TJ | 1 |
| Be, X | 1 |
| Miranda, LP | 1 |
| Biswas, K | 1 |
| Lewis, Z | 1 |
| George, DN | 1 |
| Cowdell, F | 1 |
| Tsianakas, A | 1 |
| Nippe, N | 1 |
| Hamper, CM | 1 |
| Cordes, AF | 1 |
| Zeidler, C | 1 |
| Schmelz, M | 19 |
| Ständer, S | 8 |
| Rosen, JD | 1 |
| Hsiang, J | 1 |
| Romanelli, P | 1 |
| Bernigaud, C | 1 |
| Guillot, J | 1 |
| Chosidow, O | 1 |
| Zschiebsch, K | 1 |
| Fischer, C | 1 |
| Wilken-Schmitz, A | 1 |
| Geisslinger, G | 1 |
| Channon, K | 1 |
| Watschinger, K | 1 |
| Tegeder, I | 1 |
| Bae, S | 1 |
| Yu, J | 1 |
| Jeong, H | 1 |
| Oh, T | 1 |
| Velez, TE | 1 |
| Byrne, AJ | 1 |
| Wechsler, JB | 1 |
| Krier-Burris, RA | 1 |
| Hulse, KE | 1 |
| Bryce, PJ | 1 |
| Henry, TD | 1 |
| Chen, YB | 1 |
| Li, JN | 1 |
| Yang, J | 1 |
| Li, YQ | 2 |
| Hidding, J | 1 |
| Agelopoulos, K | 1 |
| Pereira, MP | 1 |
| Conrad, H | 1 |
| Hatt, H | 1 |
| Lotts, T | 1 |
| Osada, N | 1 |
| Pogatzki-Zahn, E | 1 |
| Su, XY | 1 |
| Yuan, Y | 1 |
| Guo, SS | 1 |
| Luo, HQ | 1 |
| Huang, C | 1 |
| Sun, W | 1 |
| Liu, MG | 1 |
| Hu, J | 1 |
| Xu, TL | 1 |
| Meixiong, J | 1 |
| Anderson, M | 1 |
| Limjunyawong, N | 1 |
| Sabbagh, MF | 1 |
| Hu, E | 1 |
| Oetjen, LK | 1 |
| Banovic, F | 1 |
| Denley, T | 1 |
| Blubaugh, A | 1 |
| Jurcakova, D | 2 |
| Ru, F | 3 |
| Undem, BJ | 4 |
| Roberts, CA | 1 |
| Giesbrecht, T | 1 |
| Stancak, A | 1 |
| Fallon, N | 1 |
| Thomas, A | 1 |
| Kirkham, TC | 1 |
| Bartsch, VB | 1 |
| Niehaus, JK | 1 |
| Taylor-Blake, B | 3 |
| Zylka, MJ | 3 |
| Altrichter, S | 2 |
| Church, MK | 8 |
| Marzell, R | 1 |
| Reichwein, G | 1 |
| Gieler, U | 2 |
| Kupfer, J | 2 |
| Schut, C | 1 |
| Schley, M | 1 |
| Rukwied, R | 6 |
| Blunk, J | 1 |
| Menzer, C | 1 |
| Konrad, C | 1 |
| Dusch, M | 2 |
| Benrath, J | 2 |
| Inami, Y | 3 |
| Andoh, T | 14 |
| Kuraishi, Y | 19 |
| Sandilands, EA | 1 |
| Crowe, J | 1 |
| Cuthbert, H | 1 |
| Jenkins, PJ | 1 |
| Johnston, NR | 1 |
| Eddleston, M | 1 |
| Bateman, DN | 2 |
| Webb, DJ | 1 |
| McCoy, ES | 2 |
| Street, SE | 1 |
| Pribisko, AL | 1 |
| Zheng, J | 1 |
| Tanizaki, H | 3 |
| Nakahigashi, K | 2 |
| Miyachi, Y | 8 |
| Kabashima, K | 3 |
| Moser, HR | 2 |
| O'Brien, DE | 1 |
| Brenner, DS | 1 |
| Gutmann, DH | 1 |
| Gereau, RW | 2 |
| Fukuoka, M | 2 |
| Ikoma, A | 10 |
| Roberson, DP | 1 |
| Gudes, S | 1 |
| Sprague, JM | 1 |
| Patoski, HA | 1 |
| Robson, VK | 1 |
| Blasl, F | 1 |
| Duan, B | 1 |
| Oh, SB | 1 |
| Bean, BP | 1 |
| Ma, Q | 1 |
| Binshtok, AM | 1 |
| Woolf, CJ | 1 |
| Wang, JN | 1 |
| Liu, QY | 1 |
| Yao, CH | 1 |
| Chen, SJ | 1 |
| Song, LY | 1 |
| Pin, G | 1 |
| Shao, LJ | 1 |
| She, YY | 1 |
| Chi, HY | 1 |
| Nabe, T | 1 |
| Kijitani, Y | 1 |
| Kitagawa, Y | 1 |
| Sakano, E | 1 |
| Ueno, T | 1 |
| Nakao, S | 1 |
| Sakai, M | 1 |
| Takai, S | 1 |
| Descalzi, G | 3 |
| Koga, K | 2 |
| Li, XY | 2 |
| Yamada, K | 1 |
| Zhuo, M | 3 |
| Dhand, A | 1 |
| Aminoff, MJ | 1 |
| van Laarhoven, AI | 4 |
| Kraaimaat, FW | 5 |
| Wilder-Smith, OH | 5 |
| van Riel, PL | 2 |
| van de Kerkhof, PC | 2 |
| Evers, AW | 4 |
| Jang, SE | 3 |
| Ryu, KR | 2 |
| Park, SH | 1 |
| Chung, S | 1 |
| Teruya, Y | 1 |
| Han, MJ | 4 |
| Woo, JT | 1 |
| Kim, DH | 7 |
| Nakamizo, S | 1 |
| Yamaura, K | 2 |
| Tomono, A | 1 |
| Suwa, E | 2 |
| Ueno, K | 2 |
| Stumpf, A | 2 |
| Burgmer, M | 2 |
| Schneider, G | 3 |
| Heuft, G | 3 |
| Phan, NQ | 1 |
| Pfleiderer, B | 2 |
| Takeo, T | 1 |
| Kasugai, C | 1 |
| Tanaka, R | 1 |
| Ando, T | 1 |
| Ogawa, A | 1 |
| Akita, Y | 1 |
| Watanabe, D | 1 |
| Savall, BM | 1 |
| Chavez, F | 1 |
| Tays, K | 1 |
| Dunford, PJ | 3 |
| Cowden, JM | 1 |
| Hack, MD | 1 |
| Wolin, RL | 1 |
| Thurmond, RL | 4 |
| Edwards, JP | 1 |
| Sasaki, A | 2 |
| Zhang, L | 2 |
| Jiang, GY | 2 |
| Song, NJ | 1 |
| Huang, Y | 2 |
| Chen, JY | 2 |
| Wang, QX | 2 |
| Ding, YQ | 2 |
| Kollmeier, A | 1 |
| Francke, K | 1 |
| Chen, B | 1 |
| Greenspan, AJ | 2 |
| Xia, Y | 1 |
| Xu, XL | 1 |
| Zhou, B | 1 |
| Hartmann, EM | 1 |
| Handwerker, HO | 14 |
| Forster, C | 7 |
| Piecha, D | 1 |
| Steppan, S | 1 |
| Abe, K | 1 |
| Kobayashi, K | 1 |
| Yoshino, S | 1 |
| Taguchi, K | 1 |
| Nojima, H | 5 |
| Seifert, R | 1 |
| Papoiu, AD | 5 |
| Emerson, NM | 1 |
| Patel, TS | 4 |
| Kraft, RA | 3 |
| Valdes-Rodriguez, R | 1 |
| Coghill, RC | 6 |
| Koganemaru, G | 1 |
| Kuramashi, A | 1 |
| Ikeda, T | 1 |
| Gibson, RA | 1 |
| Robertson, J | 1 |
| Mistry, H | 1 |
| McCallum, S | 1 |
| Fernando, D | 1 |
| Wyres, M | 1 |
| Min, H | 2 |
| Lee, H | 3 |
| Lim, H | 1 |
| Jang, YH | 1 |
| Chung, SJ | 1 |
| Lee, CJ | 2 |
| Lee, SJ | 2 |
| Zhao, ZQ | 2 |
| Huo, FQ | 1 |
| Krieger, S | 1 |
| Liu, ZC | 1 |
| Xu, J | 1 |
| Rogers, BE | 1 |
| Fluhr, JW | 2 |
| Mengeaud, V | 1 |
| Redoulès, D | 1 |
| Jansen, NA | 1 |
| Vierow, V | 1 |
| Vogelgsang, R | 1 |
| Dörfler, A | 1 |
| Bauer, M | 1 |
| Schwameis, R | 1 |
| Scherzer, T | 1 |
| Lang-Zwosta, I | 1 |
| Nishino, K | 1 |
| Zeitlinger, M | 1 |
| van de Sand, MF | 1 |
| Sprenger, C | 1 |
| Büchel, C | 1 |
| Valtcheva, MV | 1 |
| Davidson, S | 4 |
| Zhao, C | 1 |
| Leitges, M | 1 |
| Darragh, M | 1 |
| Chang, JW | 1 |
| Booth, RJ | 1 |
| Consedine, NS | 1 |
| Haruna, T | 1 |
| Soga, M | 1 |
| Morioka, Y | 1 |
| Hikita, I | 2 |
| Imura, K | 1 |
| Furue, Y | 1 |
| Yamamoto, M | 1 |
| Imura, C | 1 |
| Ikeda, M | 2 |
| Yamauchi, A | 1 |
| Deguchi, M | 2 |
| Shichijo, M | 1 |
| Arimura, A | 2 |
| Yasui, K | 1 |
| Weinkauf, B | 2 |
| van der Ham, J | 1 |
| Szallasi, A | 1 |
| Kazerouni, K | 1 |
| Chaplan, SR | 1 |
| Obara, I | 1 |
| Medrano, MC | 1 |
| Signoret-Genest, J | 1 |
| Jiménez-Díaz, L | 1 |
| Géranton, SM | 1 |
| Hunt, SP | 1 |
| Mollanazar, NK | 1 |
| Smith, PK | 1 |
| Brennan, FP | 1 |
| Josland, E | 1 |
| Kelly, JJ | 1 |
| Pall, PS | 1 |
| Hurwitz, OE | 1 |
| King, BA | 1 |
| Pradhananga, S | 1 |
| Nakagawa, K | 1 |
| Mochizuki, H | 2 |
| Koyama, S | 1 |
| Tanaka, S | 1 |
| Sadato, N | 2 |
| Kakigi, R | 1 |
| Dai, MH | 1 |
| Huang, K | 1 |
| Chai, GD | 1 |
| Chen, L | 1 |
| Lang, B | 1 |
| St Clair, D | 1 |
| McCaig, C | 1 |
| Shimizu, K | 1 |
| Yoshihisa, Y | 1 |
| Shimizu, T | 1 |
| Donders, AR | 1 |
| Hopman, MT | 1 |
| Peters, ML | 1 |
| Huang, CC | 1 |
| Kim, YS | 1 |
| Olson, WP | 1 |
| Guo, C | 1 |
| Luo, W | 1 |
| Huang, AJW | 1 |
| Zerey, V | 1 |
| Ivanov, M | 2 |
| Cevikbas, F | 2 |
| Kempkes, C | 1 |
| Buddenkotte, J | 2 |
| Steinhoff, M | 5 |
| Chuquilin, M | 1 |
| Alghalith, Y | 1 |
| Fernandez, KH | 1 |
| Yuan, T | 1 |
| Shen, L | 1 |
| Zhang, W | 1 |
| Xu, Y | 1 |
| Zhu, J | 1 |
| Nakasone, T | 1 |
| Sugimoto, Y | 2 |
| Kamei, C | 10 |
| Chen, Y | 1 |
| Fang, Q | 1 |
| MacLeod, AS | 1 |
| Hall, RP | 1 |
| Liedtke, WB | 1 |
| Sutherland, S | 1 |
| Melholt, C | 1 |
| Hilborg, SD | 1 |
| Jerwiarz, A | 1 |
| Randers, A | 1 |
| Simoni, A | 1 |
| Yang, NN | 1 |
| Shi, H | 1 |
| Yu, G | 1 |
| Wang, CM | 1 |
| Zhu, C | 1 |
| Yuan, XL | 1 |
| Tang, M | 1 |
| Wang, ZL | 1 |
| Gegen, T | 1 |
| He, Q | 1 |
| Tang, K | 1 |
| Lan, L | 1 |
| Tang, ZX | 1 |
| Imai, Y | 1 |
| Petersen, KK | 1 |
| Koenig, J | 1 |
| Kusube, F | 1 |
| Kawasaki, H | 2 |
| Yamakura, F | 1 |
| Naito, H | 1 |
| Ogawa, H | 1 |
| Tomooka, Y | 1 |
| Sørensen, AR | 1 |
| Nielsen, GA | 1 |
| Mølgaard, MS | 1 |
| Stilling, P | 1 |
| Boudreau, SA | 1 |
| Lee, JS | 1 |
| Han, JS | 1 |
| Lee, K | 2 |
| Bang, J | 1 |
| Bregman, H | 2 |
| Chakka, N | 1 |
| Bojic, EF | 1 |
| Fremeau, R | 1 |
| Hall, BE | 1 |
| Lee, J | 2 |
| Ortuno, D | 1 |
| Rose, PE | 2 |
| Schenkel, LB | 1 |
| Zuberbier, T | 2 |
| Christensen, AJ | 1 |
| Iyer, SM | 1 |
| François, A | 1 |
| Vyas, S | 1 |
| Ramakrishnan, C | 1 |
| Vesuna, S | 1 |
| Deisseroth, K | 1 |
| Scherrer, G | 1 |
| Delp, SL | 1 |
| Marker, JB | 1 |
| Hoeck, EA | 1 |
| Yamada, Y | 1 |
| Ueda, Y | 2 |
| Nakamura, A | 1 |
| Kanayama, S | 1 |
| Tamura, R | 1 |
| Hashimoto, K | 1 |
| Matsumoto, T | 1 |
| Ishii, R | 1 |
| Sharma, N | 1 |
| Hauberg, LE | 1 |
| Gazerani, P | 2 |
| Sun, H | 1 |
| Herbstsomer, RA | 1 |
| Meixong, J | 1 |
| Boezio, A | 1 |
| Graceffa, R | 1 |
| Youngblood, BD | 1 |
| Carr, R | 1 |
| Johanek, LM | 4 |
| Meyer, RA | 3 |
| Friedman, RM | 1 |
| Greenquist, KW | 1 |
| Shim, B | 2 |
| Borzan, J | 2 |
| Hartke, T | 2 |
| Theunis, J | 2 |
| Black, D | 2 |
| Degouy, A | 1 |
| Schmitt, AM | 1 |
| BAER, RL | 1 |
| SULZBERGER, MB | 1 |
| WITTEN, VH | 1 |
| Tsujii, K | 1 |
| Lee, JB | 5 |
| Carr, MN | 1 |
| Torres, SM | 1 |
| Koch, SN | 1 |
| Reiter, LV | 1 |
| Nakano, Y | 2 |
| Takahashi, Y | 1 |
| Ono, R | 1 |
| Kurata, Y | 1 |
| Kagawa, Y | 2 |
| Merrill, AW | 1 |
| Zanotto, K | 1 |
| Sikand, P | 2 |
| Green, BG | 1 |
| Nagai, M | 1 |
| Okunishi, I | 1 |
| Kosteletzky, F | 1 |
| Pedersen, NS | 1 |
| Oda, M | 1 |
| Suzuki, M | 1 |
| Sato, H | 1 |
| Saito, A | 1 |
| Meng, XL | 1 |
| Oshiro, Y | 2 |
| Vieira Dos Santos, R | 1 |
| Magerl, M | 1 |
| Martus, P | 3 |
| Escribano, L | 1 |
| Pfab, F | 5 |
| Valet, M | 4 |
| Sprenger, T | 3 |
| Huss-Marp, J | 2 |
| Athanasiadis, GI | 3 |
| Baurecht, HJ | 1 |
| Konstantinow, A | 1 |
| Zimmer, C | 2 |
| Behrendt, H | 6 |
| Ring, J | 11 |
| Tölle, TR | 4 |
| Darsow, U | 10 |
| Maruani, A | 1 |
| Vierron, E | 1 |
| Machet, L | 1 |
| Giraudeau, B | 1 |
| Boucaud, A | 1 |
| Shinmei, Y | 3 |
| Yano, H | 2 |
| Izawa, K | 1 |
| Akagi, M | 1 |
| Inoue, T | 2 |
| Surdenikova, L | 1 |
| Patel, KN | 4 |
| Kim, A | 1 |
| Guan, Y | 2 |
| Weng, HJ | 2 |
| Geng, Y | 1 |
| Kollarik, M | 1 |
| Anderson, DJ | 1 |
| Amatya, B | 1 |
| Nordlind, K | 2 |
| Wahlgren, CF | 11 |
| Trinh, HT | 3 |
| Joh, EH | 2 |
| Kwak, HY | 1 |
| Baek, NI | 1 |
| Zhang, Q | 2 |
| Konno, M | 1 |
| Hattori, M | 2 |
| Ricks, R | 1 |
| Banga, R | 1 |
| Porter, M | 1 |
| Smith, ES | 1 |
| Blass, GR | 1 |
| Lewin, GR | 1 |
| Park, TJ | 1 |
| Kaur, S | 1 |
| Sur, R | 1 |
| Liebel, FT | 1 |
| Southall, MD | 1 |
| Tran, BW | 1 |
| Russoniello, CV | 1 |
| Wang, H | 4 |
| Lee, B | 2 |
| Lee, IA | 1 |
| Oh, S | 1 |
| Hirakawa, N | 1 |
| Yanoshita, R | 1 |
| Yoshii, M | 1 |
| Su, X | 1 |
| Carstens, IM | 1 |
| Yamamoto, T | 2 |
| Tayama, M | 2 |
| Tanaka, K | 1 |
| Xu, ZZ | 1 |
| Park, CK | 1 |
| Berta, T | 1 |
| Ji, RR | 1 |
| Lagerström, MC | 1 |
| Rogoz, K | 1 |
| Abrahamsen, B | 1 |
| Persson, E | 1 |
| Reinius, B | 1 |
| Nordenankar, K | 1 |
| Olund, C | 1 |
| Smith, C | 1 |
| Mendez, JA | 1 |
| Wood, JN | 1 |
| Wallén-Mackenzie, A | 1 |
| Kullander, K | 1 |
| Gal-Oz, A | 1 |
| Rogowski, O | 1 |
| Swartzon, M | 1 |
| Kivity, S | 2 |
| Grundmann, S | 1 |
| Hyun, YJ | 1 |
| Kim, SJ | 1 |
| Park, GH | 1 |
| Kim, D | 1 |
| Wall, E | 1 |
| Simon, MI | 2 |
| Han, SK | 2 |
| Liang, J | 1 |
| Ji, Q | 1 |
| Ji, W | 1 |
| Kerr, K | 1 |
| Schwartz, JR | 1 |
| Filloon, T | 1 |
| Fieno, A | 1 |
| Wehmeyer, K | 1 |
| Szepietowski, JC | 2 |
| Mills, KJ | 1 |
| Vogelaar, ML | 1 |
| van Riel, PLCM | 1 |
| Wilson, SR | 1 |
| Gerhold, KA | 1 |
| Bifolck-Fisher, A | 1 |
| Bautista, DM | 1 |
| Meeker, S | 1 |
| Ling, J | 1 |
| Gu, J | 1 |
| Raap, U | 1 |
| Bergeret, L | 1 |
| Chauveau, N | 1 |
| Aubry, F | 1 |
| Gros, H | 1 |
| Viallard, G | 1 |
| Celsis, P | 1 |
| Orita, K | 1 |
| Hiramoto, K | 1 |
| Kobayashi, H | 1 |
| Ishii, M | 1 |
| Sekiyama, A | 1 |
| Inoue, M | 1 |
| Akasaka, Y | 1 |
| Yoshida, T | 1 |
| Tsukahara, M | 1 |
| Hatta, A | 1 |
| Inoue, H | 1 |
| Gu, Q | 1 |
| Schepers, RJ | 1 |
| Tanaka, T | 2 |
| Satoh, T | 1 |
| Tanaka, A | 1 |
| Yokozeki, H | 1 |
| Kim, JI | 1 |
| Lee, HR | 1 |
| Kleyn, CE | 1 |
| McKie, S | 1 |
| Ross, A | 1 |
| Elliott, R | 1 |
| Griffiths, CE | 1 |
| Myers, AL | 1 |
| Gaedigk, A | 1 |
| Dai, H | 1 |
| James, LP | 1 |
| Jones, BL | 1 |
| Neville, KA | 1 |
| Han, N | 1 |
| Zu, JY | 1 |
| Chai, J | 1 |
| Samukawa, K | 1 |
| Izumi, Y | 1 |
| Shiota, M | 1 |
| Nakao, T | 1 |
| Osada-Oka, M | 1 |
| Miura, K | 1 |
| Iwao, H | 1 |
| Walker, AL | 1 |
| Kroeze, S | 1 |
| Gomes, LO | 1 |
| Hara, DB | 1 |
| Rae, GA | 2 |
| Carstens, EE | 1 |
| Honda, CN | 2 |
| Napadow, V | 1 |
| Rukwied, RR | 1 |
| Main, M | 1 |
| Jung, IH | 1 |
| Wallengren, J | 2 |
| Marino, M | 1 |
| Huang, P | 1 |
| Malkmus, S | 1 |
| Robertshaw, E | 1 |
| Mac, EA | 1 |
| Shatterman, Y | 1 |
| Yaksh, TL | 1 |
| Bin Saif, GA | 1 |
| McMichael, A | 1 |
| Kwatra, SG | 1 |
| Blansit, K | 2 |
| Horwitz, A | 2 |
| Schoepke, N | 1 |
| Rausl, A | 1 |
| Han, L | 1 |
| Cui, Y | 1 |
| Kim, Y | 1 |
| Qu, L | 1 |
| McNeil, B | 1 |
| He, S | 1 |
| Xiao, B | 1 |
| Kaliner, MA | 1 |
| Harding, CR | 1 |
| Moore, AE | 1 |
| Rogers, JS | 1 |
| Meldrum, H | 1 |
| Scott, AE | 1 |
| McGlone, FP | 1 |
| Zeck, S | 1 |
| McGlone, F | 3 |
| Laidlaw, A | 1 |
| Flecknell, P | 1 |
| Rees, JL | 2 |
| Morita, K | 1 |
| Koga, T | 1 |
| Moroi, Y | 1 |
| Urabe, K | 1 |
| Furue, M | 1 |
| Weisshaar, E | 7 |
| Dunker, N | 3 |
| Domröse, U | 1 |
| Neumann, KH | 1 |
| Gollnick, H | 5 |
| Schmidt, R | 2 |
| Weidner, C | 1 |
| Hilliges, M | 2 |
| Torebjork, HE | 2 |
| Dvorak, M | 1 |
| Watkinson, A | 1 |
| Neisius, U | 1 |
| Fartasch, M | 2 |
| Heyer, G | 10 |
| Skov, PS | 1 |
| Luger, TA | 2 |
| Hossen, MA | 3 |
| Kayasuga, R | 1 |
| CORMIA, FE | 4 |
| KUYKENDALL, V | 2 |
| BROADBENT, JL | 2 |
| WALKER, VB | 1 |
| HISSARD, R | 1 |
| JACQUET, J | 1 |
| ROBIN, M | 1 |
| KEPECS, JG | 1 |
| FRANK, L | 1 |
| EPSTEIN, WL | 1 |
| SULLIVAN, FJ | 1 |
| FERGUSON, EH | 1 |
| BRACK, W | 1 |
| DEMIS, DJ | 1 |
| ISHIMOVA, LM | 1 |
| AN, NN | 1 |
| BEALL, GN | 1 |
| Denham, KJ | 1 |
| Boutsiouki, P | 1 |
| Clough, GF | 1 |
| Imaizumi, A | 1 |
| Kawakami, T | 1 |
| Murakami, F | 1 |
| Soma, Y | 1 |
| Mizoguchi, M | 1 |
| Stener-Victorin, E | 1 |
| Lundeberg, T | 3 |
| Kowalski, J | 1 |
| Opdal, L | 1 |
| Sjöström, J | 1 |
| Lundeberg, L | 1 |
| Zhang, JM | 1 |
| Igarashi, A | 1 |
| Hoshina, F | 1 |
| Yamada, M | 1 |
| Toyoda, Y | 1 |
| Notsu, Y | 1 |
| Kohno, S | 1 |
| Handwerker, H | 2 |
| SHELLEY, WB | 2 |
| MELTON, FM | 2 |
| Minami, K | 1 |
| Ko, MC | 1 |
| Song, MS | 1 |
| Edwards, T | 1 |
| Naughton, NN | 1 |
| Bell, JK | 1 |
| McQueen, DS | 1 |
| Wasner, G | 2 |
| Schwarz, K | 2 |
| Schattschneider, J | 2 |
| Binder, A | 1 |
| Jensen, TS | 1 |
| Baron, R | 2 |
| Kim, BM | 1 |
| Lee, SH | 1 |
| Oh, U | 1 |
| Röhl, FW | 2 |
| Okihara, K | 1 |
| Sugimoto, H | 1 |
| Yamada, H | 1 |
| HAAS, H | 1 |
| KEENEY, EL | 1 |
| LUBOWE, II | 1 |
| Arai, I | 1 |
| Takano, N | 1 |
| Hashimoto, Y | 1 |
| Futaki, N | 1 |
| Sugimoto, M | 1 |
| Takahashi, N | 1 |
| Nakaike, S | 1 |
| Jiang, S | 4 |
| Takubo, M | 3 |
| Tsumuro, T | 2 |
| Murata, Y | 1 |
| Sugiura, M | 1 |
| Seike, M | 1 |
| Kodama, H | 1 |
| Terui, T | 1 |
| Ohtsu, H | 1 |
| Baolin, L | 1 |
| Weiwei, W | 1 |
| Ning, T | 1 |
| Walter, B | 1 |
| Sadlo, MN | 1 |
| Niemeier, V | 1 |
| Brosig, B | 1 |
| Stark, R | 1 |
| Vaitl, D | 1 |
| Shin, YW | 2 |
| Saxena, AK | 1 |
| Fujii, Y | 2 |
| Hammes, M | 1 |
| Bäcker, M | 1 |
| Ui, H | 1 |
| Kupczyk, M | 1 |
| Kupryś, I | 1 |
| Górski, P | 1 |
| Kuna, P | 1 |
| Yatsuzuka, R | 2 |
| Green, AD | 1 |
| Young, KK | 1 |
| Lehto, SG | 1 |
| Smith, SB | 1 |
| Mogil, JS | 1 |
| Trentin, PG | 1 |
| Fernandes, MB | 1 |
| D'Orléans-Juste, P | 1 |
| Yoshioka, T | 1 |
| Asakawa, M | 1 |
| Hirasawa, T | 1 |
| Matsutani, T | 1 |
| Oku, H | 1 |
| Horikawa, T | 1 |
| Hosogi, M | 1 |
| Leknes, SG | 1 |
| Bantick, S | 1 |
| Willis, CM | 1 |
| Wilkinson, JD | 1 |
| Wise, RG | 1 |
| Tracey, I | 1 |
| Kesting, MR | 1 |
| Thurmüller, P | 1 |
| Hölzle, F | 1 |
| Wolff, KD | 1 |
| Holland-Letz, T | 1 |
| Stücker, M | 1 |
| Toelle, TR | 1 |
| Carlsson, CP | 1 |
| Sundler, F | 1 |
| Toomey, M | 1 |
| Biddle, C | 1 |
| Mancino, V | 1 |
| Williams, KN | 1 |
| Desai, PJ | 1 |
| Karlsson, L | 1 |
| McQueen, D | 1 |
| Marincsák, R | 1 |
| Dobrosi, N | 1 |
| Géczy, T | 1 |
| Paus, R | 1 |
| Saito, DN | 1 |
| Toyoda, H | 1 |
| Tashiro, M | 1 |
| Okamura, N | 1 |
| Yanai, K | 1 |
| Hobelmann, JG | 1 |
| Maine, DN | 1 |
| Wöller, A | 1 |
| Antonijoan, R | 1 |
| García-Gea, C | 1 |
| Puntes, M | 1 |
| Pérez, J | 1 |
| Esbrí, R | 1 |
| Serra, C | 1 |
| Fortea, J | 1 |
| Barbanoj, MJ | 1 |
| Herde, L | 1 |
| Yoon, CH | 1 |
| Ganesh, A | 1 |
| Maxwell, LG | 1 |
| Dawn, A | 1 |
| Fountain, J | 1 |
| GREYGHTON, JW | 1 |
| Driesch, G | 1 |
| Weckesser, M | 1 |
| Asero, R | 1 |
| Tedeschi, A | 1 |
| Reich, A | 1 |
| Han, SJ | 1 |
| Rahman, MA | 1 |
| Nakano, T | 2 |
| Kosaka, M | 1 |
| Chapman, PH | 1 |
| Rawlins, MD | 1 |
| Mikuni, I | 1 |
| Garafalo, J | 1 |
| Kaplan, AP | 1 |
| Fjellner, B | 10 |
| Hägermark, O | 17 |
| Belgrade, MJ | 1 |
| Solomon, LM | 1 |
| Lichter, EA | 1 |
| Chee, YC | 1 |
| Ekblom, A | 7 |
| Hansson, P | 2 |
| Davies, MG | 2 |
| Greaves, MW | 7 |
| Ushakov, IV | 1 |
| Angelova, VS | 1 |
| Farnam, J | 1 |
| Grant, JA | 1 |
| Guernsey, BG | 1 |
| Jorizzo, JL | 1 |
| Petrusa, ER | 1 |
| Scott, PV | 1 |
| Fischer, HB | 1 |
| Black, AK | 1 |
| Eady, RA | 1 |
| Coutts, A | 1 |
| Granerus, G | 1 |
| Olafsson, JH | 1 |
| Roupe, G | 1 |
| Medansky, RS | 1 |
| Handler, RM | 1 |
| Bernstein, JE | 1 |
| Swift, RM | 1 |
| Soltani, K | 1 |
| Lorincz, AL | 1 |
| Lewis, J | 1 |
| Lieberman, P | 1 |
| Treadwell, G | 1 |
| Erffmeyer, J | 1 |
| Davis, RS | 1 |
| Remigio, LK | 1 |
| Schocket, AL | 1 |
| Bock, SA | 1 |
| Nagasawa, T | 2 |
| Hayashi, K | 1 |
| Satoh, M | 2 |
| Johansson, O | 1 |
| Virtanen, M | 1 |
| Bromm, B | 3 |
| Scharein, E | 3 |
| Abila, B | 1 |
| Ezeamuzie, IC | 1 |
| Igbigbi, PS | 1 |
| Ambakederemo, AW | 1 |
| Asomugha, L | 1 |
| Woodward, DF | 1 |
| Nieves, AL | 1 |
| Spada, CS | 1 |
| Williams, LS | 1 |
| Tuckett, RP | 1 |
| Muller, EW | 1 |
| de Wolf, JT | 1 |
| Egger, R | 1 |
| Wijermans, PW | 1 |
| Huijgens, PC | 1 |
| Halie, MR | 1 |
| Vellenga, E | 1 |
| Matsui, C | 1 |
| Ida, M | 1 |
| Hamada, M | 1 |
| Morohashi, M | 1 |
| Hasegawa, M | 1 |
| Hsieh, JC | 1 |
| Ståhle-Bäckdahl, M | 4 |
| Ericson, K | 1 |
| Eriksson, L | 1 |
| Stone-Elander, S | 1 |
| Ingvar, M | 1 |
| Leynadier, F | 1 |
| Murrieta, M | 1 |
| Dry, J | 1 |
| Colin, JN | 1 |
| Gillotin, C | 1 |
| Steru, D | 1 |
| Beckers, RC | 1 |
| Vermeer, BJ | 1 |
| Boom, BW | 1 |
| Wood-Baker, R | 1 |
| Emanuel, MB | 1 |
| Hutchinson, K | 1 |
| Howarth, PH | 1 |
| O'Sullivan, TL | 1 |
| Ruffing, MJ | 1 |
| Lamp, KC | 1 |
| Warbasse, LH | 1 |
| Rybak, MJ | 1 |
| Berbis, P | 1 |
| Michel, L | 1 |
| Hesse, S | 1 |
| Privat, Y | 1 |
| Piazza, V | 2 |
| De Filippi, C | 2 |
| Aprile, C | 1 |
| Efficace, E | 1 |
| Pisati, P | 2 |
| Sacchi, S | 2 |
| Salvadeo, A | 2 |
| Koppert, W | 4 |
| Regazzini, R | 1 |
| Galli, F | 1 |
| Ulmer, FJ | 1 |
| Schmitz, J | 1 |
| Cremer, B | 1 |
| Heimann, A | 1 |
| Dippel, E | 1 |
| Czarnetzki, BM | 1 |
| Szolar, C | 2 |
| Hui, XY | 2 |
| Maibach, H | 2 |
| Lind, G | 1 |
| Meyerson, BA | 1 |
| Lengstam, I | 2 |
| Ward, L | 1 |
| Wright, E | 1 |
| McMahon, SB | 1 |
| Peer, G | 1 |
| Agami, O | 1 |
| Fireman, E | 1 |
| Silverberg, D | 1 |
| Blum, M | 1 |
| laina, A | 1 |
| Ademola, J | 1 |
| Lui, P | 1 |
| Amin, S | 1 |
| Maibach, HI | 3 |
| Wang, D | 1 |
| Smitz, J | 1 |
| Waterschoot, S | 1 |
| Clement, P | 1 |
| Matsuda, H | 1 |
| Dai, Y | 1 |
| Ido, Y | 1 |
| Yoshikawa, M | 1 |
| Nilsson, HJ | 1 |
| Levinsson, A | 1 |
| Schouenborg, J | 1 |
| Katayama, I | 1 |
| Nishioka, K | 1 |
| Bickel, A | 1 |
| Kanthawatana, S | 1 |
| Maturim, W | 1 |
| Fooanant, S | 1 |
| Manorot, M | 1 |
| Trakultivakorn, M | 1 |
| Ziethen, B | 2 |
| Dotzer, M | 2 |
| Diepgen, LT | 1 |
| Handwerker, OH | 1 |
| Renz, C | 1 |
| Lynch, J | 1 |
| Thurn, J | 1 |
| Moss, J | 1 |
| Balaskas, EV | 1 |
| Bamihas, GI | 1 |
| Karamouzis, M | 1 |
| Voyiatzis, G | 1 |
| Tourkantonis, A | 1 |
| Jinks, SL | 3 |
| Heyer, GR | 1 |
| Hornstein, OP | 2 |
| Yamaguchi, T | 2 |
| Atanassoff, PG | 2 |
| Brull, SJ | 2 |
| Greenquist, K | 1 |
| Silverman, DG | 2 |
| Zhai, H | 1 |
| Hannon, W | 1 |
| Hahn, GS | 1 |
| Harper, RA | 1 |
| Pelosi, A | 1 |
| Greaves, M | 1 |
| Lischetzki, G | 1 |
| Drzezga, A | 2 |
| Frisch, M | 2 |
| Munz, F | 2 |
| Weilke, F | 2 |
| Bartenstein, P | 2 |
| Schwaiger, M | 2 |
| Andrew, D | 1 |
| Craig, AD | 1 |
| Inagaki, N | 2 |
| Nakamura, N | 1 |
| Nagao, M | 2 |
| Nagai, H | 2 |
| Maekawa, T | 2 |
| Nishikawa, Y | 1 |
| Kaneko, M | 1 |
| Kawakita, T | 1 |
| Miyamoto, T | 1 |
| Ahluwalia, P | 1 |
| McGill, JI | 1 |
| Treede, RD | 2 |
| Siebner, H | 1 |
| Marsella, R | 1 |
| Nicklin, CF | 1 |
| Reitamo, S | 1 |
| Ansel, JC | 1 |
| Takizawa, T | 1 |
| Matsumoto, J | 1 |
| Tohma, T | 1 |
| Kanke, T | 1 |
| Wada, Y | 1 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Ohtsuka, E | 1 |
| Kawai, S | 1 |
| Ichikawa, T | 1 |
| Kitagawa, K | 1 |
| Shirai, Y | 1 |
| Kamimura, K | 1 |
| Kleinert, A | 1 |
| Braun, M | 1 |
| Lowitt, MH | 1 |
| Togashi, Y | 1 |
| Umeuchi, H | 1 |
| Okano, K | 1 |
| Ando, N | 1 |
| Yoshizawa, Y | 1 |
| Honda, T | 1 |
| Kawamura, K | 1 |
| Endoh, T | 1 |
| Utsumi, J | 1 |
| Kamei, J | 1 |
| Nagase, H | 1 |
| Nicolson, TA | 1 |
| Bevan, S | 1 |
| Richards, CD | 1 |
| Thomsen, JS | 2 |
| Sonne, M | 1 |
| Benfeldt, E | 2 |
| Jensen, SB | 2 |
| Serup, J | 2 |
| Menné, T | 2 |
| Kirchner, A | 1 |
| Stefan, H | 1 |
| Haslbeck, KM | 1 |
| Birklein, F | 1 |
| Arnold, AJ | 1 |
| Simpson, JG | 1 |
| Jones, HE | 1 |
| Ahmed, AR | 1 |
| Soter, NA | 1 |
| Wasserman, SI | 1 |
| Austen, KF | 1 |
| Filipp, G | 1 |
| Strandberg, K | 3 |
| Rhoades, RB | 1 |
| Leifer, KN | 1 |
| Cohan, R | 1 |
| Wittig, HJ | 1 |
| Marks, R | 3 |
| Horton, RJ | 1 |
| Storari, FE | 1 |
| Hamberg, M | 1 |
| Lovell, CR | 1 |
| Burton, PA | 1 |
| Duncan, EH | 1 |
| Burton, JL | 1 |
| Yao, GL | 1 |
| Tohyama, M | 1 |
| Senba, E | 1 |
| Phillips, WG | 1 |
| Aoki, T | 1 |
| Pedersen, EB | 1 |
| De Marchi, S | 1 |
| Cecchin, E | 1 |
| Villalta, D | 1 |
| Sepiacci, G | 1 |
| Santini, G | 1 |
| Bartoli, E | 1 |
| Owada, S | 1 |
| Toyama, K | 1 |
| Maeba, T | 1 |
| Ishida, M | 1 |
| Healy, DP | 3 |
| Sahai, JV | 1 |
| Fuller, SH | 1 |
| Polk, RE | 3 |
| Kaku, H | 1 |
| Fujita, Y | 1 |
| Yago, H | 1 |
| Naka, F | 1 |
| Kawakubo, H | 1 |
| Nakano, K | 1 |
| Nishikawa, K | 1 |
| Suehiro, S | 1 |
| Mettang, T | 1 |
| Fritz, P | 1 |
| Weber, J | 1 |
| Machleidt, C | 1 |
| Hübel, E | 1 |
| Kuhlmann, U | 1 |
| Bergström, R | 2 |
| Alreja, M | 1 |
| Francos, GC | 1 |
| Kauh, YC | 1 |
| Gittlen, SD | 2 |
| Schulman, ES | 2 |
| Besarab, A | 1 |
| Goyal, S | 1 |
| Burke, JF | 1 |
| Lever, LR | 1 |
| Hill, S | 2 |
| Dykes, PJ | 1 |
| Kirchhoff, C | 1 |
| Wallace, MR | 1 |
| Mascola, JR | 1 |
| Oldfield, EC | 1 |
| Gill, DS | 1 |
| Fonseca, VA | 1 |
| Barradas, MA | 1 |
| Balliod, R | 1 |
| Moorhead, JF | 1 |
| Dandona, P | 1 |
| Maddrey, WC | 1 |
| Durand-Malgouyres, C | 1 |
| Bazex, J | 1 |
| Marguery, MC | 1 |
| Stockenhuber, F | 1 |
| Kurz, RW | 1 |
| Sertl, K | 1 |
| Grimm, G | 1 |
| Balcke, P | 1 |
| Arnetz, BB | 2 |
| Eneroth, P | 1 |
| Kallner, A | 1 |
| Schwartz, LB | 1 |
| Rock, DT | 1 |
| Garson, ML | 1 |
| Roller, K | 1 |
| Lins, LE | 1 |
| Sahai, J | 1 |
| Garris, R | 1 |
| Berry, A | 1 |
| Giannetti, A | 1 |
| Girolomoni, G | 1 |
| Lindelöf, B | 1 |
| Halkier-Sørensen, L | 1 |
| Thestrup-Pedersen, K | 1 |
| Hanifin, JM | 1 |
| Winkelmann, RK | 1 |
| Shuttleworth, D | 1 |
| Connelly, DM | 1 |
| Ngeow, JY | 1 |
| Whitehouse, J | 1 |
| Becerra-Cabal, L | 1 |
| Putterman, GJ | 1 |
| Bondesson, L | 1 |
| Thomas, M | 1 |
| Sanada, S | 1 |
| Kuze, M | 1 |
| Yoshida, O | 1 |
| Mygind, N | 1 |
| Borum, P | 1 |
| Secher, C | 1 |
| Kirkegaard, J | 1 |
| Denman, ST | 1 |
| Casale, TB | 1 |
| Keahey, TM | 2 |
| Kaliner, M | 1 |
| Steinman, HK | 1 |
| Kobza-Black, A | 1 |
| Lotti, TM | 1 |
| Brunetti, L | 1 |
| Panconesi, E | 1 |
| Tóth-Kása, I | 1 |
| Jancsó, G | 1 |
| Bognár, A | 1 |
| Husz, S | 1 |
| Obál, F | 1 |
| Burtin, C | 1 |
| Noirot, C | 1 |
| Giroux, C | 1 |
| Scheinmann, P | 1 |
| Jackson, N | 1 |
| Burt, D | 1 |
| Crocker, J | 1 |
| Boughton, B | 1 |
| Milsmann, E | 1 |
| Rohdewald, P | 1 |
| Martin, J | 1 |
| Fruhstorfer, H | 1 |
| Hermanns, M | 1 |
| Latzke, L | 1 |
| Wuepper, KD | 1 |
| Bokisch, VA | 1 |
| Müller-Eberhard, HJ | 1 |
| Stoughton, RB | 1 |
| Youman, JD | 1 |
| Taddeini, L | 1 |
| Cooper, T | 1 |
| Savin, JA | 1 |
| Keele, CA | 1 |
| Nilzén, A | 1 |
| Suvorova, NM | 1 |
| de Moragas, JM | 1 |
| Giménez-Camarasa, JM | 1 |
| Noguera, J | 1 |
| McDonald-Gibson, W | 1 |
| Reinhard, M | 1 |
| Lampe, P | 1 |
| Berg, B | 1 |
| Wetterqvist, H | 1 |
| White, T | 1 |
| Gilbert, HS | 1 |
| Warner, RR | 1 |
| Wasserman, LR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Two Part Randomized, Double-blind, Placebo Controlled Study to Investigate the Effects of Topical Doses of SB705498 Oncapsaicin, Histamine, and Cowhage Responses in Healthy Volunteers.[NCT01673529] | Phase 1 | 16 participants (Actual) | Interventional | 2012-07-17 | Completed | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Itch Relieving Effect of Botox: a Study in Healthy Subjects[NCT02639052] | Phase 1/Phase 2 | 35 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial[NCT02168634] | 60 participants (Anticipated) | Interventional | 2013-11-30 | Recruiting | |||
| Genetic Polymorphisms Associated With Histamine Disposition in Children With Vancomycin Associated Red Man Syndrome (RMS)[NCT00824122] | 544 participants (Actual) | Observational | 2008-01-31 | Completed | |||
| Comparison of Efficacy and Consistency of Action of Levocetirizine 5 mg Once Daily With Fexofenadine 60 mg Twice Daily in the Histamine Induced Wheal, Flare and Itch Response[NCT01586091] | Phase 4 | 18 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery[NCT01451762] | 90 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
A secondary endpoint is to see if Botox has a relieving effect on heat pain using a pain visual analog scale (VAS) intensity scale as an outcome measure. The pain VAS intensity scale ranges from a minimum of 0 (no pain - best) to a maximum of 10 (maximum pain - worst). Participants will rate pain intensity after pain is induced with a heat thermode. (NCT02639052)
Timeframe: Baseline, 1 week, 1 month, 3 months
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 Week | 1 Month | 3 Months | All Visits | |
| Botox | 3.6 | 3.7 | 3.7 | 4.1 | 3.8 |
| Saline | 3.7 | 3.7 | 4.1 | 4.3 | 4.0 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 1 Month from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Month (Visit 3), 0 seconds | 1 Month (Visit 3), 30 seconds | 1 Month (Visit 3), 60 seconds | 1 Month (Visit 3), 90 seconds | 1 Month (Visit 3), 120 seconds | 1 Month (Visit 3), 150 seconds | 1 Month (Visit 3), 180 seconds | 1 Month (Visit 3), 210 seconds | 1 Month (Visit 3), 240 seconds | 1 Month (Visit 3), 270 seconds | 1 Month (Visit 3), 300 seconds | 1 Month (Visit 3), All Times | |
| Botox | 3.2 | 5.0 | 5.1 | 4.3 | 3.5 | 2.3 | 1.5 | 0.9 | 0.7 | 0.3 | 0.2 | 2.5 |
| Saline | 3.8 | 6.2 | 6.2 | 5.7 | 4.5 | 3.3 | 2.2 | 1.4 | 0.9 | 0.6 | 0.4 | 3.2 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 1 week from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Week (Visit 2), 0 seconds | 1 Week (Visit 2), 30 seconds | 1 Week (Visit 2), 60 seconds | 1 Week (Visit 2), 90 seconds | 1 Week (Visit 2), 120 seconds | 1 Week (Visit 2), 150 seconds | 1 Week (Visit 2), 180 seconds | 1 Week (Visit 2), 210 seconds | 1 Week (Visit 2), 240 seconds | 1 Week (Visit 2), 270 seconds | 1 Week (Visit 2), 300 seconds | 1 Week (Visit 2), All Times | |
| Botox | 3.3 | 5.4 | 5.9 | 4.9 | 3.7 | 2.7 | 2.0 | 1.4 | 0.9 | 0.6 | 0.4 | 2.8 |
| Saline | 4.0 | 6.7 | 6.9 | 6.1 | 4.8 | 3.8 | 2.7 | 1.9 | 1.3 | 0.9 | 0.7 | 3.6 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 3 Months from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 Months (Visit 4), 0 seconds | 3 Months (Visit 4), 30 seconds | 3 Months (Visit 4), 60 seconds | 3 Months (Visit 4), 90 seconds | 3 Months (Visit 4), 120 seconds | 3 Months (Visit 4), 150 seconds | 3 Months (Visit 4), 180 seconds | 3 Months (Visit 4), 210 seconds | 3 Months (Visit 4), 240 seconds | 3 Months (Visit 4), 270 seconds | 3 Months (Visit 4), 300 seconds | 3 Months (Visit 4), All Times | |
| Botox | 2.3 | 4.5 | 4.9 | 4.6 | 3.8 | 3.0 | 2.1 | 1.5 | 1.0 | 0.7 | 0.3 | 2.6 |
| Saline | 3.3 | 5.4 | 5.9 | 5.2 | 4.7 | 3.6 | 2.8 | 1.9 | 1.4 | 0.9 | 0.6 | 3.2 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: Baseline (Visit 1)
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (Visit 1), 0 seconds | Baseline (Visit 1), 30 seconds | Baseline (Visit 1), 60 seconds | Baseline (Visit 1), 90 seconds | Baseline (Visit 1), 120 seconds | Baseline (Visit 1), 150 seconds | Baseline (Visit 1), 180 seconds | Baseline (Visit 1), 210 seconds | Baseline (Visit 1), 240 seconds | Baseline (Visit 1), 270 seconds | Baseline (Visit 1), 300 seconds | Baseline (Visit 1), All Times | |
| Botox | 4.5 | 6.5 | 6.8 | 5.9 | 5.1 | 4.1 | 2.8 | 2.0 | 1.3 | 0.9 | 0.6 | 3.7 |
| Saline | 4.3 | 6.3 | 6.5 | 6.3 | 5.1 | 3.9 | 2.8 | 2.0 | 1.4 | 0.9 | 0.9 | 3.7 |
Flaire diameter was measured with a transparent ruler as the mean of the largest diameter and the diameter at right angles to this. (NCT01586091)
Timeframe: 24 hours per treatment
| Intervention | mm (Mean) |
|---|---|
| Placebo | 69.4 |
| Levocetirizin | 20.4 |
| Fexofenadine | 39.9 |
"We measured drug concentrations and various aspects of skin provocation testing such as itch intensity and wheal size. Measurements made at each time point were as followed: Pruritus was assessed every 30 s for 10 min after SPT using a visual analogue scale (VAS) score with a 0 and 100 at the two ex- tremes of an unmarked 100 mm line with higher values indicating greater puritus. The mean VAS for each 10 min was calculated and used as a primary end Point." (NCT01586091)
Timeframe: up to 10 minutes after skin prick test performed 24 hours after drug administration
| Intervention | mm (Mean) |
|---|---|
| Levocetirizin | 11.5 |
| Fexofenadine | 25.4 |
| Placebo | 46.0 |
Wheal volume was measured by a non-contact three dimensional measurement system (PRIMOS contact, GFM Messtechnik GmbH, Teltow, Germany). (NCT01586091)
Timeframe: 24 hours per treatment
| Intervention | cm3 (Mean) |
|---|---|
| Placebo | 174.6 |
| Levocetirizin | 35.2 |
| Fexofenadine | 106.3 |
Scores on QOR (quality of recovery) 40 questionnaire.The QoR-40 score, which ranges from 40 to 200, representing very poor to outstanding quality of recovery, respectively. (NCT01451762)
Timeframe: 24 hours post operatively
| Intervention | units on scale 40 (low) - 200 (high) (Median) |
|---|---|
| Placebo | 164 |
| 25 mg Diphenhydramine IV | 169 |
| 50 mg Diphenhydramine IV | 172 |
54 reviews available for histamine and Pruritus
| Article | Year |
|---|---|
Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Cytokines; Gene Expression; Histamine; Histamine A | 2021 |
Pharmacotherapy of Itch-Antihistamines and Histamine Receptors as G Protein-Coupled Receptors.
Topics: Histamine; Histamine Antagonists; Humans; Pruritus; Quality of Life; Receptors, G-Protein-Coupled; R | 2022 |
Neuropathic pain and itch: mechanisms in allergic conjunctivitis.
Topics: Conjunctiva; Conjunctivitis, Allergic; Histamine; Humans; Inflammation; Neuralgia; Pruritus | 2022 |
Pruritus in allergy and immunology.
Topics: Animals; Histamine; Humans; Hypersensitivity; Immunoglobulin E; Mast Cells; Pruritus | 2019 |
Itch and Cough - Similar Role of Sensory Nerves in Their Pathogenesis.
Topics: Animals; Capsaicin; Cough; Histamine; Histamine Agonists; Humans; Nerve Fibers, Myelinated; Nerve Fi | 2020 |
The Return of the Mast Cell: New Roles in Neuroimmune Itch Biology.
Topics: Animals; Histamine; Humans; Mast Cells; Neuroimmunomodulation; Neurons; Pruritus; Skin Physiological | 2020 |
Itch processing in the brain.
Topics: Brain; Histamine; Humans; Mucuna; Pain; Pruritus | 2021 |
The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis.
Topics: Cholestasis; Cytokines; Dermatitis, Atopic; Histamine; Humans; Inflammation Mediators; Models, Biolo | 2021 |
Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T-cell lymphoma.
Topics: Analgesics, Opioid; Histamine; Humans; Interleukins; Lymphoma, T-Cell, Cutaneous; Nerve Growth Facto | 2018 |
Chronic Pruritus in the Geriatric Population.
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Antipruritics; Calcineurin Inhibitors; Capsai | 2018 |
Where Is Itch Represented in the Brain, and How Does it Differ from Pain? An Activation Likelihood Estimation Meta-Analysis of Experimentally-Induced Itch.
Topics: Adult; Allergens; Brain Mapping; Cluster Analysis; Diagnosis, Differential; Electric Stimulation; Fe | 2019 |
The neurology of itch.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamidines; Guanidines; Histamine; Histamine Ant | 2014 |
Transient receptor potential channels and itch: how deep should we scratch?
Topics: Animals; Histamine; Humans; Inflammation Mediators; Nerve Growth Factors; Pruritus; Transient Recept | 2015 |
Antihistamines and itch.
Topics: Animals; Histamine; Histamine Antagonists; Humans; Pruritus; Receptors, Histamine | 2015 |
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Topics: Basophils; Combined Modality Therapy; Cytokines; Dermatitis, Atopic; Drug Discovery; Epidermis; Hist | 2016 |
Methods for preclinical assessment of antipruritic agents and itch mechanisms independent of mast-cell histamine.
Topics: Animals; Antipruritics; Disease Models, Animal; Drug Evaluation, Preclinical; Histamine; Humans; Hyp | 2015 |
Neurocutaneous disease: Cutaneous neuroanatomy and mechanisms of itch and pain.
Topics: Analgesics, Opioid; Animals; Calcineurin; Histamine; Humans; Neural Pathways; Pain; Peptide Hydrolas | 2016 |
Assessment of Itch and Pain in Animal Models and Human Subjects.
Topics: Analgesics; Animals; Antipruritics; Avoidance Learning; Capsaicin; Conditioning, Classical; Emotions | 2016 |
The peripheral and central mechanisms underlying itch.
Topics: Animals; Brain; Ganglia, Spinal; Histamine; Humans; Magnetic Resonance Imaging; Positron-Emission To | 2016 |
Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: mechanisms and management of itch in atopic dermatitis.
Topics: Animals; Brain; Dermatitis, Atopic; Histamine; Humans; Inflammation; Inflammation Mediators; Nervous | 2009 |
Gustatory itching: an unusual complication following superficial parotidectomy.
Topics: Adenoma, Pleomorphic; Administration, Cutaneous; Biopsy, Fine-Needle; Female; Histamine; Histamine A | 2010 |
Pruritus: an overview of current concepts.
Topics: Acute Disease; Administration, Cutaneous; Animals; Antipruritics; Chronic Disease; Histamine; Humans | 2011 |
Histamine and antihistamines in atopic dermatitis.
Topics: Animals; Clinical Trials as Topic; Dermatitis, Atopic; Histamine; Histamine Antagonists; Humans; Pru | 2010 |
Pathophysiology of itch and new treatments.
Topics: Anti-Allergic Agents; Brain-Derived Neurotrophic Factor; Histamine; Humans; Interleukins; Keratinocy | 2011 |
[Mechanisms of itch and the pharmacology of anti-pruritic agents].
Topics: Animals; Antipruritics; Ceramides; Cytokines; Endothelin-1; Histamine; Humans; Peptide Hydrolases; P | 2012 |
Itch and the brain.
Topics: Brain; Dermatitis, Atopic; Histamine; Humans; Magnetic Resonance Imaging; Neuroimaging; Positron-Emi | 2012 |
[Surfactant-induced itching and the involvement of histamine released from keratinocytes].
Topics: Administration, Topical; Animals; Cells, Cultured; Epidermal Cells; Epidermis; Histamine; Histamine | 2012 |
H1-antihistamines in the elderly.
Topics: Aged; Anaphylaxis; Conjunctivitis, Allergic; Histamine; Histamine H1 Antagonists; Humans; Hypersensi | 2002 |
URTICARIA: A REVIEW OF LABORATORY AND CLINICAL OBSERVATIONS.
Topics: Acetylcholine; Anatomy; Angioedema; Bradykinin; Capillaries; Drug Hypersensitivity; Endocrinology; F | 1964 |
Update for nurse anesthetists--pt 4. Itching, the "little" big problem as an orphan symptom.
Topics: Acetylcholine; Analgesics, Opioid; Anesthesia; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; | 2006 |
TRP channels as novel players in the pathogenesis and therapy of itch.
Topics: Animals; Cannabinoids; Capsaicin; Central Nervous System; Histamine; Humans; Inflammation Mediators; | 2007 |
Pathophysiology and management of opioid-induced pruritus.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Dopamine Agonists; Histamine; Histamine | 2007 |
Mediators of pruritus in psoriasis.
Topics: Analgesics, Opioid; Cell Adhesion; Central Nervous System; Gene Expression Regulation; Histamine; Hu | 2007 |
[Mechanisms of cutaneous itch: new itch mediators and enhancement factors produced by keratinocytes].
Topics: Animals; Autocrine Communication; Drug Design; Free Radicals; Histamine; Humans; Hydrogen Peroxide; | 2008 |
Eye itching in ophthalmology and its treatment.
Topics: Conjunctiva; Cromolyn Sodium; Dermatitis; Eczema; Edema; Emotions; Eye; Histamine; Histamine H1 Anta | 1984 |
Spinal opiate analgesia and facial pruritus: a neural theory.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Animals; Cerebral Ventricles; Facial Dermatoses; Female | 1982 |
Dermatopsychosomatics: classification, physiology, and therapeutic approaches.
Topics: Anxiety; Delusions; Dermatitis; Eczema; Factitious Disorders; Histamine; Humans; Neurotic Disorders; | 1981 |
[Pruritus in systemic diseases; pathogenesis and treatment].
Topics: Cholestasis; Histamine; Hodgkin Disease; Humans; Kidney Failure, Chronic; Polycythemia Vera; Prostag | 1994 |
[Pruritus sine materia: a pharmacological approach].
Topics: Cholestasis; Hematologic Diseases; Histamine; Humans; Injections, Intradermal; Kidney Failure, Chron | 1993 |
Itch mediators.
Topics: Histamine; Humans; Inflammation Mediators; Opioid Peptides; Pruritus | 1995 |
Recent studies of cutaneous nociception in atopic and non-atopic subjects.
Topics: Acetylcholine; Dermatitis, Atopic; Eczema; Histamine; Humans; Naltrexone; Nociceptors; Pruritus; Pso | 1999 |
Pruritus.
Topics: Acupuncture; Administration, Topical; Anti-Inflammatory Agents; Antipruritics; Combined Modality The | 2001 |
Itch--mediators and mechanisms.
Topics: Antipruritics; Histamine; Humans; Models, Biological; Neurons; Nociceptors; Opioid Peptides; Pain; P | 2002 |
Physiology of skin.
Topics: Animals; Histamine; Humans; Lymph; Pain; Prostaglandins E; Prostaglandins F; Pruritus; Receptors, Ad | 1976 |
Pruritus. What to do when the itching won't stop.
Topics: Administration, Oral; Administration, Topical; Family Practice; Histamine; Histamine H1 Antagonists; | 1992 |
Some methods for evaluating clinical itch and their application for studying pathophysiological mechanisms.
Topics: Administration, Topical; Anti-Inflammatory Agents; Betamethasone; Cytokines; Dermatitis, Atopic; Glu | 1992 |
[Itching and allergic diseases].
Topics: Dermatitis, Atopic; Histamine; Humans; Hypersensitivity; Paresthesia; Pruritus; Sensation; Serotonin | 1992 |
Peripheral and central mediators of itch.
Topics: Eicosanoids; Endorphins; Histamine; Humans; Lymphokines; Neuropeptides; Pruritus; Serotonin | 1992 |
Histamine, antihistamines and atopic eczema.
Topics: Dermatitis, Atopic; Histamine; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Pruritus | 1990 |
Pharmacophysiology of atopic dermatitis.
Topics: Biofeedback, Psychology; Catecholamines; Cyclic AMP; Dermatitis, Atopic; Female; Histamine; Humans; | 1986 |
Pruritus.
Topics: Histamine; Humans; Peptides; Pruritus; Skin | 1988 |
A review of pruritus.
Topics: Antipruritics; Cholestasis; Histamine; Humans; Nociceptors; Peptide Hydrolases; Polycythemia Vera; P | 1986 |
Pruritus.
Topics: Cholestasis, Intrahepatic; Endopeptidases; Endorphins; Histamine; Humans; Kidney Failure, Chronic; N | 1985 |
Chemical causes of pain and itch.
Topics: Arthritis; Cholestasis; Drug Eruptions; Histamine; Histamine Release; Humans; Muscular Diseases; Pai | 1970 |
109 trials available for histamine and Pruritus
| Article | Year |
|---|---|
Antipruritic Effect of Topical Acetaminophen Gel in Histaminergic and Non-histaminergic Itch Provocation: A Double-blind, Vehicle-controlled Pilot Study.
Topics: Acetaminophen; Antipruritics; Gels; Histamine; Humans; Pilot Projects; Pruritus | 2022 |
Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial.
Topics: Analgesics, Opioid; Histamine; Humans; Morphine; Neurogenic Inflammation; Pain; Pruritus | 2023 |
Targeted Use of Placebo Effects Decreases Experimental Itch in Atopic Dermatitis Patients: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Aged; Conditioning, Classical; Dermatitis, Atopic; Dimethindene; Double-Blind Met | 2021 |
Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel.
Topics: Adult; Drug Eruptions; Female; Histamine; Humans; Iontophoresis; Male; Pilot Projects; Pruritus; Ski | 2017 |
Minimizing nocebo effects by conditioning with verbal suggestion: A randomized clinical trial in healthy humans.
Topics: Adult; Conditioning, Psychological; Electric Stimulation; Female; Healthy Volunteers; Histamine; Hum | 2017 |
Placebo Effects of Open-label Verbal Suggestions on Itch.
Topics: Administration, Cutaneous; Adolescent; Adult; Female; Healthy Volunteers; Histamine; Humans; Iontoph | 2018 |
Anti-pruritic effect of topical capsaicin against histamine-induced pruritus on canine skin.
Topics: Administration, Topical; Animals; Capsaicin; Dog Diseases; Dogs; Female; Histamine; Injections, Intr | 2018 |
Antipruritic effects of transient heat stimulation on histaminergic and nonhistaminergic itch.
Topics: Adult; Chronic Disease; Female; Healthy Volunteers; Histamine; Hot Temperature; Humans; Male; Mucuna | 2019 |
Itch induction by audiovisual stimuli and histamine iontophoresis: a randomized, controlled noninferiority study.
Topics: Histamine; Humans; Iontophoresis; Pain Measurement; Pruritus; Skin | 2020 |
Histamine-induced vasodilatation in the human forearm vasculature.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Forearm; Histamine | 2013 |
Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations.
Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Ant | 2013 |
Mechanically evoked itch in humans.
Topics: Adult; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Physical Stim | 2013 |
A double dose of levocetirizine leads to better control of histamine-induced flare, wheal and itch in healthy donors.
Topics: Adult; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female | 2013 |
Sex differences in itch perception and modulation by distraction--an FMRI pilot study in healthy volunteers.
Topics: Adult; Female; Histamine; Histamine Agonists; Humans; Magnetic Resonance Imaging; Male; Perception; | 2013 |
Evaluation of the antihistamine effects of olopatadine and levocetirizine during a 24-h period: a double-blind, randomized, cross-over, placebo-controlled comparison in skin responses induced by histamine iontophoresis.
Topics: Adult; Cetirizine; Cognition; Cross-Over Studies; Dibenzoxepins; Double-Blind Method; Female; Health | 2013 |
The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.
Topics: Adolescent; Adult; Cetirizine; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Histamin | 2014 |
Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin.
Topics: Adult; Capsaicin; Female; Germany; Histamine; Humans; Laser-Doppler Flowmetry; Male; Mucuna; Pain; P | 2015 |
A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers.
Topics: Administration, Topical; Adult; Capsaicin; Healthy Volunteers; Histamine; Humans; Male; Middle Aged; | 2014 |
Polidocanol inhibits cowhage - but not histamine-induced itch in humans.
Topics: Adult; Antipruritics; Double-Blind Method; Female; Histamine; Humans; Male; Middle Aged; Mucuna; Pol | 2014 |
A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain.
Topics: Administration, Topical; Adult; Benzocaine; Double-Blind Method; Histamine; Humans; Male; Ointments; | 2015 |
The placebo effect in inflammatory skin reactions: the influence of verbal suggestion on itch and weal size.
Topics: Adult; Female; Histamine; Humans; Male; Persuasive Communication; Placebo Effect; Pruritus; Urticari | 2015 |
A transcranial direct current stimulation over the sensorimotor cortex modulates the itch sensation induced by histamine.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Histamine; Humans; Male; Pruritus; Psychomot | 2016 |
Inducing Expectations for Health: Effects of Verbal Suggestion and Imagery on Pain, Itch, and Fatigue as Indicators of Physical Sensitivity.
Topics: Adolescent; Cold Temperature; Electrocardiography; Exercise; Fatigue; Female; Heart Rate; Histamine; | 2015 |
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
Topics: Acrolein; Antipruritics; Cold Temperature; Doxepin; Female; Healthy Volunteers; Histamine; Histamine | 2017 |
Antipruritic effect of pretreatment with topical capsaicin 8% on histamine- and cowhage-evoked itch in healthy volunteers: a randomized, vehicle-controlled, proof-of-concept trial.
Topics: Administration, Cutaneous; Antipruritics; Capsaicin; Cross-Over Studies; Double-Blind Method; Female | 2017 |
Comparison of perceived itch induced by skin prick-tests with histamine and codeine.
Topics: Adolescent; Adult; Analgesics, Opioid; Codeine; Double-Blind Method; Histamine; Histamine Agonists; | 2008 |
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.
Topics: Area Under Curve; Capsaicin; Dose-Response Relationship, Drug; Female; Histamine; Humans; Incidence; | 2009 |
Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin.
Topics: Adult; Antipruritics; Botulinum Toxins, Type A; Dermatitis; Double-Blind Method; Histamine; Humans; | 2009 |
Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin.
Topics: Adult; Antipruritics; Botulinum Toxins, Type A; Dermatitis; Double-Blind Method; Histamine; Humans; | 2009 |
Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin.
Topics: Adult; Antipruritics; Botulinum Toxins, Type A; Dermatitis; Double-Blind Method; Histamine; Humans; | 2009 |
Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin.
Topics: Adult; Antipruritics; Botulinum Toxins, Type A; Dermatitis; Double-Blind Method; Histamine; Humans; | 2009 |
Topical sodium cromoglicate relieves allergen- and histamine-induced dermal pruritus.
Topics: Administration, Cutaneous; Adult; Allergens; Anti-Allergic Agents; Cromolyn Sodium; Dermatitis, Alle | 2010 |
Temperature modulated histamine-itch in lesional and nonlesional skin in atopic eczema - a combined psychophysical and neuroimaging study.
Topics: Adult; Brain Mapping; Cerebral Cortex; Child; Dermatitis, Atopic; Histamine; Humans; Magnetic Resona | 2010 |
Efficiency of low-frequency ultrasound sonophoresis in skin penetration of histamine: a randomized study in humans.
Topics: Administration, Cutaneous; Adult; Allergens; Drug Delivery Systems; Equipment Design; Female; Histam | 2010 |
Responses to intradermal injections of substance P in psoriasis patients with pruritus.
Topics: Adult; Area Under Curve; Case-Control Studies; Double-Blind Method; Female; Histamine; Humans; Injec | 2010 |
Ethyl chloride as an antipruritic agent: a double-blind placebo-controlled prospective study.
Topics: Adult; Antipruritics; Double-Blind Method; Ethyl Chloride; Female; Histamine; Humans; Male; Middle A | 2010 |
Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment.
Topics: Administration, Topical; Adult; Analysis of Variance; Antipruritics; Biomarkers; Chromatography, Hig | 2011 |
Induction of nocebo and placebo effects on itch and pain by verbal suggestions.
Topics: Adolescent; Analysis of Variance; Double-Blind Method; Female; Histamine; Histamine Agonists; Humans | 2011 |
Contagious itch in humans: a study of visual 'transmission' of itch in atopic dermatitis and healthy subjects.
Topics: Adolescent; Adult; Cues; Dermatitis, Atopic; Female; Histamine; Histamine Agonists; Humans; Male; Mi | 2011 |
Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Male; Middle Aged; Model | 2011 |
Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Male; Middle Aged; Model | 2011 |
Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Male; Middle Aged; Model | 2011 |
Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Male; Middle Aged; Model | 2011 |
A temporal analysis of the central neural processing of itch.
Topics: Adult; Cerebral Cortex; Double-Blind Method; Histamine; Histamine Agonists; Humans; Magnetic Resonan | 2012 |
Defining risk factors for red man syndrome in children and adults.
Topics: Adolescent; Amine Oxidase (Copper-Containing); Child; Child, Preschool; Erythema; Exanthema; Female; | 2012 |
Topical aprepitant in clinical and experimental pruritus.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Antiemetics; Aprepitant; Double-Blind Met | 2012 |
The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers.
Topics: Adult; Asian People; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind | 2013 |
Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses.
Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; | 2002 |
Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy.
Topics: Adult; Cetirizine; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Indoles; Male; | 2003 |
Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.
Topics: Acetylcholine; Adult; Bradykinin; Capsaicin; Dinoprostone; Electric Stimulation; Female; Histamine; | 2003 |
Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.
Topics: Administration, Topical; Adult; Axons; Cannabinoid Receptor Agonists; Capillary Permeability; Dronab | 2003 |
Topical capsaicin therapy in humans with hemodialysis-related pruritus.
Topics: Administration, Topical; Adult; Capsaicin; Case-Control Studies; Drug Administration Schedule; Femal | 2003 |
Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.
Topics: Adult; Analgesics, Opioid; Biopsy; Cell Degranulation; Codeine; Dermatitis, Atopic; Dose-Response Re | 2003 |
Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.
Topics: Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Erythema; Histamin | 2003 |
Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels.
Topics: Adult; Dermatitis, Atopic; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; P | 2003 |
Interaction between histamine-induced itch and experimental muscle pain.
Topics: Adult; Afferent Pathways; Capsaicin; Central Nervous System; Female; Histamine; Humans; Male; Models | 2004 |
Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients.
Topics: Adult; Aged; Antipruritics; Cetirizine; Female; Histamine; Histamine H1 Antagonists; Humans; Indoles | 2004 |
Electrically evoked itch in humans.
Topics: Adult; Dermatitis, Atopic; Dose-Response Relationship, Radiation; Electric Stimulation; Erythema; Fe | 2005 |
Preventive effect of acupuncture on histamine-induced itch: a blinded, randomized, placebo-controlled, crossover trial.
Topics: Acupuncture Therapy; Cross-Over Studies; Histamine; Humans; Prospective Studies; Pruritus | 2005 |
The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests.
Topics: Acetates; Allergens; Antipruritics; Capsules; Codeine; Cross-Over Studies; Cyclopropanes; Double-Bli | 2007 |
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine; Hista | 2007 |
Influence of ultraviolet light on itch and flare reactions in human skin induced by histamine and the histamine liberator compound 48/80.
Topics: Adult; Female; Histamine; Histamine Release; Humans; Male; Middle Aged; p-Methoxy-N-methylphenethyla | 1982 |
The influence of the opiate antagonist naloxone on experimental pruritus.
Topics: Adult; Double-Blind Method; Female; Histamine; Humans; Middle Aged; Morphine; Naloxone; Pruritus | 1984 |
Effect of acupuncture on experimentally induced itch.
Topics: Acupuncture Therapy; Adult; Clinical Trials as Topic; Female; Histamine; Humans; Male; Pruritus; Ran | 1984 |
The influence of mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on experimental pruritus induced by histamine.
Topics: Adult; Electric Stimulation Therapy; Female; Histamine; Humans; Injections, Intradermal; Male; Middl | 1984 |
Sensory responses of human skin to synthetic histamine analogues and histamine.
Topics: Adult; Chlorpheniramine; Dimaprit; Female; Histamine; Humans; Male; Methylhistamines; Pruritus; Rece | 1980 |
Antipruritic effect of an opiate antagonist, naloxone hydrochloride.
Topics: Adult; Double-Blind Method; Histamine; Humans; Naloxone; Narcotic Antagonists; Pruritus | 1982 |
Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Black People; Chloroquine; Clemastine | 1994 |
Long-term treatment with interferon-alpha 2b for severe pruritus in patients with polycythaemia vera.
Topics: Aged; Aged, 80 and over; Bloodletting; Bone Marrow; Erythroid Precursor Cells; Female; Follow-Up Stu | 1995 |
Effects of azelastin on pruritus and plasma histamine levels in hemodialysis patients.
Topics: Adult; Aged; Erythropoietin; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; | 1994 |
Urge to scratch represented in the human cerebral cortex during itch.
Topics: Adult; Cerebral Cortex; Cerebrovascular Circulation; Histamine; Humans; Image Processing, Computer-A | 1994 |
Effects of acrivastine and terfenadine on skin reactivity to histamine.
Topics: Drug Hypersensitivity; Histamine; Histamine H1 Antagonists; Humans; Pruritus; Skin; Skin Tests; Terf | 1994 |
The time course of action of three differing doses of noberastine, a novel H1-receptor antagonist, on histamine-induced skin wheals and the relationship to plasma drug concentrations in normal human volunteers.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Histamine; Histamine H1 Antagonists; H | 1993 |
High-potency topical corticosteroid rapidly decreases histamine-induced itch but not thermal sensation and pain in human beings.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Anti-Inflammatory Agents; Clobetasol; Double | 1996 |
Two-point discrimination of itch in patients with atopic dermatitis and healthy subjects.
Topics: Adolescent; Adult; Dermatitis, Atopic; Female; Histamine; Humans; Male; Pruritus; Sensation; Sensory | 1996 |
Correlations between histamine-induced wheal, flare and itch.
Topics: Adult; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Histamine; Humans; Iontophore | 1996 |
A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain.
Topics: Adult; Female; Histamine; Hot Temperature; Humans; Male; Mustard Plant; Pain; Physical Stimulation; | 1996 |
Randomised crossover trial of naltrexone in uraemic pruritus.
Topics: beta-Endorphin; Cross-Over Studies; Double-Blind Method; Histamine; Humans; Naltrexone; Narcotic Ant | 1996 |
Cutaneous field stimulation (CFS): a new powerful method to combat itch.
Topics: Administration, Cutaneous; Adult; Female; Histamine; Humans; Male; Middle Aged; Nerve Fibers; Neuron | 1997 |
Skin testing of the pruritogenic activity of histamine and cytokines (interleukin-2 and tumour necrosis factor-alpha) at the dermal-epidermal junction.
Topics: Adult; Cross-Over Studies; Cytokines; Double-Blind Method; Histamine; Humans; Interleukin-2; Male; P | 1997 |
Experimentally induced pruritus and cutaneous reactions with topical antihistamine and local analgesics in atopic eczema.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Antipruritics | 1997 |
Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis.
Topics: Adult; Cross-Over Studies; Dermatitis, Atopic; Double-Blind Method; Female; Histamine; Histamine H1 | 1997 |
Histamine release during rapid vancomycin administration.
Topics: Anti-Bacterial Agents; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Exan | 1998 |
Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Histamine; Humans; Kidney Failure, Chr | 1998 |
Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin.
Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Dermatitis, Allergic Contact; Dermatitis, Ato | 1998 |
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.
Topics: Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Forearm; Histamine; Humans; Hy | 1999 |
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Ag | 1999 |
Strontium nitrate decreased histamine-induced itch magnitude and duration in man.
Topics: Adult; Antipruritics; Double-Blind Method; Female; Histamine; Humans; Male; Middle Aged; Nitrates; P | 2000 |
Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch.
Topics: Adult; Dermatitis, Contact; Double-Blind Method; Edema; Erythema; Female; Histamine; Humans; Injecti | 2002 |
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Me | 2002 |
Influence of vagus nerve stimulation on histamine-induced itching.
Topics: Adult; Electric Stimulation Therapy; Epilepsy; Female; Histamine; Humans; Iontophoresis; Male; Pruri | 2002 |
Suppression of histamine-induced pruritus by hydroxyzine and various neuroleptics.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Double-Blind Method; Histamine; Humans; Hydro | 1979 |
Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement.
Topics: Adult; Aged; Aspirin; Blood Platelets; Clinical Trials as Topic; Double-Blind Method; Female; Histam | 1979 |
Suppression of histamine-induced pruritus by three antihistaminic drugs.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cyproheptadine; Differential Threshold; Diphenhydramine | 1975 |
The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus.
Topics: Adult; Chlorpheniramine; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Co | 1979 |
Prostaglandins and pruritus.
Topics: Adolescent; Adult; Aged; Drug Synergism; Histamine; Humans; Male; Middle Aged; Papain; Prostaglandin | 1976 |
Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia.
Topics: Double-Blind Method; Erythropoietin; Female; Histamine; Humans; Male; Middle Aged; Pruritus; Recombi | 1992 |
Perception of histamine-induced itch elicited in three different skin regions.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Erythema; Histamine; Human | 1991 |
Vancomycin-induced histamine release and "red man syndrome": comparison of 1- and 2-hour infusions.
Topics: Adult; Double-Blind Method; Erythema; Histamine; Histamine Release; Humans; Infusions, Intravenous; | 1990 |
Efficacy of topical dimetindene in experimentally induced pruritus and weal and flare reactions.
Topics: Administration, Topical; Adult; Dimethindene; Double-Blind Method; Female; Histamine; Humans; Inject | 1991 |
Red man syndrome: incidence, etiology, and prophylaxis.
Topics: Adult; Diphenhydramine; Double-Blind Method; Female; Flushing; Histamine; Humans; Male; Prospective | 1991 |
The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis.
Topics: Adolescent; Adult; Benzhydryl Compounds; Clemastine; Dermatitis, Atopic; Double-Blind Method; Female | 1990 |
Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin.
Topics: Adult; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Female; Histamine; Humans; M | 1985 |
Vancomycin and the red-man syndrome: pharmacodynamics of histamine release.
Topics: Adult; Angioedema; Drug Eruptions; Erythema; Female; Histamine; Histamine Release; Humans; Male; Pru | 1988 |
Some aspects of the experimental induction and measurement of itch.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine; Humans; Intradermal | 1989 |
Influence of antihistamine pretreatment on vancomycin-induced red-man syndrome.
Topics: Double-Blind Method; Erythema; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans | 1989 |
Influence of grenz rays and psychological factors on experimental pruritus induced by histamine and compound 48/80.
Topics: Adult; Epidermis; Female; Histamine; Humans; Male; Middle Aged; p-Methoxy-N-methylphenethylamine; Pr | 1989 |
Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents.
Topics: Adult; Double-Blind Method; Drug Combinations; Female; Histamine; Humans; Lidocaine; Lidocaine, Pril | 1988 |
Effect of acupuncture on experimentally induced itch.
Topics: Acupuncture Therapy; Adolescent; Adult; Female; Histamine; Humans; Male; Pruritus; Time Factors | 1987 |
The influence of extrasegmental mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on histamine-induced itch.
Topics: Adult; Combined Modality Therapy; Electric Stimulation Therapy; Female; Histamine; Humans; Male; Mid | 1985 |
Placebo-controlled study of the efficacy of topical antihistaminics against histamine-induced pruritus.
Topics: Administration, Topical; Adult; Antipruritics; Clinical Trials as Topic; Dermatologic Agents; Female | 1985 |
Influence of antihistamines, sedatives, and aspirin on experimental itch.
Topics: Aspirin; Clinical Trials as Topic; Depression, Chemical; Diazepam; Erythema; Histamine; Histamine H1 | 1973 |
Studies on experimental itch induced by kallikrein and bradykinin.
Topics: Bradykinin; Clinical Trials as Topic; Depression, Chemical; Histamine; Histamine H1 Antagonists; His | 1974 |
Comparison of the antihistaminic effects in skin of a tertiary (promethazine) and a quarternary phenothiazine (N-hydroxyethylpromethazine).
Topics: Adolescent; Adult; Drug Evaluation; Histamine; Histamine H1 Antagonists; Humans; Injections, Subcuta | 1974 |
Itch: role of prostaglandins.
Topics: Adolescent; Adult; Aged; Bradykinin; Child; Drug Synergism; Edema; Erythema; Female; Histamine; Huma | 1973 |
389 other studies available for histamine and Pruritus
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch.
Topics: Alkaloids; Animals; Antipruritics; Cell Membrane; Chloroquine; Chromatography; Disease Models, Anima | 2021 |
Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study.
Topics: Histamine; Humans; Laboratories; Mucuna; Pruritus; Quality of Life; Skin | 2021 |
BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
Topics: Animals; Ganglia, Spinal; HEK293 Cells; Histamine; Humans; Male; Mice; Mice, Inbred C57BL; Natriuret | 2021 |
Induction and generalization of nocebo effects on itch.
Topics: Healthy Volunteers; Histamine; Humans; Nocebo Effect; Pruritus; Suggestion; Treatment Outcome | 2022 |
Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans.
Topics: Heating; Histamine; Humans; Pruritus; Quality of Life; Skin | 2022 |
Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.
Topics: Animals; Disease Models, Animal; Ficain; Histamine; Humans; Mice; Pain; Pruritus | 2022 |
Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.
Topics: Animals; beta-Alanine; Capsaicin; Glycols; Histamine; Hot Temperature; Humans; Mice; Nanoparticles; | 2022 |
Histamine Is Responsible for the Neuropathic Itch Induced by the Pseudorabies Virus Variant in a Mouse Model.
Topics: Animals; Disease Models, Animal; Herpesvirus 1, Suid; Histamine; Mammals; Mice; Pruritus; Pseudorabi | 2022 |
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
Topics: Animals; Histamine; Mice; Pruritus; Receptors, Histamine H1; Sensory Receptor Cells; Sumoylation; TR | 2022 |
Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar
Topics: Animals; Histamine; Humans; Lepidoptera; Manduca; Nerve Tissue Proteins; Pain; Pruritus; Receptors, | 2022 |
The Investigation of Therapeutic Implications of Mast Cell Stabilizer Cromolyn Sodium on Cholestasis and Cholestatic Pruritus in Experimental Cholestasis.
Topics: Animals; Cholestasis; Cromolyn Sodium; Histamine; Ligation; Liver; Mast Cell Stabilizers; Pruritus; | 2023 |
Footedness for scratching itchy eyes in rodents.
Topics: Animals; Eye; Functional Laterality; Histamine; Pruritus; Rats; Receptors, Bombesin | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3.
Topics: Animals; Dermatitis, Atopic; Dinitrofluorobenzene; Histamine; Mice; Molecular Docking Simulation; Pr | 2023 |
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3.
Topics: Animals; Dermatitis, Atopic; Dinitrofluorobenzene; Histamine; Mice; Molecular Docking Simulation; Pr | 2023 |
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3.
Topics: Animals; Dermatitis, Atopic; Dinitrofluorobenzene; Histamine; Mice; Molecular Docking Simulation; Pr | 2023 |
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3.
Topics: Animals; Dermatitis, Atopic; Dinitrofluorobenzene; Histamine; Mice; Molecular Docking Simulation; Pr | 2023 |
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice.
Topics: Animals; Histamine; Mice; Pruritus; RNA, Long Noncoding; Sensation; Sensory Receptor Cells | 2023 |
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice.
Topics: Animals; Histamine; Mice; Pruritus; RNA, Long Noncoding; Sensation; Sensory Receptor Cells | 2023 |
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice.
Topics: Animals; Histamine; Mice; Pruritus; RNA, Long Noncoding; Sensation; Sensory Receptor Cells | 2023 |
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice.
Topics: Animals; Histamine; Mice; Pruritus; RNA, Long Noncoding; Sensation; Sensory Receptor Cells | 2023 |
Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice.
Topics: Animals; Dermatitis, Atopic; Histamine; Humans; Inflammation; Mice; Pruritus; Receptors, Histamine; | 2023 |
GABAergic neurons in the ventral lateral geniculate nucleus and intergeniculate leaflet are involved in itch processing in mice.
Topics: Animals; Antipruritics; GABAergic Neurons; Geniculate Bodies; Histamine; Mice; Proto-Oncogene Protei | 2023 |
Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity.
Topics: Animals; Calcium; Histamine; Mice; Molecular Docking Simulation; Pruritus; Signal Transduction; TRPV | 2023 |
Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch.
Topics: Animals; Calcium; Gyrus Cinguli; Histamine; Mice; Neurons; Pruritus | 2023 |
Cowhage-induced itch scores and the current perception threshold in assessing sensitive skin: An observational laboratory study.
Topics: Histamine; Humans; Pain; Perception; Pruritus; Sensation; Skin | 2023 |
The lateral habenula nucleus regulates pruritic sensation and emotion.
Topics: Animals; Emotions; Habenula; Histamine; Mice; Pruritus; Sensation | 2023 |
Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways.
Topics: Animals; Chloroquine; Histamine; Mice; Mice, Transgenic; Microglia; Pain; Pruritus; Signal Transduct | 2023 |
Novel H
Topics: Antipruritics; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Humans; Hydrogen Sulfide; | 2023 |
Role of kainate receptors in pruriceptive processing in the mouse spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chloroquine; Excitatory Amino Acid Antagonists; Gluta | 2023 |
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neu | 2023 |
Oxytocin increases itch sensitivity of mice in late pregnancy and its peripheral receptor mechanism of itch-promoting effect.
Topics: Animals; Female; Histamine; Mice; Oxytocin; Pregnancy; Pruritus; Receptors, Oxytocin; Receptors, Vas | 2023 |
An atlas of itch-associated neural dynamics in the mouse brain.
Topics: Animals; Brain; Chloroquine; Histamine; Mice; Pruritus | 2023 |
Assessment of the impact of sex in intensity, skin flares and central processing of histaminergic itch-A pilot study.
Topics: Adult; Brain; Female; Histamine; Humans; Magnetic Resonance Imaging; Male; Pilot Projects; Pruritus; | 2019 |
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Gang | 2019 |
Optimizing audiovisual itch induction: the role of attention and expectancy.
Topics: Attention; Histamine; Humans; Iontophoresis; Pruritus | 2020 |
Pharmacological characteristics of hemokinin-1-derived peptides in rat pruriceptive processing.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Chloroquine; Dose-Response Relationship, Drug | 2020 |
Bulleyaconitine A Inhibits Itch and Itch Sensitization Induced by Histamine and Chloroquine.
Topics: Aconitine; Animals; China; Chloroquine; Histamine; Mice; Posterior Horn Cells; Pruritus; Quality of | 2020 |
Fermented
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Mode | 2020 |
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
Topics: Animals; Behavior Rating Scale; Behavior, Animal; Chloroquine; Gene Knockout Techniques; Histamine; | 2020 |
Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation.
Topics: Animals; Anterior Thalamic Nuclei; Gyrus Cinguli; Histamine; Male; Mice; Mice, Inbred C57BL; Neural | 2020 |
Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors.
Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Gene Knockout Techniques; Histamine; Mic | 2020 |
The lateral habenula is critically involved in histamine-induced itch sensation.
Topics: Animals; Habenula; Histamine; Mice; Proto-Oncogene Proteins c-fos; Pruritus; Sensation | 2020 |
Cav3.2 T-type calcium channels control acute itch in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Calcium Channels, T-Type; Chloroquine; Female; Histamine; | 2020 |
IL-23 modulates histamine-evoked itch and responses of pruriceptors in mice.
Topics: Animals; Behavior, Animal; Calcium; Cells, Cultured; Chloroquine; Ganglia, Spinal; Histamine; Interl | 2020 |
Thermal Hyperalgesia and Mechanical Allodynia Elicited by Histamine and Non-histaminergic Itch Mediators: Respective Involvement of TRPV1 and TRPA1.
Topics: Animals; Histamine; Hyperalgesia; Male; Mice; Pruritus; Receptors, G-Protein-Coupled; Transient Rece | 2020 |
Mast cells and thymic stromal lymphopoietin (TSLP) expression positively correlates with pruritus intensity in dermatitis herpetiformis.
Topics: Adult; Aged; Cytokines; Dermatitis Herpetiformis; Enzyme-Linked Immunosorbent Assay; Female; Histami | 2020 |
Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice.
Topics: Animals; Behavior, Animal; Chloroquine; Cyclopropanes; Disease Models, Animal; Histamine; Hypodermoc | 2020 |
Flare Size but Not Intensity Reflects Histamine-Induced Itch.
Topics: Adult; Capsaicin; Female; Histamine; Humans; Male; Pain Measurement; Pruritus; Regional Blood Flow; | 2020 |
The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators.
Topics: Animals; Capsaicin; Endothelin-1; Histamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, T | 2021 |
Vaccination Granuloma Itch Treated with Capsaicin 8% Patches.
Topics: Capsaicin; Granuloma; Histamine; Humans; Pruritus; Vaccination | 2020 |
Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch.
Topics: Acute Disease; Animals; Behavior, Animal; Chronic Disease; Dopamine Plasma Membrane Transport Protei | 2021 |
A basophil-neuronal axis promotes itch.
Topics: Acute Disease; Allergens; Animals; Basophils; Chronic Disease; Dermatitis, Atopic; Disease Models, A | 2021 |
The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
Topics: Animals; Calcium; Capsaicin; Cattle; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Hista | 2021 |
Ethosuximide inhibits acute histamine- and chloroquine-induced scratching behavior in mice.
Topics: Animals; Behavior, Animal; Chloroquine; Ethosuximide; Female; Histamine; Male; Mice, Inbred C57BL; P | 2021 |
Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates.
Topics: Adult; Animals; beta-Alanine; Female; Ganglia, Spinal; Histamine; Humans; Macaca nemestrina; Male; M | 2021 |
Differential roles of prelimbic and anterior cingulate cortical region in the modulation of histaminergic and non-histaminergic itch.
Topics: Animals; Cerebral Cortex; Gyrus Cinguli; Histamine; Male; Prefrontal Cortex; Pruritus; Rats; Rats, S | 2021 |
Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin.
Topics: Animals; Histamine; Humans; Lysophospholipids; Nerve Fibers, Unmyelinated; Neuralgia; Nociceptors; P | 2022 |
Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons.
Topics: Animals; Estradiol; Female; Histamine; Male; Progesterone; Pruritus; Rats; Rats, Wistar; Sex Factors | 2021 |
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch.
Topics: Acetanilides; Animals; Calcium; Capsaicin; Female; Ganglia, Spinal; Gene Expression; Histamine; Male | 2021 |
Sulfonamides as Selective Na
Topics: Analgesics; Animals; Capsaicin; Cell Line; Dogs; Histamine; Mice, Inbred C57BL; Molecular Docking Si | 2017 |
Specific patterns of spinal metabolites underlying α-Me-5-HT-evoked pruritus compared with histamine and capsaicin assessed by proton nuclear magnetic resonance spectroscopy.
Topics: Animals; Capsaicin; Histamine; Magnetic Resonance Spectroscopy; Male; Mice; Pruritus; Serotonin; Spi | 2017 |
Nonhistaminergic and mechanical itch sensitization in atopic dermatitis.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Male; Mucuna; Pain Measu | 2017 |
ITCH AND BRAIN FUNCTION IN ATOPIC DERMATITIS.
Topics: Brain; Dermatitis, Atopic; Histamine; Humans; Pruritus | 2017 |
Comment on "Molecular and neural basis of contagious itch behavior in mice".
Topics: Animals; Behavior, Animal; Histamine; Mice; Pruritus | 2017 |
Response to Comment on "Molecular and neural basis of contagious itch behavior in mice".
Topics: Animals; Behavior, Animal; Histamine; Mice; Pruritus | 2017 |
Histamine poisoning from insect consumption: an outbreak investigation from Thailand.
Topics: Adolescent; Animals; Bombyx; Bronchial Spasm; Cohort Studies; Disease Outbreaks; Exanthema; Female; | 2018 |
[Three cases of scombroid poisoning].
Topics: Adrenal Cortex Hormones; Adult; Animals; Erythema; Female; Food Preservation; Foodborne Diseases; Ga | 2018 |
Neuroimmunology: Scratching the surface of chronic itch.
Topics: Histamine; Humans; Neuroimmunomodulation; Pruritus | 2017 |
Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.
Topics: Cell Degranulation; Cysteine Proteases; HEK293 Cells; Histamine; Humans; Mast Cells; Mucuna; Nerve T | 2018 |
Distinct roles of NMB and GRP in itch transmission.
Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Disease Models, Animal; Gastrin-Releasing Pepti | 2017 |
Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.
Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Chloroquine; Chronic Disease; Cryotherapy; Dise | 2018 |
UVB- and NGF-induced cutaneous sensitization in humans selectively augments cowhage- and histamine-induced pain and evokes mechanical hyperknesis.
Topics: Adult; Female; Histamine; Humans; Hyperalgesia; Male; Mucuna; Nerve Growth Factor; Nociception; Pain | 2018 |
Capsaicin-sensitive cutaneous primary afferents convey electrically induced itch in humans.
Topics: Administration, Cutaneous; Adult; Capsaicin; Electric Stimulation; Histamine; Humans; Male; Nocicept | 2018 |
Different perception levels of histamine-induced itch sensation in young adult mice.
Topics: Age Factors; Animals; Body Weight; Calcium; Cells, Cultured; Disease Models, Animal; Ganglia, Spinal | 2018 |
GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way.
Topics: Animals; Cell Line; Chloroquine; Dermatitis, Contact; Dinitrochlorobenzene; Disease Models, Animal; | 2018 |
ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation.
Topics: Animals; Corpus Striatum; Gyrus Cinguli; Histamine; Male; Mice; Mice, Inbred C57BL; Neurons; Nocicep | 2018 |
The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging.
Topics: Adolescent; Adult; Capsaicin; Histamine; Histamine Agonists; Humans; Male; Nerve Fibers, Unmyelinate | 2018 |
Nocebo Effects and Scratching Behaviour on Itch.
Topics: Adolescent; Behavior; Conditioning, Psychological; Cues; Electric Stimulation; Female; Healthy Volun | 2018 |
BP180 dysfunction triggers spontaneous skin inflammation in mice.
Topics: Adaptive Immunity; Animals; Autoantigens; Collagen Type XVII; Cytokines; Histamine; Humans; Immunogl | 2018 |
Responses of thalamic neurons to itch- and pain-producing stimuli in rats.
Topics: Action Potentials; Animals; Antipruritics; beta-Alanine; Capsaicin; Chloroquine; Histamine; Injectio | 2018 |
Effects of pruritogens and algogens on rostral ventromedial medullary ON and OFF cells.
Topics: Animals; Capsaicin; Chloroquine; Evoked Potentials; Hindlimb; Histamine; Male; Medulla Oblongata; Mi | 2018 |
Modulation of Itch by Localized Skin Warming and Cooling.
Topics: Animals; Antipruritics; Body Temperature Regulation; Dermatitis, Atopic; Disease Models, Animal; His | 2018 |
The behavioral study on the interactive aggravation between pruritus and depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chloroquine; Depression; Depressive Disorder; Dise | 2018 |
Assessing Punctate Administration of Beta-alanine as a Potential Human Model of Non-histaminergic Itch.
Topics: Administration, Cutaneous; beta-Alanine; Dose-Response Relationship, Drug; Histamine; Humans; Mucuna | 2019 |
Discovery of Tarantula Venom-Derived Na
Topics: Animals; Drug Discovery; HEK293 Cells; Histamine; Humans; Mice; Molecular Docking Simulation; NAV1.7 | 2018 |
Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch.
Topics: Administration, Cutaneous; Adolescent; Adult; Cold Temperature; Dose-Response Relationship, Drug; Fe | 2019 |
Exploratory Study of Intracutaneous Histamine Stimulation in Patient Populations with Chronic Pruritus.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Chronic Disease; Diagnosis, Diffe | 2019 |
Non-Histaminergic Itch Mediators Elevated in the Skin of a Porcine Model of Scabies and of Human Scabies Patients.
Topics: Aged; Animals; Biomarkers; Biopsy; Disease Models, Animal; Female; Histamine; Humans; Immunohistoche | 2019 |
Mast cell tetrahydrobiopterin contributes to itch in mice.
Topics: Animals; Biopterins; Calcium; Cell Degranulation; Chronic Pain; Female; Gene Expression; GTP Cyclohy | 2019 |
Histamine-driven responses are sustained via a bioactive metabolite.
Topics: Anaphylaxis; Animals; Eosinophils; Histamine; Humans; Imidazoles; Mice, Knockout; Peritoneal Lavage; | 2019 |
A Subpopulation of Amygdala Neurons Mediates the Affective Component of Itch.
Topics: Amygdala; Animals; Avoidance Learning; Chloroquine; Female; Histamine; Male; Mice; Mice, Inbred C57B | 2019 |
Serotoninergic projection from dorsal raphe nucleus to insular cortex is involved in acute itch sensation processing in mice.
Topics: Animals; Brain Stem; Cerebral Cortex; Chloroquine; Dorsal Raphe Nucleus; Histamine; Male; Mice; Mice | 2019 |
Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study.
Topics: Adult; Aged; Aged, 80 and over; Antipruritics; Capsaicin; Case-Control Studies; Chronic Disease; Fem | 2019 |
Central Processing of Itch in the Midbrain Reward Center.
Topics: Animals; Behavior, Animal; Calcium Signaling; Chloroquine; Dopaminergic Neurons; Electrophysiologica | 2019 |
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Female; Histamine; Histamine Antagonists; Human | 2019 |
Dose-dependent pruritogenic and inflammatory effects of intradermal injections of histamine, compound 48/80 and anti-canine IgE in healthy dogs.
Topics: Animals; Antibodies, Anti-Idiotypic; Dogs; Dose-Response Relationship, Drug; Erythema; Histamine; In | 2019 |
Allergen-induced histaminergic and non-histaminergic activation of itch C-fiber nerve terminals in mouse skin.
Topics: Allergens; Animals; Histamine; Histamine H1 Antagonists; Male; Mice; Mice, Inbred C57BL; Mice, Knock | 2019 |
Signal Transducer and Activator of Transcription 3 in Keratinocytes Regulates Histaminergic Itch but Not Nonhistaminergic Itch.
Topics: Animals; Chloroquine; Disease Models, Animal; Female; Histamine; Keratinocytes; Male; Mice, Knockout | 2019 |
Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.
Topics: Animals; Behavior, Animal; Calcium; Diacylglycerol Kinase; Disease Models, Animal; Female; Ganglia, | 2019 |
Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage.
Topics: Adult; Capsaicin; Female; Healthy Volunteers; Histamine; Humans; Male; Mucuna; Pain Measurement; Pru | 2019 |
Mechano-insensitive nociceptors are sufficient to induce histamine-induced itch.
Topics: Adult; Electric Stimulation; Femoral Nerve; Histamine; Hot Temperature; Humans; Iontophoresis; Male; | 2013 |
Prevention of topical surfactant-induced itch-related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis.
Topics: Administration, Topical; Animals; Chlorogenic Acid; Depression, Chemical; Epidermis; Histamine; Hist | 2013 |
Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Diphtheria Toxin; Excitatory | 2013 |
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Electric Stimulat | 2013 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam | 2013 |
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Antipruritics; Antirheumatic Agents; Behavior, Anima | 2013 |
The cells and circuitry for itch responses in mice.
Topics: Animals; Chloroquine; Endothelin-1; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mice, Inbred C | 2013 |
[Normative research on bacteriostasis and relieving itching external therapeutic function of kochiae fructus].
Topics: Administration, Cutaneous; Animals; Anti-Bacterial Agents; Antipruritics; Arthrodermataceae; Bassia | 2012 |
Involvement of chymase in allergic conjunctivitis of guinea pigs.
Topics: Allergens; Animals; Chymases; Conjunctivitis, Allergic; Disease Models, Animal; Enzyme Inhibitors; G | 2013 |
Cortical GluK1 kainate receptors modulate scratching in adult mice.
Topics: Animals; Antipruritics; Cerebral Cortex; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Ge | 2013 |
Sensitivity to itch and pain in patients with psoriasis and rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cold Temperature; Female; Histamine; Humans; Inflammation; Middl | 2013 |
Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Cell Line, Tumor; Flavones; Histamine; Interleukin- | 2013 |
Sex-related differences in SLIGRL-induced pruritus in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Female; Histamine | 2014 |
Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
Topics: Animals; Arthritis; Collagen; Dogs; Drug Design; Drug Discovery; Histamine; Histamine Antagonists; I | 2014 |
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamin | 2014 |
Surfactant-induced chronic pruritus: Role of L-histidine decarboxylase expression and histamine production in epidermis.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enzyme Induction; Epidermis; Histamine; Histamine | 2014 |
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord.
Topics: Animals; Butadienes; Chloroquine; Dinitrofluorobenzene; Disease Models, Animal; Enzyme Activation; E | 2014 |
Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice.
Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Disease Models, Animal; Histamine; Ichthyosis | 2015 |
Withdrawal of repeated morphine enhances histamine-induced scratching responses in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Corticosterone; Dose-Response Relationship, Drug; His | 2015 |
Therapeutic efficacy of a H₄ receptor antagonist in humans: a milestone in histamine research.
Topics: Histamine; Histamine Antagonists; Humans; Male; Pruritus; Pyrimidines; Pyrrolidines; Receptors, G-Pr | 2014 |
Voxel-based morphometry and arterial spin labeling fMRI reveal neuropathic and neuroplastic features of brain processing of itch in end-stage renal disease.
Topics: Adult; Aged; Brain Mapping; Cerebral Cortex; Female; Gray Matter; Histamine; Humans; Kidney Failure, | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; P | 2014 |
Role of spinal bombesin-responsive neurons in nonhistaminergic itch.
Topics: Animals; Bombesin; Capsaicin; Chloroquine; Histamine; Hot Temperature; Isothiocyanates; Male; Mice; | 2014 |
TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity.
Topics: Animals; Calcium; Capsaicin; Chloroquine; HEK293 Cells; Histamine; Humans; Intracellular Space; Ion | 2014 |
Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
Topics: Animals; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neura | 2014 |
Response characteristics of pruriceptive and nociceptive trigeminoparabrachial tract neurons in the rat.
Topics: Action Potentials; Animals; beta-Alanine; Capsaicin; Cheek; Chloroquine; Histamine; Hot Temperature; | 2015 |
Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin.
Topics: Adolescent; Adult; Amygdala; Brain Mapping; Capsaicin; Caudate Nucleus; Cerebral Cortex; Cross-Over | 2015 |
BOLD responses to itch in the human spinal cord.
Topics: Adult; Cervical Vertebrae; Cold Temperature; Female; Forearm; Histamine; Humans; Interoception; Magn | 2015 |
Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.
Topics: Animals; beta-Alanine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chloroq | 2015 |
S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission.
Topics: Animals; Behavior, Animal; Female; Ganglia, Spinal; Histamine; Mice, Inbred ICR; Neurons; p-Methoxy- | 2015 |
Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin.
Topics: Adult; Histamine; Hot Temperature; Humans; Iontophoresis; Male; Mechanoreceptors; Nociceptors; Pain; | 2016 |
Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice.
Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Histamine; Hypoglycemic Agents; Male; Me | 2015 |
Chronic Pruritus: Histamine Is Not Always the Answer!
Topics: Aged; Antipruritics; Chronic Disease; Female; Histamine; Histamine Antagonists; Humans; Hypersensiti | 2015 |
Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis.
Topics: Adjuvants, Immunologic; Cyclobutanes; Dermatitis, Allergic Contact; Female; Histamine; Histamine Ago | 2015 |
Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice.
Topics: Animals; Behavior, Animal; Caffeic Acids; Chloroquine; HEK293 Cells; Histamine; Humans; Menthol; Mic | 2015 |
Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch.
Topics: Animals; Calbindins; Histamine; LIM-Homeodomain Proteins; Male; MAP Kinase Signaling System; Mice; M | 2015 |
Histamine released from epidermal keratinocytes plays a role in α-melanocyte-stimulating hormone-induced itching in mice.
Topics: alpha-MSH; Animals; Behavior, Animal; Cell Line; Epidermis; Histamine; Histamine Release; Histidine | 2015 |
A histamine-independent itch pathway is required for allergic ocular itch.
Topics: Animals; Biomarkers; Conjunctivitis, Allergic; Histamine; Mice; Mice, Knockout; Pruritus; Transient | 2016 |
Itch Perception and Skin Reactions as Modulated by Verbal Suggestions: Role of Participant's and Investigator's Sex.
Topics: Female; Healthy Volunteers; Histamine; Humans; Male; Perception; Pruritus; Sex Factors; Skin Tests; | 2016 |
Involvement of TRPV4 in Serotonin-Evoked Scratching.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Histamine; Immunohistochemistry; Injections, Intr | 2016 |
The interaction between histamine H1 receptor and μ- opioid receptor in scratching behavior in ICR mice.
Topics: Animals; Behavior, Animal; Chlorpheniramine; Histamine; Male; Mice; Mice, Inbred ICR; Morphine; Nalo | 2016 |
Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
Topics: Animals; Calcium Signaling; Endothelin-1; Epidermis; Gene Expression Regulation; Histamine; Keratino | 2016 |
The Maddening Sensation of Itch.
Topics: Animals; Histamine; Histamine Antagonists; Humans; Neurons; Pain; Peptide Hydrolases; Pruritus; Rece | 2016 |
Osthole inhibits histamine-dependent itch via modulating TRPV1 activity.
Topics: Animals; Antipruritics; Calcium; Calcium Channel Blockers; Capsaicin; Cells, Cultured; Coumarins; Ga | 2016 |
Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers.
Topics: Adult; Female; Galvanic Skin Response; Healthy Volunteers; Heart Rate; Histamine; Histamine Agonists | 2016 |
Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission.
Topics: Action Potentials; Animals; Chloroquine; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mice, Inb | 2016 |
A Test-Retest Reliability Study of Human Experimental Models of Histaminergic and Non-histaminergic Itch.
Topics: Histamine; Humans; Male; Models, Biological; Mucuna; Plant Components, Aerial; Pruritus; Reproducibi | 2017 |
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
Topics: Animals; Benzamides; Cell Line; Female; Histamine; Humans; Male; Mice, Inbred C57BL; Microsomes, Liv | 2016 |
Skin provocation tests may help to diagnose atopic dermatitis.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Male; Pruritus; Skin; Sk | 2016 |
Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.
Topics: Action Potentials; Afferent Pathways; Animals; Calcium Signaling; Disease Models, Animal; Ganglia, S | 2017 |
In Vivo Interrogation of Spinal Mechanosensory Circuits.
Topics: Animals; Female; Histamine; Interneurons; Light; Mechanotransduction, Cellular; Mice, Inbred C57BL; | 2016 |
Immediate-type allergic and protease-mediated reactions are involved in scratching behaviour induced by topical application of Dermatophagoides farinae extract in NC/Nga mice.
Topics: Animals; Antibodies; Antipruritics; Behavior, Animal; Capillary Permeability; Chlorpheniramine; Comp | 2018 |
Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study.
Topics: Adult; Capsaicin; Female; Healthy Volunteers; Histamine; Humans; Hyperalgesia; Male; Nociceptors; Pa | 2017 |
Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin.
Topics: Action Potentials; Animals; Anoctamin-1; Chloroquine; Histamine; Male; Mice; Mice, Inbred C57BL; Neu | 2017 |
Sulfonamides as Selective Na
Topics: Animals; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Enzyme Inductio | 2017 |
Separate peripheral pathways for pruritus in man.
Topics: Capsaicin; Electric Stimulation; Electrophysiology; Histamine; Hot Temperature; Humans; Mechanorecep | 2008 |
A role for polymodal C-fiber afferents in nonhistaminergic itch.
Topics: Afferent Pathways; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Histamine | 2008 |
Behavioral differentiation between itch and pain in mouse.
Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Forelimb; Hindlimb; H | 2008 |
The treatment of itching dermatoses with antihistaminic drugs with particular reference to pyribenzamine.
Topics: Anti-Allergic Agents; Histamine; Histamine Antagonists; Humans; Pruritus; Skin Diseases; Tripelennam | 1947 |
Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists, No | 2008 |
Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs.
Topics: Analgesics, Non-Narcotic; Animals; Dog Diseases; Dogs; Female; Histamine; Histamine Agonists; Interl | 2009 |
Role of histamine H(4) receptor in allergic conjunctivitis in mice.
Topics: Animals; Conjunctivitis, Allergic; Histamine; Histamine Agonists; Male; Mice; Mice, Inbred ICR; Mole | 2009 |
Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Histamine; Injections, Intradermal; Mice; Morphine; Naltrexone | 2009 |
Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Haplorhini; Histamine; Histamine Agonists; Mechanorec | 2009 |
The effect of wasabi rhizome extract on atopic dermatitis-like symptoms in HR-1 hairless mice.
Topics: Animals; Antibodies; Behavior, Animal; Brassicaceae; Chemokine CCL17; Chemokines, CC; Dermatitis, At | 2009 |
Impact of scratching on itch and sympathetic reflexes induced by cowhage (Mucuna pruriens) and histamine.
Topics: Adult; Analysis of Variance; Female; Forearm; Histamine; Humans; Laser-Doppler Flowmetry; Male; Mucu | 2009 |
Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch.
Topics: Action Potentials; Animals; Capsaicin; Cold Temperature; Histamine; Hot Temperature; Male; Mice; Mic | 2009 |
Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist.
Topics: Animals; Disease Models, Animal; Epidermis; Histamine; Histamine Antagonists; Humans; Indoles; Kerat | 2009 |
Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin.
Topics: Animals; Calcium; Dermatitis, Atopic; Ganglia, Spinal; Histamine; Histamine H1 Antagonists, Non-Seda | 2009 |
Cellular basis of itch sensation.
Topics: Afferent Pathways; Animals; Behavior, Animal; Bombesin; Chronic Disease; Histamine; Humans; Male; Mi | 2009 |
Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis.
Topics: Adult; Brain; Brain Mapping; Dermatitis, Atopic; Female; Histamine; Humans; Magnetic Resonance Imagi | 2009 |
Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice.
Topics: Allergens; Animals; Brazil; Histamine; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Nose; Prop | 2009 |
Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Topics: Animals; Capsaicin; Chloroquine; Ganglia, Spinal; Histamine; Humans; Mice; Pruritus; Receptors, G-Pr | 2009 |
Role of attentional focus on bodily sensations in sensitivity to itch and pain.
Topics: Administration, Topical; Adult; Attention; Capsaicin; Cold Temperature; Electric Stimulation; Female | 2010 |
Heterotopic pruritic conditioning and itch--analogous to DNIC in pain?
Topics: Adult; Aged; Central Nervous System; Chronic Disease; Conditioning, Psychological; Electric Stimulat | 2010 |
Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice.
Topics: Animals; Anti-Bacterial Agents; Antipruritics; Feces; Flavanones; Flavonoids; Guinea Pigs; Histamine | 2010 |
Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice.
Topics: Afferent Pathways; Animals; Behavior, Animal; Biological Products; Dose-Response Relationship, Drug; | 2010 |
Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P.
Topics: Animals; Calcium; Histamine; Male; Mice; Mice, Inbred C57BL; Mole Rats; Posterior Horn Cells; Prurit | 2010 |
Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate.
Topics: Administration, Topical; Animals; Antifungal Agents; Cell Degranulation; Cell Line; Drug Interaction | 2010 |
Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis.
Topics: Adaptation, Psychological; Administration, Cutaneous; Adolescent; Adult; Autonomic Nervous System; C | 2010 |
Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice.
Topics: Animals; Anti-Allergic Agents; Antipruritics; Ceramides; Guinea Pigs; Histamine; Interleukin-4; Mice | 2010 |
Relation between cooling sheet effect and tear histamine concenration in allergic conjunctivitis.
Topics: Conjunctivitis, Allergic; Cryotherapy; Enzyme-Linked Immunosorbent Assay; Histamine; Histamine H1 An | 2010 |
Antipruritic activity of extracts of Humulus scandens, the combinations of bioactive flavonoids.
Topics: 4-Aminopyridine; Animals; Antipruritics; Chloroquine; Dexamethasone; Flavonoids; Histamine; Humulus; | 2010 |
Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch.
Topics: Animals; Antibodies; Behavior, Animal; Calcium; Capsaicin; Disease Models, Animal; Ganglia, Spinal; | 2010 |
Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice.
Topics: Action Potentials; Animals; Capsaicin; Electrophysiology; Histamine; Male; Mice; Mice, Inbred ICR; M | 2010 |
Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males.
Topics: Administration, Oral; Adult; Area Under Curve; Cyproheptadine; Histamine; Histamine H1 Antagonists; | 2010 |
Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice.
Topics: Animals; Antipruritics; Culicidae; Drugs, Chinese Herbal; Fruit; Histamine; Histamine H1 Antagonists | 2010 |
Toll-like receptor 7 mediates pruritus.
Topics: Aminoquinolines; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Histamine; Imiq | 2010 |
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
Topics: Animals; Behavior, Animal; Female; Histamine; Humans; Immunohistochemistry; In Situ Hybridization; M | 2010 |
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; D | 2010 |
Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from kimchi in mice.
Topics: Animals; Antipruritics; Colon; Feces; Histamine; Interleukin-1beta; Interleukin-4; Lactobacillus pla | 2011 |
Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons.
Topics: Aminoquinolines; Animals; Chloroquine; Histamine; Imiquimod; Interferon Inducers; Mice; Neurons; Pru | 2011 |
Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1.
Topics: Animals; Behavior, Animal; Capsaicin; Endothelin-1; Enzyme Inhibitors; Histamine; Irritants; Male; M | 2011 |
Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model.
Topics: Acetone; Action Potentials; Analysis of Variance; Animals; Antipruritics; Capsaicin; Disease Models, | 2011 |
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antirheumatic Agents; Calcium; Capsaicin; Cells, Cu | 2011 |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
Topics: Animals; Carrier Proteins; Cells, Cultured; Ganglia, Spinal; Histamine; Membrane Proteins; Mice; Mic | 2011 |
Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord.
Topics: Action Potentials; Animals; Evoked Potentials; Excitatory Postsynaptic Potentials; Gastrin-Releasing | 2011 |
Validation of a model of itch induction for brain positron emission tomography studies using histamine iontophoresis.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Brain; Brain Mapping; Discrimination, Psycho | 2011 |
Inducible nitric oxide synthase (iNOS) and α-melanocyte-stimulating hormones of iNOS origin play important roles in the allergic reactions of atopic dermatitis in mice.
Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Dermatitis, Atopic; Disease Models, Animal; Enzyme | 2011 |
Glycyrrhetinic acid prevents cutaneous scratching behavior in mice elicited by substance P or PAR-2 agonist.
Topics: Animals; Antipruritics; Behavior, Animal; Glycyrrhetinic Acid; Histamine; Leukotriene B4; Male; Mice | 2011 |
In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans.
Topics: Animals; Histamine; Male; Mechanoreceptors; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; | 2012 |
A role for nociceptive, myelinated nerve fibers in itch sensation.
Topics: Action Potentials; Animals; Area Under Curve; Biophysics; Capsaicin; Electric Stimulation; Female; H | 2011 |
Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation.
Topics: Child; Hereditary Sensory and Autonomic Neuropathies; Histamine; Histamine Agonists; Humans; Male; M | 2012 |
A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch.
Topics: Adult; Brain; Brain Mapping; Female; Histamine; Humans; Magnetic Resonance Imaging; Male; Mucuna; Pr | 2012 |
Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ).
Topics: Animals; Behavior, Animal; Class Ib Phosphatidylinositol 3-Kinase; Genetic Enhancement; Histamine; M | 2011 |
Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch.
Topics: Adult; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Pruritu | 2012 |
Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice.
Topics: Animals; Bombesin; Chloroquine; Denervation; Histamine; Histamine Agonists; Hypersensitivity; Immuno | 2012 |
Red ginseng inhibits scratching behavior associated with atopic dermatitis in experimental animal models.
Topics: Administration, Topical; Animals; Anti-Allergic Agents; Behavior, Animal; Capillary Permeability; De | 2012 |
Role of induced negative and positive emotions in sensitivity to itch and pain in women.
Topics: Analysis of Variance; Cold Temperature; Electric Stimulation; Emotions; Female; Histamine; Histamine | 2012 |
Mouse model of touch-evoked itch (alloknesis).
Topics: Animals; Disease Models, Animal; Histamine; Mice; Mice, Inbred C57BL; Naltrexone; Oligopeptides; Pep | 2012 |
Endothelin-1 induces itch and pain in the mouse cheek model.
Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Endothelin A Receptor | 2012 |
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Chloroquine; Female; Ga | 2012 |
Site-dependent and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching.
Topics: Animals; Capsaicin; Chloroquine; Evoked Potentials; Histamine; Male; Mice; Mice, Inbred C57BL; Poste | 2012 |
Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate.
Topics: Animals; Axons; Brain Mapping; Capsaicin; Electroencephalography; Histamine; Macaca fascicularis; Mu | 2012 |
NGF sensitizes nociceptors for cowhage- but not histamine-induced itch in human skin.
Topics: Adult; Histamine; Hot Temperature; Humans; Male; Middle Aged; Mucuna; Nerve Growth Factor; Nocicepto | 2013 |
Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice.
Topics: Adult; Aged; Animals; Anti-Allergic Agents; Anti-Bacterial Agents; Bacteria, Anaerobic; Behavior, An | 2012 |
Development and validation of an automated system for detection and assessment of scratching in the rodent.
Topics: Algorithms; Analog-Digital Conversion; Animals; Anti-Allergic Agents; Automation; Behavior, Animal; | 2012 |
Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch.
Topics: Adult; Alopecia; Black or African American; Case-Control Studies; Female; Histamine; Hot Temperature | 2013 |
Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.
Topics: Animals; Behavior, Animal; Calcium Signaling; Chloroquine; Ganglia, Spinal; Histamine; Male; Mice; M | 2012 |
Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors.
Topics: Animals; Calcium; Chloroquine; Ganglia, Spinal; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mi | 2013 |
Pruritic and vascular responses induced by serotonin in patients with atopic dermatitis and in healthy controls.
Topics: Adult; Case-Control Studies; Dermatitis, Atopic; Female; Histamine; Humans; Injections, Intradermal; | 2013 |
A subpopulation of nociceptors specifically linked to itch.
Topics: Action Potentials; Animals; Antirheumatic Agents; Calcium; Capsaicin; Cells, Cultured; Chloroquine; | 2013 |
Dandruff: a condition characterized by decreased levels of intercellular lipids in scalp stratum corneum and impaired barrier function.
Topics: Administration, Cutaneous; Adult; Case-Control Studies; Cholesterol; Dermatitis, Seborrheic; Epiderm | 2002 |
Sensitivity of human scalp skin to pruritic stimuli investigated by intradermal microdialysis in vivo.
Topics: Adult; Forearm; Histamine; Humans; Male; Microdialysis; p-Methoxy-N-methylphenethylamine; Pruritus; | 2002 |
Production of acute and chronic itch with histamine and contact sensitizers in the mouse and guinea pig.
Topics: Acute Disease; Animals; Capsaicin; Chronic Disease; Dinitrochlorobenzene; Disease Models, Animal; Fe | 2002 |
Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Histamine; Histamine Antagonist | 2003 |
Experimental histamine pruritus. II. Nature; physical and environmental factors influencing development and severity.
Topics: Histamine; Histamine Agents; Humans; Physical Examination; Pruritus | 1953 |
Observations on itching produced by cowhage, and on the part played by histamine as a mediator of the itch sensation.
Topics: Histamine; Humans; Pruritus; Sensation | 1953 |
Experimental histamine pruritus. III. Influence of drugs on the itch threshold.
Topics: Histamine; Humans; Pruritus | 1954 |
The child with the itching skin.
Topics: Child; Eczema; Histamine; Humans; Infant; Ion Exchange; Phosphates; Pruritus | 1954 |
Heparin, histamine and pruritus.
Topics: Heparin; Histamine; Humans; Pruritus | 1956 |
Studies on itching. III. The effect of topical hydrocortisone on pruritus.
Topics: Histamine; Histamine Agents; Humans; Hydrocortisone; Pruritus | 1957 |
A study of antipruritic effects of topical steroids.
Topics: Antipruritics; Histamine; Histamine Agents; Hydrocortisone; Pruritus; Steroids | 1958 |
A histamine analogue that does not cause itching.
Topics: Histamine; Humans; Pruritus; Skin | 1961 |
[On the pathogenesis of prurirus].
Topics: Epinephrine; Histamine; Humans; Morphine; Prednisone; Pruritus; Skin; Vasomotor System | 1962 |
THE MASTOCYTOSIS SYNDROME: CLINICAL AND BIOLOGICAL STUDIES.
Topics: Adolescent; Carbon Isotopes; Carboxy-Lyases; Child; Diagnosis, Differential; Histamine; Histidine; H | 1963 |
[USE OF THE ATROPINE TEST IN THE DIAGNOSIS OF ALLERGIC DISEASES].
Topics: Asthma; Atropine; Coombs Test; Eczema; Histamine; Humans; Hypersensitivity; Pruritus; Rhinitis, Alle | 1963 |
THE BASIS OF ITCHING.
Topics: Bradykinin; Chemical Phenomena; Chemistry; Eczema; Histamine; Humans; Infant; Kallikreins; Neurophys | 1965 |
Observations on histamine-induced pruritus and pain.
Topics: Histamine; Pain; Pruritus | 1955 |
Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis.
Topics: Adult; Axons; Case-Control Studies; Central Nervous System; Dermatitis, Atopic; Female; Histamine; H | 2003 |
Perceptual matching for assessment of itch; reliability and responsiveness analyzed by a rank-invariant statistical method.
Topics: Adult; Aged; Eczema; Electric Stimulation; Female; Histamine; Humans; Male; Middle Aged; Models, Sta | 2003 |
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
Topics: Action Potentials; Analysis of Variance; Animals; Capsaicin; Electrophysiology; Evoked Potentials; H | 2004 |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; | 2003 |
Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch.
Topics: Adult; Dermatitis, Atopic; Electric Stimulation; Female; Histamine; Hot Temperature; Humans; Male; M | 2004 |
Relative effect of local anesthetics on experimental histamine pruritus in man.
Topics: Anesthetics; Anesthetics, Local; Histamine; Humans; Male; Pruritus | 1950 |
The effect of topical antipruritic therapy on experimentally induced pruritus in man.
Topics: Antipruritics; Histamine; Humans; Male; Pruritus | 1950 |
Experimental histamine pruritus. I. Influence of physical and psychological factors on threshold reactivity.
Topics: Histamine; Histamine Agents; Humans; Leadership; Physical Examination; Pruritus | 1952 |
A chronic model for evaluating the itching associated with allergic conjunctivitis in rats.
Topics: Animals; Anti-Allergic Agents; Antigens; Chronic Disease; Conjunctivitis, Allergic; Disease Models, | 2004 |
The role of central mu opioid receptors in opioid-induced itch in primates.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Histamine; | 2004 |
Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Histamine; Histamine Agonists; Mice; Mice, Inbred | 2004 |
Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons.
Topics: Animals; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme I | 2004 |
Effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in mice.
Topics: Animals; Behavior, Animal; Brazil; Capillary Permeability; Dose-Response Relationship, Drug; Drug In | 2004 |
[Effect of Antistin and Aludrin on itching].
Topics: Histamine; Humans; Pruritus | 1949 |
Histamine and the antihistaminic drugs.
Topics: Allergens; Anaphylaxis; Animals; Anti-Allergic Agents; Asthma; Guinea Pigs; Histamine; Humans; Hyper | 1950 |
Evaluation of a potentiated antihistaminic ointment.
Topics: Histamine; Humans; Ointments; Pruritus | 1950 |
Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis.
Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachid | 2004 |
Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on nasal rubbing and scratching behavior in ICR mice.
Topics: Animals; Drugs, Chinese Herbal; Female; Fruit; Histamine; Histamine Release; Mast Cells; Mice; Mice, | 2005 |
Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice.
Topics: Animals; Behavior, Animal; Cadherins; Dermatitis, Contact; Histamine; Histidine Decarboxylase; Mice; | 2005 |
Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice.
Topics: Administration, Cutaneous; Animals; Anti-Allergic Agents; Behavior, Animal; Female; Histamine; Luteo | 2005 |
Brain activation by histamine prick test-induced itch.
Topics: Adult; Brain; Histamine; Humans; Magnetic Resonance Imaging; Male; Pruritus; Skin Tests | 2005 |
Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models.
Topics: Animals; Antipruritics; Behavior, Animal; Capillary Permeability; Disease Models, Animal; Ginsenosid | 2005 |
"Uremic pruritus": a misnomer.
Topics: Histamine; Humans; Kidney Failure, Chronic; Mast Cells; Pruritus; Renal Dialysis | 2005 |
Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.
Topics: Administration, Oral; Animals; Ascomycota; Behavior, Animal; Capillary Permeability; Complex Mixture | 2005 |
Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.
Topics: Animals; Antibodies; Antipruritics; Benzamidines; Dose-Response Relationship, Drug; Extravasation of | 2006 |
Characteristics of scratching behavior induced by some chemical mediators in hairless mice.
Topics: Animals; Antipruritics; Behavior, Animal; Dermatitis, Atopic; Disease Models, Animal; Dose-Response | 2006 |
Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chloroquine; Dose-Response Relationship, Drug; Fema | 2006 |
Endothelin-1 causes pruritus in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Endothelin-1; Histamine; Histamine Rele | 2006 |
Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis.
Topics: Animals; Antipruritics; Cells, Cultured; Dermatitis, Atopic; Disease Models, Animal; Histamine; Hist | 2006 |
Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch.
Topics: Adult; Bradykinin; Cross-Over Studies; Dermatitis, Atopic; Female; Histamine; Histamine H1 Antagonis | 2006 |
Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.
Topics: Adult; Allergens; Brain; Female; Hand; Histamine; Humans; Hyperemia; Magnetic Resonance Imaging; Mal | 2007 |
Electrical ear acupuncture reduces histamine-induced itch (alloknesis).
Topics: Acupuncture, Ear; Adult; Electroacupuncture; Female; Histamine; Humans; Male; Pruritus | 2006 |
Short-term alternating temperature enhances histamine-induced itch: a biphasic stimulus model.
Topics: Adult; Cold Temperature; Forearm; Histamine; Histamine Agents; Humans; Male; Pain Measurement; Pruri | 2006 |
Cutaneous innervation before and after one treatment period of acupuncture.
Topics: Acupuncture Analgesia; Acupuncture Therapy; Adult; Aged; Biopsy; Calcitonin Gene-Related Peptide; Fe | 2006 |
Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Female; Ganglia, Spinal; Histam | 2006 |
Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.
Topics: Animals; Disease Models, Animal; Edema; Female; Foot; Histamine; Histamine Agonists; Histamine Antag | 2007 |
Neural correlates of perceptual difference between itching and pain: a human fMRI study.
Topics: Adult; Cold Temperature; Data Interpretation, Statistical; Gyrus Cinguli; Histamine; Humans; Image P | 2007 |
Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.
Topics: Administration, Topical; Adult; Afferent Pathways; Capsaicin; Female; Histamine; Histamine H1 Antago | 2007 |
Cerebral processing of histamine-induced itch using short-term alternating temperature modulation--an FMRI study.
Topics: Adult; Brain Mapping; Cerebral Cortex; Histamine; Histamine Agonists; Humans; Magnetic Resonance Ima | 2008 |
Itch induced by a novel method leads to limbic deactivations a functional MRI study.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Brain; Codeine; Data Interpretation, Statistical; Fem | 2007 |
The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons.
Topics: Action Potentials; Animals; Female; Histamine; Macaca fascicularis; Macaca mulatta; Male; Neurons; P | 2007 |
Repetitive scratching and noxious heat do not inhibit histamine-induced itch in atopic dermatitis.
Topics: Adult; Dermatitis, Atopic; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Male; Middle A | 2008 |
A case of pruritus ani treated with anti-histamine preparations.
Topics: Histamine; Histamine Antagonists; Pruritus; Pruritus Ani | 1949 |
Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects.
Topics: Adult; Afferent Pathways; Brain; Brain Mapping; Caudate Nucleus; Cerebrovascular Circulation; Dermat | 2008 |
AAITO Position Paper. Pruritus: causes, diagnostic workup and treatment.
Topics: Cytokines; Histamine; Humans; Neuropeptides; Prostaglandins; Pruritus; Skin Diseases | 2007 |
Evaluation of antipruritic effects of red ginseng and its ingredients in mice.
Topics: Acetic Acid; Animals; Antipruritics; Ginsenosides; Histamine; Immunoglobulin E; Interleukin-4; Mice; | 2008 |
Effects of a Dictamnus dasycarpus T. extract on allergic models in mice.
Topics: Animals; Dictamnus; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Hypersensit | 2008 |
Effects of topical application of tacrolimus on acute itch-associated responses in mice.
Topics: Administration, Topical; Aedes; Animals; Antipruritics; Behavior, Animal; Capsaicin; Female; Histami | 2008 |
Different dorsal horn neurons responding to histamine and allergic itch stimuli.
Topics: Afferent Pathways; Animals; Histamine; Hypersensitivity; Immunohistochemistry; Mice; Mice, Inbred IC | 2008 |
The effects of astemizole on histamine-induced weal and flare.
Topics: Adult; Aged; Astemizole; Benzimidazoles; Drug Hypersensitivity; Drug Interactions; Female; Histamine | 1983 |
Histamine release and therapy of severe dermatographism.
Topics: Adolescent; Animals; Cyproheptadine; Diphenhydramine; Female; Histamine; Histamine Release; Humans; | 1981 |
Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK-33-824, beta-endorphin and morphine.
Topics: Adolescent; Adult; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dinoprostone; Drug Synerg | 1982 |
Effects of cimetidine, ranitidine and promethazine on histamine--induced dermal weals and pruritus--a case study.
Topics: Adult; Cimetidine; Drug Eruptions; Drug Therapy, Combination; Histamine; Humans; Male; Methyltestost | 1983 |
[Comparative evaluation of the electrophysiologic indices of the functional state of the nervous system following intradermal administration of histamine and serotonin].
Topics: Animals; Histamine; Muscles; Nervous System; Pruritus; Rabbits; Serotonin | 1984 |
Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone.
Topics: Angioedema; Chlorpheniramine; Cimetidine; Double-Blind Method; Drug Therapy, Combination; Histamine; | 1984 |
Aquagenic pruritus.
Topics: Acetylcholine; Adult; Cytoplasmic Granules; Female; Histamine; Histamine Antagonists; Humans; Male; | 1981 |
Studies on histamine metabolism in mastocytosis.
Topics: Adult; Aged; Female; Histamine; Humans; Imidazoles; Male; Mast Cells; Middle Aged; Pruritus; Skin; U | 1983 |
Exercise-induced urticaria, angioedema, and anaphylactoid episodes.
Topics: Adolescent; Adult; Anaphylaxis; Angioedema; Blood Pressure; Complement System Proteins; Epinephrine; | 1981 |
Evaluation of a patient with both aquagenic and cholinergic urticaria.
Topics: Anxiety; Child; Cholinergic Fibers; Female; Heart Rate; Histamine; Hot Temperature; Humans; Hydroxyz | 1981 |
Influence of calcitonin gene-related peptide on histamine- and substance P-induced itch, flare and weal in humans.
Topics: Adult; Calcitonin Gene-Related Peptide; Dermatitis, Contact; Female; Histamine; Humans; Injections, | 1993 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylpheneth | 1995 |
Histaminergic nerves demonstrated in the skin. A new direct mode of neurogenic inflammation?
Topics: Animals; Dermatitis; Feedback; Histamine; Histamine Release; Intradermal Tests; Male; Mast Cells; Mi | 1995 |
Effects of menthol and cold on histamine-induced itch and skin reactions in man.
Topics: Adult; Cold Temperature; Histamine; Humans; Male; Menthol; Pruritus; Skin; Temperature; Time Factors | 1995 |
Characterization of a behavioral model for peripherally evoked itch suggests platelet-activating factor as a potent pruritogen.
Topics: Animals; Azepines; Female; Guinea Pigs; Histamine; Male; Platelet Activating Factor; Pruritus; Pyrid | 1995 |
Prospective evaluation of red man syndrome in patients receiving vancomycin.
Topics: Abdomen; Adult; Aged; Anaphylaxis; Female; Head; Histamine; Humans; Male; Middle Aged; Prospective S | 1993 |
Uraemic pruritus and plasma histamine concentrations.
Topics: Erythropoietin; Histamine; Humans; Pruritus; Renal Dialysis; Uremia | 1993 |
Conditioning of histamine by bradykinin alters responses of rat nociceptor and human itch sensation.
Topics: Adult; Animals; Bradykinin; Female; Histamine; Humans; Iontophoresis; Male; Middle Aged; Models, Bio | 1993 |
Uraemic pruritus is not related to plasma histamine concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Histamine; Humans; Male; M | 1995 |
Histamine-induced itch and alloknesis (itchy skin) in atopic eczema patients and controls.
Topics: Administration, Cutaneous; Adolescent; Adult; Analysis of Variance; Cold Temperature; Dermatitis, At | 1995 |
Pruritogenic effects of mitogen-stimulated peripheral blood mononuclear cells in atopic eczema.
Topics: Adult; Cells, Cultured; Concanavalin A; Cytokines; Dermatitis, Atopic; Histamine; Humans; Leukocytes | 1995 |
Atopic eczema and histamine-induced sensations.
Topics: Adult; Dermatitis, Atopic; Female; Histamine; Humans; Iontophoresis; Male; Middle Aged; Pain Measure | 1996 |
Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin.
Topics: Administration, Topical; Adult; Biophysical Phenomena; Biophysics; Female; Histamine; Hot Temperatur | 1996 |
Sympathectomy does not influence experimental itch and cutaneous temperature perception thresholds.
Topics: Adult; Female; Histamine; Humans; Hyperhidrosis; Male; Pain Threshold; Pruritus; Skin; Skin Temperat | 1996 |
Topically applied aspirin rapidly decreases histamine-induced itch.
Topics: Administration, Topical; Adult; Aspirin; Female; Histamine; Humans; Injections, Intradermal; Male; P | 1997 |
An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge.
Topics: Adult; Allergens; Chymases; Female; Histamine; Humans; Leukotriene C4; Male; Nasal Mucosa; Nasal Obs | 1997 |
[Studies on Kochiae Fructus. I. Antipruritogenic effect of 70% ethanol extract from kochiae fructus and its active component].
Topics: Animals; Antipruritics; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Histamine; Male; Mic | 1997 |
Role of mast cell and stem cell factor in hyperpigmented mycosis fungoides.
Topics: Acanthosis Nigricans; Cytokines; Female; Histamine; Humans; Male; Mast Cells; Middle Aged; Mycosis F | 1997 |
Effect of topical pramoxine on experimentally induced pruritus in humans.
Topics: Adult; Anesthetics, Local; Antipruritics; Cold Temperature; Female; Histamine; Hot Temperature; Huma | 1997 |
Specific C-receptors for itch in human skin.
Topics: Adult; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Leg; Male; Nerve Fibers; Neural Co | 1997 |
Specific C-receptors for itch in human skin.
Topics: Adult; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Leg; Male; Nerve Fibers; Neural Co | 1997 |
Specific C-receptors for itch in human skin.
Topics: Adult; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Leg; Male; Nerve Fibers; Neural Co | 1997 |
Specific C-receptors for itch in human skin.
Topics: Adult; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Leg; Male; Nerve Fibers; Neural Co | 1997 |
Evaluation of threshold criteria for the nasal histamine challenge test in perennial allergic rhinitis.
Topics: Adolescent; Adult; Child; Female; Histamine; Humans; Male; Middle Aged; Nasal Mucosa; Nasal Obstruct | 1997 |
Can a serotonin type 3 (5-HT3) receptor antagonist reduce experimentally-induced itch?
Topics: Adult; Cetirizine; Female; Histamine; Histamine H1 Antagonists; Humans; Indoles; Iontophoresis; Male | 1997 |
Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria.
Topics: Acute Disease; Adult; Case-Control Studies; Dermatitis, Atopic; Dermatologic Agents; Female; Histami | 1998 |
Skin cooling attenuates rat dorsal horn neuronal responses to intracutaneous histamine.
Topics: Animals; Cold Temperature; Histamine; Injections, Intradermal; Male; Microinjections; Neurons; Pruri | 1998 |
The antipruritic effect of a 5-HT3 receptor antagonist (tropisetron) is dependent on mast cell depletion--an experimental study.
Topics: Adult; Antipruritics; Cell Count; Female; Histamine; Humans; Indoles; Male; Mast Cells; p-Methoxy-N- | 1999 |
Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Histam | 1999 |
Mast cell mediators other than histamine induced pruritus in atopic dermatitis patients - a dermal microdialysis study.
Topics: Dermatitis, Atopic; Histamine; Humans; Inflammation Mediators; Mast Cells; Microdialysis; Pruritus | 2000 |
Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study.
Topics: Adult; Cetirizine; Dermatitis, Atopic; Female; Histamine; Histamine H1 Antagonists; Humans; Inflamma | 2000 |
Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine.
Topics: Analgesics, Opioid; Animals; Capsaicin; Electrophysiology; Ganglionic Stimulants; Histamine; Hot Tem | 2000 |
Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice.
Topics: Animals; Anti-Allergic Agents; Benzimidazoles; Dose-Response Relationship, Drug; Histamine; Injectio | 2000 |
Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions.
Topics: Adult; Central Nervous System; Cerebral Cortex; Histamine; Humans; Injections, Intradermal; Male; Pr | 2000 |
A neural pathway for itch.
Topics: Afferent Pathways; Animals; Capsaicin; Cats; Histamine; Humans; Posterior Horn Cells; Pruritus; Spin | 2001 |
Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch.
Topics: Animals; Cats; Histamine; Iontophoresis; Lumbosacral Region; Mustard Plant; Nerve Fibers; Neural Con | 2001 |
Inhibition of passive cutaneous anaphylaxis-associated scratching behavior by mu-opioid receptor antagonists in ICR mice.
Topics: Animals; Behavior, Animal; Capillary Permeability; Female; Histamine; Humans; Mice; Mice, Inbred ICR | 2000 |
Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis.
Topics: Animals; Attention; Chronic Disease; Dermatitis; Female; Histamine; Immunoglobulin E; Mice; Mice, In | 2001 |
Nedocromil sodium inhibits histamine-induced itch and flare in human skin.
Topics: Adult; Anti-Inflammatory Agents; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; | 2001 |
Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Free Radical Scavengers; Histamine; Ma | 2000 |
Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies.
Topics: Adult; Cerebral Cortex; Cerebrovascular Circulation; Histamine; Humans; Male; Oxygen Radioisotopes; | 2001 |
Interactions of histamine and bradykinin on polymodal C-fibres in isolated rat skin.
Topics: Animals; Bradykinin; Dermatitis, Atopic; Drug Interactions; Histamine; Hot Temperature; In Vitro Tec | 2001 |
Intradermal skin test reactivity to histamine and substance P is blunted in dogs with atopic dermatitis.
Topics: Animals; Case-Control Studies; Dermatitis, Atopic; Dog Diseases; Dogs; Dose-Response Relationship, D | 2001 |
Itch in atopic dermatitis.
Topics: Adrenal Cortex Hormones; Antipruritics; Cytokines; Dermatitis, Atopic; Histamine; Humans; Immunosupp | 2001 |
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs | 2001 |
Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice.
Topics: Aedes; Animals; Capillary Permeability; Coloring Agents; Histamine; Hypersensitivity; Immunoglobulin | 2001 |
Histamine-induced itch converts into pain in neuropathic hyperalgesia.
Topics: Histamine; Hot Temperature; Humans; Hyperalgesia; Nociceptors; Pain; Pruritus | 2001 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonist | 2002 |
Inhibitory effects of azelastine on substance P-induced itch-associated response in mice.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Calcium; Dinoprostone; Dose-Response Relationship, | 2002 |
Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Disinfectants; Electrophysiology; Formaldehyde; Histamine; Inj | 2002 |
Characterisation of the calcium responses to histamine in capsaicin-sensitive and capsaicin-insensitive sensory neurones.
Topics: Animals; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; G | 2002 |
Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge.
Topics: Anaphylaxis; Chemotaxis; Cold Temperature; Complement System Proteins; Eosinophils; Erythema; Histam | 1976 |
[Clinical experiences with histamine-azoprotein and serotonine-azo-protein in the therapy of allergic diseases (author's transl)].
Topics: Asthma; Azo Compounds; Dermatitis; Dermatitis, Atopic; Dermatitis, Contact; gamma-Globulins; Haptens | 1977 |
Pruritogenic activity of prostaglandin E2.
Topics: Adolescent; Adult; Drug Synergism; Histamine; Histamine Release; Humans; Injections, Intradermal; Pi | 1977 |
Potentiation of itch and flare responses in human skin by prostaglandins E2 and H2 and a prostaglandin endoperoxide analog.
Topics: Adolescent; Adult; Drug Synergism; Histamine; Humans; Inflammation; Prostaglandin Endoperoxides; Pro | 1977 |
Introduction to the pharmacology and physiology of itch.
Topics: Histamine; Humans; Prostaglandins E; Pruritus; Sensory Receptor Cells; Skin | 1975 |
Histamine-caused itch induces Fos-like immunoreactivity in dorsal horn neurons: effect of morphine pretreatment.
Topics: Animals; Histamine; Immunoenzyme Techniques; Male; Morphine; Nerve Tissue Proteins; Neurons; Proto-O | 1992 |
Vasodilator flare due to activation of superficial cutaneous afferents in humans: heat-sensitive versus histamine-sensitive fibers.
Topics: Histamine; Hot Temperature; Humans; Microcirculation; Nerve Fibers; Neurons, Afferent; Pain; Pruritu | 1992 |
[Erythropoietin in treatment of pruritus in chronic renal failure].
Topics: Erythropoietin; Histamine; Humans; Kidney Failure, Chronic; Pruritus | 1992 |
Itching--research has barely scratched the surface.
Topics: Erythropoietin; Histamine; Humans; Pruritus; Uremia | 1992 |
Pruritus in hemodialysis patients.
Topics: Histamine; Humans; Parathyroid Hormone; Pruritus; Renal Dialysis; Skin | 1992 |
[Uremic pruritus in chronic kidney failure with hemodialysis].
Topics: Diazepam; Histamine; Histamine Antagonists; Humans; Kidney Failure, Chronic; Lidocaine; Parathyroide | 1992 |
Study on pruritus in hemodialysis patients and the antipruritic effect of neurotropin: plasma levels of substance P, somatostatin, IgE, PTH and histamine.
Topics: Adjuvants, Immunologic; Female; Histamine; Humans; Immunoglobulin E; Male; Middle Aged; Parathyroid | 1990 |
Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells.
Topics: Adult; Biopsy; Cell Count; Female; Histamine; Histamine Release; Humans; Male; Mast Cells; Peritonea | 1990 |
Patients' perception of itch induced by histamine, compound 48/80 and wool fibres in atopic dermatitis.
Topics: Adolescent; Adult; Animals; Dermatitis, Atopic; Female; Histamine; Histamine Release; Humans; Male; | 1991 |
Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine.
Topics: Adult; Female; Histamine; Humans; Injections, Intradermal; Male; Middle Aged; Pruritus; Psychophysic | 1991 |
Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus.
Topics: Chronic Disease; Histamine; Humans; Ketotifen; Mast Cells; Pilot Projects; Pruritus; Renal Dialysis; | 1991 |
Discharge patterns of human C-fibers induced by itching and burning stimuli.
Topics: Adult; Electric Stimulation; Female; Histamine; Humans; Male; Middle Aged; Mustard Plant; Nerve Fibe | 1991 |
Plasma histamine in patients with chronic renal failure and nephrotic syndrome.
Topics: Adolescent; Adult; Aged; Female; Histamine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Neph | 1991 |
Raised histamine concentrations in chronic cholestatic liver disease.
Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Cholangitis, Sclerosing; Chronic Disease; Female; Hi | 1990 |
[Aquagenic pruritus (A.P.)].
Topics: Acetylcholine; Age Factors; Aspirin; Bicarbonates; Fibrinolysis; Fluoxetine; Globulins; Histamine; H | 1990 |
Increased plasma histamine levels in uraemic pruritus.
Topics: Adult; Female; Histamine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pruritus; Radioimmunoa | 1990 |
Pruritus during standardized mental stress. Relationship to psychoneuroendocrine and metabolic parameters.
Topics: Adult; Epinephrine; Histamine; Humans; Male; Pruritus; Stress, Psychological | 1985 |
Psychological predictors of pruritus during mental stress.
Topics: Adult; Blood Glucose; Blood Pressure; Epinephrine; Histamine; Humans; Hydrocortisone; Prolactin; Pru | 1985 |
The sensitivity of uremic and normal human skin to histamine.
Topics: Adult; Aged; Female; Histamine; Humans; Intradermal Tests; Kidney Failure, Chronic; Male; Middle Age | 1988 |
Skin reactivity to neuropeptides in atopic dermatitis.
Topics: Adult; Dermatitis, Atopic; Dose-Response Relationship, Drug; Histamine; Humans; Intradermal Tests; N | 1989 |
Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and controls.
Topics: Administration, Cutaneous; Adolescent; Adult; Dermatitis, Atopic; Female; Histamine; Humans; Lasers; | 1989 |
Uremic pruritus. Clinical and experimental studies.
Topics: Adult; Aged; Body Water; Histamine; Humans; Middle Aged; Parathyroid Hormone; Pruritus; Renal Dialys | 1989 |
The relevance of low skin temperature inhibiting histamine-induced itch to the location of contact urticarial symptoms in the fish processing industry.
Topics: Adult; Aged; Cold Temperature; Erythema; Female; Fish Products; Histamine; Humans; Male; Middle Aged | 1989 |
The magnitude and duration of itch produced by intracutaneous injections of histamine.
Topics: Dose-Response Relationship, Drug; Histamine; Humans; Injections, Intradermal; Pruritus | 1987 |
[Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels].
Topics: Administration, Oral; Adult; Female; Histamine; Humans; Kidney Failure, Chronic; Male; Pruritus; Ren | 1987 |
Nasal challenge.
Topics: Airway Resistance; Allergens; Histamine; Humans; Nasal Mucosa; Nasal Provocation Tests; Pruritus; Sn | 1986 |
Exercise-induced anaphylactic syndromes. Insights into diagnostic and pathophysiologic features.
Topics: Adult; Anaphylaxis; Angioedema; Body Temperature Regulation; Diagnosis, Differential; Dizziness; End | 1986 |
Polycythaemia rubra vera and water-induced pruritus: blood histamine levels and cutaneous fibrinolytic activity before and after water challenge.
Topics: Fibrinolysis; Histamine; Humans; Immersion; Male; Middle Aged; Polycythemia Vera; Pruritus; Water | 1987 |
Capsaicin prevents histamine-induced itching.
Topics: Administration, Topical; Adolescent; Adult; Axons; Capsaicin; Female; Histamine; Humans; Male; Musta | 1986 |
Decreased skin response to intradermal histamine in cancer patients.
Topics: Adult; Aged; Dose-Response Relationship, Immunologic; Electrophysiology; Female; Histamine; Humans; | 1986 |
Skin mast cells in polycythaemia vera: relationship to the pathogenesis and treatment of pruritus.
Topics: Basophils; Cell Count; Histamine; Humans; Leukocyte Count; Mast Cells; Polycythemia Vera; Pruritus; | 1987 |
The pathogenesis of urticaria.
Topics: Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Histamine; Humans; Mast Cells; Peptide | 1985 |
The effects of thermal stimulation on clinical and experimental itch.
Topics: Adult; Cold Temperature; Dermatitis, Atopic; Female; Forearm; Histamine; Hot Temperature; Humans; Im | 1986 |
Cutaneous responses to human C 3 anaphylatoxin in man.
Topics: Biopsy; Cell Movement; Complement System Proteins; Erythema; Histamine; Histamine H1 Antagonists; Hi | 1972 |
Histamine excess symptoms in basophilic chronic granulocytic leukemia.
Topics: Adult; Basophils; Busulfan; Cold Temperature; Histamine; Histamine H1 Antagonists; Histamine Release | 1973 |
Diseases of the skin. The management of pruritus.
Topics: Clothing; Dermatologic Agents; Diabetes Complications; Drug Eruptions; Environment; Exercise Test; H | 1973 |
The antihistaminic effect of human eosinophils.
Topics: Anaphylaxis; Asthma; Dermatitis, Atopic; Dermatitis, Exfoliative; Eczema; Eosinophils; Exanthema; Fe | 1970 |
[Causes of pruritus in pregnant women].
Topics: Adolescent; Adult; Female; Histamine; Humans; Hypersensitivity; Pre-Eclampsia; Pregnancy; Pregnancy | 1974 |
Localized heat urticaria.
Topics: Adult; Atropine; Epinephrine; Female; Forearm; Histamine; Hot Temperature; Humans; Immunization, Pas | 1973 |
[Experimental histamine determination in the diagnosis of teleangiectasia macularis eruptive perstans].
Topics: Adolescent; Diagnosis, Differential; Female; Histamine; Humans; Male; Middle Aged; Pruritus; Telangi | 1971 |
Mastocytosis treated with l-hyoscyamine (Egazil).
Topics: Adult; Atropa belladonna; Diarrhea; Female; Gastritis; Histamine; Humans; Phytotherapy; Plants, Medi | 1968 |
A study of histamine in myeloproliferative disease.
Topics: Bone Marrow Diseases; Cyproheptadine; Histamine; Humans; Myeloproliferative Disorders; Polycythemia; | 1966 |