Page last updated: 2024-12-08

valencene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

valencene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(+)-valencene : A carbobicyclic compound and sesquiterpene that is 1,2,3,4,4a,5,6,7-octahydronaphthalene which is substituted a prop-1-en-2-yl group at position 3 and by methyl groups at positions 4a and 5 (the 3R,4aS,5R- diastereoisomer). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID9855795
CHEMBL ID3186909
CHEBI ID61700
MeSH IDM0493635

Synonyms (44)

Synonym
4630-07-3
valencene
valencen
(+)-valencene
valencene, natural, >=65%
(+)-valencene, technical, >=70%
C17277
ent-7betah-eremophila-10(1),11-diene
(3r,4as,5r)-4a,5-dimethyl-3-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene ,
CHEBI:61700 ,
(1r-(1alpha,7beta,8alpha))-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylvinyl)naphthalene
dtxsid8047052 ,
cas-4630-07-3
tox21_302397
dtxcid6027052
NCGC00256249-01
fema no. 3443
naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, (1r-(1alpha,7beta,8aalpha))-
naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, (1r,7r,8as)-
1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)naphthalene, (1r-(1alpha,7beta,8aalpha))-
nsc 148969
96h21p91ig ,
unii-96h21p91ig
4alpha,10alpha-dimethyl-6beta-isopropyl-.delta.1,9-octalin
4betah,5alpha-eremophila-1(10),11-diene
4alpha,10alpha-dimethyl-6beta-isopropyl-delta1,9-octalin
einecs 225-047-6
naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, (1r-(1.alpha.,7.beta.,8a.alpha.))-
valencene [fhfi]
valencene [inci]
CHEMBL3186909
mfcd00075884
AKOS027460688
(+)-valencene, analytical standard
(+)-valencene 1000 microg/ml in isopropanol
Q289496
QEBNYNLSCGVZOH-NFAWXSAZSA-N
CS-0044199
HY-N6636
(a+/-)-valencene
MS-23110
(3r,4as,5r)-4a,5-dimethyl-3-prop-1-en-2-yl-2,3,4,5,6,7-hexahydro-1h-naphthalene
F71379
(+)-valencene, tech grade
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
sesquiterpeneA C15 terpene.
carbobicyclic compoundA bicyclic compound in which all the ring atoms are carbon.
polycyclic olefinA polycyclic hydrocarbon having any number of double bonds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
valencene and 7-epi-u03B1-selinene biosynthesis34
valencene and 7-epi-u03B1-selinene biosynthesis24

Protein Targets (15)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency62.94170.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency26.35540.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency25.82120.000221.22318,912.5098AID1259243; AID1259247
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency48.55770.001022.650876.6163AID1224838
progesterone receptorHomo sapiens (human)Potency56.09680.000417.946075.1148AID1346784; AID1347036
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency48.96620.000214.376460.0339AID720692
retinoid X nuclear receptor alphaHomo sapiens (human)Potency41.19990.000817.505159.3239AID1159531
pregnane X nuclear receptorHomo sapiens (human)Potency38.57080.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency61.64480.000229.305416,493.5996AID743069
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency68.58960.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency54.84420.001628.015177.1139AID1224843; AID1224895
Histone H2A.xCricetulus griseus (Chinese hamster)Potency1.79100.039147.5451146.8240AID1224845
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency68.58960.000323.4451159.6830AID743065
heat shock protein beta-1Homo sapiens (human)Potency30.89560.042027.378961.6448AID743210
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency56.65580.000627.21521,122.0200AID743202; AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1634814Inhibition of UV-induced melanogenesis in mouse B16F10 cells assessed as reduction in melanin level pretreated with compound prior to UVB exposure measured after 48 hrs by spectrophotometric method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634809Antagonist activity at human ORAI1 expressed in HEK293T cells assessed as capsaicin-induced inwardly rectifying current at 90 uM and -120 mV by whole cell patch-clamp method relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634804Antagonist activity at human TRPV1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced inward transient currents at 90 uM and -60 mV by whole cell patch-clamp method relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634813Inhibition of SOCE signalling in human Jurkat-T cells assessed as reduction in alpha-CD3 induced cytoplasmic calcium concentration at 50 uM measured at every 2 sec interval by Fura-2 dye based fluorimetric analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634812Inhibition of SOCE signalling in human Jurkat-T cells assessed as reduction in alpha-CD3 induced cytoplasmic calcium concentration at 30 uM measured at every 2 sec interval by Fura-2 dye based fluorimetric analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634815Inhibition of UV-induced melanogenesis in mouse B16F10 cells assessed as reduction in melanin level pretreated at 7.5 ug/ml prior to UVB exposure measured after 48 hrs by spectrophotometric method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634805Antagonist activity at human TRPV1 expressed in HEK293T cells assessed as capsaicin-induced inward transient currents at 90 uM and -60 mV by whole cell patch-clamp method relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634808Antagonist activity at human ORAI1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced inwardly rectifying current at 90 uM and -120 mV by whole cell patch-clamp method relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634819Inhibition of mushroom tyrosinase using L-DOPA as substrate measured after 10 mins by spectrophotometry2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634807Antagonist activity at human ORAI1 expressed in HEK293T cells assessed as inhibition of capsaicin induced inwardly rectifying current at 30 uM and -120 mV by whole cell patch-clamp method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634810Inhibition of SOCE signalling in human Jurkat-T cells assessed as reduction in alpha-CD3 induced cytoplasmic calcium concentration measured at every 2 sec interval by Fura-2 dye based fluorimetric analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634818Cytotoxicity in mouse B16F10 cells at <15 ug/ml measured after 48 hrs by MTT assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634803Antagonist activity at human ORAI1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced inwardly rectifying current at 10 uM and -120 mV by whole cell patch-clamp method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634817Inhibition of UV-induced melanogenesis in mouse B16F10 cells assessed as reduction in melanin level pretreated at 3 ug/ml prior to UVB exposure measured after 48 hrs by spectrophotometric method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634811Inhibition of SOCE signalling in human Jurkat-T cells assessed as reduction in alpha-CD3 induced cytoplasmic calcium concentration at 10 uM measured at every 2 sec interval by Fura-2 dye based fluorimetric analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634806Antagonist activity at human ORAI1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced inwardly rectifying current at -120 mV by whole cell patch-clamp method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
AID1634816Inhibition of UV-induced melanogenesis in mouse B16F10 cells assessed as reduction in melanin level pretreated at 15 ug/ml prior to UVB exposure measured after 48 hrs by spectrophotometric method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (52)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (11.54)29.6817
2010's34 (65.38)24.3611
2020's12 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other48 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]