| Assay ID | Title | Year | Journal | Article |
|---|
| AID230229 | Inhibitory selectivity for A2 receptor in rat striatal membranes and A1 receptor in rat cortical membranes | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. |
| AID78490 | Inhibition of stimulation of adenylate cyclase in guinea pig brain slices at A2 receptor (2-chloroadenosine-elicited accumulations of cyclic AMP) | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
| AID33176 | Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand | 2002 | Journal of medicinal chemistry, May-23, Volume: 45, Issue:11
| Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. |
| AID32868 | Binding affinity for adenosine A2A receptor using [3H]-NECA in rat brain striatal membranes | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. |
| AID30341 | Evaluated for binding affinity against Adenosine A1 receptor | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4
| A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor. |
| AID33728 | Inhibition of binding of [3H]5'-(N-ethylcarbamoyl)-adenosine to adenosine A2 receptor in rat striatal membranes | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. |
| AID32500 | Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranes | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. |
| AID54313 | log(1000/IC50 determined from bovine brain membrane) expressed as potency | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
| Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application. |
| AID31856 | Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranes | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
| 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. |
| AID32495 | Inhibition of [3H]- PIA binding at adenosine A1 receptor on rat cerebral cortex membranes. | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Xanthine functionalized congeners as potent ligands at A2-adenosine receptors. |
| AID33907 | Selectivity ratio was expressed as the ratio of binding affinity towards Adenosine A2 receptor to that of Adenosine A1 receptor in rat | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. |
| AID33441 | Binding affinity against adenosine A2 receptor in rat striatum by the displacement of [3H]N-ethyladenosine-5''-uronamide(NECA). | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| 1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity. |
| AID21139 | Solubility in water at PH 7.4 in the presence of Tris.HCl buffer | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
| AID31692 | Antagonistic activity on N6-([3H]-phenylisopropyl)adenosine binding to rat brain membrane (Adenosine A1 receptor) | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
| AID33579 | Binding affinity to A2 adenosine receptor from rat striatal membrane in presence of [3H]5'-(N-ethylcarboximido)-adenosine | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. |
| AID31887 | Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors. |
| AID34727 | Binding affinity for human adenosine A3 receptor using [3H]PBS-11 in CHO cell membranes; ND denotes not determined | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. |
| AID31838 | Log IC50 value was determined against adenosine A1 receptor in bovine brain membranes | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
| Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application. |
| AID92373 | Inhibition of 5'-(N-ethylcarbamoyl)adenosine-elicited stimulation of adenylate cyclase in human platelet membranes | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
| AID227036 | A1 selectivity is the ratio between A2 and A1 receptor | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. |
| AID32487 | Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
| Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
| AID230900 | Ratio of antagonist activity at A1 and A2 receptors | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
| AID32862 | Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680 | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors. |
| AID30796 | Inhibition of stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via A2 adenosine receptor in human platelet membranes | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
| Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
| AID30797 | Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
| Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
| AID33753 | Ratio of the binding affinities of A2 /A1 receptor | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| 1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity. |
| AID32491 | Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
| Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
| AID33734 | Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via Adenosine A2 receptor in rat PC12 membranes | 1989 | Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
| Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
| AID32020 | Binding affinity against A1 adenosine receptors of the central nervous system | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. |
| AID32039 | Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]R-(phenylisopropyl)-adenosine | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. |
| AID30621 | Antagonism of cyclic [3H]AMP accumulation in guinea pig cerebral cortical slices (elicited by 15 uM 2-chloroadenosine at adenosine A2 receptor) | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
| 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. |
| AID33180 | Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. |
| AID32046 | Binding affinity for adenosine A1 receptor using [3H]PIA in rat brain cortical membrane | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. |
| AID156510 | Inhibition of 5'-(N-ethylcarbamoyl)adenosine-elicited stimulation of adenylate cyclase in rat PC12 cell membranes | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. |
| AID33568 | Binding affinity against A2 adenosine receptors of the central nervous system | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. |
| AID30635 | Antagonism of NECA-induced stimulation of adenylate cyclase activity in human platelet membranes at A2-adenosine receptor | 1987 | Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
| Xanthine functionalized congeners as potent ligands at A2-adenosine receptors. |
| AID30335 | Log IC50 value was determined against adenosine A1 receptor in rat brain membranes | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
| Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application. |
| AID31869 | Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]cyclohexyladenosine (CHA). | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| 1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity. |
| AID229822 | Ratio of antagonism at A2 versus A1 receptors (Ki values) | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
| 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. |
| AID31836 | Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosine | 1985 | Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
| Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID493017 | Wombat Data for BeliefDocking | 1994 | Journal of medicinal chemistry, May-13, Volume: 37, Issue:10
| Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |