Farmer's Lung

A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.

Synonym
Mushroom Worker's Lung
Farmer's Lung

Excerpt	Reference
"Farmer's Lung is an extrinsic allergic alveolitis due to the inhalation of actinomycetes thermophiles."	( Gari, M; Pinon, JM; Recco, P; Séguéla, JP, 1984)
"Farmer's lung is a frequent form of extrinsic allergic alveolitis."	( Becker, WM; Mundt, C; Schlaak, M, 1996)

Excerpt	Reference
"Byssinosis and farmer's lung have now been acknowledged as occupational diseases."	( Antweiler, H, 1979)

Excerpt	Reference
"They were diagnosed with farmer's lung and treated with pulse therapy with methylprednisolone and tapering of steroid."	( Ashitani, J; Imai, K; Imazu, Y; Nakazato, M; Sano, A; Tokojima, M; Yanagi, S, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	189 (75.90)	23.3326
1990's	37 (14.86)	12.5806
2000's	15 (6.02)	18.1394
2010's	8 (3.21)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
carbon monoxide	low	1	0
chlorine	low	1	0
glycerol	low	1	0
histamine	low	4	0
methanol	low	5	0
propionic acid	low	1	0
ambroxol	low	33	0
glutaral	low	1	0
guaifenesin	low	2	0
procainamide	low	1	0
prednisolone	medium	10	1
hydroxyproline	low	1	0
prednisone	low	2	0
galactose	low	1	0
edetic acid	low	1	0
methacholine chloride	low	3	0
egtazic acid	low	1	0
ampicillin	low	1	0
isocyanic acid	low	1	0
trichloroacetic acid	low	4	0
phencyclidine	low	103	0
methylprednisolone	low	2	0
acridines	low	1	0
fusarium	low	1	0
reticulin	low	1	0
erythromycin	low	1	0
d-alpha tocopherol	low	1	0
paraquat	low	1	0
fluorescein-5-isothiocyanate	low	1	0
sabinene	low	1	0
mannose	low	1	0
manganese	low	1	0
cadmium	low	1	0
chromium	low	1	0
galactosamine	low	1	0
copper sulfate	low	1	0
cromolyn sodium	medium	4	1
trazodone hydrochloride	low	1	0
glucose, (beta-d)-isomer	low	4	0
10,10'-dimethyl-9,9'-biacridinium	low	1	0
metaperiodate	low	1	0
nicotine	low	1	0
glycidyl nitrate	low	1	0
cobalt	low	1	0
cyanates	low	3	0
methotrexate	low	1	0
biotin	low	1	0
arabinose	low	1	0
epiglucan	low	2	0
puromycin	low	1	0
arachidonic acid	low	1	0
1,3-dimethylthiourea	low	1	0
thiourea	low	1	0
nitrogen dioxide	low	2	0
di-(2-amino-5-nitrothiazole)dichloroplatinum(ii)	low	1	0
alpha-chymotrypsin	low	3	0
calcitriol	low	1	0
amphotericin b	low	2	0
phenylephrine hydrochloride	low	1	0
aluminum	low	1	0
enalapril	low	1	0
beryllium	low	3	0
phosphorus	low	1	0
nystatin a1	low	2	0
acid phosphatase	low	1	0
cellulose	low	1	0
egg white	low	2	0
mannans	low	2	0
glycolipids	low	1	0
thymosin	low	1	0
interleukin-8	low	3	0
oxytetracycline, anhydrous	low	1	0
salicylates	low	1	0
agar	low	2	0
copper bis(3,5-diisopropylsalicylate)	low	1	0
muramidase	low	4	0
folic acid	low	1	0
acetylcellulose	low	1	0
concanavalin a	low	4	0

Protein Targets (687)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	6	0	0	6
chromobox protein homolog 1	12	0	0	12
geminin	12	0	0	12
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	8	0	0	8
GLI family zinc finger 3	16	0	0	16
AR protein	20	0	0	20
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	9	0	0	9
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	15	0	0	15
thyroid hormone receptor beta isoform 2	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
Chain A, Ferritin light chain	5	0	0	5
thioredoxin reductase	7	0	0	7
TDP1 protein	12	0	0	12
Microtubule-associated protein tau	8	0	0	8
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
alpha-galactosidase	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	6	0	0	6
DNA topoisomerase 2-alpha	0	0	0	1
Acetylcholinesterase	0	3	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
cytochrome P450 2D6	5	0	0	5
glucocerebrosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
lamin isoform A-delta10	11	0	0	11
Rap guanine nucleotide exchange factor 3	5	0	0	5
Lysosomal acid glucosylceramidase	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Sodium-dependent serotonin transporter	0	2	0	2
TAR DNA-binding protein 43	4	0	0	4
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Cruzipain	3	0	0	3
interleukin 8	3	0	0	3
phosphopantetheinyl transferase	5	0	0	5
GLS protein	4	0	0	4
glucocorticoid receptor [Homo sapiens]	10	0	0	10
farnesoid X nuclear receptor	5	0	0	5
peroxisome proliferator-activated receptor delta	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
peripheral myelin protein 22	6	0	0	6
Cytochrome P450 1A2	0	2	0	3
Cytochrome P450 3A4	0	5	0	6
Cytochrome P450 2C9	0	4	0	5
Cytochrome P450 2C19	0	2	0	2
Nuclear receptor ROR-gamma	5	0	0	5
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Beta-lactamase	0	0	0	1
acid sphingomyelinase	5	0	0	5
apical membrane antigen 1, AMA1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
DNA polymerase beta	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	6	0	0	6
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	4	1	7
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	2	0	2
Spike glycoprotein	3	0	0	3
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	1	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	1	0	2
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	1	0	2
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
15-lipoxygenase, partial	2	0	0	2
USP1 protein, partial	10	0	0	10
thioredoxin glutathione reductase	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Bloom syndrome protein isoform 1	5	0	0	5
cellular tumor antigen p53 isoform a	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Prostaglandin G/H synthase 1	0	0	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
Aromatase	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Prostaglandin G/H synthase 2	0	1	1	3
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	2	0	1	3
Calmodulin	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Lanosterol 14-alpha demethylase	0	2	0	2
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
nonstructural protein 1	0	1	0	1
estrogen nuclear receptor alpha	20	0	0	20
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	11
Bile salt export pump	0	12	0	12
Interferon beta	4	0	0	4
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	3	0	3
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	8	0	8
Vitamin D3 receptor A	0	0	2	2
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	2	0	3
pregnane X nuclear receptor	8	0	0	8
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
activating transcription factor 6	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
heat shock protein beta-1	3	0	0	3
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cellular tumor antigen p53	11	0	0	11
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	4	0	0	4
Eyes absent homolog 2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Glutamate receptor 2	3	0	0	3
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
endonuclease IV	2	0	0	2
arylsulfatase A	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Angiotensin-converting enzyme 2	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	4
30S ribosomal protein S7	0	2	1	4
50S ribosomal protein L15	0	2	1	4
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
50S ribosomal protein L10	0	2	1	4
50S ribosomal protein L11	0	2	1	4
50S ribosomal protein L7/L12	0	2	1	4
50S ribosomal protein L19	0	2	1	4
50S ribosomal protein L1	0	2	1	4
50S ribosomal protein L20	0	2	1	4
50S ribosomal protein L27	0	2	1	4
50S ribosomal protein L28	0	2	1	4
50S ribosomal protein L29	0	2	1	4
50S ribosomal protein L31	0	2	1	4
50S ribosomal protein L31 type B	0	2	1	4
50S ribosomal protein L32	0	2	1	4
50S ribosomal protein L33	0	2	1	4
50S ribosomal protein L34	0	2	1	4
50S ribosomal protein L35	0	2	1	4
50S ribosomal protein L36	0	2	1	4
30S ribosomal protein S10	0	2	1	4
30S ribosomal protein S11	0	2	1	4
30S ribosomal protein S12	0	2	1	4
30S ribosomal protein S13	0	2	1	4
30S ribosomal protein S16	0	2	1	4
30S ribosomal protein S18	0	2	1	4
30S ribosomal protein S19	0	2	1	4
30S ribosomal protein S20	0	2	1	4
30S ribosomal protein S2	0	2	1	4
30S ribosomal protein S3	0	2	1	4
30S ribosomal protein S4	0	2	1	4
30S ribosomal protein S5	0	2	1	4
30S ribosomal protein S8	0	2	1	4
30S ribosomal protein S9	0	2	1	4
50S ribosomal protein L13	0	2	1	4
50S ribosomal protein L14	0	2	1	4
50S ribosomal protein L16	0	2	1	4
50S ribosomal protein L23	0	2	1	4
30S ribosomal protein S15	0	2	1	4
50S ribosomal protein L17	0	2	1	4
50S ribosomal protein L21	0	2	1	4
50S ribosomal protein L30	0	2	1	4
50S ribosomal protein L6	0	2	1	4
30S ribosomal protein S14	0	2	1	4
30S ribosomal protein S17	0	2	1	4
30S ribosomal protein S1	0	2	1	4
50S ribosomal protein L18	0	2	1	4
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
50S ribosomal protein L2	0	2	1	4
50S ribosomal protein L3	0	2	1	4
50S ribosomal protein L24	0	2	1	4
50S ribosomal protein L4	0	2	1	4
50S ribosomal protein L22	0	2	1	4
50S ribosomal protein L5	0	2	1	4
30S ribosomal protein S21	0	2	1	4
50S ribosomal protein L25	0	2	1	4
Cytochrome P450 1B1	0	1	0	1
50S ribosomal protein L36 2	0	2	1	4
peroxisome proliferator activated receptor gamma	4	0	0	4
thyrotropin-releasing hormone receptor	2	0	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
glp-1 receptor, partial	4	0	0	4
thyroid stimulating hormone receptor	6	0	0	6
lysosomal alpha-glucosidase preproprotein	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
thyroid hormone receptor beta isoform a	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	3	0	0	3
regulator of G-protein signaling 4	3	0	0	3
EWS/FLI fusion protein	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	1	0	4
Carbonic anhydrase 12	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	0	0	1
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	4
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Solute carrier family 22 member 1	0	4	0	5
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Histamine H3 receptor	0	1	2	3
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
Alpha-mannosidase 2C1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
thyroid stimulating hormone receptor	3	0	0	3
galanin receptor type 3	0	1	0	1
survival motor neuron protein isoform d	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
ATAD5 protein, partial	2	0	0	2
67.9K protein	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Integrin beta-3	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
acetylcholinesterase	1	0	0	1
nonstructural protein 1	1	0	0	1
G	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Inositol hexakisphosphate kinase 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
aryl hydrocarbon receptor	5	0	0	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	1	1	2
Muscarinic acetylcholine receptor M4	0	2	1	3
Muscarinic acetylcholine receptor M5	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	2	2	7
Muscarinic acetylcholine receptor M2	0	1	1	2
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	2	2	2	7
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Translocator protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Delta-type opioid receptor	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Mu-type opioid receptor	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	1	1	3
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Photosystem I iron-sulfur center	0	0	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Free fatty acid receptor 2	0	0	1	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Puromycin-sensitive aminopeptidase	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Luciferase	1	0	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease	0	2	0	3
Urease subunit alpha	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (249)

Protein Targets (687)

Farmer's Lung

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (249)

Drugs Studied (103)

Protein Targets (687)