Phimosis

A condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.

Synonym
Phimosis

Excerpt	Reference
"Problems such as phimosis are not common, and can usually be treated medically without resort to circumcision."	( Wright, JE, 1994)
"Phimosis is a physiological condition in neonates due to natural adhesion between the foreskin and the glans."	( Chen, KC; Chu, CC; Diau, GY, 1999)
"Phimosis is defined as the inability to retract the foreskin."	( Leonard, MP; McGregor, TB; Pike, JG, 2007)
"Physiologic phimosis is often seen by family physicians."	( Leonard, MP; McGregor, TB; Pike, JG, 2007)
"Phimosis is a common paediatric urological disorder and often necessitates circumcision."	( Deshpande, P; Dubey, M; Jain, V; Reddy, S; Singal, AK, 2012)
"Phimosis is a common condition affecting most infant boys and generally resolves over time without symptoms."	( Abdelhalim, A; Chalmers, CL; Chamberlin, JD; Chuang, KW; Davis-Dao, CA; Dorgalli, C; Kelly, MS; Khoury, AE; McAleer, IM; Stephany, HA; Wang, ZT; Wehbi, EJ, 2019)

Excerpt	Reference
"Phimosis has been defined as unretractable foreskin without adherences or a circular band of tight prepuce preventing full retraction."	( Camoglio, FS; Corroppolo, M; Giacomello, L; Ottolenghi, A; Zampieri, N, 2005)
"Phimosis has been defined as unretractable foreskin without adherences and/or a circular band of tight prepuce preventing full retraction."	( Bianchi, S; Camoglio, FS; Corroppolo, M; Zampieri, N; Zuin, V, 2007)
"Until recently, phimosis has been treated surgically by circumcision or prepuceplasty; however, recent reports of non-invasive treatment using topical corticosteroids applied for four to eight weeks have been favourable."	( Corbalán, J; Moreno, G; Pantoja, T; Peñaloza, B, 2014)

Excerpt	Reference
"A new conservative method for the treatment of phimosis is presented: similar to the labio-synechia of girls a local treatment with an oestrogen containing cream is performed successfully."	( Müller, H; Müller, I, 1993)
"No guideline exists on how to treat boy's phimosis."	( Furuta, A; Hatano, T; Iwamuro, S; Iwanaga, S; Nakajo, H; Noda, K; Tashiro, K, 1997)
"The authors treated phimosis in a total of 44 boys."	( Havránek, P; Voborilová, V, 1997)
"Topical steroid for the treatment of phimosis is a safe, simple, and inexpensive procedure that avoids surgery and its associated risks."	( Caffaratti, J; Garat, JM; Orsola, A, 2000)
"The current treatment of phimosis in Denmark is surgical."	( Christiansen, P; Klarskov, OP; Klyver, H; Mortensen, SO, 2001)
"Circumcision has been the traditional treatment for phimosis."	( Leonard, MP; Webster, TM, 2002)
"Surgical treatment of phimosis should therefore be reserved for failures of medical treatment and has now become much less frequent."	( Ben Mouelli, S; Beurton, D; Fontaine, E; Iken, A; Quenneville, V; Thomas, L, 2002)
"Topical steroids for the treatment of phimosis is a highly effective treatment alternative to surgery."	( Basar, H; Basar, MM; Batislam, E; Yilmaz, E, 2003)
"To evaluate the treatment of phimosis using topical steroid."	( Lund, L; Mui, LM; Wai, KH; Yeung, CK, 2005)
"The mean pre-treatment phimosis grades in the steroid and control groups were 5."	( Lund, L; Mui, LM; Wai, KH; Yeung, CK, 2005)
"Conservative treatment of phimosis is highly effective and safe method which may also be an initial stage to operative treatment or to cure scarring after surgical treatment as well."	( Janik, P; Ratajczak, D; Zwolińska, E, 2008)
"Topical steroid treatment for phimosis is successful in young children."	( Porncharoenpong, S; Sookpotarom, P; Vejchapipat, P, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	57 (33.14)	23.3326
1990's	36 (20.93)	12.5806
2000's	45 (26.16)	18.1394
2010's	27 (15.70)	28.8240
2020's	7 (4.07)	9.53

Drug	Relationship Strength	Studies	Trials
glycerol	low	1	0
histamine	low	1	0
nitrous oxide	low	1	0
3,4-methylenedioxyamphetamine	low	1	0
atenolol	low	1	0
bupivacaine	medium	1	1
ciprofloxacin	low	1	0
dapsone	low	1	0
diclofenac	medium	2	1
diphenhydramine	low	1	0
flumazenil	medium	1	1
flutamide	low	1	0
halothane	low	2	0
lidocaine	low	6	0
2-propanol	medium	2	1
ketamine	low	1	0
midazolam	medium	3	2
modafinil	low	1	0
nifedipine	low	1	0
oxyphenbutazone	medium	4	2
pentoxifylline	low	1	0
phenylbutazone	low	1	0
prilocaine	low	3	0
propofol	medium	2	1
propranolol	low	2	0
resorcinol	low	1	0
sevoflurane	low	1	0
sulfamethoxazole	low	2	0
trimethoprim	low	1	0
hydrocortisone acetate	medium	1	1
prednisolone	low	1	0
estriol	low	1	0
aldosterone	low	1	0
colchicine	low	1	0
triamcinolone acetonide	low	2	0
betamethasone	medium	31	9
triethylenephosphoramide	low	1	0
gentian violet	low	1	0
flumethasone	low	1	0
betamethasone valerate	medium	4	2
enbucrilate	low	1	0
octyl 2-cyanoacrylate	low	2	0
iridium	low	1	0
titanium	low	1	0
fluorine	low	1	0
triamcinolone	medium	8	2
propiconazole	low	1	0
atracurium	low	1	0
itraconazole	low	1	0
cisatracurium	low	1	0
clobetasone butyrate	medium	1	1
betamethasone-17,21-dipropionate	medium	2	1
atropine	low	1	0
ropivacaine	low	2	0
inositol 3-phosphate	low	1	0
mometasone furoate	medium	4	2
tacrolimus	low	1	0
bromochloroacetic acid	low	3	0
thiopental	medium	3	1
alpha-chymotrypsin	low	2	0
phenylephrine hydrochloride	low	1	0
granisetron	medium	3	3
clobetasol	medium	15	3
dexmedetomidine	low	1	0
fluticasone	medium	1	1
beta-escin	low	1	0
psd 502	low	3	0
losartan potassium	low	1	0
podophyllin	low	2	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
sodium ethylxanthate	low	1	0
rome	low	2	0
hyaluronoglucosaminidase	low	1	0
acyclovir	low	1	0

Protein Targets (709)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	10	0	0	10
chromobox protein homolog 1	15	0	0	15
geminin	28	0	0	28
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
RAR-related orphan receptor gamma	19	0	0	19
GLI family zinc finger 3	25	0	0	25
AR protein	33	0	0	33
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	19	0	0	19
retinoid X nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	30	0	0	30
peroxisome proliferator-activated receptor delta	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Histone H2A.x	6	0	0	6
thyroid hormone receptor beta isoform a	7	0	0	7
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
lamin isoform A-delta10	25	0	0	25
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Glutamate receptor 2	12	0	0	12
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	5	1	6
5-hydroxytryptamine receptor 1A	0	4	3	8
Sodium-dependent noradrenaline transporter	0	7	0	7
Sodium-dependent dopamine transporter	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	7	1	8
Sodium-dependent serotonin transporter	0	3	1	4
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Sodium-dependent dopamine transporter	0	6	0	6
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	1	0	1
thioredoxin reductase	12	0	0	12
phosphopantetheinyl transferase	8	0	0	8
GLS protein	8	0	0	8
TDP1 protein	20	0	0	20
Smad3	7	0	0	7
thyroid stimulating hormone receptor	14	0	0	14
EWS/FLI fusion protein	9	0	0	9
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	24	0	0	24
Bloom syndrome protein isoform 1	9	0	0	9
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Solute carrier family 22 member 1	0	4	0	7
ATP-binding cassette sub-family C member 3	0	20	0	20
Multidrug resistance-associated protein 4	0	20	0	20
Solute carrier family 22 member 6	0	1	0	2
Bile salt export pump	0	6	0	6
Bile salt export pump	0	30	0	30
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	10	0	11
Cytochrome P450 2J2	0	8	0	8
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	19	0	19
Thymidine kinase	0	1	0	1
glucocorticoid receptor [Homo sapiens]	23	0	0	23
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	7	0	7
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
regulator of G-protein signaling 4	7	0	0	7
Beta-1 adrenergic receptor	0	1	2	4
D(1A) dopamine receptor	6	0	0	6
DNA polymerase iota isoform a (long)	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	13	7	3	23
Fatty acid-binding protein, liver	0	3	0	3
Urease	0	1	0	1
Beta-2 adrenergic receptor	0	4	2	6
Beta-1 adrenergic receptor	0	4	2	6
Beta-3 adrenergic receptor	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	13	7	3	23
Gamma-aminobutyric acid receptor subunit delta	13	7	3	23
Gamma-aminobutyric acid receptor subunit gamma-2	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-5	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-3	13	7	3	23
Gamma-aminobutyric acid receptor subunit gamma-1	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-2	13	7	3	23
Alpha-1D adrenergic receptor	0	6	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	13	7	3	23
Gamma-aminobutyric acid receptor subunit gamma-3	13	7	3	23
Gamma-aminobutyric acid receptor subunit alpha-6	13	7	3	23
Alpha-1A adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	13	7	3	23
Gamma-aminobutyric acid receptor subunit beta-3	13	7	3	23
Gamma-aminobutyric acid receptor subunit beta-2	13	7	3	23
TAR DNA-binding protein 43	7	0	0	7
Beta-2 adrenergic receptor	0	1	2	5
GABA theta subunit	13	7	3	23
Gamma-aminobutyric acid receptor subunit epsilon	13	7	3	23
ATP-dependent phosphofructokinase	5	0	0	5
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
pregnane X nuclear receptor	22	0	0	22
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	10	0	10
Muscarinic acetylcholine receptor M2	0	7	2	13
Muscarinic acetylcholine receptor M4	0	6	1	10
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	6	1	10
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	7	2	13
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	7	2	12
5-hydroxytryptamine receptor 2C	0	10	1	11
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	9	0	1	12
5-hydroxytryptamine receptor 7	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
pregnane X receptor	7	0	0	7
progesterone receptor	18	0	0	18
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
estrogen-related nuclear receptor alpha	21	0	0	21
farnesoid X nuclear receptor	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
aryl hydrocarbon receptor	11	0	0	11
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	11	1	17
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
G	12	0	0	12
cytochrome P450 2D6	11	0	0	11
peroxisome proliferator activated receptor gamma	12	0	0	12
thyroid stimulating hormone receptor	7	0	0	7
thyroid hormone receptor beta isoform 2	19	0	0	19
Interferon beta	15	0	0	15
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Inositol hexakisphosphate kinase 1	12	0	0	12
cytochrome P450 2C9, partial	12	0	0	12
Cellular tumor antigen p53	19	0	0	19
Nuclear receptor ROR-gamma	7	0	0	7
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Potassium channel subfamily K member 9	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, Cruzipain	3	0	0	3
cytochrome P450 2C9 precursor	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
Cytochrome P450 1A2	0	3	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Cytochrome P450 3A4	0	9	0	9
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	3	0	3
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	3	0	3
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	8	0	9
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
Chain A, Beta-lactamase	11	0	0	11
glp-1 receptor, partial	6	0	0	6
Fumarate hydratase	6	0	0	6
Microtubule-associated protein tau	8	0	0	9
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
estrogen receptor 2 (ER beta)	11	0	0	11
nonstructural protein 1	5	0	0	5
polyprotein	6	0	0	6
nuclear receptor ROR-gamma isoform 1	11	0	0	11
survival motor neuron protein isoform d	8	0	0	8
neuropeptide S receptor isoform A	3	0	0	3
Luciferase	9	0	0	9
interleukin 8	6	0	0	6
endonuclease IV	5	0	0	5
PAX8	0	0	0	1
ATAD5 protein, partial	9	0	0	9
USP1 protein, partial	12	0	0	12
PPM1D protein	1	0	0	1
Thrombopoietin	3	0	0	3
67.9K protein	7	0	0	7
glucocerebrosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	6	0	0	6
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C19 precursor	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
flap endonuclease 1	4	0	0	4
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
peripheral myelin protein 22	8	0	0	8
cytochrome P450 3A4 isoform 1	13	0	0	13
muscleblind-like protein 1 isoform 1	7	0	0	7
caspase-1 isoform alpha precursor	1	0	0	1
muscarinic acetylcholine receptor M1	10	0	0	10
lethal factor (plasmid)	3	0	0	3
Solute carrier family 22 member 3	0	2	0	3
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	5	0	6
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	12	0	0	12
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
5-hydroxytryptamine receptor 6	0	5	1	6
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	4	3	8
Alpha-1B adrenergic receptor	0	6	1	7
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	4	3	8
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	6	1	7
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	5
Transthyretin	0	0	1	3
Albumin	0	2	2	4
Prostaglandin G/H synthase 1	0	2	1	3
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	5
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	2
vitamin D3 receptor isoform VDRA	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
huntingtin isoform 2	3	0	0	3
Aldo-keto reductase family 1 member B1	0	4	0	4
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	1	7
Histamine H1 receptor	0	1	3	5
Histamine H1 receptor	0	4	2	6
5-hydroxytryptamine receptor 2B	0	6	1	7
Histamine N-methyltransferase	0	0	0	1
Sodium channel protein type 5 subunit alpha	0	4	0	4
Solute carrier family 22 member 1	0	2	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	2	2	4
Histamine H3 receptor	0	1	0	2
Solute carrier family 22 member 2	0	2	0	3
Estrogen receptor	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Alpha-synuclein	1	1	0	2
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	4
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	4
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	2	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	2	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
acetylcholinesterase	3	0	0	3
15-lipoxygenase, partial	1	0	0	1
alpha-galactosidase	1	0	0	1
peripheral myelin protein 22 isoform 1	4	0	0	4
mitogen-activated protein kinase 1	6	0	0	6
M-phase phosphoprotein 8	3	0	0	3
Cocaine esterase	0	1	0	2
Androgen receptor	0	4	0	4
Arylacetamide deacetylase	0	0	0	1
Spike glycoprotein	11	0	0	11
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	3	0	0	3
luciferase	1	0	0	1
caspase-3	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Caspase-7	4	0	0	4
tumor necrosis factor	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
caspase-3	4	0	0	4
histone deacetylase 9 isoform 3	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Epidermal growth factor receptor	0	1	0	1
Integrin beta-3	2	0	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
Integrin alpha-IIb	2	0	0	2
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	5	1	6
60 kDa heat shock protein, mitochondrial	0	1	0	1
D(2) dopamine receptor	0	4	1	5
Alpha-2B adrenergic receptor	0	2	1	4
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	3	1	4
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	3	2	5
Adenosine receptor A2a	0	4	1	5
Mu-type opioid receptor	0	3	1	4
D(3) dopamine receptor	0	3	0	3
Kappa-type opioid receptor	0	3	1	4
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Fatty-acid amide hydrolase 1	1	2	0	3
Inositol monophosphatase 1	3	0	0	3
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Leukotriene B4 receptor 1	1	0	0	2
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	1	0	1
Leukotriene B4 receptor 2	1	0	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	3	0	0	3
apical membrane antigen 1, AMA1	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Carbonic anhydrase 12	0	1	0	2
Carbonic anhydrase 3	0	1	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Carboxylic ester hydrolase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Histamine H3 receptor	0	1	2	3
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Sodium channel protein type 4 subunit alpha	0	3	0	3
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Translocator protein	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
D(4) dopamine receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	1	0	1
Transporter	0	2	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Progesterone receptor	0	2	1	4
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
NFKB1 protein, partial	4	0	0	4
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
beta-2 adrenergic receptor	2	0	0	2
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Beta lactamase (plasmid)	0	1	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
dopamine D1 receptor	2	0	0	2
vasopressin V1b receptor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A2b	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, Bacterial regulatory proteins, tetR family	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Polyphenol oxidase 2	0	1	0	3
Tyrosinase	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
Protein-arginine deiminase type-4	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
D	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (172)

Protein Targets (709)

Phimosis

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (172)

Drugs Studied (90)

Protein Targets (709)