Batten Turner Congenital Myopathy

Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulation and other movements. It is classified as Thomsen (autosomal dominant) or Becker (autosomal recessive) generalized myotonia mainly based on the inheritance pattern. Becker type is also clinically more severe. An autosomal dominant variant with milder symptoms and later onset is known as myotonia levior. Mutations in the voltage-dependent skeletal muscle chloride channel are associated with the disorders.

Synonym
Becker Generalized Myotonia
Becker Disease
Batten Turner Congenital Myopathy
Thomsens Disease
Thomsen's Disease
Myotonia, Generalized, Becker
Thomsen Disease
Myotonia, Generalized
Generalized Myotonia of Thomsen
Myotonia Levior
Myotonia Congenita, Autosomal Recessive
Generalized Myotonia of Becker
Myotonia Congenita, Autosomal Dominant
Myotonia Congenita
Myopathy, Congenital
Batten-Turner Congenital Myopathy
Congenital Myotonia

Excerpt	Reference
"Autosomal dominant myotonia congenita is an inherited disorder of skeletal muscle caused by mutations in a voltage-gated Cl- channel gene (CLCN1, 7q35)."	( Beck, CL; Fahlke, C; George, AL, 1997)
"1."	( Bendahhou, S; Cummins, TR; Kwiecinski, H; Ptácek, LJ; Waxman, SG, 1999)
"Myotonia congenita is an inherited disorder of sarcolemmal excitation leading to delayed relaxation of skeletal muscle following contractions."	( Fahlke, C; George, AL; Giger, U; Patterson, DF; Rhodes, TH; Vite, CH, 1999)
"Myotonia congenita is a rare disease of skeletal muscle characterized by painless myotonia, generalized muscular hypertrophy and a non-progressive course."	( Hyderi, A; Krishnamurthy, B; Ramachandra, NB; Savitha, MR, 2006)
"Myotonia congenita is caused by mutations in the voltage-gated chloride channel ClC-1."	( Fialho, D; Hanna, MG; Kullmann, DM; Schorge, S, 2008)
"Myotonia congenita is a nondystrophic muscle disorder characterized by muscle stiffness and muscle hypertrophy."	( Duron, R; Holden, KR; Lyons, MJ; Molinero, I; Sangiuolo, F, 2010)
"Myotonia congenita is a genetic condition that is caused by mutations in the muscle chloride channel gene CLCN1 and characterized by delayed muscle relaxation and muscle stiffness."	( Becher, T; Begemann, B; Fahlke, C; Fischer, M; Jurkat-Rott, K; Lehmann-Horn, F; Sternberg, D; Weinberger, S; Wojciechowski, D, 2012)
"Myotonia congenita is an inherited muscle disorder sustained by mutations in the skeletal muscle chloride channel gene CLCN1."	( Corbetta, S; Mendola, M; Passeri, E; Sansone, VA; Verdelli, C, 2014)

Excerpt	Reference
"Patients with myotonia congenita have muscle hyperexcitability due to loss-of-function mutations in the chloride channel in skeletal muscle, which causes spontaneous firing of muscle action potentials (myotonia), producing muscle stiffness."	( Mitchell, JR; Norman, J; Novak, KR; Pinter, MJ; Rich, MM, 2015)

Excerpt	Reference
"Six patients with congenital myotonia and 4 patients with myotonic dystrophy have been examined clinically before and after the administration of N-propyl-ajmalin, an alkaloid frequently used as a cardiac antiarrhythmic drug."	( Birnberger, KL; Rüdel, R; Struppler, A, 1975)
"A patient with paramyotonia congenita, a related disorder with myotonia and episodic weakness, was studied during treatment with acetazolamide."	( Griggs, RC; Moxley, RT; Riggs, JE, 1977)
"A patient with recessive generalized congenital myotonia and severe, disabling weakness underwent various forms of treatment while being monitored electrophysiologically."	( Streib, EW, 1986)
"Treatment of paramyotonia congenita with acetazolamide has been shown to reduce myotonic symptoms but severe weakness has developed in some patients leading to a recommendation not to use the drug in this disorder."	( Benstead, TJ; Camfield, PR; King, DB, 1987)
"We evaluated 21 patients with recessive myotonia congenita referred to our institute from 1990 to 2013 and treated with mexiletine chlorhydrate."	( D'Amico, A; Desaphy, JF; Lo Monaco, M; Luigetti, M; Modoni, A, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	141 (59.75)	23.3326
1990's	27 (11.44)	12.5806
2000's	18 (7.63)	18.1394
2010's	35 (14.83)	28.8240
2020's	15 (6.36)	9.53

Drug	Relationship Strength	Studies	Trials
carbamates	low	1	0
carnitine	low	3	0
chlorine	low	19	0
creatine	low	3	0
glycine	low	2	0
glycerol	low	1	0
histamine	low	1	0
nitrous oxide	low	2	0
oxalic acid	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
2,4-dichlorophenoxyacetic acid	low	3	0
phenytoin	medium	13	2
acetazolamide	medium	13	1
antazoline	low	1	0
9-anthroic acid	low	2	0
aspirin	low	1	0
bumetanide	low	1	0
bupivacaine	low	1	0
caffeine	low	2	0
carbamazepine	low	8	0
dantrolene	low	2	0
decamethonium	low	1	0
disopyramide	medium	1	1
edrophonium	low	3	0
berotek	low	1	0
flecainide	low	6	0
furosemide	low	2	0
glyphosate	low	1	0
guanethidine	low	2	0
halothane	low	4	0
hydrochlorothiazide	low	1	0
lidocaine	low	5	0
lamotrigine	medium	2	1
mexiletine	medium	19	2
neostigmine	low	6	0
orphenadrine	low	1	0
pindolol	low	1	0
potassium chloride	low	2	0
4-aminobenzoic acid	low	1	0
procainamide	medium	11	1
procaine	low	1	0
propafenone	low	1	0
propofol	low	1	0
riluzole	low	1	0
succinylcholine	low	14	0
tolbutamide	low	1	0
trimeprazine	low	1	0
prednisolone	low	2	0
thyroxine	low	2	0
spironolactone	low	2	0
aldosterone	low	1	0
prednisone	low	4	0
alanine	low	1	0
serine	low	1	0
aspartic acid	low	3	0
lysine	low	1	0
tubocurarine	low	3	0
galactose	low	1	0
edetic acid	low	1	0
adenosine monophosphate	low	1	0
leucine	low	1	0
methionine	low	1	0
phenylalanine	low	1	0
desoxycorticosterone	low	1	0
ornithine	low	1	0
asparagine	low	1	0
histidine	low	1	0
threonine	low	3	0
methandrostenolone	low	1	0
isoleucine	low	2	0
arginine	medium	3	1
pyridostigmine bromide	low	2	0
pyrroles	low	1	0
tecnazene	low	2	0
thiazoles	low	1	0
methysergide	low	1	0
lithium carbonate	low	1	0
d-alpha tocopherol	low	1	0
sodium selenite	low	1	0
trolamine salicylate	low	1	0
iodine	low	1	0
transferrin	low	1	0
glutamic acid	low	1	0
torpedo	low	1	0
tocainide	medium	7	1
fomesafen	low	1	0
ranolazine	medium	3	1
lubeluzole	low	1	0
leucinocaine mesylate	low	1	0
entonox	low	1	0
ezogabine	low	1	0
proline	low	2	0
succinylmonocholine	low	1	0
atropine	low	2	0
leupeptins	low	1	0
glycogen	low	2	0
n-acetylneuraminic acid	low	1	0
ouabain	medium	2	1
desmosterol	low	1	0
inositol 3-phosphate	low	1	0
quinidine	low	2	0
pancuronium	low	1	0
rocuronium	low	1	0
indican	low	1	0
acetyl coenzyme a	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
hc-067047	low	1	0
thiopental	low	2	0
lithium	low	1	0
quinine	low	3	0
17-ketosteroids	low	1	0
xylulose	low	1	0
cesium	low	1	0
phosphorus	low	1	0
ajmaline	low	3	0
tetrodotoxin	low	3	0
selenium	low	1	0
oxalates	low	1	0
phosphocreatine	low	2	0
azacosterol	low	1	0
ribose	low	2	0
calcimycin	low	1	0
acid phosphatase	low	1	0
phosphatidylcholines	low	1	0
vendex	low	1	0
ubiquinone	low	1	0
cardiovascular agents	medium	2	1
piperidines	low	1	0
vu0467154	low	1	0
eye	low	1	0

Protein Targets (973)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	25	0	0	25
USP1 protein, partial	15	0	0	15
TDP1 protein	20	0	0	20
vitamin D3 receptor isoform VDRA	7	0	0	7
importin subunit beta-1 isoform 1	4	0	0	4
flap endonuclease 1	10	0	0	10
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	19	0	0	19
DNA polymerase kappa isoform 1	8	0	0	8
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	3
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Luciferase	5	0	0	5
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
AR protein	32	0	0	32
progesterone receptor	11	0	0	11
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	27	0	0	27
estrogen nuclear receptor alpha	34	0	0	34
peroxisome proliferator-activated receptor delta	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
thyroid hormone receptor beta isoform 2	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	0	1	0	1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	0	1	0	1
Chain A, Toluene-4-monooxygenase system protein A	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	20	0	0	20
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
peroxisome proliferator activated receptor gamma	11	0	0	11
alpha-galactosidase	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
Histone H2A.x	7	0	0	7
cytochrome P450 2C19 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
GALC protein	4	0	0	4
GLI family zinc finger 3	21	0	0	21
cytochrome P450 family 3 subfamily A polypeptide 4	19	0	0	19
glucocorticoid receptor [Homo sapiens]	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
arylsulfatase A	13	0	0	13
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	32	0	0	32
Bloom syndrome protein isoform 1	10	0	0	10
thyroid hormone receptor beta isoform a	11	0	0	11
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	8	0	0	8
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	6	4	1	11
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	21
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	5	1	13
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	34	0	34
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	12	1	27
Carbonic anhydrase 2	0	13	1	28
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	4	0	4
Carbonic anhydrase 3	0	5	1	11
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	4	1	6
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	9	0	9
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	15	1	16
5-hydroxytryptamine receptor 2A	0	2	0	2
Androgen receptor	0	5	0	6
Gamma-aminobutyric acid receptor subunit beta-1	6	4	1	11
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	6	4	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	6	4	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	6	4	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	6	4	1	11
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	8	1	15
Carbonic anhydrase 6	0	5	1	12
Gamma-aminobutyric acid receptor subunit gamma-1	6	4	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	6	4	1	11
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	8
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	6	4	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	6	4	1	11
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	6	4	1	11
Adenosine receptor A2a	0	4	0	9
5-hydroxytryptamine receptor 2B	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	6	1	14
Carbonic anhydrase	0	3	0	6
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	5	1	12
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	5
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	5	1	12
Gamma-aminobutyric acid receptor subunit beta-3	6	4	1	11
Gamma-aminobutyric acid receptor subunit beta-2	6	4	1	11
Cholinesterase	0	4	0	4
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	6	2	11
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	6	1	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	5
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	7
GABA theta subunit	6	4	1	11
Canalicular multispecific organic anion transporter 1	0	20	0	20
Carbonic anhydrase 4	0	2	0	6
Carbonic anhydrase 15	0	3	0	7
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	11
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	6	4	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	5	1	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	13
N-alpha-acetyltransferase 50	0	0	1	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
regulator of G-protein signaling 4	12	0	0	12
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	1	2	5
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	4
Glutamate receptor ionotropic, NMDA 1	0	7	2	12
Proton-coupled amino acid transporter 1	0	7	0	8
Adenosine deaminase	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	5	3	9
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	4
thyroid stimulating hormone receptor	14	0	0	14
cytochrome P450 2D6 isoform 1	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
lethal factor (plasmid)	8	0	0	8
lamin isoform A-delta10	28	0	0	28
Histamine H1 receptor	0	1	4	5
Inositol monophosphatase 1	2	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	4	0	0	4
GLS protein	15	0	0	15
chromobox protein homolog 1	12	0	0	12
muscarinic acetylcholine receptor M1	15	0	0	15
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	4
Cationic amino acid transporter 3	0	2	0	2
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	3	0	3
Chain A, Ferritin light chain	6	0	0	6
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	2	10
Glutamate receptor ionotropic, NMDA 2C	0	5	2	10
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	5	2	10
Glutamate receptor ionotropic, NMDA 3B	0	5	2	10
Glutamate receptor ionotropic, NMDA 3A	0	5	2	10
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	11	0	0	11
cytochrome P450 2D6	12	0	0	12
glucocerebrosidase	2	0	0	2
Rac1 protein	0	0	1	1
IDH1	9	0	0	9
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	1	1	1	3
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	1	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	2	0	1	3
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
pregnane X nuclear receptor	18	0	0	18
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	9	0	13
5-hydroxytryptamine receptor 4	0	10	0	10
Muscarinic acetylcholine receptor M2	0	4	2	9
Muscarinic acetylcholine receptor M4	0	4	2	8
Muscarinic acetylcholine receptor M1	0	3	2	7
Muscarinic acetylcholine receptor M3	0	2	2	6
Muscarinic acetylcholine receptor M4	0	2	2	6
Muscarinic acetylcholine receptor M5	0	2	2	6
Muscarinic acetylcholine receptor M5	0	4	2	8
Muscarinic acetylcholine receptor M2	0	2	2	7
Muscarinic acetylcholine receptor M1	0	4	2	9
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	2	8
Alpha-1D adrenergic receptor	0	2	0	3
5-hydroxytryptamine receptor 2C	0	11	0	11
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	4	0	1	7
5-hydroxytryptamine receptor 7	0	6	0	6
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	4	0	0	4
PPM1D protein	3	0	0	3
polyprotein	4	0	0	4
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Interferon beta	14	0	0	14
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	3	0	3
Aromatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
glp-1 receptor, partial	5	0	0	5
beta-2 adrenergic receptor	2	0	0	2
Beta-2 adrenergic receptor	0	5	2	7
Beta-2 adrenergic receptor	0	1	1	2
ATAD5 protein, partial	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
histone acetyltransferase KAT2A isoform 1	9	0	0	9
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 12 member 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Potassium channel subfamily K member 3	0	4	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	4	4	8
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
farnesoid X nuclear receptor	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	7	0	0	7
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Cholinesterase	0	5	0	5
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	1	0	1
Glutamate receptor 2	9	2	1	12
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	9	0	9
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Guanine deaminase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	2	0	0	2
endonuclease IV	5	0	0	5
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Microtubule-associated protein tau	6	0	0	6
TSHR protein	1	0	0	1
Smad3	3	0	0	3
apical membrane antigen 1, AMA1	3	0	0	3
nonstructural protein 1	4	0	0	4
67.9K protein	2	0	0	2
Parkin	3	0	0	3
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
peripheral myelin protein 22 isoform 1	7	0	0	7
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
glucokinase regulatory protein	2	0	0	2
huntingtin isoform 2	1	0	0	1
mitogen-activated protein kinase 1	7	0	0	7
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	3	0	0	3
streptokinase A precursor	0	0	1	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Amyloid-beta precursor protein	1	1	0	2
Alpha-synuclein	2	0	0	2
TAR DNA-binding protein 43	3	0	0	3
Ataxin-2	7	0	0	7
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
acetylcholinesterase	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
Bile salt export pump	0	3	0	3
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Cellular tumor antigen p53	15	0	0	15
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 2 subunit alpha	0	7	1	8
Sodium channel protein type 3 subunit alpha	0	5	0	5
UDP-glucuronosyltransferase 2B7	0	2	1	4
Sodium channel protein type 4 subunit alpha	0	5	0	8
Cytochrome P450 2J2	0	7	0	7
Potassium voltage-gated channel subfamily H member 2	0	14	0	14
Sodium channel protein type 9 subunit alpha	0	8	0	8
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
heat shock protein beta-1	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
G	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	3	0	3
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Inositol hexakisphosphate kinase 1	10	0	0	10
Histamine H3 receptor	0	2	2	4
cytochrome P450 2C9, partial	10	0	0	10
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	11	0	13
Solute carrier family 22 member 2	0	5	0	7
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
Spike glycoprotein	8	0	0	8
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Solute carrier family 22 member 1	0	10	0	14
Multidrug and toxin extrusion protein 2	0	3	0	3
Multidrug and toxin extrusion protein 1	0	7	0	7
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
dopamine D1 receptor	2	0	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	3
UDP-glucuronosyltransferase 1A9	0	0	1	2
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	2	1	3
UDP-glucuronosyltransferase 1A1	0	4	1	6
UDP-glucuronosyltransferase 1A4	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	1	1
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	2	1	3
UDP-glucuronosyltransferase 2B15	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	1	1
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 5	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily A member 5	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	8	0	8
Potassium voltage-gated channel subfamily D member 2	0	3	0	3
estrogen receptor 2 (ER beta)	7	0	0	7
aryl hydrocarbon receptor	8	0	0	8
thyrotropin-releasing hormone receptor	1	0	0	1
Albumin	0	4	2	6
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	6	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Solute carrier family 22 member 3	0	4	0	5
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	3	2	5
Histamine H1 receptor	0	2	1	3
Histamine H1 receptor	0	4	2	6
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
cytochrome P450 3A4 isoform 1	6	0	0	6
Histidine-binding periplasmic protein	0	0	1	1
Hsf1 protein	0	0	1	1
cytochrome P450 2C9 precursor	3	0	0	3
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 10 subunit alpha	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Calmodulin	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Alpha-2A adrenergic receptor	0	4	0	5
D(2) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	4	0	5
5-hydroxytryptamine receptor 1A	0	7	0	7
D(1A) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 1B	0	6	0	6
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	10	0	10
5-hydroxytryptamine receptor 6	0	6	0	6
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Aldo-keto reductase family 1 member B1	0	8	0	8
Sodium-dependent noradrenaline transporter	0	8	0	8
Sodium-dependent serotonin transporter	0	2	0	2
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
ATPase family AAA domain-containing protein 5	5	0	0	5
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Gamma-aminobutyric acid	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	1	2	3
Beta-2 adrenergic receptor	0	0	0	1
Beta-3 adrenergic receptor	0	4	1	5
Beta-1 adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
Alpha-1A adrenergic receptor	0	0	0	1
Alpha-1B adrenergic receptor	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Glucocorticoid receptor	0	6	3	14
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
pregnane X receptor	2	0	0	2
thioredoxin glutathione reductase	1	0	0	1
Solute carrier family 22 member 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Glutamate 5-kinase	0	0	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
ATP-dependent translocase ABCB1	0	7	1	10
Sodium-dependent dopamine transporter	0	2	0	2
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Histidine-rich protein PFHRP-II	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 2D4	0	2	0	2
Multidrug resistance protein 1a	0	0	0	1
Voltage-gated sodium channel Nav1.5 cardiac isoform	0	1	0	1
pyruvate kinase	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
pyruvate kinase PKM isoform b	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Pteridine reductase 1	0	2	0	2
Pyruvate kinase PKM	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Trypanothione reductase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Batten Turner Congenital Myopathy

Synonyms(17)

Research Excerpts

Overview

Context

Treatment

Research

Studies (236)

Protein Targets (973)

Batten Turner Congenital Myopathy

Synonyms(17)

Research Excerpts

Overview

Context

Treatment

Research

Studies (236)

Drugs Studied (151)

Protein Targets (973)