Compounds > 5-aminoindole
Page last updated: 2024-12-07

5-aminoindole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-Aminoindole is a heterocyclic compound with potential biological activity. It is an indole derivative with an amino group at the 5-position. 5-Aminoindole has been studied for its potential as a precursor to various biologically active compounds, including pharmaceuticals and agrochemicals. Its synthesis typically involves the reaction of indole with an appropriate amine source, followed by deprotection or other modifications. Research has explored its role in various biological processes, including its interaction with enzymes, its effects on cell signaling, and its potential as an anticancer agent. The compound is also studied for its photophysical properties and its potential in materials science applications.'

5-aminoindole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1H-indol-5-amine : An indolamine carrying an amino group at position 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID78867
CHEMBL ID325916
CHEBI ID33067
SCHEMBL ID130519
MeSH IDM0500331

Synonyms (52)

Synonym
AC-5465
BIDD:GT0124
EN300-28737
unii-q732pg0y16
einecs 225-977-2
q732pg0y16 ,
nsc 61452
SDCCGMLS-0066200.P001
1h-indol-5-amine
5192-03-0
nsc-61452
nsc61452
indole, 5-amino-
5-aminoindole
indol-5-ylamine
CHEBI:33067 ,
5-aminoindole, 97%
A-5640
inchi=1/c8h8n2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10h,9h2
zcbifhndzbscep-uhfffaoysa-
AKOS000280236
CHEMBL325916
A22084
5-indolamine
A-5645 ,
STK711129
FT-0601203
PS-4506
AM1048
AB00443549-03
SCHEMBL130519
5 -aminoindole
1h-indol-5-ylamine
5-indole amine
5-amino-indole
1h-indole-5-amine
(1h-indole-5-yl)-amine
5amino-1h-indole
5-amino-1h-indole
1h-5-indolylamine
5-amino indole
DTXSID5063734
cid_78867
bdbm32210
CS-W007509
mfcd00005679
NCGC00342252-01
SY014519
Q27115500
SB14953
(indol-5-yl)amine
Z271138340
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indolamine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
90-kda heat shock protein beta HSP90 beta, partialHomo sapiens (human)IC50 (µMol)50.00000.17369.803229.2701AID712
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)IC50 (µMol)50.00000.17369.803229.2701AID712
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID54188Residual Cyclin-dependent kinase 5-p35nck5a activity with L240C/N297Q mutant cytochrome P450 2A6 extract2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
AID73213Residual porcine GSK-3-alpha/beta kinase activity with L240C/N297Q mutant cytochrome P450 2A6 extract2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
AID1890260Antitubercular activity against Mycobacterium smegmatis ATCC 700084 after 48 hrs by microdilution assay2022Bioorganic & medicinal chemistry letters, 05-01, Volume: 63Structure-activity relationship of 2-aminodibenzothiophene pharmacophore and the discovery of aminobenzothiophenes as potent inhibitors of Mycobacterium smegmatis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (20.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.69

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.69 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.69)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		7.110aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
indole
[no description available]		7.3620indole;
polycyclic heteroarene		Escherichia coli metabolite
tryptamine
[no description available]		7.110aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.4110carbohydrazideantitubercular agent;
drug allergen
acrylic acid
acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.		6.9410alpha,beta-unsaturated monocarboxylic acidmetabolite
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.110pyrrole;
secondary amine
7-azaindole
[no description available]		2.0210pyrrolopyridine
indirubin
[no description available]		2.0210
indigo
[no description available]		2.0210hydroxyindoles
5-methylindole
[no description available]		2.0210
5-methoxyindole
5-methoxyindole: structure in first source		2.0210indoles
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.1110metal allergen;
nickel group element atom;
platinum group metal atom
Methyl indole-5-carboxylate
[no description available]		2.0210indolyl carboxylic acid
sepharose
agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.		2.0410
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.0410
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		02.4110
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.4110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1710
Injury, Myocardial Reperfusion
[description not available]		02.1710
Blood Pressure, High
[description not available]		01.9310
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		01.9310