Idiopathic Hypersomnia

A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)

Synonym
Idiopathic Hypersomnia

Excerpt	Reference
"Idiopathic hypersomnia is most often a chronic condition though spontaneous remission may occur."	( Billiard, M; Sonka, K, 2016)
"Idiopathic hypersomnia is characterized by excessive daytime sleepiness, despite normal or long sleep time."	( Boucetta, S; Dang-Vu, TT; Gravel, P; Lachapelle, F; Montplaisir, J; Soucy, JP; Zadra, A, 2017)
"Idiopathic hypersomnia is a disorder of excessive daytime sleepiness, often accompanied by long sleep times or pronounced difficulty in awakening, in the absence of a known cause."	( Becker, LA; Friederich Murray, C; Hoque, R; Trotti, LM, 2021)
"Idiopathic hypersomnia is a central hypersomnolence disorder mainly characterised by excessive daytime sleepiness, with prolonged night-time sleep and pronounced sleep inertia."	( Arnulf, I; Black, J; Bogan, RK; Chandler, P; Chen, D; Dauvilliers, Y; Foldvary-Schaefer, N; Mignot, E; Morse, AM; Parvataneni, R; Skobieranda, F; Šonka, K; Sterkel, A; Thorpy, MJ, 2022)
"Narcolepsy and idiopathic hypersomnia are rare, chronic sleep disorders that can debilitate patients’ cognitive function, social functioning and health-related quality of life."	( Heo, YA, 2022)
"Idiopathic hypersomnia is a central hypersomnolence disorder of unknown origin characterized by excessive daytime sleepiness despite normal or long sleep time, and frequent severe sleep inertia."	( Arnulf, I; Dauvilliers, Y; Roy, A; Thomas, R, 2023)

Excerpt	Reference
"Until now, the treatment of idiopathic hypersomnia has mirrored that of the sleepiness of narcolepsy type 1 or 2."	( Billiard, M; Sonka, K, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	4 (10.26)	18.1394
2010's	21 (53.85)	28.8240
2020's	14 (35.90)	9.53

Drug	Relationship Strength	Studies	Trials
histamine	low	1	0
melatonin	low	1	0
caffeine	low	1	0
mazindol	medium	2	1
methylphenidate	low	2	0
modafinil	medium	20	5
pemoline	low	1	0
thyroxine	medium	1	1
dextroamphetamine	low	2	0
methamphetamine	low	1	0
aripiprazole	low	1	0
cysteine	low	1	0
alpha-synuclein	low	1	0
piperidines	low	2	0
cholestyramine resin	low	1	0
ego	low	1	0
technetium tc 99m bicisate	low	1	0
leptin	low	2	0

Protein Targets (384)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
RAR-related orphan receptor gamma	4	0	0	4
SMAD family member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
USP1 protein, partial	3	0	0	3
PPM1D protein	1	0	0	1
SMAD family member 3	1	0	0	1
TDP1 protein	3	0	0	3
GLI family zinc finger 3	4	0	0	4
Microtubule-associated protein tau	1	0	0	1
AR protein	4	0	0	4
estrogen receptor 2 (ER beta)	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	2	0	0	2
EWS/FLI fusion protein	5	0	0	5
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
retinoid X nuclear receptor alpha	2	0	0	2
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	4	0	0	4
estrogen nuclear receptor alpha	5	0	0	5
G	4	0	0	4
cytochrome P450 2D6	3	0	0	3
polyprotein	1	0	0	1
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	5	0	0	5
heat shock protein beta-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	3	0	0	3
geminin	6	0	0	6
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 2	0	1	0	2
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
5-hydroxytryptamine receptor 3A	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Bile salt export pump	0	7	0	7
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Cellular tumor antigen p53	3	0	0	3
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	1	2
5-hydroxytryptamine receptor 2C	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
D(2) dopamine receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
Glutamate receptor 2	2	0	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	2	2	4
Sodium-dependent serotonin transporter	0	8	2	10
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H1 receptor	0	5	2	7
Alpha-1B adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	2	1	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Spike glycoprotein	2	0	0	2
D(2) dopamine receptor	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
5-hydroxytryptamine receptor 3D	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	6	0	6
Multidrug and toxin extrusion protein 1	0	1	0	1
Histamine H3 receptor	0	5	2	8
cytochrome P450 2C9, partial	4	0	0	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
phosphopantetheinyl transferase	4	0	0	4
GLS protein	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
chromobox protein homolog 1	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
DNA polymerase beta	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	1	0	0	1
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase 1	0	1	0	2
Carbonic anhydrase 2	0	1	0	3
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	2	0	2
Adenosine receptor A1	0	2	0	4
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	2	0	5
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
importin subunit beta-1 isoform 1	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
streptokinase A precursor	0	0	1	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	2
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Sodium-dependent noradrenaline transporter	0	7	2	9
Sodium-dependent dopamine transporter	0	5	1	6
5-hydroxytryptamine receptor 1B	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
5-hydroxytryptamine receptor 2B	0	0	1	1
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	4	1	5
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Amine oxidase [flavin-containing] B	0	2	0	2
Sodium-dependent dopamine transporter	0	10	1	12
5-hydroxytryptamine receptor 4	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
5-hydroxytryptamine receptor 3B	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
endonuclease IV	1	0	0	1
thioredoxin reductase	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
arylsulfatase A	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
flap endonuclease 1	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	1	2	0	3
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Bile salt export pump	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	1	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	1	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	1	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	1	2	0	3
Gamma-aminobutyric acid receptor subunit beta-2	1	2	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
GABA theta subunit	1	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	2	0	3
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
lamin isoform A-delta10	4	0	0	4
Solute carrier family 22 member 1	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Histamine H2 receptor	0	1	2	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Histamine H2 receptor	0	0	1	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	2	2	4
Histamine H3 receptor	0	2	1	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transporter	0	3	0	3
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
interleukin 8	1	0	0	1
ClpP	1	0	0	1
ATAD5 protein, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	1	0	0	1
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	1	0	1
Cholinesterase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (39)

Protein Targets (384)

Idiopathic Hypersomnia

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (39)

Drugs Studied (27)

Protein Targets (384)