| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Disease Exacerbation
[description not available] | 0 | 2.21 | 1 | 0 |
Basedow Disease
[description not available] | 0 | 2.21 | 1 | 0 |
Central Hypothyroidism
[description not available] | 0 | 2.21 | 1 | 0 |
Chronic Lymphocytic Thyroiditis
[description not available] | 0 | 2.21 | 1 | 0 |
Graves Disease
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). | 0 | 2.21 | 1 | 0 |
Hypothyroidism
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. | 0 | 2.21 | 1 | 0 |
Hashimoto Disease
Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM. | 0 | 2.21 | 1 | 0 |
Breast Cancer
[description not available] | 0 | 3.59 | 3 | 0 |
Breast Neoplasms
Tumors or cancer of the human BREAST. | 0 | 3.59 | 3 | 0 |
Menopause
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age. | 0 | 2.05 | 1 | 0 |
Cancer of Ovary
[description not available] | 0 | 2.06 | 1 | 0 |
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. | 0 | 2.06 | 1 | 0 |
Multiple System Atrophy Syndrome
[description not available] | 0 | 2.05 | 1 | 0 |
Idiopathic Parkinson Disease
[description not available] | 0 | 2.05 | 1 | 0 |
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) | 0 | 2.05 | 1 | 0 |
Multiple System Atrophy
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92) | 0 | 2.05 | 1 | 0 |
Cancer of Colon
[description not available] | 0 | 3.99 | 5 | 0 |
Colonic Neoplasms
Tumors or cancer of the COLON. | 0 | 3.99 | 5 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 1.96 | 1 | 0 |
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. | 0 | 1.96 | 1 | 0 |
Benign Neoplasms, Brain
[description not available] | 0 | 3.98 | 5 | 0 |
Leukemia, Lymphocytic
[description not available] | 0 | 3.28 | 2 | 0 |
Arachnoidal Cerebellar Sarcoma, Circumscribed
[description not available] | 0 | 2.88 | 1 | 0 |
Benign Neoplasms
[description not available] | 0 | 3.57 | 3 | 0 |
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 3.98 | 5 | 0 |
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. | 0 | 3.28 | 2 | 0 |
Medulloblastoma
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1) | 0 | 2.88 | 1 | 0 |
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 3.57 | 3 | 0 |
Acute Myelogenous Leukemia
[description not available] | 0 | 1.96 | 1 | 0 |
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) | 0 | 1.96 | 1 | 0 |
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES. | 0 | 1.96 | 1 | 0 |
Adenocarcinoma, Basal Cell
[description not available] | 0 | 3.58 | 3 | 0 |
Adenoma, Basal Cell
[description not available] | 0 | 2.88 | 1 | 0 |
Cancer of Rectum
[description not available] | 0 | 2.88 | 1 | 0 |
Adenocarcinoma
A malignant epithelial tumor with a glandular organization. | 0 | 3.58 | 3 | 0 |
Adenoma
A benign epithelial tumor with a glandular organization. | 0 | 2.88 | 1 | 0 |
Rectal Neoplasms
Tumors or cancer of the RECTUM. | 0 | 2.88 | 1 | 0 |
Experimental Hepatoma
[description not available] | 0 | 3.79 | 4 | 0 |
Malignant Melanoma
[description not available] | 0 | 2.36 | 2 | 0 |
Experimental Mammary Neoplasms
[description not available] | 0 | 1.96 | 1 | 0 |
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) | 0 | 2.36 | 2 | 0 |
Germinoblastoma
[description not available] | 0 | 1.96 | 1 | 0 |
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue. | 0 | 1.96 | 1 | 0 |
Leucocythaemia
[description not available] | 0 | 1.96 | 1 | 0 |
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) | 0 | 1.96 | 1 | 0 |
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed) | 0 | 1.96 | 1 | 0 |
Colorectal Cancer
[description not available] | 0 | 1.98 | 1 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 1.98 | 1 | 0 |
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI. | 0 | 1.98 | 1 | 0 |
Encephalopathy, Hepatic
[description not available] | 0 | 1.98 | 1 | 0 |
Cirrhosis, Liver
[description not available] | 0 | 1.98 | 1 | 0 |
Hepatic Encephalopathy
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5) | 0 | 1.98 | 1 | 0 |
Hepatitis
INFLAMMATION of the LIVER. | 0 | 1.98 | 1 | 0 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 1.98 | 1 | 0 |
Carcinoma, Epidermoid
[description not available] | 0 | 1.98 | 1 | 0 |
Fibromatosis
[description not available] | 0 | 1.98 | 1 | 0 |
Epulides
[description not available] | 0 | 1.98 | 1 | 0 |
Atypical Lipoma
[description not available] | 0 | 1.98 | 1 | 0 |
Cancer of Mouth
[description not available] | 0 | 1.98 | 1 | 0 |
Papilloma, Squamous Cell
[description not available] | 0 | 1.98 | 1 | 0 |
Epulides, Giant Cell
[description not available] | 0 | 1.98 | 1 | 0 |
Congenital Epulides
[description not available] | 0 | 1.98 | 1 | 0 |
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) | 0 | 1.98 | 1 | 0 |
Fibroma
A benign tumor of fibrous or fully developed connective tissue. | 0 | 1.98 | 1 | 0 |
Gingival Diseases
Diseases involving the GINGIVA. | 0 | 1.98 | 1 | 0 |
Granuloma, Giant Cell
A non-neoplastic inflammatory lesion, usually of the jaw or gingiva, containing large, multinucleated cells. It includes reparative giant cell granuloma. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis); central refers to the jaw. | 0 | 1.98 | 1 | 0 |
Lipoma
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule. | 0 | 1.98 | 1 | 0 |
Mouth Neoplasms
Tumors or cancer of the MOUTH. | 0 | 1.98 | 1 | 0 |
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed) | 0 | 1.98 | 1 | 0 |
Glial Cell Tumors
[description not available] | 0 | 1.98 | 1 | 0 |
Delayed Effects, Prenatal Exposure
[description not available] | 0 | 1.98 | 1 | 0 |
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 1.98 | 1 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 1.98 | 1 | 0 |
Alcohol Abuse
[description not available] | 0 | 2.9 | 1 | 0 |
Alcohol Drinking
Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. | 0 | 2.9 | 1 | 0 |
Alcoholism
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) | 0 | 2.9 | 1 | 0 |
Local Neoplasm Recurrence
[description not available] | 0 | 1.98 | 1 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 2.38 | 2 | 0 |
Endotoxin Shock
[description not available] | 0 | 1.99 | 1 | 0 |
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status. | 0 | 1.99 | 1 | 0 |
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. | 0 | 2 | 1 | 0 |
Arterial Obstructive Diseases
[description not available] | 0 | 2 | 1 | 0 |
Acute Brain Injuries
[description not available] | 0 | 2 | 1 | 0 |
Anterior Circulation Transient Ischemic Attack
[description not available] | 0 | 2 | 1 | 0 |
Injury, Ischemia-Reperfusion
[description not available] | 0 | 2 | 1 | 0 |
Arterial Occlusive Diseases
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency. | 0 | 2 | 1 | 0 |
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. | 0 | 2 | 1 | 0 |
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6) | 0 | 2 | 1 | 0 |
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. | 0 | 2 | 1 | 0 |
Leukemia L 1210
[description not available] | 0 | 2 | 1 | 0 |
Deficiency, Vitamin E
[description not available] | 0 | 1.97 | 1 | 0 |
Acute Promyelocytic Leukemia
[description not available] | 0 | 1.97 | 1 | 0 |
Leukemia, Promyelocytic, Acute
An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION. | 0 | 1.97 | 1 | 0 |
Condition, Preneoplastic
[description not available] | 0 | 3.29 | 2 | 0 |
Precancerous Conditions
Pathological conditions that tend eventually to become malignant. | 0 | 3.29 | 2 | 0 |
Cerebro-Hepato-Renal Syndrome
[description not available] | 0 | 1.97 | 1 | 0 |
Zellweger Syndrome
An autosomal recessive disorder due to defects in PEROXISOME biogenesis which involves more than 13 genes encoding peroxin proteins of the peroxisomal membrane and matrix. Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; MUSCLE HYPOTONIA; SENSORINEURAL HEARING LOSS; visual compromise; SEIZURES; progressive degeneration of the KIDNEYS and the LIVER. Zellweger-like syndrome refers to phenotypes resembling the neonatal Zellweger syndrome but seen in children or adults with apparently intact peroxisome biogenesis. | 0 | 1.97 | 1 | 0 |
Cyst
[description not available] | 0 | 2.37 | 2 | 0 |
Adenocarcinoma Of Kidney
[description not available] | 0 | 2.89 | 1 | 0 |
Cancer of Kidney
[description not available] | 0 | 2.89 | 1 | 0 |
Carcinoma, Renal Cell
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma. | 0 | 2.89 | 1 | 0 |
Kidney Neoplasms
Tumors or cancers of the KIDNEY. | 0 | 2.89 | 1 | 0 |
Aortic Stenosis
[description not available] | 0 | 1.97 | 1 | 0 |
Cardiac Hypertrophy
Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. | 0 | 1.97 | 1 | 0 |
Aortic Valve Stenosis
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA. | 0 | 1.97 | 1 | 0 |
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. | 0 | 1.97 | 1 | 0 |