Food Intolerance

Digestive system disorder where a particular food irritates the digestive tract or cannot be properly digested (i.e., due to a lack of a digestive enzyme). It differs from FOOD HYPERSENSITIVITY which is an immune system disorder, usually due to specific proteins in food. http://my.clevelandclinic.org/health/articles/problem-foods-is-it-an-allergy-or-intolerance.

Synonym
Food, Sensitivity
Food Intolerance

Excerpt	Reference
"Food intolerance is an abnormal non-immunological response of the organism to the ingestion of food or its components in a dosage normally tolerated."	( Danis, R; Hrubisko, M; Huorka, M; Wawruch, M, 2021)
"Food intolerance is associated with IBS, anxiety, depression, and decreased health-related QOL and frequently leads to food elimination."	( Jansson-Knodell, CL; Lockett, C; Shin, A; White, M; Xu, H, 2022)
"Common symptoms of food intolerance are caused by chemical components within food that have a pharmacological activity to alter the motility of the gastrointestinal tract."	( Abdalla, A; Brooks, EL; Hussain, KK; Kotecha, K; Patel, BA, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	13 (43.33)	28.8240
2020's	17 (56.67)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
histamine	low	9	0
nickel	low	1	0
erythrosine	low	3	0
metoclopramide	medium	1	1
apnea	medium	1	1
lactose	low	3	0
erythromycin	low	1	0
potassium citrate	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
trazodone hydrochloride	medium	5	1
clarithromycin	medium	2	1
sodium bicarbonate	low	1	0
D-fructopyranose	low	1	0
losartan potassium	medium	1	1
n-(3-fluorophenyl)-1-((4-(((3s)-3-methyl-1-piperazinyl)methyl)phenyl)acetyl)-4-piperidinamine	medium	1	1
piperidines	medium	1	1
caseins	low	1	0

Protein Targets (322)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
thioredoxin reductase	3	0	0	3
ATAD5 protein, partial	2	0	0	2
TDP1 protein	4	0	0	4
Microtubule-associated protein tau	1	0	0	1
estrogen-related nuclear receptor alpha	6	0	0	6
arylsulfatase A	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
Bloom syndrome protein isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
lamin isoform A-delta10	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
GLI family zinc finger 3	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
estrogen nuclear receptor alpha	5	0	0	5
thyroid hormone receptor beta isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	3	0	0	3
streptokinase A precursor	0	0	2	2
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Bile salt export pump	0	6	0	6
ATP-dependent translocase ABCB1	0	3	0	3
Cytochrome P450 3A4	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, Beta-lactamase	3	0	0	3
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Motilin receptor	0	1	2	3
Rap guanine nucleotide exchange factor 3	1	0	0	1
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Genome polyprotein	0	1	1	2
Luciferase	1	0	0	1
acetylcholinesterase	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
RAR-related orphan receptor gamma	1	0	0	1
SMAD family member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
GLS protein	2	0	0	2
SMAD family member 3	1	0	0	1
AR protein	3	0	0	3
thioredoxin glutathione reductase	1	0	0	1
hypothetical protein, conserved	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	2	0	0	2
farnesoid X nuclear receptor	1	0	0	1
G	1	0	0	1
cytochrome P450 2D6	4	0	0	4
polyprotein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
activating transcription factor 6	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Cellular tumor antigen p53	1	0	0	1
Glutamate receptor 2	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
large T antigen	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
USP1 protein, partial	1	0	0	1
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase 12	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Carbonic anhydrase 1	0	1	0	2
Carbonic anhydrase 2	0	1	0	3
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	0	0	1
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 7	0	0	0	1
Histamine H2 receptor	0	0	1	1
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Histamine H3 receptor	0	1	2	3
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Smad3	1	0	0	1
chromobox protein homolog 1	2	0	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 3E	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
glucocorticoid receptor [Homo sapiens]	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 3B	0	0	1	1
Albumin	0	0	1	1
Myeloperoxidase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	3	0	3
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 7	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Amyloid-beta precursor protein	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
progesterone receptor	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
67.9K protein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Research

Studies (30)

Protein Targets (322)

Food Intolerance

Synonyms(2)

Research Excerpts

Overview

Research

Studies (30)

Drugs Studied (20)

Protein Targets (322)