Page last updated: 2024-09-27

MEA 2a

A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.

Synonyms(17)

Synonym
Neoplasms, Multiple Endocrine Type 2a
Multiple Endocrine Neoplasia Type 2
MEA II
MEA 2a
Multiple Endocrine Neoplasms Type 2a
MEA IIa
Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia Type 2a
Neoplasia, Multiple Endocrine Type 2a
Multiple Endocrine Neoplasia, Type IIa
MEN IIa
MEN 2
MEN 2a
MEN-2A Syndrome
Sipple Syndrome
MEN2a
MEN II

Research Excerpts

Overview

ExcerptReference
"In particular, MEN2A is a more complex and aggressive disease than FMTC, being characterized by pheochromocytomas and parathyroid alterations, in addition to medullary thyroid carcinomas."( Billaud, M; Carlomagno, F; Cirafici, AM; de Franciscis, V; De Vita, G; Fusco, A; Melillo, RM; Salvatore, G; Santoro, M, 1997)
"Nearly 100% of MEN2A are associated with germ line mutation of the RET proto-oncogene (RET), and DNA-based RET genotype analysis is now considered essential for earlier diagnosis."( Dora, JM; Maia, AL; Meyer, EL; Puñales, MK; Siqueira, DR, 2008)

Actions

ExcerptReference
"All MEN 2A affected family members suffered from medullary thyroid carcinoma and two of ten patients for pheochromocytoma."( Altaner, C; Altanerova, V; Breza, J; Kostalova, L; Poturnajova, M, 2005)

Treatment

ExcerptReference
"In comparing sporadic and MEN 2A phaeochromocytoma we found differences in age at presentation, mode of presentation, clinical data, duration of clinical features, imaging findings bilaterality and type of surgical treatment required."( Cañas, R; Hernandez, AM; Parrilla, P; Pomares, FJ; Rodriguez, JM; Tebar, FJ, 1998)
"We selected 11 females from multiple endocrine neoplasia type 2A kindred treated with thyroidectomy due to hypercalcitoninemia."( Blanes, A; de Miguel, M; Diaz-Cano, SJ; Tashjian, R; Wolfe, HJ, 2001)
"Of 82 MTC (MEN 2A) patients genetically diagnosed and surgically treated at our center, 22 received a prophylactic thyroidectomy (RET +, bCT and pCT with normal values and asymptomatic)."( Balsalobre, MD; Carbonell, P; Glower, G; Parrilla, P; Pomares, F; Ríos, A; Rodríguez, GJ; Sola, J; Tébar, J; Torregrosa, NM, 2002)

Research

Studies (210)

TimeframeStudies, This Condition (%)All Conditions %
pre-19905 (2.38)23.3326
1990's63 (30.00)12.5806
2000's78 (37.14)18.1394
2010's50 (23.81)28.8240
2020's14 (6.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
glycine0low50
histamine0low10
indoleacetic acid0low10
dihydroxyphenylalanine0low30
niacinamide0low20
niacin0low10
urea0low10
normetanephrine0low70
vanilmandelic acid0low80
homovanillic acid0low10
hydroxyindoleacetic acid0low10
bupivacaine0low10
pentetic acid0low10
doxazosin0low20
fluorouracil0low20
labetalol0low10
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one0low10
metoprolol0low20
omeprazole0low30
pd 980590low10
phenoxybenzamine0low20
ag 18790low10
propofol0low10
sevoflurane0low10
temozolomide0low10
thyroxine0low20
prednisone0low10
alanine0low20
serine0low60
bromodeoxyuridine0low20
tyrosine0low190
adenosine monophosphate0low10
leucine0low20
methionine0low60
phenylalanine0low20
histidine0low10
valine0low30
threonine0low30
tryptophan0low10
isoleucine0low20
arginine0low70
quinazolines0low60
thiazoles0low10
calcium gluconate0low10
deoxycytidine0low10
digoxigenin0low10
sulfur hexafluoride0low10
metanephrine0low260
technetium0low10
magnesium sulfate0low10
tetradecanoylphorbol acetate0low10
phosphotyrosine0low40
fluorodopa f 180low20
remifentanil0low10
3-iodobenzylguanidine0medium131
capecitabine0low10
thiazolyl blue0low10
fluorodeoxyglucose f180low20
paxilline0low10
5-fluorodopamine0low20
imatinib mesylate0low20
gefitinib0low10
biotin0medium21
sorafenib0low10
sodium arsenite0low10
tacrolimus0low10
capsaicin0low10
succimer0low10
zd 64740low50
calcitriol0low10
dexmedetomidine0low10
cysteine0low320
phosphorus0low20
lenvatinib0low10
pentagastrin0medium211
lipid a0low10
losartan potassium0low10
(dtpa-phe(1))-octreotide0low10
gastrins0low10
neuropeptide y0low10
sphingosine kinase0low10
technetium tc 99m sestamibi0low30
cabozantinib0low10
piperidines0low60
thymosin0low10
epidermal growth factor0low10
calca protein, human0low10
cyclin d10low20
ap201870low10
lewis x antigen0low10
gallium ga 68 dotatate0low10
cord factors0low10
technetium tc 99m dimercaptosuccinic acid0low10
guanine0low10
dacarbazine0low40
nintedanib0low10
eye0low10

Protein Targets (1,271)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, Cruzipain2002
Chain A, Methyltransferase Wbdd0101
thioredoxin reductase140014
15-lipoxygenase, partial5005
ATAD5 protein, partial9009
NFKB1 protein, partial4004
TDP1 protein230023
Thrombopoietin4004
aldehyde dehydrogenase 1 family, member A1140014
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
thyroid stimulating hormone receptor130013
regulator of G-protein signaling 48008
EWS/FLI fusion protein140014
67.9K protein7007
Parkin2002
euchromatic histone-lysine N-methyltransferase 2230023
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a5005
cytochrome P450 2C19 precursor7007
cytochrome P450 2C9 precursor4004
chromobox protein homolog 1140014
flap endonuclease 18008
serine/threonine-protein kinase mTOR isoform 16006
survival motor neuron protein isoform d9009
cytochrome P450 3A4 isoform 17007
M-phase phosphoprotein 85005
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0348
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha0101
Serine/threonine-protein kinase PLK40268
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0145
Gamma-aminobutyric acid receptor subunit pi71210
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Bromodomain-containing protein 40101
5-hydroxytryptamine receptor 40606
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Integrin beta-33003
Cytochrome P450 1A20304
Integrin alpha-IIb3003
Neuronal acetylcholine receptor subunit alpha-41102
Serine/threonine-protein kinase pim-10167
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit beta-171210
Gamma-aminobutyric acid receptor subunit delta71210
Gamma-aminobutyric acid receptor subunit gamma-271210
Casein kinase II subunit alpha'0167
Gamma-aminobutyric acid receptor subunit alpha-571210
Gamma-aminobutyric acid receptor subunit alpha-371210
Gamma-aminobutyric acid receptor subunit gamma-171210
Gamma-aminobutyric acid receptor subunit alpha-271210
Proteinase-activated receptor 10001
Bromodomain-containing protein 20101
Phosphatidylinositol 3-kinase regulatory subunit alpha0102
5-hydroxytryptamine receptor 2A0303
5-hydroxytryptamine receptor 2C0707
Gamma-aminobutyric acid receptor subunit alpha-471210
Gamma-aminobutyric acid receptor subunit gamma-371210
Gamma-aminobutyric acid receptor subunit alpha-671210
Sodium-dependent serotonin transporter0303
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Type-1 angiotensin II receptor0202
5-hydroxytryptamine receptor 2B0909
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0449
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0349
Serine/threonine-protein kinase mTOR0448
Serine/threonine-protein kinase mTOR0101
Histamine H2 receptor7018
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0348
Glycogen synthase kinase-3 beta0268
D(1A) dopamine receptor2002
Serine/threonine-protein kinase PLK10459
Gamma-aminobutyric acid receptor subunit alpha-171210
Gamma-aminobutyric acid receptor subunit beta-371210
Gamma-aminobutyric acid receptor subunit beta-271210
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0145
DNA-dependent protein kinase catalytic subunit0404
Mu-type opioid receptor0101
Serine-protein kinase ATM0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
Serine/threonine-protein kinase ATR0134
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
Bromodomain-containing protein 30101
Serine/threonine-protein kinase pim-30145
Phosphoinositide 3-kinase regulatory subunit 50101
GABA theta subunit71210
Gamma-aminobutyric acid receptor subunit epsilon71210
Serine/threonine-protein kinase PLK30347
Serine/threonine-protein kinase PLK20246
ATP-dependent phosphofructokinase140014
dopamine D1 receptor1001
GLS protein110011
ras-related protein Rab-9A3003
histone acetyltransferase KAT2A isoform 14004
lethal factor (plasmid)5005
POU domain, class 2, transcription factor 10001
Spike glycoprotein110011
Alpha-1B adrenergic receptor0404
Beta-1 adrenergic receptor0314
Alpha-2B adrenergic receptor0314
Alpha-2C adrenergic receptor0314
Alpha-2A adrenergic receptor0314
Alpha-1D adrenergic receptor0404
Alpha-1A adrenergic receptor0516
Beta-2 adrenergic receptor0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma140014
AR protein190019
nuclear receptor subfamily 1, group I, member 3120012
cytochrome P450 family 3 subfamily A polypeptide 4100010
glucocorticoid receptor [Homo sapiens]130013
estrogen-related nuclear receptor alpha210021
pregnane X nuclear receptor130013
estrogen nuclear receptor alpha220022
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
nuclear factor erythroid 2-related factor 2 isoform 26006
heat shock protein beta-14004
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein2002
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta10120012
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump015015
Cyclin-dependent kinase 10369
Heat shock protein HSP 90-beta0101
Glutamate receptor 29009
Xanthine dehydrogenase/oxidase0202
TAR DNA-binding protein 433003
Protein mono-ADP-ribosyltransferase PARP150202
Leucine-rich repeat serine/threonine-protein kinase 20246
ATPase family AAA domain-containing protein 57007
Ataxin-29009
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
v-jun sarcoma virus 17 oncogene homolog (avian)9009
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Mitogen-activated protein kinase kinase kinase 70055
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
5'-AMP-activated protein kinase subunit beta-20011
Transient receptor potential cation channel subfamily M member 20101
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
L-lactate dehydrogenase A chain0112
Adenylate kinase isoenzyme 10001
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0304
Fructose-1,6-bisphosphatase 10101
2-dehydropantoate 2-reductase0112
Inosine-5'-monophosphate dehydrogenase0101
Cytochrome P450 2C9 0618
Proto-oncogene tyrosine-protein kinase Src08615
Amine oxidase [flavin-containing] B0202
5'-nucleotidase0001
Choline O-acetyltransferase0101
Adenylate kinase 2, mitochondrial0102
GTP:AMP phosphotransferase AK3, mitochondrial0001
Adenosine receptor A10011
Adenylate kinase isoenzyme 1 0102
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
5'-AMP-activated protein kinase subunit gamma-10088
5'-AMP-activated protein kinase catalytic subunit alpha-20055
Adenylate kinase 2, mitochondrial0067
Glycine--tRNA ligase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10088
Adenosine deaminase-like protein0001
Protease 0112
P2Y purinoceptor 110011
Histamine H3 receptor0101
5'-AMP-activated protein kinase subunit gamma-30011
5'-AMP-activated protein kinase subunit gamma-20077
5'-AMP-activated protein kinase subunit beta-10022
Chain A, Lck Kinase0101
Chain A, BCL-2-RELATED PROTEIN A10001
Chain A, Tyrosine-protein kinase Lyn0101
Chain A, Tyrosine-protein kinase Lyn0101
glp-1 receptor, partial6006
Skn7p0002
Smad36006
nonstructural protein 14004
LAP40011
RPL19A0011
amino acid transporter AGP10011
geminin180018
Receptor-interacting serine/threonine-protein kinase 20268
Tyrosine-protein kinase JAK20167
Tyrosine-protein kinase ABL107714
Proto-oncogene tyrosine-protein kinase Src0112
Epidermal growth factor receptor011718
Tyrosine-protein kinase Lck04611
Proto-oncogene tyrosine-protein kinase LCK 0101
Tyrosine-protein kinase Fyn0167
Tyrosine-protein kinase Lyn0268
Tyrosine-protein kinase HCK0369
Ephrin type-A receptor 30055
Ephrin type-B receptor 20178
Alpha-synuclein3003
Tyrosine-protein kinase CSK0167
Tyrosine-protein kinase ZAP-700145
Casein kinase I isoform delta0167
Mitogen-activated protein kinase 140268
HSP40, subfamily A [Plasmodium falciparum 3D7]0002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Carbonic anhydrase 104011
Carbonic anhydrase 204012
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0003
Glutamate receptor ionotropic, NMDA 1 0319
Proton-coupled amino acid transporter 10506
Adenosine deaminase0001
Carbonic anhydrase 40003
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
phosphopantetheinyl transferase6006
alpha-galactosidase2002
DNA polymerase iota isoform a (long)8008
muscarinic acetylcholine receptor M16006
Cytochrome P450 3A40609
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor4004
progesterone receptor110011
retinoid X nuclear receptor alpha9009
peroxisome proliferator-activated receptor delta9009
Endolysin0011
Cellular tumor antigen p53110011
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A5005
apical membrane antigen 1, AMA14004
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA5005
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
interleukin 83003
Microtubule-associated protein tau110011
retinoic acid nuclear receptor alpha variant 1140014
bromodomain adjacent to zinc finger domain 2B6006
arylsulfatase A8008
IDH17007
nuclear receptor subfamily 1, group I, member 22002
Nuclear hormone receptor family member daf-120011
thyroid hormone receptor beta isoform 2120012
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
peripheral myelin protein 22120012
Thymidine kinase, cytosolic0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma3003
Thymidine kinase0001
Thymidylate kinase0101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
Fumarate hydratase7007
PPM1D protein6006
G6006
polyprotein7007
tyrosine-protein kinase Yes6006
Bone morphogenetic protein receptor type-1B0066
Membrane-associated progesterone receptor component 10044
Cell division cycle 7-related protein kinase0044
ATP-dependent RNA helicase DDX3X0066
Pyridoxal kinase0066
Citron Rho-interacting kinase0066
Serine/threonine-protein kinase Chk10167
Aurora kinase A0167
Cyclin-G-associated kinase0167
Ephrin type-B receptor 60066
Peroxisomal acyl-coenzyme A oxidase 30066
Mitotic checkpoint serine/threonine-protein kinase BUB10066
Dynamin-like 120 kDa protein, mitochondrial0066
Eukaryotic translation initiation factor 5B0033
Rho-associated protein kinase 20066
Serine/threonine-protein kinase ULK10066
Serine/threonine-protein kinase/endoribonuclease IRE10066
Ribosomal protein S6 kinase alpha-50066
U5 small nuclear ribonucleoprotein 200 kDa helicase0066
Ribosomal protein S6 kinase alpha-40066
Serine/threonine-protein kinase 160066
Serine/threonine-protein kinase 100066
Serine/threonine-protein kinase D30077
Structural maintenance of chromosomes protein 20066
Mitogen-activated protein kinase kinase kinase 60066
Mitogen-activated protein kinase kinase kinase kinase 40066
Serine/threonine-protein kinase LATS10066
Serine/threonine-protein kinase PAK 40066
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 6006
High affinity nerve growth factor receptor0156
Guanine nucleotide-binding protein G(i) subunit alpha-20055
ADP/ATP translocase 20066
Protein kinase C beta type0178
Insulin receptor0369
Glycogen phosphorylase, liver form0066
Acyl-CoA desaturase 10101
Tyrosine-protein kinase Fes/Fps0066
Adenine phosphoribosyltransferase0055
Tyrosine-protein kinase Yes0066
Proto-oncogene tyrosine-protein kinase receptor Ret08614
Insulin-like growth factor 1 receptor0369
Signal recognition particle receptor subunit alpha0055
Cytochrome c1, heme protein, mitochondrial0066
Hepatocyte growth factor receptor0269
Platelet-derived growth factor receptor beta04610
Serine/threonine-protein kinase A-Raf0167
Mast/stem cell growth factor receptor Kit0459
Glycogen phosphorylase, brain form0066
Breakpoint cluster region protein0178
Fibroblast growth factor receptor 104611
Cyclin-dependent kinase 40268
ADP/ATP translocase 30066
Inosine-5'-monophosphate dehydrogenase 20066
cAMP-dependent protein kinase type II-alpha regulatory subunit0066
Serine/threonine-protein kinase B-raf04711
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0066
Ribosyldihydronicotinamide dehydrogenase [quinone]0066
Platelet-derived growth factor receptor alpha05510
Tyrosine-protein kinase Fer0066
Protein kinase C alpha type0178
cAMP-dependent protein kinase catalytic subunit alpha0066
Vascular endothelial growth factor receptor 1 0549
General transcription and DNA repair factor IIH helicase subunit XPD0066
Ras-related protein Rab-6A0066
Multifunctional protein ADE20066
cAMP-dependent protein kinase catalytic subunit gamma0066
cAMP-dependent protein kinase catalytic subunit beta0066
Ferrochelatase, mitochondrial0066
Ribosomal protein S6 kinase beta-10055
Tyrosine-protein kinase JAK10066
Cyclin-dependent kinase 20268
Beta-adrenergic receptor kinase 10066
Probable ATP-dependent RNA helicase DDX60066
Mitogen-activated protein kinase 3 0168
MAP/microtubule affinity-regulating kinase 30066
Deoxycytidine kinase0067
Mitogen-activated protein kinase 10268
Ephrin type-A receptor 20066
Non-receptor tyrosine-protein kinase TYK20066
UMP-CMP kinase 0044
Phosphatidylethanolamine-binding protein 10044
Wee1-like protein kinase0066
Heme oxygenase 20066
Tyrosine-protein kinase receptor UFO0145
S-adenosylmethionine synthase isoform type-20066
DnaJ homolog subfamily A member 10066
RAC-alpha serine/threonine-protein kinase0066
RAC-beta serine/threonine-protein kinase0066
Kinesin-1 heavy chain0404
Dual specificity protein kinase TTK0055
DNA replication licensing factor MCM40066
Myosin-100055
Vascular endothelial growth factor receptor 30549
Vascular endothelial growth factor receptor 208616
Dual specificity mitogen-activated protein kinase kinase 20066
Receptor-type tyrosine-protein kinase FLT304610
Bone morphogenetic protein receptor type-1A0066
Activin receptor type-1B0066
TGF-beta receptor type-10066
TGF-beta receptor type-20066
Electron transfer flavoprotein subunit beta0055
Glycine--tRNA ligase0066
Protein kinase C iota type0077
Exosome RNA helicase MTR40066
Tyrosine-protein kinase Tec0066
Tyrosine-protein kinase ABL20167
Tyrosine-protein kinase FRK0066
Tyrosine-protein kinase SYK0066
26S proteasome regulatory subunit 6B0066
Mitogen-activated protein kinase 80066
Mitogen-activated protein kinase 90066
Dual specificity mitogen-activated protein kinase kinase 30066
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0066
Casein kinase I isoform alpha0268
MAP kinase-activated protein kinase 20066
Elongation factor Tu, mitochondrial0066
Cysteine--tRNA ligase, cytoplasmic0044
Casein kinase I isoform epsilon0066
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0066
Dual specificity protein kinase CLK10066
Dual specificity protein kinase CLK20066
Dual specificity protein kinase CLK30066
Glycogen synthase kinase-3 alpha0066
Cyclin-dependent kinase 70066
Cyclin-dependent kinase 90066
Ras-related protein Rab-27A0066
Interleukin-1 receptor-associated kinase 10066
Ribosomal protein S6 kinase alpha-30066
Serine/threonine-protein kinase Nek20066
Serine/threonine-protein kinase Nek30066
Dual specificity mitogen-activated protein kinase kinase 60066
LIM domain kinase 10066
LIM domain kinase 20066
Mitogen-activated protein kinase 100066
Tyrosine--tRNA ligase, cytoplasmic0055
Ephrin type-B receptor 30066
Ephrin type-A receptor 50066
Ephrin type-B receptor 40268
Ephrin type-A receptor 40066
Adenosine kinase0066
Ras-related protein Rab-100066
Actin-related protein 30066
Actin-related protein 20066
GTP-binding nuclear protein Ran0066
Casein kinase I isoform gamma-20055
Cyclin-dependent kinase 30055
Cyclin-dependent kinase 60167
Cyclin-dependent-like kinase 5 0066
Cyclin-dependent kinase 160066
Cyclin-dependent kinase 170066
ATP-dependent 6-phosphofructokinase, platelet type0055
Dual specificity mitogen-activated protein kinase kinase 10268
Angiopoietin-1 receptor0347
DNA topoisomerase 2-beta0066
Protein kinase C theta type0077
Activin receptor type-10066
Macrophage-stimulating protein receptor0268
Focal adhesion kinase 10066
Protein kinase C zeta type0066
Protein kinase C delta type0178
Tyrosine-protein kinase BTK0066
Activated CDC42 kinase 10066
Epithelial discoidin domain-containing receptor 10066
Potassium voltage-gated channel subfamily H member 20404
Mitogen-activated protein kinase kinase kinase kinase 20066
Serine/threonine-protein kinase 40066
Dual specificity mitogen-activated protein kinase kinase 50066
Mitogen-activated protein kinase 70066
Serine/threonine-protein kinase PAK 20066
Serine/threonine-protein kinase 30066
Mitogen-activated protein kinase kinase kinase 10066
Integrin-linked protein kinase0066
Rho-associated protein kinase 10066
Non-receptor tyrosine-protein kinase TNK10066
Calcium/calmodulin-dependent protein kinase type II subunit gamma0066
Calcium/calmodulin-dependent protein kinase type II subunit delta0066
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0066
Activin receptor type-2B0066
Bone morphogenetic protein receptor type-20066
Protein-tyrosine kinase 60066
cGMP-dependent protein kinase 1 0066
Cyclin-dependent kinase 130066
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0066
Protein-tyrosine kinase 2-beta0066
Maternal embryonic leucine zipper kinase0268
Structural maintenance of chromosomes protein 1A0066
Chromodomain-helicase-DNA-binding protein 40066
Peroxisomal acyl-coenzyme A oxidase 10055
Ephrin type-A receptor 70055
Delta(24)-sterol reductase0066
Ribosomal protein S6 kinase alpha-10066
Myosin light chain kinase, smooth muscle0066
Mitogen-activated protein kinase 110066
Serine/threonine-protein kinase STK110066
Coiled-coil domain-containing protein 60404
Serine/threonine-protein kinase N10066
Serine/threonine-protein kinase N20066
Calcium/calmodulin-dependent protein kinase type IV0066
Mitogen-activated protein kinase kinase kinase 110066
Discoidin domain-containing receptor 20167
AP2-associated protein kinase 10066
Myosin light chain kinase 30066
Putative heat shock protein HSP 90-beta 20066
Rab-like protein 30055
Serine/threonine-protein kinase MRCK alpha0066
Serine/threonine-protein kinase MRCK gamma0066
Acyl-CoA dehydrogenase family member 100066
Serine/threonine-protein kinase ULK30066
Uncharacterized protein FLJ452520066
Acyl-CoA dehydrogenase family member 110066
Serine/threonine-protein kinase/endoribonuclease IRE20055
Serine/threonine-protein kinase MARK20066
ATP-dependent RNA helicase DHX300044
Serine/threonine-protein kinase TAO10066
STE20-related kinase adapter protein alpha0066
Myosin-140066
AarF domain-containing protein kinase 10066
ATP-dependent RNA helicase DDX420055
Mitogen-activated protein kinase kinase kinase kinase 30066
MAP kinase-activated protein kinase 50066
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Atypical kinase COQ8A, mitochondrial0066
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0066
Mitogen-activated protein kinase 150066
Serine/threonine-protein kinase Nek90066
Serine/threonine-protein kinase Nek70066
ATP-dependent RNA helicase DDX10066
Inositol hexakisphosphate kinase 16006
Mitogen-activated protein kinase kinase kinase kinase 10066
Aurora kinase B0066
MAP/microtubule affinity-regulating kinase 40066
Serine/threonine-protein kinase Nek10066
Calcium/calmodulin-dependent protein kinase kinase 20066
EKC/KEOPS complex subunit TP53RK0066
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0066
Mitogen-activated protein kinase kinase kinase 50066
Mitogen-activated protein kinase kinase kinase 30066
Eukaryotic translation initiation factor 2-alpha kinase 10066
Nucleolar GTP-binding protein 10066
Serine/threonine-protein kinase D20066
NUAK family SNF1-like kinase 20066
RNA cytidine acetyltransferase0066
Serine/threonine-protein kinase SIK20066
STE20-like serine/threonine-protein kinase 0066
Serine/threonine-protein kinase TAO30066
dCTP pyrophosphatase 10066
Dual specificity protein kinase CLK40066
Casein kinase I isoform gamma-10066
Serine/threonine-protein kinase PAK 60055
Phenylalanine--tRNA ligase beta subunit0066
Isoleucine--tRNA ligase, mitochondrial0044
BMP-2-inducible protein kinase0066
Obg-like ATPase 10055
Midasin0066
SAFB-like transcription modulator0101
Interleukin-1 receptor-associated kinase 40066
Mitogen-activated protein kinase kinase kinase 200066
Cyclin-dependent kinase 120066
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130066
Serine/threonine-protein kinase 260066
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0055
Serine/threonine-protein kinase NLK0066
Serine/threonine-protein kinase TBK10066
Septin-90066
Ribosomal protein S6 kinase alpha-60066
TRAF2 and NCK-interacting protein kinase0066
Serine/threonine-protein kinase TAO20066
Long-chain-fatty-acid--CoA ligase 50066
ALK tyrosine kinase receptor0055
Serine/threonine-protein kinase ICK0066
RAC-gamma serine/threonine-protein kinase0066
Serine/threonine-protein kinase SIK30066
Mitogen-activated protein kinase kinase kinase 20066
Thyroid hormone receptor-associated protein 30066
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0055
Mitogen-activated protein kinase kinase kinase kinase 50066
Receptor-interacting serine/threonine-protein kinase 30167
Serine/threonine-protein kinase MRCK beta0066
Interleukin-1 receptor-associated kinase 30066
Serine/threonine-protein kinase 240066
Casein kinase I isoform gamma-30066
Mitogen-activated protein kinase kinase kinase 40066
cytochrome P450 2C9, partial6006
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase4004
Chain A, Ferritin light chain3003
Vitamin D3 receptor0011
USP1 protein, partial110011
thioredoxin glutathione reductase4004
mitogen-activated protein kinase 14004
nuclear receptor ROR-gamma isoform 19009
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Vitamin D-binding protein0011
Androgen receptor0101
Cytochrome P450 2D60303
Vitamin D3 receptor0124
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0033
Cytochrome P450 2C190304
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Canalicular multispecific organic anion transporter 10808
Vitamin D3 receptor A0022
Liver carboxylesterase 10001
GLI family zinc finger 3130013
estrogen receptor 2 (ER beta)9009
glucocerebrosidase2002
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
nuclear factor erythroid 2-related factor 2 isoform 1110011
transient receptor potential cation channel subfamily V member 11001
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0101
NADH-ubiquinone oxidoreductase chain 10101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cannabinoid receptor 10101
Acetylcholinesterase0101
Prostaglandin G/H synthase 10303
Cannabinoid receptor 2 0101
D(2) dopamine receptor0112
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily A member 10101
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
Transient receptor potential cation channel subfamily V member 40011
Transient receptor potential cation channel subfamily V member 20011
hypoxia-inducible factor 1 alpha subunit3003
cytochrome P450 2D64004
thyroid stimulating hormone receptor5005
activating transcription factor 65005
Matrix metalloproteinase-90101
Isocitrate lyase0101
Thymidine kinase 2 0101
Probable deoxycytidylate deaminase0001
Cytidine deaminase0001
AAA family ATPase 0001
Reverse transcriptase/RNaseH 0011
Alpha-1B adrenergic receptor 0011
Alpha-2A adrenergic receptor0213
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0213
Alpha-1D adrenergic receptor0517
Chain A, DigA160011
Chain A, DigA160011
PAX80001
SMAD family member 23003
SMAD family member 33003
NPC intracellular cholesterol transporter 1 precursor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20202
Solute carrier organic anion transporter family member 4C10202
Rap guanine nucleotide exchange factor 41001
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
endonuclease IV4004
Bloom syndrome protein isoform 16006
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
DNA polymerase kappa isoform 16006
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Caspase-71001
D(1A) dopamine receptor2002
Alpha-1A adrenergic receptor0101
Interstitial collagenase0101
Beta-2 adrenergic receptor0628
Angiotensin-converting enzyme0202
Alpha-2B adrenergic receptor0101
Sodium-dependent serotonin transporter0202
Alpha-1A adrenergic receptor0113
Alpha-1B adrenergic receptor0113
Sodium-dependent dopamine transporter 0404
Nuclear receptor subfamily 3 group C member 3 0202
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase5005
acetylcholinesterase6006
farnesoid X nuclear receptor6006
Histone H2A.x4004
peripheral myelin protein 22 isoform 15005
hemoglobin subunit beta1001
huntingtin isoform 24004
Vpr1001
muscleblind-like protein 1 isoform 13003
Solute carrier family 22 member 80001
Amyloid-beta precursor protein1102
Thymidylate synthase0101
Aromatase0202
Leukotriene C4 synthase0044
caspase 7, apoptosis-related cysteine protease3003
caspase-33003
aryl hydrocarbon receptor9009
Caspase-72002
potassium voltage-gated channel subfamily H member 2 isoform d4004
caspase-32002
epidermal growth factor receptor isoform a precursor1102
Serine/threonine-protein kinase 250044
Serine/threonine-protein kinase RIO30044
Dual specificity mitogen-activated protein kinase kinase 70044
Inhibitor of nuclear factor kappa-B kinase subunit beta0044
Peripheral plasma membrane protein CASK0044
Serine/threonine-protein kinase DCLK10044
Inhibitor of nuclear factor kappa-B kinase subunit alpha0044
Muscle, skeletal receptor tyrosine-protein kinase0044
Mitogen-activated protein kinase 130044
3-phosphoinositide-dependent protein kinase 10044
Mitogen-activated protein kinase kinase kinase 130044
Death-associated protein kinase 30044
NUAK family SNF1-like kinase 10044
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0044
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0044
Serine/threonine-protein kinase PAK 30044
Cyclin-dependent kinase-like 50044
Serine/threonine-protein kinase 17B0044
Cyclin-dependent kinase 140044
Serine/threonine-protein kinase OSR10044
Serine/threonine-protein kinase Chk20044
RAF proto-oncogene serine/threonine-protein kinase0347
Receptor tyrosine-protein kinase erbB-20347
Cytochrome P450 2E10101
Macrophage colony-stimulating factor 1 receptor0246
ATP-dependent translocase ABCB10428
Proto-oncogene tyrosine-protein kinase ROS0044
Tyrosine-protein kinase Fgr0044
Quinolone resistance protein NorA0101
Wee1-like protein kinase 20044
Uncharacterized serine/threonine-protein kinase SBK30044
Cytochrome P450 2C80102
DNA topoisomerase 2-alpha0055
Myosin light chain kinase, smooth muscle0033
Insulin receptor-related protein0044
Interferon-induced, double-stranded RNA-activated protein kinase0044
Serine/threonine-protein kinase MAK0044
Cyclin-dependent kinase 11B0044
Ephrin type-A receptor 10055
Fibroblast growth factor receptor 20145
Receptor tyrosine-protein kinase erbB-30145
Fibroblast growth factor receptor 40145
Fibroblast growth factor receptor 30145
Sodium-dependent dopamine transporter0101
Protein kinase C eta type0055
Cruzipain0101
Activin receptor type-2A0044
Ephrin type-A receptor 80044
Leukocyte tyrosine kinase receptor0044
Mitogen-activated protein kinase 40044
G protein-coupled receptor kinase 40044
Prostaglandin G/H synthase 20044
Tyrosine-protein kinase receptor Tie-10044
Serine/threonine-protein kinase receptor R30044
Mitogen-activated protein kinase kinase kinase 80101
Megakaryocyte-associated tyrosine-protein kinase0044
Tyrosine-protein kinase TXK0044
G protein-coupled receptor kinase 60055
Dual specificity mitogen-activated protein kinase kinase 40044
Cyclin-dependent kinase 80145
Tyrosine-protein kinase Blk0044
Cytoplasmic tyrosine-protein kinase BMX0044
cAMP-dependent protein kinase catalytic subunit PRKX0044
Serine/threonine-protein kinase Nek40044
Tyrosine-protein kinase JAK30145
Death-associated protein kinase 10044
Mitogen-activated protein kinase 120044
Ephrin type-B receptor 10044
Beta-secretase 10101
Hormonally up-regulated neu tumor-associated kinase0044
Serine/threonine-protein kinase SIK10044
Receptor-interacting serine/threonine-protein kinase 40044
Cell division control protein 2 homolog0044
Calcium-dependent protein kinase 10044
Tubulin alpha-1A chain0033
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0044
SRSF protein kinase 20044
Mitogen-activated protein kinase kinase kinase 90044
Serine/threonine-protein kinase PknB0044
Cyclin-dependent kinase-like 10044
Synaptic vesicular amine transporter0101
Protein kinase C epsilon type0156
Mitogen-activated protein kinase kinase kinase 100044
Transcription factor p650101
Tyrosine-protein kinase receptor TYRO30044
Cyclin-dependent kinase 180044
Tyrosine-protein kinase ITK/TSK0044
Myotonin-protein kinase0044
Mitogen-activated protein kinase kinase kinase 120044
Tyrosine-protein kinase Mer0145
Serine/threonine-protein kinase PAK 10044
cGMP-dependent protein kinase 20044
Serine/threonine-protein kinase PRP4 homolog0044
Receptor-interacting serine/threonine-protein kinase 10145
Calcium/calmodulin-dependent protein kinase type II subunit beta0044
Calcium/calmodulin-dependent protein kinase type 10044
Serine/threonine-protein kinase D10055
Serine/threonine-protein kinase 380044
Receptor tyrosine-protein kinase erbB-40145
Ribosomal protein S6 kinase alpha-20044
Dual specificity testis-specific protein kinase 10055
Rhodopsin kinase GRK10044
NT-3 growth factor receptor0044
BDNF/NT-3 growth factors receptor0044
Mitogen-activated protein kinase 60044
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0044
Uncharacterized aarF domain-containing protein kinase 50033
Serine/threonine-protein kinase ULK30011
Serine/threonine-protein kinase SBK10044
Mitogen-activated protein kinase kinase kinase 190044
Serine/threonine-protein kinase TNNI3K0145
Serine/threonine-protein kinase Nek50044
Serine/threonine-protein kinase N30055
Dual serine/threonine and tyrosine protein kinase0044
Mitogen-activated protein kinase kinase kinase 150044
Serine/threonine-protein kinase tousled-like 20044
Serine/threonine-protein kinase 32C0044
Serine/threonine-protein kinase VRK20044
Myosin light chain kinase family member 40044
Homeodomain-interacting protein kinase 10145
Calcium/calmodulin-dependent protein kinase type 1D0044
Cyclin-dependent kinase-like 30044
Serine/threonine-protein kinase BRSK20044
Serine/threonine-protein kinase NIM10044
Serine/threonine-protein kinase ULK20044
Misshapen-like kinase 10055
Serine/threonine-protein kinase DCLK20044
Calcium/calmodulin-dependent protein kinase kinase 10044
Casein kinase I isoform alpha-like0044
Homeodomain-interacting protein kinase 40145
Myosin-IIIa0044
Ankyrin repeat and protein kinase domain-containing protein 10044
Serine/threonine-protein kinase Nek110044
Serine/threonine-protein kinase BRSK10044
Serine/threonine-protein kinase 350044
Rhodopsin kinase GRK70044
Serine/threonine-protein kinase 32A0044
Myosin-IIIb0044
Dual specificity tyrosine-phosphorylation-regulated kinase 20044
Cyclin-dependent kinase-like 20044
Serine/threonine-protein kinase Sgk30044
Atypical kinase COQ8B, mitochondrial0044
Calcium/calmodulin-dependent protein kinase type 1G0044
Cyclin-dependent kinase 150044
PAS domain-containing serine/threonine-protein kinase0055
SRSF protein kinase 10044
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0044
Serine/threonine-protein kinase RIO10044
MAP kinase-interacting serine/threonine-protein kinase 10044
Serine/threonine-protein kinase RIO20044
Cyclin-dependent kinase 190145
Transient receptor potential cation channel subfamily M member 60044
Testis-specific serine/threonine-protein kinase 10044
Serine/threonine-protein kinase 330044
Serine/threonine-protein kinase DCLK30044
Myosin light chain kinase 2, skeletal/cardiac muscle0044
Homeodomain-interacting protein kinase 20145
Tyrosine-protein kinase Srms0044
Homeodomain-interacting protein kinase 30145
MAP kinase-interacting serine/threonine-protein kinase 20145
Serine/threonine-protein kinase Nek60044
SNF-related serine/threonine-protein kinase0044
Serine/threonine-protein kinase LATS20044
Serine/threonine-protein kinase 360044
Serine/threonine-protein kinase 32B0044
Serine/threonine-protein kinase MARK10044
Serine/threonine-protein kinase pim-20044
Serine/threonine-protein kinase PAK 50044
eIF-2-alpha kinase GCN20044
Phosphatidylinositol 4-kinase beta0044
Serine/threonine-protein kinase 17A0044
STE20/SPS1-related proline-alanine-rich protein kinase0044
Ephrin type-A receptor 60044
Death-associated protein kinase 20044
Serine/threonine-protein kinase tousled-like 10044
Broad substrate specificity ATP-binding cassette transporter ABCG20516
SRSF protein kinase 30044
Cyclin-dependent kinase 11A0044
Aurora kinase C0044
Calcium/calmodulin-dependent protein kinase type II subunit alpha0044
Serine/threonine-protein kinase 38-like0055
Microtubule-associated serine/threonine-protein kinase 10044
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0218
Glutamate receptor ionotropic, NMDA 2B0218
Glutamate receptor ionotropic, NMDA 2C0218
Large neutral amino acids transporter small subunit 109010
Glutamate receptor ionotropic, NMDA 2D0218
Glutamate receptor ionotropic, NMDA 3B0218
Serine racemase0101
Olfactory receptor 51E20022
Glutamate receptor ionotropic, NMDA 3A0218
Sodium- and chloride-dependent glycine transporter 20101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0102
Carbonic anhydrase 120106
Solute carrier family 22 member 30203
Plasma kallikrein0005
Carbonic anhydrase 30005
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40005
Carbonic anhydrase 60005
Histamine H2 receptor0123
Adenosine receptor A10004
Adenosine receptor A2a0004
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0106
Histamine H1 receptor0224
Carbonic anhydrase0005
Carbonic anhydrase 70106
Carbonic anhydrase0006
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0202
Carbonic anhydrase 90207
Carbonic anhydrase 0006
Carbonic anhydrase-like protein, putative0005
Carbonic anhydrase0006
Carbonic anhydrase0006
Solute carrier family 22 member 10102
Carbonic anhydrase 0006
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130003
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 150005
Carbonic anhydrase 130004
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Carbonic anhydrase 140005
Carbonic anhydrase 5B, mitochondrial0005
Histamine H3 receptor0123
Chain A, HISTIDINE-BINDING PROTEIN0011
Histidine-binding periplasmic protein0011
ClpP2002
lysosomal alpha-glucosidase preproprotein2002
Solute carrier family 22 member 80001
hypothetical protein, conserved1001
neuropeptide S receptor isoform A3003
Uracil nucleotide/cysteinyl leukotriene receptor0202
DNA repair protein RAD52 homolog isoform a0001
Cytochrome P450 3A50203
Peptide deformylase 1A, chloroplastic/mitochondrial0101
Peptide deformylase 0101
Beta-1 adrenergic receptor 0022
Aldo-keto reductase family 1 member B10404
Beta-1 adrenergic receptor0426
Beta-3 adrenergic receptor0022
5-hydroxytryptamine receptor 1A0314
Sodium-dependent noradrenaline transporter 0415
5-hydroxytryptamine receptor 1B0202
Beta-2 adrenergic receptor0022
Sigma non-opioid intracellular receptor 10202
Heparanase0011
Nuclear receptor coactivator 40101
MAP kinase-activated protein kinase 30022
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Intestinal-type alkaline phosphatase0303
Phospholipase A-2-activating protein0303
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0303
Beta-1 adrenergic receptor0101
Cytochrome P450 2J20202
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Polyphenol oxidase 20102
Cholesteryl ester transfer protein0101
D-amino-acid oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
Multidrug and toxin extrusion protein 10101
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Chain A, NAD-dependent deacetylase0101
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Poly [ADP-ribose] polymerase 10101
Tissue factor0101
NAD-dependent protein deacetylase HST20101
Fatty-acid amide hydrolase 10303
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
NAD-dependent protein deacetylase 0101
Platelet-derived growth factor receptor beta0202
Platelet-derived growth factor receptor alpha 0101
Vascular endothelial growth factor receptor 20202
Choline-phosphate cytidylyltransferase A0022
Cyclin-dependent kinase 100011
Mcl-10101
pyruvate kinase PKM isoform a1001
serine/threonine-protein kinase PLK12002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
UDP-glucuronosyltransferase 2B70102
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1-60101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40102
Bombesin receptor subtype-30011
UDP-glucuronosyltransferase 2B10 0101
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 20001
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
WD repeat-containing protein 50101
Glutathione S-transferase omega-10101
Histone-lysine N-methyltransferase 2A0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Cytosolic endo-beta-N-acetylglucosaminidase0101
Muscarinic acetylcholine receptor0101
TPA: protein transporter TIM100101
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
POsterior Segregation0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30101
Zinc finger protein mex-50011
BZLF20101
pyruvate kinase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
atrial natriuretic peptide receptor 2 precursor1001
pyruvate kinase PKM isoform b1001
Luciferin 4-monooxygenase0112
Ornithine decarboxylase1001
Dual specificity mitogen-activated protein kinase kinase 2 0101
Dual specificity mitogen-activated protein kinase kinase 1 0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0011
Gastrin/cholecystokinin type B receptor0112
D0101
D(3) dopamine receptor0101
D(1B) dopamine receptor0101
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 70101
thyroid hormone receptor beta isoform a2002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0003
Large neutral amino acids transporter small subunit 1 0101
Monocarboxylate transporter 100003
Growth factor receptor-bound protein 20001
Tyrosine-protein phosphatase non-receptor type 110001
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Cholinesterase0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
melanocortin receptor 40112
Tyrosine-protein kinase ABL10101
5-hydroxytryptamine receptor 1A0101
G1/S-specific cyclin-D10101
Cyclin-C0112
Serine/threonine-protein kinase B-raf 0101
Delta-type opioid receptor0011
Bifunctional epoxide hydrolase 20101
5-hydroxytryptamine receptor 70101
Vascular endothelial growth factor receptor 30101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60101
Protein delta homolog 10011
Vascular endothelial growth factor receptor 20101
Dual specificity testis-specific protein kinase 20011
Poly [ADP-ribose] polymerase tankyrase-20011
RuvB-like 20112
RuvB-like 10101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
Nuclear receptor subfamily 1 group I member 20022
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Solute carrier organic anion transporter family member 1B10102
polyadenylate-binding protein 10101
Protein kinase C gamma type0112
Ras guanyl-releasing protein 30011
Thymidine phosphorylase0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 32002
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Myeloperoxidase0101
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Urease subunit alpha0101
Urease subunit beta0101
Chain A, Arginase 10101
atrial natriuretic peptide receptor 1 precursor1001
Histone deacetylase 30101
Histone deacetylase 40101
Histone deacetylase 10101
Tubulin beta-2B chain0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]