Refractory Depression

Synonym
Treatment Resistant Depression
Therapy-Resistant Depression
Refractory Depression

Excerpt	Reference
"Treatment-refractory depression is a devastating condition with significant morbidity, mortality, and societal cost."	( Baca, CA; Brent, DA; Diler, R; Dobrowolski, SK; Finegold, DN; Hughes, M; Hyland, K; Kassiff, S; Martin, P; McKain, BW; Naviaux, RK; Pan, LA; Pasquino, M; Perel, J; Peters, DG; Rengasamy, M; Segreti, AM; Steinfeld, R; Vockley, J; Walano, N; Zimmer, T, 2017)
"Treatment resistant depression is associated with a poorer prognosis and higher mortality rates."	( Attenburrow, MJ; Cipriani, A; Cleare, AJ; Dietch, D; Geddes, J; Goldsmith, K; Holland, R; Hutchinson, J; Marwood, L; McAllister-Williams, RH; Nair, R; Pickles, A; Romeo, R; Taylor, R; Young, AH, 2017)
"Treatment resistant depression is a significant source of morbidity and mortality."	( Agapoff, JR; Goebert, D; Lu, BY; Olson, DJ; Roller, A; Williams, SR, 2020)
"Refractory depression is a devastating condition with significant morbidity, mortality, and societal cost."	( Brent, DA; Finegold, DN; Hughes, M; Hyland, K; Naviaux, RK; Pan, LA; Peters, DG; Segreti, AM; Shaw, A; Vockley, J; Wrobleski, J, 2023)

Excerpt	Reference
"Treatment-refractory depression properties include increased serotonin and norepinephrine availability, PCP, NMDR-2B, presynaptic alpha-2 antagonism, and the multiplicity of other antidepressant receptor mechanisms."	( Lauterbach, EC, 2012)
"Patients with medication-refractory depression received an average of 10 treatments of bifrontal ECT (n = 20) or isoflurane (n = 8) over 3 weeks."	( Bushnell, L; Cahalan, MK; Chelune, GJ; Clark, E; Iacob, E; Landvatter, JD; Light, AR; Light, KC; Saccoman, M; Sakata, D; Smith, KW; Suchy, Y; Tadler, SC; Weeks, HR; White, AT, 2013)
"Treatment-refractory depression is a devastating condition with significant morbidity, mortality, and societal cost."	( Baca, CA; Brent, DA; Diler, R; Dobrowolski, SK; Finegold, DN; Hughes, M; Hyland, K; Kassiff, S; Martin, P; McKain, BW; Naviaux, RK; Pan, LA; Pasquino, M; Perel, J; Peters, DG; Rengasamy, M; Segreti, AM; Steinfeld, R; Vockley, J; Walano, N; Zimmer, T, 2017)
"We present a case of treatment refractory depression with recent suicide attempt and active suicidal ideations who was on an Opioid partial agonist, Buprenorphine, for management of pain."	( Hosanagar, A; LeBlanc, A; Schmale, A, 2021)
"Ketamine has emerged as a promising new treatment for treatment resistant depression (TRD)."	( Cao, B; Di Vincenzo, JD; Gill, H; Ho, R; Lin, K; Lipsitz, O; Lui, LMW; McIntyre, RS; Ng, J; Rodrigues, NB; Rosenblat, JD; Siegel, A; Teopiz, KM, 2021)
"Esketamine is a novel treatment for treatment resistant depression (TRD) and was approved by the FDA in early 2019."	( Cook, J; Halaris, A, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	485 (53.47)	28.8240
2020's	422 (46.53)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	4	0
5-hydroxytryptophan	low	1	0
carbamates	low	1	0
carnitine	medium	2	1
choline	low	1	0
salicylic acid	low	1	0
bupropion	medium	16	6
glycine	medium	1	1
histamine	low	1	0
indoleacetic acid	low	1	0
kynurenine	medium	12	2
melatonin	low	2	0
niacin	low	1	0
nitrous oxide	medium	6	3
orotic acid	medium	1	1
quinolinic acid	low	1	0
urea	low	1	0
7-hydroxy-2-n,n-dipropylaminotetralin	low	1	0
n-methyl-3,4-methylenedioxyamphetamine	low	2	0
hydroxyindoleacetic acid	low	1	0
dan 2163	low	1	0
amitriptyline	low	3	0
buspirone	medium	3	2
caffeine	low	1	0
celecoxib	medium	2	2
citalopram	medium	32	18
clonidine	medium	2	1
desipramine	low	4	0
diazoxide	medium	1	1
valproic acid	medium	7	3
ethosuximide	medium	1	1
fluoxetine	medium	15	4
phenelzine	medium	2	1
imipramine	low	7	0
isocarboxazid	low	1	0
isoflurane	medium	2	1
ketamine	medium	542	137
kynurenic acid	low	1	0
lamotrigine	medium	9	2
lorazepam	low	1	0
mecamylamine	medium	1	1
methadone	low	1	0
methylphenidate	low	2	0
metyrapone	medium	2	2
mianserin	low	1	0
midazolam	medium	18	16
mirtazapine	medium	7	3
mitoxantrone	medium	1	1
moclobemide	low	1	0
apnea	low	1	0
nimodipine	low	1	0
nitrazepam	low	1	0
nortriptyline	medium	4	2
pindolol	low	1	0
pioglitazone	low	1	0
propofol	medium	7	3
riluzole	medium	5	5
risperidone	medium	3	2
sevoflurane	low	1	0
vorinostat	low	1	0
succinylcholine	low	2	0
tipepidine	medium	1	1
trazodone	low	1	0
tyramine	low	2	0
urapidil	low	1	0
corticosterone	low	4	0
prednisolone	medium	1	1
lysergic acid diethylamide	low	2	0
dextroamphetamine	medium	3	1
spironolactone	medium	1	1
aldosterone	low	1	0
dehydroepiandrosterone	low	1	0
serine	medium	1	1
aspartic acid	medium	3	1
glutamine	medium	2	1
sucrose	low	2	0
carbostyril	medium	15	6
phenylethyl alcohol	medium	2	1
n,n-dimethyltryptamine	low	1	0
methionine	low	1	0
phenylalanine	low	1	0
cycloserine	medium	3	2
cytarabine	medium	1	1
ornithine	low	1	0
valine	low	2	0
tryptophan	low	5	0
arginine	low	1	0
quinoxalines	low	1	0
xanthenes	low	1	0
cyclohexanol	medium	14	7
thiophenes	medium	9	5
pregnenolone	low	1	0
methohexital	medium	2	1
methysergide	low	1	0
citrulline	low	1	0
psilocybin	medium	35	7
lithium carbonate	medium	7	1
glycopyrrolate	low	1	0
acetylcysteine	medium	3	1
dehydroepiandrosterone sulfate	medium	2	1
canrenone	medium	1	1
s,n,n'-tripropylthiocarbamate	low	4	0
tranylcypromine	medium	7	1
n-methylaspartate	low	1	0
magnesium sulfate	medium	1	1
selegiline	low	1	0
pregnanolone	medium	4	1
8-bromo cyclic adenosine monophosphate	low	1	0
glutamic acid	medium	15	3
s-adenosylmethionine	medium	2	1
paroxetine	medium	11	7
aripiprazole	medium	33	13
duloxetine hydrochloride	medium	7	5
venlafaxine hydrochloride	medium	36	16
caffeine, sodium benzoate drug combination	low	1	0
n-acetylaspartic acid	medium	3	1
milnacipran	low	1	0
fluorodeoxyglucose f18	medium	8	4
sertraline	medium	12	8
tianeptine	medium	2	2
s20098	medium	4	2
nicotine	low	1	0
brexanolone	low	3	0
vitamin b 6	low	1	0
pramipexole	medium	6	2
ezogabine	low	1	0
norketamine	medium	4	3
4-chlorokynurenine	medium	1	1
esketamine	medium	151	29
alpha-fluoromethylhistidine	low	1	0
s-adenosylhomocysteine	medium	1	1
oxytocin	medium	2	1
quinidine	medium	2	1
rocuronium	low	1	0
betadex	low	3	0
cocaine	low	1	0
isomethyleugenol	low	1	0
cannabidiol	low	1	0
buprenorphine	medium	13	2
etomidate	low	2	0
thiopental	low	2	0
lithium	medium	25	6
u-50488	low	1	0
magnesium orotate	medium	1	1
ssr 125543a	low	1	0
dothiepin hydrochloride	low	1	0
4-hydroxy-2-nonenal	medium	1	1
dexmedetomidine	low	1	0
lysophosphatidylcholines	medium	1	1
mdl 100907	medium	2	1
fluvoxamine	medium	2	1
naltrexone	medium	6	2
dextromethorphan	medium	5	1
dextrorphan	low	1	0
cysteine	low	1	0
dizocilpine maleate	low	1	0
ro 25-6981	low	2	0
ganaxolone	medium	1	1
fpl 15896ar	medium	3	2
desvenlafaxine succinate	medium	2	1
dextromethorphan - quinidine combination	low	1	0
vortioxetine	medium	4	1
ly 341495	low	1	0
cariprazine	medium	1	1
lurasidone hydrochloride	low	3	0
losartan potassium	medium	8	8
scopolamine hydrobromide	low	2	0
brexpiprazole	medium	7	4
glyx-13 peptide	low	2	0
jaw	low	1	0
nad	low	1	0
5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	low	1	0
quetiapine fumarate	medium	9	4
ly2456302	low	1	0
piperidines	medium	4	2
bryostatin 1	low	1	0
interleukin-8	low	1	0
minocycline	medium	8	5
grn-529	low	1	0
lysophosphatidylethanolamine	medium	1	1
glucagon-like peptide 2	low	1	0
acyclovir	low	1	0
guanosine	low	1	0
sapropterin	low	2	0
folic acid	low	3	0
neopterin	low	1	0
clozapine	low	2	0
valacyclovir	low	1	0
olanzapine	medium	7	2
5-methyltetrahydrofolate	medium	6	1
olanzapine-fluoxetine combination	medium	3	2
technetium tc 99m bicisate	low	1	0

Protein Targets (1,377)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Microtubule-associated protein tau	11	0	0	11
vitamin D3 receptor isoform VDRA	12	0	0	12
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
dopamine D1 receptor	7	0	0	7
thioredoxin reductase	36	0	0	36
arylsulfatase A	26	0	0	26
euchromatic histone-lysine N-methyltransferase 2	55	0	0	55
D(1A) dopamine receptor	26	0	0	26
D(2) dopamine receptor	0	33	6	42
D(3) dopamine receptor	0	12	2	14
5-hydroxytryptamine receptor 1A	0	33	3	36
Sodium-dependent dopamine transporter	0	21	2	23
D(3) dopamine receptor	0	27	5	35
Histamine H2 receptor	17	6	1	29
D(2) dopamine receptor	0	21	1	22
Histamine H3 receptor	0	2	1	4
Sigma non-opioid intracellular receptor 1	0	9	1	10
ATP-dependent phosphofructokinase	26	0	0	26
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
acetylcholinesterase	15	0	0	15
15-lipoxygenase, partial	7	0	0	7
pregnane X receptor	5	0	0	5
phosphopantetheinyl transferase	19	0	0	19
RAR-related orphan receptor gamma	29	0	0	29
USP1 protein, partial	20	0	0	20
NFKB1 protein, partial	11	0	0	11
Thrombopoietin	5	0	0	5
AR protein	47	0	0	47
regulator of G-protein signaling 4	25	0	0	25
glucocorticoid receptor [Homo sapiens]	36	0	0	36
retinoic acid nuclear receptor alpha variant 1	33	0	0	33
retinoid X nuclear receptor alpha	22	0	0	22
farnesoid X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	50	0	0	50
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
Bloom syndrome protein isoform 1	16	0	0	16
thyroid hormone receptor beta isoform a	12	0	0	12
thyroid hormone receptor beta isoform 2	34	0	0	34
heat shock protein beta-1	8	0	0	8
flap endonuclease 1	9	0	0	9
geminin	41	0	0	41
peripheral myelin protein 22	25	0	0	25
survival motor neuron protein isoform d	12	0	0	12
muscarinic acetylcholine receptor M1	27	0	0	27
Histone deacetylase 3	0	7	1	11
Solute carrier family 22 member 6	0	2	0	3
Histone deacetylase 4	0	7	1	11
Guanine nucleotide-binding protein G	4	0	0	4
Histone deacetylase 1	0	7	2	12
Histone deacetylase 7	0	7	2	12
Histone deacetylase 2	0	7	2	12
Polyamine deacetylase HDAC10	0	7	1	11
Histone deacetylase 11	0	7	1	11
Ataxin-2	25	0	0	25
Histone deacetylase 8	0	7	2	12
Histone deacetylase 6	0	7	2	12
Histone deacetylase 9	0	7	1	11
Histone deacetylase 5	0	7	1	11
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, Ferritin light chain	11	0	0	11
Thymidine kinase	0	1	0	1
GLS protein	33	0	0	33
TDP1 protein	45	0	0	45
Smad3	12	0	0	12
thyroid stimulating hormone receptor	25	0	0	25
EWS/FLI fusion protein	24	0	0	24
activating transcription factor 6	10	0	0	10
Histone H2A.x	10	0	0	10
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
lamin isoform A-delta10	38	0	0	38
Solute carrier family 22 member 1	0	17	0	25
ATP-binding cassette sub-family C member 3	0	37	0	37
Multidrug resistance-associated protein 4	0	38	0	40
Bile salt export pump	0	7	0	7
Bile salt export pump	0	55	0	55
Purine nucleoside phosphorylase	0	1	0	2
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	19	1	21
Cytochrome P450 2J2	0	11	0	12
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	34	0	34
Thymidine kinase	0	2	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	12
Sex hormone-binding globulin	0	0	4	4
Corticosteroid-binding globulin	0	5	0	5
Mineralocorticoid receptor	0	5	4	10
Androgen receptor	0	8	0	9
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	37	0	0	37
cytochrome P450 2D6	39	0	0	39
cytochrome P450 2D6 isoform 1	19	0	0	19
chromobox protein homolog 1	32	0	0	32
atrial natriuretic peptide receptor 2 precursor	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	27	0	0	27
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Voltage-dependent L-type calcium channel subunit alpha-1F	0	9	0	9
5-hydroxytryptamine receptor 4	0	26	0	26
Albumin	0	0	5	5
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	26	0	26
Muscarinic acetylcholine receptor M2	0	20	1	21
Muscarinic acetylcholine receptor M4	0	20	1	21
Muscarinic acetylcholine receptor M1	0	7	1	8
Muscarinic acetylcholine receptor M3	0	5	1	6
Muscarinic acetylcholine receptor M4	0	6	1	7
5-hydroxytryptamine receptor 2C	0	23	3	26
Muscarinic acetylcholine receptor M5	0	7	1	8
Muscarinic acetylcholine receptor M5	0	19	0	19
Alpha-2A adrenergic receptor	0	28	2	31
Muscarinic acetylcholine receptor M2	0	7	2	9
Muscarinic acetylcholine receptor M1	0	22	2	24
Angiotensin-converting enzyme	0	19	0	19
5-hydroxytryptamine receptor 2A	0	26	5	31
Alpha-2B adrenergic receptor	0	30	1	32
Alpha-2C adrenergic receptor	0	25	2	28
Muscarinic acetylcholine receptor M3	0	21	1	22
D(1A) dopamine receptor	0	21	1	24
D(1B) dopamine receptor	0	6	0	7
UDP-glucuronosyltransferase 1A4	0	3	1	9
Sodium-dependent noradrenaline transporter	0	42	6	48
Histamine H2 receptor	0	12	4	16
Alpha-1D adrenergic receptor	0	23	1	25
5-hydroxytryptamine receptor 2A	0	35	5	42
5-hydroxytryptamine receptor 2C	0	38	2	40
5-hydroxytryptamine receptor 1B	0	23	3	26
5-hydroxytryptamine receptor 1D	0	11	3	14
5-hydroxytryptamine receptor 1F	0	11	3	14
5-hydroxytryptamine receptor 2B	0	21	4	25
5-hydroxytryptamine receptor 6	0	6	3	9
Histamine H1 receptor	0	9	1	10
Sodium-dependent serotonin transporter	0	47	7	54
5-hydroxytryptamine receptor 7	0	11	3	14
5-hydroxytryptamine receptor 5A	0	6	3	9
5-hydroxytryptamine receptor 5B	0	6	3	9
Histamine H1 receptor	0	26	6	34
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	4	0	5
UDP-glucuronosyltransferase 1A3	0	0	1	3
5-hydroxytryptamine receptor 3A	0	9	3	12
5-hydroxytryptamine receptor 2B	0	30	2	32
Alpha-1A adrenergic receptor	0	29	4	33
D(1A) dopamine receptor	8	0	0	8
5-hydroxytryptamine receptor 6	0	20	0	22
5-hydroxytryptamine receptor 7	0	6	0	6
Voltage-dependent N-type calcium channel subunit alpha-1B	0	5	0	5
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	9	0	9
Sodium-dependent dopamine transporter	0	33	5	38
Potassium voltage-gated channel subfamily H member 2	0	37	0	37
Voltage-dependent L-type calcium channel subunit alpha-1S	0	9	0	9
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
Sodium channel protein type 5 subunit alpha	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	9	1	10
5-hydroxytryptamine receptor 4	0	6	3	9
Nuclear receptor subfamily 3 group C member 3	0	19	0	19
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	23	0	23
5-hydroxytryptamine receptor 3B	0	9	3	12
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	9	2	11
Sodium channel protein type 10 subunit alpha	0	3	0	3
ATAD5 protein, partial	16	0	0	16
estrogen-related nuclear receptor alpha	39	0	0	39
neuropeptide S receptor isoform A	7	0	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	6	0	0	6
cytochrome P450 2C19 precursor	14	0	0	14
DNA polymerase iota isoform a (long)	14	0	0	14
lethal factor (plasmid)	10	0	0	10
Cytochrome P450 3A4	0	18	0	22
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	1	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
5-hydroxytryptamine receptor 3E	0	6	0	6
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
SMAD family member 2	6	0	0	6
Fumarate hydratase	8	0	0	8
PPM1D protein	8	0	0	8
SMAD family member 3	6	0	0	6
GLI family zinc finger 3	36	0	0	36
estrogen receptor 2 (ER beta)	17	0	0	17
nuclear receptor subfamily 1, group I, member 3	27	0	0	27
progesterone receptor	21	0	0	21
pregnane X nuclear receptor	29	0	0	29
G	21	0	0	21
polyprotein	8	0	0	8
67.9K protein	10	0	0	10
peroxisome proliferator-activated receptor delta	11	0	0	11
peroxisome proliferator activated receptor gamma	16	0	0	16
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
thyroid stimulating hormone receptor	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
lysosomal alpha-glucosidase preproprotein	6	0	0	6
mu-type opioid receptor isoform MOR-1	0	0	2	2
potassium voltage-gated channel subfamily H member 2 isoform d	21	0	0	21
transcriptional regulator ERG isoform 3	4	0	0	4
nuclear receptor ROR-gamma isoform 1	9	0	0	9
histone acetyltransferase KAT2A isoform 1	12	0	0	12
5-hydroxytryptamine receptor 2A	0	0	2	2
Solute carrier family 22 member 2	0	7	0	9
5-hydroxytryptamine receptor 3A	0	2	1	3
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
5-hydroxytryptamine receptor 3B	0	6	0	6
Interferon beta	28	0	0	28
HLA class I histocompatibility antigen, B alpha chain	21	0	0	21
Cellular tumor antigen p53	23	0	0	23
ATP-dependent translocase ABCB1	0	10	0	14
5-hydroxytryptamine receptor 1A	0	21	14	35
Neuronal acetylcholine receptor subunit alpha-4	3	4	3	11
Neuronal acetylcholine receptor subunit beta-2	3	4	3	11
Alpha-1B adrenergic receptor	0	26	3	29
D	0	14	0	14
Glutamate receptor 2	15	5	1	24
D(4) dopamine receptor	0	13	1	16
Alpha-1D adrenergic receptor	0	23	3	26
D(4) dopamine receptor	0	9	0	9
Histamine H1 receptor	0	5	3	8
5-hydroxytryptamine receptor 7	0	15	0	15
Alpha-1A adrenergic receptor	0	12	1	14
Alpha-1B adrenergic receptor	0	6	1	8
5-hydroxytryptamine receptor 3A	0	10	1	11
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Spike glycoprotein	25	0	1	26
Inositol monophosphatase 1	11	0	0	11
5-hydroxytryptamine receptor 3D	0	6	0	6
Multidrug and toxin extrusion protein 2	0	5	0	5
5-hydroxytryptamine receptor 3C	0	6	0	6
Inositol hexakisphosphate kinase 1	21	0	0	21
Multidrug and toxin extrusion protein 1	0	9	0	9
cytochrome P450 2C9, partial	21	0	0	21
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	7	0	13
Carbonic anhydrase 2	0	9	1	17
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	3	0	5
Glutamate receptor ionotropic, NMDA 1	0	19	4	28
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	18	4	27
Glutamate receptor ionotropic, NMDA 2B	0	19	4	28
Glutamate receptor ionotropic, NMDA 2C	0	18	4	27
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	6
Glutamate receptor ionotropic, NMDA 2D	0	18	4	27
Glutamate receptor ionotropic, NMDA 3B	0	18	4	27
Carbonic anhydrase 4	0	2	0	4
Glutamate receptor ionotropic, NMDA 3A	0	18	4	27
Chain A, D-MALTODEXTRIN BINDING PROTEIN	0	0	1	1
Chain A, Limit Dextrinase	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain B, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, Alpha-hemolysin	0	0	1	1
Chain B, Alpha-hemolysin	0	0	1	1
Chain C, Alpha-hemolysin	0	0	1	1
Chain D, Alpha-hemolysin	0	0	1	1
Chain E, Alpha-hemolysin	0	0	1	1
Chain F, Alpha-hemolysin	0	0	1	1
Chain G, Alpha-hemolysin	0	0	1	1
Gamma-aminobutyric acid	0	0	3	3
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit pi	22	9	1	32
Gamma-aminobutyric acid receptor subunit delta	0	6	1	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	5
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	5
Glucose-6-phosphate 1-dehydrogenase	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	9	5	14
Gamma-aminobutyric acid receptor subunit beta-1	22	9	1	32
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	3	3
Gamma-aminobutyric acid receptor subunit beta-1	0	7	4	11
Gamma-aminobutyric acid receptor subunit delta	22	9	1	32
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	5	13
Gamma-aminobutyric acid receptor subunit gamma-2	22	9	2	33
Gamma-aminobutyric acid receptor subunit alpha-5	22	9	1	32
Gamma-aminobutyric acid receptor subunit alpha-3	22	9	1	32
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	3	3
Gamma-aminobutyric acid receptor subunit delta	0	0	3	3
Gamma-aminobutyric acid receptor subunit gamma-1	22	9	1	32
Gamma-aminobutyric acid receptor subunit alpha-2	22	9	1	32
Sodium- and chloride-dependent GABA transporter 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	3	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	3	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	3	3
Gamma-aminobutyric acid receptor subunit alpha-4	22	9	1	32
Gamma-aminobutyric acid receptor subunit beta-3	0	8	4	12
Gamma-aminobutyric acid receptor subunit gamma-3	22	9	1	32
Gamma-aminobutyric acid receptor subunit alpha-6	22	9	1	32
Gamma-aminobutyric acid receptor subunit alpha-5	0	7	4	11
Sodium- and chloride-dependent GABA transporter 2	0	5	0	5
Sodium- and chloride-dependent GABA transporter 3	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	7	4	11
Gamma-aminobutyric acid receptor subunit alpha-2	0	7	5	12
Gamma-aminobutyric acid receptor subunit beta-2	0	8	5	13
Sodium- and chloride-dependent betaine transporter	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	7	4	11
Gamma-aminobutyric acid receptor subunit beta-1	0	0	3	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	3	5
Gamma-aminobutyric acid receptor subunit alpha-1	22	10	2	34
Gamma-aminobutyric acid receptor subunit beta-3	22	9	1	32
Gamma-aminobutyric acid receptor subunit beta-3	0	0	3	3
Gamma-aminobutyric acid receptor subunit beta-2	22	9	2	33
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	7	4	11
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	3	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit pi	0	0	3	3
GABA theta subunit	22	9	1	32
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	3	3
Gamma-aminobutyric acid receptor subunit epsilon	22	9	1	32
Gamma-aminobutyric acid receptor subunit theta	0	0	3	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	3	3
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
Kappa-type opioid receptor	0	7	0	8
Kappa-type opioid receptor	0	8	3	16
Acetylcholine receptor subunit alpha	0	3	2	5
Acetylcholine receptor subunit gamma	0	3	2	5
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	3	2	5
UDP-glucuronosyltransferase 2B7	0	4	1	6
Neuronal acetylcholine receptor subunit beta-2	0	5	1	8
UDP-glucuronosyltransferase 1-6	0	3	1	5
Cytochrome P450 2B6	0	3	0	5
UDP-glucuronosyltransferase 1A1	0	4	1	7
Neuronal acetylcholine receptor subunit beta-4	0	4	1	7
Neuronal acetylcholine receptor subunit alpha-3	0	4	1	5
Cytochrome P450 2C19	0	13	0	15
UDP-glucuronosyltransferase 2B10	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	6	2	8
Neuronal acetylcholine receptor subunit alpha-4	0	4	1	7
Acetylcholine receptor subunit delta	0	3	2	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
cytochrome P450 2C9 precursor	11	0	0	11
cytochrome P450 3A4 isoform 1	22	0	0	22
Beta-2 adrenergic receptor	0	3	0	4
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	3	0	4
Alpha-2B adrenergic receptor	0	15	3	18
D(2) dopamine receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	15	3	18
Alpha-2A adrenergic receptor	0	15	3	18
D(1B) dopamine receptor	0	7	0	7
Beta-3 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
D	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
D	0	4	0	4
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
DNA polymerase beta	3	0	0	3
DNA polymerase kappa isoform 1	6	0	0	6
Potassium channel subfamily K member 2	0	1	2	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	4	0	4
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	1	1	2
Amine oxidase [flavin-containing] A	0	14	0	16
Acetylcholinesterase	0	8	0	8
Adenosine receptor A1	0	6	0	9
Amine oxidase [flavin-containing] B	0	16	1	19
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	1	4
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	3	1	8
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
Acetylcholinesterase	0	6	0	6
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 1A1	0	3	0	3
Cytochrome P450 1A2	0	6	0	7
Cytochrome P450 2C11	0	2	0	2
Cytochrome P450 2D6	0	23	0	27
Cytochrome P450 2A6	0	5	1	6
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 3A5	0	2	0	2
Cannabinoid receptor 1	0	3	0	4
Cytochrome P450 3A7	0	2	0	2
Caspase-1	0	0	1	1
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	8	4	15
Peroxisome proliferator-activated receptor gamma	0	2	3	6
Delta-type opioid receptor	0	8	3	14
Cholinesterase	0	4	0	4
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	4	0	4
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
glp-1 receptor, partial	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
Vpr	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	3	0	6
Carbonic anhydrase 3	0	3	0	6
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	3	0	6
Carbonic anhydrase 6	0	3	0	6
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Carbonic anhydrase 7	0	3	0	6
Carbonic anhydrase 9	0	5	1	9
Carbonic anhydrase 13	0	2	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	3	0	6
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	3	0	0	3
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
caspase 7, apoptosis-related cysteine protease	8	0	0	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	8	0	0	8
IDH1	10	0	0	10
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	3	0	0	3
interferon gamma precursor	0	0	0	2
prostaglandin E2 receptor EP2 subtype	0	0	0	1
caspase-3	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Procathepsin L	0	1	1	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Quinolone resistance protein NorA	0	2	0	2
Beta-3 adrenergic receptor	0	5	1	6
Calpain-2 catalytic subunit	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	5
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	22	4	27
Delta-type opioid receptor	0	7	1	10
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	8	1	9
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	5	1	7
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	1	0	4
Urotensin-2 receptor	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Carbonic anhydrase	0	1	0	5
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	7	2	10
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	9	0	9
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	1	0	5
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
ATPase family AAA domain-containing protein 5	11	0	0	11
Carbonic anhydrase 15	0	2	0	5
P2Y purinoceptor 12	0	1	0	1
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-2	0	3	3	7
Neuronal acetylcholine receptor subunit beta-3	0	3	3	7
Neuronal acetylcholine receptor subunit beta-4	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-5	0	3	3	7
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	3	3	7
Neuronal acetylcholine receptor subunit alpha-9	0	3	3	7
Neuronal acetylcholine receptor subunit alpha-7	0	3	3	7
Solute carrier family 22 member 1	0	11	0	15
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	3	3	7
Solute carrier family 22 member 2	0	9	0	12
NPC intracellular cholesterol transporter 1 precursor	8	0	0	8
Sodium-dependent noradrenaline transporter	0	4	0	4
Tryptophan 5-hydroxylase 1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	3	0	3
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	6	0	6
Transporter	0	24	1	26
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	7	0	8
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Nischarin	0	2	0	2
Nischarin	0	1	0	1
Luciferase	5	0	0	5
glucocerebrosidase	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
Adenylate cyclase type 1	0	1	0	1
peripheral myelin protein 22 isoform 1	9	0	0	9
mitogen-activated protein kinase 1	13	0	0	13
short transient receptor potential channel 6 isoform 1	0	0	1	1
M-phase phosphoprotein 8	10	0	0	10
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Calmodulin-1	0	1	0	1
Endothelin receptor type B	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
5-hydroxytryptamine receptor 3A	0	3	0	3
Endothelin receptor type B	0	2	0	2
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 5A	0	3	0	3
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Calmodulin	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Transporter	0	5	0	5
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	0	3
Adenylyl cyclase 7	0	1	0	1
Histamine H4 receptor	0	3	4	7
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	1	3	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
GALC protein	5	0	0	5
nonstructural protein 1	6	0	0	6
Solute carrier family 22 member 3	0	2	0	2
C-8 sterol isomerase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
aryl hydrocarbon receptor	16	0	0	16
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
D-alanine--D-alanine ligase	0	1	0	1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	4
endonuclease IV	5	0	0	5
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	1	0	2
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Deoxynucleoside kinase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Alpha-synuclein	5	1	0	6
TAR DNA-binding protein 43	6	1	0	7
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Steryl-sulfatase	0	1	0	2
Multidrug resistance-associated protein 1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
huntingtin isoform 2	5	0	0	5
Albumin	0	2	2	4
Solute carrier family 22 member 4	0	1	0	1
cellular tumor antigen p53 isoform a	6	0	0	6
Phenylethanolamine N-methyltransferase	0	3	0	3
Amine oxidase [flavin-containing] B	0	7	0	8
Amine oxidase [flavin-containing] B	0	5	0	5
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	3	3
Trace amine-associated receptor 1	0	0	3	3
Glutamate receptor ionotropic, NMDA 2D	0	8	0	8
Glutamate receptor ionotropic, NMDA 3B	0	8	0	8
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	4	1	5
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cytochrome P450 2D1	0	3	0	3
Cytochrome P450 2D26	0	3	0	3
Cytochrome P450 2D3	0	3	0	3
Taste receptor type 2 member 46	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	11	0	11
Glutamate receptor ionotropic, NMDA 2A	0	11	0	11
Glutamate receptor ionotropic, NMDA 2B	0	10	0	10
Glutamate receptor ionotropic, NMDA 2C	0	8	0	8
Cytochrome P450 2D4	0	3	0	3
Glutamate receptor ionotropic, NMDA 3A	0	8	0	8
Chain A, Beta-lactamase	9	0	0	9
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Coagulation factor VII	0	1	0	1
Tissue factor	0	2	0	2
Glutamate receptor 1	0	5	1	9
Glutamate receptor 3	0	5	1	9
Glutamate receptor 4	0	5	1	9
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
Voltage-dependent T-type calcium channel subunit alpha-1I	0	2	0	2
Acetylcholine receptor subunit alpha	0	3	1	4
Acetylcholine receptor subunit beta	0	3	1	4
Acetylcholine receptor subunit gamma	0	3	1	4
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	3	1	4
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	3
UDP-glucuronosyltransferase 1A9	0	0	1	3
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B15	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	1	1
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 5	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
ras-related protein Rab-9A	9	0	0	9
Cytochrome P450 2C8	0	6	0	6
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	7	0	0	7
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	4	0	1	5
Integrin alpha-IIb	4	0	1	5
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	4	1	6
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	4	1	6
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	4	0	5
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	4	0	5
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	4	0	5
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	6
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Adenosylhomocysteinase	0	1	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	1	0	4
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
hypothetical protein, conserved	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Snq2p	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Major prion protein	0	0	1	1
Sphingomyelin phosphodiesterase	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Envelope glycoprotein	0	0	3	3
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Parkin	5	0	0	5
Mitogen-activated protein kinase 13	0	1	0	1
Aryl hydrocarbon receptor	0	0	1	1
Mitogen-activated protein kinase 12	0	1	0	1
Mitogen-activated protein kinase 11	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
Vesicular glutamate transporter 3	0	1	0	1
G-protein coupled receptor 35	0	2	1	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Translocator protein	0	2	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Beta-2 adrenergic receptor	0	4	1	5
Beta-1 adrenergic receptor	0	3	1	4
Catechol O-methyltransferase	0	1	0	2
5-hydroxytryptamine receptor 1E	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Acetylcholine receptor subunit epsilon	0	0	2	2
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
interleukin 8	2	0	0	2
ClpP	1	0	0	1
Myeloperoxidase	0	3	0	3
Aromatase	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	4	2	6
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	2	2	4
Melatonin receptor type 1B	0	4	2	6
Melatonin receptor type 1C	0	2	2	4
Melatonin receptor type 1B	0	2	2	4
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Aldehyde oxidase 1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
DNA polymerase III, partial	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Angiotensin-converting enzyme	0	3	0	3
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Translocator protein	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	2	0	0	2
phospholipase A2, group III	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Epidermal growth factor receptor	0	2	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	2	0	0	2
DNA topoisomerase 2-alpha	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	1
Casein kinase II subunit alpha'	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
DNA topoisomerase 2-beta	0	0	0	1
Tyrosine-protein kinase BTK	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Integrase	0	1	0	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Amine oxidase [flavin-containing] A	0	6	0	7
Amine oxidase [flavin-containing] A	0	4	0	4
thioredoxin glutathione reductase	3	0	0	3
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Histidine decarboxylase	0	0	1	1
Kappa-type opioid receptor	0	4	3	8
Kappa-type opioid receptor	0	5	1	6
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	3	2	7
Polyphenol oxidase 2	0	2	0	4
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Bile acid receptor	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Lysine-specific demethylase 4C	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Lysine-specific histone demethylase 1A	0	4	0	5
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Membrane primary amine oxidase	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Lysine-specific demethylase 4E	0	2	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Advanced glycosylation end product-specific receptor	0	0	1	1
Beta-lactamase	0	1	0	1
Advanced glycosylation end product-specific receptor	0	0	1	1
histone deacetylase 9 isoform 3	2	0	0	2
Dihydrofolate reductase	0	3	0	3
Pteridine reductase 1	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Adenine-n6-dna-methyltransferase Taqi	0	0	1	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Ermc' Methyltransferase	0	1	0	1
Chain A, Ermc' Rrna Methyltransferase	0	1	0	1
Chain A, Uroporphyrin-III C-methyltransferase	0	1	0	1
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
tRNA (cytosine(38)-C(5))-methyltransferase	0	1	1	2
Protein arginine N-methyltransferase 5	0	1	1	2
Histone-lysine N-methyltransferase SUV39H1	0	2	0	2
Adenosylhomocysteinase	0	0	0	1
Protein arginine N-methyltransferase 3	0	1	0	1
Indolethylamine N-methyltransferase	0	1	0	1
Histone-lysine N-methyltransferase NSD2	0	1	0	1
Adenosylhomocysteinase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	1	3
rRNA adenine N-6-methyltransferase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Nicotinamide N-methyltransferase	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Histone-lysine N-methyltransferase SETDB1	0	1	0	1
Retinoblastoma-binding protein 5	0	1	0	1
Histone-lysine N-methyltransferase EZH2	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N6-adenosine-methyltransferase catalytic subunit	0	1	0	1
Histone-arginine methyltransferase CARM1	0	1	0	1
Histone-lysine N-methyltransferase KMT5C	0	1	0	1
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	2	1	3
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Histone-lysine N-methyltransferase EZH1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	3	0	3
Protein arginine N-methyltransferase 1	0	3	0	3
Methylosome protein 50	0	1	1	2
Protein dpy-30 homolog	0	1	0	1
Histamine N-methyltransferase	0	0	0	1
Histone-lysine N-methyltransferase SUV39H2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N-lysine methyltransferase SMYD2	0	1	0	1
Protein arginine N-methyltransferase 7	0	1	0	1
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
Set1/Ash2 histone methyltransferase complex subunit ASH2	0	1	0	1
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Non-structural protein 1	0	1	0	1
Met repressor	0	0	2	2
Histone H3K27 methylase	0	0	0	1
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Cytochrome P450 2B1	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Amine oxidase [flavin-containing] B	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Corticotropin-releasing factor receptor 1	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Cytochrome P450 2E1	0	1	0	1
Cytochrome P450 4B1	0	1	0	1
Cytochrome P450 2A7	0	1	0	1
Cytochrome P450 2F1	0	1	0	1
Cytochrome P450 2C18	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
Cytochrome P450 4F8	0	1	0	1
Cytochrome P450 4A11	0	1	0	1
Cytochrome P450 4F3	0	1	0	1
Cytochrome P450 4A22	0	1	0	1
Vitamin D 25-hydroxylase	0	1	0	1
Cytochrome P450 2U1	0	1	0	1
Cytochrome P450 2W1	0	1	0	1
Cytochrome P450 2S1	0	1	0	1
Cytochrome P450 3A43	0	1	0	1
REST corepressor 3	0	2	0	2
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Dopamine beta-hydroxylase	0	0	0	1
Beta-secretase 1	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Solute carrier family 15 member 1	0	2	0	3
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
Nrf2	1	0	0	1
PAX8	0	0	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Gli1	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
steroidogenic factor 1	0	1	0	1
protein Wnt-3a precursor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Bromodomain-containing protein 4	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
Tyrosine-protein kinase ABL1	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Protein Tat	0	0	1	1
Heat shock protein HSP 90-alpha	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Carboxypeptidase B2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (907)

Protein Targets (1,377)

Refractory Depression

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (907)

Drugs Studied (211)

Protein Targets (1,377)