Page last updated: 2024-09-28

Auriculotemporal Nerve Syndrome

An autonomic disorder characterized by excessive sweating of the forehead, upper lip, perioral region, or sternum subsequent to gustatory stimuli. The auriculotemporal syndrome features facial flushing or sweating limited to the distribution of the auriculotemporal nerve and may develop after trauma to the parotid gland, in association with PAROTID NEOPLASMS, or following their surgical removal. (From Ann Neurol 1997 Dec;42(6):973-5)

Synonyms(11)

Synonym
Auriculotemporal Nerve Syndrome
Auriculotemporal Syndrome
Hyperhidrosis, Gustatory
Baillarger Syndrome
von Frey's Syndrome
von Frey Syndrome
Salivosudoriparous Syndrome
Sweating, Gustatory
Frey Syndrome
Gustatory Sweating
Frey's Syndrome

Research Excerpts

Overview

ExcerptReference
"A case of Frey's syndrome is reported The patient obtained good relief of symptoms with scopolamine cream and atropine cream."( Bednarek, J; Matsumoto, T; Reid, W, 1976)
"Frey's syndrome is a benign condition and explanation and reassurance are usually adequate therapy."( Farrell, ML; Kalnins, IK, 1991)
"Frey's syndrome is a form of gustatory hyperhidrosis that develops following surgery, trauma, or disease of the parotid gland area."( Harper, KE; Spielvogel, RL, 1986)
"Gustatory sweating is a more common manifestation of diabetes mellitus than is appreciated."( Bobrove, AM; Urman, JD, 1999)
"Gustatory sweating is a rare disorder characterized by profuse sweating on the forehead, face, scalp, and neck occurring soon after ingesting food, which has been reported in diabetic patients."( Carter, TB; Dansby, LM; Diskin, CJ; Radcliff, L; Stokes, TJ, 2008)
"Frey syndrome is manifested clinically by hemifacial flushing and sweating after a gustatory stimulus."( Hovan, A; Ng, S; Torjek, C, 2009)
"Diabetic gustatory hyperhidrosis is a late sequela of diabetes and can have profound consequences."( Glaser, D; Tanner, J; Tinker, D, 2021)

Treatment

ExcerptReference
"Nine patients suffering from gustatory sweating (Frey's syndrome) following parotidectomy have been treated by topical applications of aluminium chloride hexahydrate."( Black, MJ; Gunn, A, 1990)
"The treatment of gustatory sweating in diabetes mellitus is usually with oral anti-cholinergic drugs, but these frequently lead to unacceptable side effects."( Abbott, CA; Boulton, AJ; Hollis, S; Shaw, JE; Tindle, K, 1997)
"Fourteen diabetic subjects with gustatory sweating were treated by intracutaneous injections of botulinum toxin type A into the affected facial skin areas."( Bramanti, P; Giuffrida, S; Lanza, S; Marchese-Ragona, R; Palmeri, A; Patti, F; Restivo, DA, 2002)

Research

Studies (87)

TimeframeStudies, This Condition (%)All Conditions %
pre-199035 (40.23)23.3326
1990's23 (26.44)12.5806
2000's19 (21.84)18.1394
2010's8 (9.20)28.8240
2020's2 (2.30)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low100
salicylic acid0low30
histamine0low10
iodine0medium161
phenol0low10
acetaminophen0low10
theophylline0low10
bupivacaine0low10
chlorpromazine0low10
clonidine0medium41
lidocaine0low40
khellin0low10
oxybutynin0medium31
tyramine0low10
thymidine0low10
pilocarpine0low10
diphemanil methylsulfate0medium11
ergotamine0low10
glycopyrrolate0medium113
erythromycin0low10
sabinene0low10
aluminum chloride0low80
triamcinolone0low10
fomesafen0low40
nicotine0low10
atropine0low10
povidone-iodine0low20
cocaine0low10
aluminum ammonium sulfate0low10
aluminum0low70
scopolamine hydrobromide0medium82
piperidines0medium11
acyclovir0low10
eye0low10

Protein Targets (787)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma8008
ATAD5 protein, partial4004
GLS protein8008
Microtubule-associated protein tau5005
Smad36006
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor6006
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha8008
estrogen nuclear receptor alpha130013
peroxisome proliferator activated receptor gamma6006
aryl hydrocarbon receptor5005
chromobox protein homolog 17007
thyroid hormone receptor beta isoform 28008
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 16006
Gamma-aminobutyric acid receptor subunit pi6006
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
Solute carrier family 22 member 60203
Carbonic anhydrase 120304
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0404
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump013013
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10607
Carbonic anhydrase 20608
Myoglobin0101
Cytochrome P450 1A10214
Cytochrome P450 1A20315
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30304
Cytochrome P450 3A40606
Cytochrome P450 2D60314
Cytochrome P450 2C9 0606
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-16006
Sulfotransferase 1A1 0002
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40405
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60405
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Carbonic anhydrase 5A, mitochondrial0304
Prostaglandin G/H synthase 20102
Carbonic anhydrase 70304
Nuclear receptor ROR-gamma3003
Cytochrome P450 2J20505
Gamma-aminobutyric acid receptor subunit alpha-16006
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
Carbonic anhydrase 90304
GABA theta subunit6006
Canalicular multispecific organic anion transporter 1010010
Carbonic anhydrase 150405
Carbonic anhydrase 130304
Gamma-aminobutyric acid receptor subunit epsilon6006
Carbonic anhydrase 140304
Carbonic anhydrase 5B, mitochondrial0304
toxin B0001
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain4004
Thymidine kinase 0203
thioredoxin reductase9009
phosphopantetheinyl transferase5005
TDP1 protein9009
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2110011
activating transcription factor 63003
Histone H2A.x4004
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta108008
Solute carrier family 22 member 1 05010
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0205
POU domain, class 2, transcription factor 20001
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60102
Thymidine kinase 0101
Solute carrier family 22 member 80102
Thymidine kinase0102
Chain A, 2-oxoglutarate Oxygenase4004
GLI family zinc finger 37007
AR protein110011
glucocorticoid receptor [Homo sapiens]7007
pregnane X nuclear receptor7007
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 40606
Muscarinic acetylcholine receptor M2010317
Muscarinic acetylcholine receptor M409112
Muscarinic acetylcholine receptor M1010114
Muscarinic acetylcholine receptor M308112
Muscarinic acetylcholine receptor M408112
Muscarinic acetylcholine receptor M507111
Muscarinic acetylcholine receptor M509112
Muscarinic acetylcholine receptor M209215
Muscarinic acetylcholine receptor M1010317
Muscarinic acetylcholine receptor M10012
Muscarinic acetylcholine receptor M309112
Alpha-1D adrenergic receptor0819
5-hydroxytryptamine receptor 2C0606
Muscarinic acetylcholine receptor M40202
Histamine H2 receptor3015
5-hydroxytryptamine receptor 70303
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0123
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20224
Potassium channel subfamily K member 90101
Carbonic anhydrase0102
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Proteasome subunit beta type-110001
acetylcholinesterase4004
Fumarate hydratase3003
USP1 protein, partial4004
NFKB1 protein, partial2002
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)2002
NADPH oxidase 10101
cytochrome P450 family 3 subfamily A polypeptide 46006
farnesoid X nuclear receptor2002
G4004
cytochrome P450 2D69009
polyprotein3003
67.9K protein1001
peroxisome proliferator-activated receptor delta3003
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
Snq2p0001
caspase-32002
IDH14004
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a1001
D(1A) dopamine receptor3003
vitamin D3 receptor isoform VDRA2002
potassium voltage-gated channel subfamily H member 2 isoform d3003
caspase-31001
histone deacetylase 9 isoform 33003
heat shock protein beta-13003
mitogen-activated protein kinase 14004
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 18008
geminin110011
DNA polymerase kappa isoform 11001
survival motor neuron protein isoform d4004
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 14004
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)2002
Proteasome subunit alpha type-70001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20112
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Epidermal growth factor receptor0101
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 4004
Albumin0123
Albumin0011
Major prion protein0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p534004
Major prion protein0011
Integrin beta-31001
Tyrosine-protein kinase Fyn0202
Procathepsin L0112
Aldo-keto reductase family 1 member B10404
ATP-dependent translocase ABCB10405
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 1A0303
5-hydroxytryptamine receptor 2C0314
Alpha-2A adrenergic receptor0617
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0213
Angiotensin-converting enzyme0202
D(2) dopamine receptor0506
5-hydroxytryptamine receptor 2A0314
Alpha-1B adrenergic receptor0404
Sphingomyelin phosphodiesterase0101
Alpha-2B adrenergic receptor0617
Alpha-2C adrenergic receptor0617
D0404
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 1A0718
Alpha-2B adrenergic receptor0505
D(2) dopamine receptor0101
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0507
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0505
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0505
Alpha-1D adrenergic receptor0404
Sodium-dependent noradrenaline transporter 0617
Sodium-dependent dopamine transporter0505
Histamine H2 receptor0325
D(1B) dopamine receptor0303
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 1B0718
Trypanothione reductase0202
D(4) dopamine receptor0303
5-hydroxytryptamine receptor 2B0314
Histamine H1 receptor0224
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0213
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0426
Mu-type opioid receptor0202
Glutamate receptor ionotropic, NMDA 1 0203
D(3) dopamine receptor0607
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0606
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0415
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60404
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein7119
Proteasome subunit alpha type-60012
D(2) dopamine receptor0405
Calmodulin 0112
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0203
Glutamate receptor ionotropic, NMDA 2B0203
Glutamate receptor ionotropic, NMDA 2C0203
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0606
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Potassium voltage-gated channel subfamily H member 20606
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2D0203
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0203
Inositol hexakisphosphate kinase 14004
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Ataxin-23003
Sigma non-opioid intracellular receptor 10606
Angiotensin-converting enzyme 2 0112
Sodium channel protein type 3 subunit alpha0202
Glutamate receptor ionotropic, NMDA 3A0203
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0224
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial4004
Chain A, Cruzipain1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
regulator of G-protein signaling 45005
Beta-1 adrenergic receptor 0011
Alpha-1B adrenergic receptor 0011
cytochrome P450 2C19 precursor4004
cytochrome P450 2C9 precursor2002
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30304
Alpha-1A adrenergic receptor0011
Amine oxidase [flavin-containing] A0203
Amine oxidase [flavin-containing] B0102
Adenosine receptor A2b0113
Adenosine receptor A2a0216
Alpha-2B adrenergic receptor0001
Delta-type opioid receptor0202
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Mu-type opioid receptor0202
Inositol monophosphatase 15005
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10305
Multidrug and toxin extrusion protein 10404
Nischarin0101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0303
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20112
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 60112
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0203
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20112
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0303
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
5-hydroxytryptamine receptor 4 0112
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0112
Leukotriene B4 receptor 20101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0315
Chain A, Beta-lactamase4004
ORF730011
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0101
ATP-dependent translocase ABCB10303
Beta-2 adrenergic receptor0202
Beta-1 adrenergic receptor0202
ATP-dependent translocase ABCB10303
Thromboxane-A synthase 0101
5-hydroxytryptamine receptor 1D0102
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 5A0101
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
streptokinase A precursor0011
Motilin receptor0112
Rap guanine nucleotide exchange factor 31001
30S ribosomal protein S60112
30S ribosomal protein S70112
50S ribosomal protein L150112
60 kDa chaperonin0101
50S ribosomal protein L100112
50S ribosomal protein L110112
50S ribosomal protein L7/L120112
50S ribosomal protein L190112
50S ribosomal protein L10112
50S ribosomal protein L200112
50S ribosomal protein L270112
50S ribosomal protein L280112
50S ribosomal protein L290112
50S ribosomal protein L310112
50S ribosomal protein L31 type B0112
50S ribosomal protein L320112
50S ribosomal protein L330112
50S ribosomal protein L340112
50S ribosomal protein L350112
50S ribosomal protein L360112
30S ribosomal protein S100112
30S ribosomal protein S110112
30S ribosomal protein S120112
30S ribosomal protein S130112
30S ribosomal protein S160112
30S ribosomal protein S180112
30S ribosomal protein S190112
30S ribosomal protein S200112
30S ribosomal protein S20112
30S ribosomal protein S30112
30S ribosomal protein S40112
30S ribosomal protein S50112
30S ribosomal protein S80112
30S ribosomal protein S90112
50S ribosomal protein L130112
50S ribosomal protein L140112
50S ribosomal protein L160112
50S ribosomal protein L230112
30S ribosomal protein S150112
50S ribosomal protein L170112
50S ribosomal protein L210112
50S ribosomal protein L300112
50S ribosomal protein L60112
30S ribosomal protein S140112
30S ribosomal protein S170112
30S ribosomal protein S10112
50S ribosomal protein L180112
60 kDa heat shock protein, mitochondrial0101
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20112
50S ribosomal protein L30112
50S ribosomal protein L240112
50S ribosomal protein L40112
50S ribosomal protein L220112
10 kDa heat shock protein, mitochondrial0101
50S ribosomal protein L50112
30S ribosomal protein S210112
50S ribosomal protein L250112
Cytochrome P450 1B10202
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
50S ribosomal protein L36 20112
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Luciferase3003
hypoxia-inducible factor 1 alpha subunit4004
Chain A, CARBONIC ANHYDRASE II0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
apical membrane antigen 1, AMA11001
bromodomain adjacent to zinc finger domain 2B3003
transforming acidic coiled-coil-containing protein 30001
DNA polymerase iota isoform a (long)2002
Solute carrier family 22 member 20102
Plasma kallikrein0001
Macrophage migration inhibitory factor0202
Adenosine receptor A10305
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase0002
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0103
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0103
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130102
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20203
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
glp-1 receptor, partial3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Cytochrome P450 2C190202
flap endonuclease 13003
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog2002
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
SMAD family member 22002
PPM1D protein1001
SMAD family member 32002
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase2002
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
luciferase1001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
thyroid hormone receptor beta isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 22002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
muscleblind-like protein 1 isoform 12002
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Cruzipain0101
Alpha-synuclein1001
Guanine nucleotide-binding protein G2002
TAR DNA-binding protein 433003
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
ATPase family AAA domain-containing protein 52002
Zinc finger protein mex-50011
phosphoglycerate kinase1001
ATP-dependent phosphofructokinase3003
5-hydroxytryptamine receptor 3E0101
interleukin 81001
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Acetylcholine receptor subunit gamma0213
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-40225
Acetylcholine receptor subunit beta0213
Cytochrome P450 2A60325
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Neuronal acetylcholine receptor subunit alpha-30213
Delta-type opioid receptor0101
Mu-type opioid receptor0202
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0112
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70225
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130224
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
alpha-galactosidase1001
Polyphenol oxidase 20104
Endolysin0011
Cannabinoid receptor 10101
Carbonic anhydrase 0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase0202
Carbonic anhydrase 30202
Muscarinic acetylcholine receptor DM10101
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
Phosphodiesterase 0202
transcriptional regulator ERG isoform 31001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Renin0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0101
Adenosine receptor A30101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Adenosine receptor A30101
Adenosine receptor A2a0225
Adenosine receptor A2b0102
Adenosine receptor A10215
Vasopressin V2 receptor0001
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Adenosine receptor A10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
Adenylate cyclase type 10001
Chitotriosidase-10101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Sigma non-opioid intracellular receptor 10101
Adenosine receptor A2b0001
Palmitoleoyl-protein carboxylesterase NOTUM0011
Endochitinase B10101
Phospholipase A-2-activating protein0101
Thymidine kinase0102
Thymidylate synthase0001
Thymidine phosphorylase0001
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
peripheral myelin protein 22 isoform 11001
procathepsin L isoform 1 preproprotein0101
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
dopamine D1 receptor1001
guanine nucleotide-binding protein subunit alpha-150112
lethal(3)malignant brain tumor-like protein 1 isoform I1001
D(3) dopamine receptor isoform e1001
trace amine-associated receptor 10112
Phenylethanolamine N-methyltransferase0101
Dopamine beta-hydroxylase 0001
Beta-secretase 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Histamine H3 receptor0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]