histamine has been researched along with Colitis, Ulcerative in 31 studies
Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of histamine-2 receptor antagonists (H2RAs) use causing inflammatory bowel diseases (IBD) has been reported in few isolated observational studies; however, pooled estimation of IBD risk has not been done." | 9.22 | Use of histamine-2 receptor antagonists and risk of inflammatory bowel diseases: A systematic review and meta-analysis of observational studies. ( Chandran, VP; D'sa, FF; Fernandes, EZ; Kesarkar, SV; Kunhikatta, V; Nair, S; Rashid, M; Swaminathan, L; Thunga, G, 2022) |
| "Ulcerative colitis (UC) patients exhibit elevated histamine, but how histamine exacerbates disease is unclear as targeting histamine 1 receptor (H1R) or H2R is clinically ineffective." | 7.88 | Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis. ( Aguiniga, LM; Barrett, TA; Brown, JB; Bryce, PJ; Carter, RG; Hsu, CL; Krier-Burris, RA; Miller, ML; Schroeder, HA; Szabo, A; Velez, TE; Wang, MY; Wechsler, JB; Wershil, BK, 2018) |
| "The effect of histamine-2 receptor antagonists (H2RAs) use causing inflammatory bowel diseases (IBD) has been reported in few isolated observational studies; however, pooled estimation of IBD risk has not been done." | 5.22 | Use of histamine-2 receptor antagonists and risk of inflammatory bowel diseases: A systematic review and meta-analysis of observational studies. ( Chandran, VP; D'sa, FF; Fernandes, EZ; Kesarkar, SV; Kunhikatta, V; Nair, S; Rashid, M; Swaminathan, L; Thunga, G, 2022) |
| "Ulcerative colitis (UC) patients exhibit elevated histamine, but how histamine exacerbates disease is unclear as targeting histamine 1 receptor (H1R) or H2R is clinically ineffective." | 3.88 | Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis. ( Aguiniga, LM; Barrett, TA; Brown, JB; Bryce, PJ; Carter, RG; Hsu, CL; Krier-Burris, RA; Miller, ML; Schroeder, HA; Szabo, A; Velez, TE; Wang, MY; Wechsler, JB; Wershil, BK, 2018) |
| " Therefore, tissue particles from normal subjects and from patients suffering from different diseases (Crohn's disease, ulcerative colitis, intestinal polyps) obtained at routine coloscopy were exposed to either Hanks or anti-IgE solution to determine the spontaneous or the anti-IgE-induced histamine release, expressed as the percentage of the total histamine content of the biopsy." | 3.67 | Histamine release from human colonic mucosa in response to anti-IgE. ( Baenkler, HW; Hörauf, AM; Matek, M; Raithel, M, 1989) |
| "Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R)." | 1.43 | Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease. ( Akdis, CA; Ferstl, R; Frei, R; Groeger, D; Jutel, M; Konieczna, P; OʼMahony, L; Perez, NR; Schiavi, E; Smolinska, S, 2016) |
| "Histamine pretreatment of non-IBD control tissues reduced anti-IgE responses to levels seen in IBD colon but had no effect in small intestine." | 1.30 | Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease. ( Crowe, SE; Luthra, GK; Perdue, MH, 1997) |
| "than in those with Crohn's disease and a control group." | 1.26 | Skin reactivity and phagocytic function of neutrophil leucocytes in Crohn's disease and ulcerative colitis. ( Juhlin, L; Krause, U; Michaëlsson, G, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (41.94) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Ibrahim, MA | 1 |
| Abdelmonaem, AA | 1 |
| Abdel-Gaber, SA | 1 |
| Hafez, HM | 1 |
| Abdel Hafez, SMN | 1 |
| Yehia Abdelzaher, W | 1 |
| D'sa, FF | 1 |
| Fernandes, EZ | 1 |
| Kesarkar, SV | 1 |
| Swaminathan, L | 1 |
| Kunhikatta, V | 1 |
| Rashid, M | 1 |
| Thunga, G | 1 |
| Chandran, VP | 1 |
| Nair, S | 1 |
| Dong, Y | 1 |
| Huang, C | 1 |
| Yang, J | 1 |
| Zheng, Z | 1 |
| Dai, Z | 1 |
| Dvornikova, KA | 1 |
| Platonova, ON | 1 |
| Bystrova, EY | 1 |
| Wechsler, JB | 1 |
| Szabo, A | 1 |
| Hsu, CL | 1 |
| Krier-Burris, RA | 1 |
| Schroeder, HA | 1 |
| Wang, MY | 1 |
| Carter, RG | 1 |
| Velez, TE | 1 |
| Aguiniga, LM | 1 |
| Brown, JB | 1 |
| Miller, ML | 1 |
| Wershil, BK | 1 |
| Barrett, TA | 1 |
| Bryce, PJ | 1 |
| Hagel, AF | 1 |
| de Rossi, T | 1 |
| Konturek, PC | 1 |
| Albrecht, H | 1 |
| Walker, S | 1 |
| Hahn, EG | 3 |
| Raithel, M | 4 |
| Smolinska, S | 1 |
| Groeger, D | 1 |
| Perez, NR | 1 |
| Schiavi, E | 1 |
| Ferstl, R | 1 |
| Frei, R | 1 |
| Konieczna, P | 1 |
| Akdis, CA | 1 |
| Jutel, M | 1 |
| OʼMahony, L | 1 |
| Singh, K | 1 |
| Jaggi, AS | 1 |
| Singh, N | 1 |
| Nägel, A | 1 |
| Zopf, Y | 1 |
| deRossi, T | 1 |
| Stengel, Ch | 1 |
| Hagel, A | 1 |
| Kressel, J | 1 |
| Konturek, P | 1 |
| PARROT, JL | 1 |
| LABORDE, C | 1 |
| DEBRAY, C | 1 |
| GASTARD, J | 1 |
| BRASHER, PH | 1 |
| LANDOR, JH | 1 |
| RIGLER, SP | 1 |
| DRAGSTEDT, LR | 1 |
| Fogel, WA | 2 |
| Wagner, W | 1 |
| Sasiak, K | 1 |
| Stasiak, A | 1 |
| Lewinski, A | 1 |
| Mawdsley, JE | 1 |
| Macey, MG | 1 |
| Feakins, RM | 1 |
| Langmead, L | 1 |
| Rampton, DS | 1 |
| Binder, V | 1 |
| Hvidberg, E | 1 |
| Kuczyńska-Sekieta, K | 1 |
| Fal, W | 1 |
| Matek, M | 2 |
| Baenkler, HW | 3 |
| Jorde, W | 1 |
| Wardle, TD | 1 |
| Hall, L | 1 |
| Turnberg, LA | 1 |
| Crowe, SE | 1 |
| Luthra, GK | 1 |
| Perdue, MH | 1 |
| Araki, Y | 1 |
| Andoh, A | 1 |
| Fujiyama, Y | 1 |
| Bamba, T | 1 |
| Kuiarov, AV | 1 |
| Vorob'ev, AA | 1 |
| Nesvizhskiĭ, IuV | 1 |
| Borisova, MA | 1 |
| Riazanova, NIa | 1 |
| Tsuchiya, M | 1 |
| Munakata, Y | 1 |
| Hibi, N | 1 |
| Nagata, H | 1 |
| Kitahora, T | 1 |
| Muraoka, M | 1 |
| Mizuno, Y | 1 |
| Asakura, H | 1 |
| Krause, U | 1 |
| Michaëlsson, G | 1 |
| Juhlin, L | 1 |
| Morita, H | 1 |
| Hörauf, AM | 1 |
| Senju, M | 1 |
| Lux, G | 1 |
| Günthner, R | 1 |
| Kohlhäufl, M | 1 |
| Matek, W | 1 |
| Yamada, T | 1 |
| Taguchi, H | 1 |
| Sjaastad, O | 1 |
| Obtulowicz, M | 1 |
| Sowa, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hypnotherapy for Prevention of Relapse in Ulcerative Colitis: a Randomised, Single-blind, Controlled Clinical Trial[NCT00553163] | 26 participants (Actual) | Interventional | 2007-10-31 | Terminated (stopped due to Unable to recruit sufficient numbers of patinets in the time available) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measure of anxiety, HADS Hospital anxiety and depression scale. HADS questionnaire consists of a 14 question validated questionnaire, developed to measure anxiety and depression in the hospital setting. Each item is answered by the patient on a four point (0-3) response category so the possible scores range from 0 (minimum) to 21 (maximum) for anxiety and 0 (minimum) to 21 (maximum) for depression. Higher scores indicate worse outcome, (NCT00553163)
Timeframe: 13 weeks
| Intervention | score on a scale (Median) |
|---|---|
| UC Patients Given Gut-focussed Hpynotherapy | 7 |
| UC Patients Given Control Educational Sessions | 10 |
Measure of depression. Each item is answered by the patient on a four point (0-3) response category so the possible scores range from 0 to 21 for anxiety and 0 to 21 for depression. Each item is answered by the patient on a four point (0-3) response category so the possible scores range from 0 (minimum) to 21 (maximum) for anxiety and (minimum) to 21 (maximum) for depression. Higher scores worse outcome. (NCT00553163)
Timeframe: 13 weeks
| Intervention | units on a scale (Median) |
|---|---|
| UC Patients Given Gut-focussed Hypnotherapy | 1.5 |
| UC Patients Given Control Educational Sessions | 4 |
IBDQ (standard measure of IBD patients' Quality of life (QoL) (Irvine et al 1982 approx). The IBDQ is a validated and reliable tool to measure of health-related quality of life in adult patients with IBD. The questionnaire consists of 32 questions scored in four domains: bowel symptoms, emotional health, systemic systems and social function. Scores range from 1 (poorest QoL) to 7 (best QoL). Higher scores indicate better QoL. Lowest score 7, highest score 224. (NCT00553163)
Timeframe: 13 weeks
| Intervention | units on a scale (Median) |
|---|---|
| UC Patients Given Gut-focussed Hypnotherapy | 195 |
| UC Patients Given Control Educational Sessions | 192 |
Measure of recent psychological stress. THE PSQ R consists of a 30 question questionnaires: recent, in which the statements used apply to the last month in which used statements apply to the last two years (Appendix 1.3). The score for both recent and general stress levels were stated as the PSQ index ranging from 0 (non-stressed) to 0.99 (highly stressed). Higher scores indicate worse outcome. (NCT00553163)
Timeframe: 13 weeks
| Intervention | units on a scale (Median) |
|---|---|
| UC Patients Given Gut-focussed Hypnotherapy | 0.3 |
| UC Patients Given Control Educational Sessions | 0.4 |
The number of patients suffering a relapse was compared between the two treatment groups, and was the primary outcome parameter of this study. (NCT00553163)
Timeframe: 1 year
| Intervention | Participants (Count of Participants) |
|---|---|
| UC Patients Given Gut-focussed Hypnotherapy | 8 |
| UC Patients Given Control Educational Sessions | 7 |
3 reviews available for histamine and Colitis, Ulcerative
| Article | Year |
|---|---|
Use of histamine-2 receptor antagonists and risk of inflammatory bowel diseases: A systematic review and meta-analysis of observational studies.
Topics: Adult; Child; Colitis, Ulcerative; Crohn Disease; Histamine; Histamine H2 Antagonists; Humans; Infla | 2022 |
Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease.
Topics: Cell Physiological Phenomena; Colitis, Ulcerative; Histamine; Humans; Inflammatory Bowel Diseases | 2023 |
[Possibility of participation of bacterial factor in the correction of histamine metabolism in the body].
Topics: Adult; Amine Oxidase (Copper-Containing); Animals; Antigens, Bacterial; Bacteria; Basophils; Birds; | 2000 |
1 trial available for histamine and Colitis, Ulcerative
| Article | Year |
|---|---|
Plasma histamine levels (H) during adjunctive H1-receptor antagonist treatment with loratadine in patients with active inflammatory bowel disease (IBD).
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Diseas | 2010 |
27 other studies available for histamine and Colitis, Ulcerative
| Article | Year |
|---|---|
Rupatadine ameliorated ulcerative colitis in rats via modulation of platelet-activatiweng factor/interleukin-6/vascular endothelial growth factor signalling pathway.
Topics: Acetic Acid; Animals; Antioxidants; Colitis, Ulcerative; Colon; Cyproheptadine; Histamine; Interleuk | 2022 |
Docosapentaenoic Acid (DPA, 22:5
Topics: Animals; Bacteria; Butyrates; Colitis, Ulcerative; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fat | 2022 |
Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis.
Topics: Adolescent; Adult; Aged; Animals; Cells, Cultured; Colitis; Colitis, Ulcerative; Colon; Dextran Sulf | 2018 |
Plasma histamine and tumour necrosis factor-alpha levels in Crohn's disease and ulcerative colitis at various stages of disease.
Topics: Adult; Aged; Colitis, Ulcerative; Crohn Disease; Disease Progression; Female; Histamine; Humans; Int | 2015 |
Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease.
Topics: Adult; Animals; Case-Control Studies; Cells, Cultured; Colitis, Ulcerative; Crohn Disease; Cytokines | 2016 |
Exploring the ameliorative potential of Punica granatum in dextran sulfate sodium induced ulcerative colitis in mice.
Topics: Animals; Anti-Ulcer Agents; Colitis, Ulcerative; Colon; Dextran Sulfate; Ellagic Acid; Histamine; Li | 2009 |
[Histamine binding by the blood in hemorrhagic and ulcerative rectocolitis].
Topics: Biophysical Phenomena; Colitis; Colitis, Ulcerative; Histamine; Humans; Proctocolitis; Signal Transd | 1960 |
Gastric, duodenal, and colonic ulceration induced by histamine.
Topics: Colitis; Colitis, Ulcerative; Histamine; Peptic Ulcer; Vagus Nerve | 1955 |
The role of histamine in experimental ulcerative colitis in rats.
Topics: Animals; Colitis, Ulcerative; Histamine; Male; Rats; Rats, Wistar | 2005 |
The effects of diamine oxidase administration on experimental ulcerative colitis in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Colitis, Ulcerative; Disease Models, Animal; Histamine; | 2006 |
The effect of acute psychologic stress on systemic and rectal mucosal measures of inflammation in ulcerative colitis.
Topics: Acute Disease; Adult; Biomarkers; Blood Flow Velocity; Colitis, Ulcerative; Disease Progression; Enz | 2006 |
Histamine content of rectal mucosa in ulcerative colitis.
Topics: Adult; Colitis, Ulcerative; Eosinophils; Exudates and Transudates; Female; Histamine; Humans; Hypers | 1967 |
[Some mediators of allergic reaction in patients with ulcerative colitis (author's transl)].
Topics: Adult; Colitis, Ulcerative; Female; Histamine; Humans; Hypersensitivity, Immediate; Intestinal Mucos | 1981 |
Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy.
Topics: Biopsy; Colitis, Ulcerative; Crohn Disease; Female; Histamine; Histamine Release; Humans; Hypersensi | 1995 |
Platelet activating factor: release from colonic mucosa in patients with ulcerative colitis and its effect on colonic secretion.
Topics: Adult; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coculture Techniques; Colitis, Ulcerati | 1996 |
Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease.
Topics: Animals; Antibodies, Anti-Idiotypic; Colforsin; Colitis, Ulcerative; Crohn Disease; Histamine; Hista | 1997 |
Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient Ws/Ws rats.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Histamine; Intestinal Mucosa; Male; Mast Cells | 2000 |
[Histamine metabolism in acute dysentery and nonspecific ulcerative colitis].
Topics: Acute Disease; Adolescent; Adult; Colitis, Ulcerative; Dysentery, Bacillary; Histamine; Humans; Midd | 1977 |
[Immediate hypersensitivity in the ulcerative colitis and effect of adrenocortical steroids (author's transl)].
Topics: Colitis, Ulcerative; Histamine; Hypersensitivity, Immediate; Immunoglobulin E; Prednisolone | 1979 |
Skin reactivity and phagocytic function of neutrophil leucocytes in Crohn's disease and ulcerative colitis.
Topics: Adolescent; Adult; Aged; Antigens, Bacterial; Bradykinin; Colitis, Ulcerative; Crohn Disease; Female | 1978 |
Histamine/serotonin ratio (H/S ratio): a new scale for determining the degree of inflammation in ulcerative colitis.
Topics: Adolescent; Adult; Colitis, Ulcerative; Female; Health Status Indicators; Histamine; Humans; Male; M | 1992 |
Histamine release from human colonic mucosa in response to anti-IgE.
Topics: Antibodies, Anti-Idiotypic; Colitis, Ulcerative; Colon; Crohn Disease; Histamine; Histamine Release; | 1989 |
[Reaginic hypersensitivity in ulcerative colitis].
Topics: Adult; Colitis, Ulcerative; Eosinophils; Female; Histamine; Humans; Hypersensitivity, Immediate; Imm | 1988 |
Biopsy histamine in ulcerative colitis and Crohn's disease.
Topics: Adult; Biopsy; Colitis, Ulcerative; Colon; Crohn Disease; Female; Histamine; Humans; Intestinal Muco | 1987 |
[A case of interstitial cystitis complicated with ulcerative colitis].
Topics: Adult; Colitis, Ulcerative; Cystitis; Histamine; Humans; Hydrocortisone; Male | 1985 |
Urinary excretion of free and conjugated histamine in various gastrointestinal disorders.
Topics: Acrodermatitis; Appendicitis; Arthritis, Rheumatoid; Celiac Disease; Child; Child, Preschool; Coliti | 1969 |
[Histaminopexy].
Topics: Animals; Colitis, Ulcerative; Guinea Pigs; Histamine; Hypersensitivity, Immediate | 1969 |