Gestational Pemphigoid

An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).

Synonym
Gestational Pemphigoid
Herpes Gestationis
Pemphigoid Gestationis

Excerpt	Reference
"Herpes gestationis is a nosologically undefined uncommon bullous disease in pregnancy."	( Bersch, A; Clorius, R; Schöpf, E; Seelig, HP; Sheikh, M, 1976)
"Herpes gestationis is a rare, pruritic, blistering disease of the skin that occurs in pregnancy and the puerperium."	( Perry, HO; Quimby, SR; Xenias, SJ, 1982)
"Herpes gestationis is a rare disease in pregnancy."	( Doi, SA; Jamiyah, H; Naganathan, K, 1994)
"Herpes gestationis is a rare autoimmune disease of pregnancy characterized by itching and skin lesions."	( Faden, D; Lojacono, A; Tanzi, P; Tarantini, M, 1994)
"Pemphigoid gestationis is an acute autoimmune subepidermal bullous dermatosis which occurs during pregnancy and post partum."	( Fazaa, B; Kamoun, MR; Mokhtar, I; Triki, S; Zeglaoui, F, 2006)
"Pemphigoid gestationis is a rare, autoimmune blistering dermatosis (Holmes and Black In: Clin Exp Dermatol 7:65-73, 1982)."	( Bedocs, PM; Kumar, V; Mahon, MJ, 2009)
"Pemphigoid gestationis is a rare autoimmune blistering disease of pregnancy."	( Kamino, H; Lu, PD; Ralston, J; Stein, JA, 2010)
"Pemphigoid gestationis is an autoimmune blistering disease of pregnancy caused by autoantibodies directed against BP180 (type XVII collagen) in the basement membrane zone."	( Intong, LR; Murrell, DF, 2011)

Excerpt	Reference
"Pemphigoid gestationis has been associated with premature delivery, small-for-gestational-age infants."	( Kamino, H; Lu, PD; Ralston, J; Stein, JA, 2010)

Excerpt	Reference
"We report a case of pemphigoid gestationis affecting a 37-year-old woman in both her pregnancies."	( Gan, DC; Webster, M; Welsh, B, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	44 (42.72)	23.3326
1990's	18 (17.48)	12.5806
2000's	15 (14.56)	18.1394
2010's	25 (24.27)	28.8240
2020's	1 (0.97)	9.53

Drug	Relationship Strength	Studies	Trials
formaldehyde	low	1	0
histamine	low	2	0
kynurenine	low	1	0
niacinamide	low	1	0
pyridoxine	low	7	0
astemizole	low	1	0
azathioprine	low	4	0
dapsone	low	5	0
diphenhydramine	low	1	0
brl 42810	low	1	0
hydroxyzine	low	1	0
sulfamethoxypyridazine	low	1	0
sulfapyridine	low	1	0
prednisolone	low	21	0
prednisone	low	20	0
idoxuridine	low	2	0
bromodeoxyuridine	medium	1	1
edetic acid	low	2	0
egtazic acid	low	1	0
valine	low	1	0
triamcinolone acetonide	low	1	0
methylprednisolone	low	2	0
fluocortolone	low	1	0
betamethasone	low	4	0
2-aminopurine	low	1	0
vidarabine	medium	3	1
triamcinolone	low	2	0
ursodeoxycholic acid	low	4	0
4-methoxyamphetamine	low	1	0
du-21220	low	3	0
transferrin	low	1	0
fibrinogen	low	1	0
vitamin b 6	low	1	0
cortisone	low	5	0
fibrin	low	2	0
tacrolimus	low	1	0
brivudine	medium	1	1
bromochloroacetic acid	low	1	0
goserelin	low	1	0
minocycline	low	1	0
salicylates	low	1	0
cyclosporine	low	5	0
acyclovir	medium	7	1
neopterin	low	1	0
valacyclovir	low	1	0
concanavalin a	low	1	0

Protein Targets (454)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	9	0	0	9
thioredoxin reductase	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
IDH1	7	0	0	7
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
TAR DNA-binding protein 43	5	0	0	5
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 1A	0	3	1	4
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	3	0	3
phosphopantetheinyl transferase	7	0	0	7
GLS protein	6	0	0	6
TDP1 protein	17	0	0	17
Smad3	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	8	0	0	8
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
activating transcription factor 6	5	0	0	5
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	5	0	0	5
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lamin isoform A-delta10	10	0	0	10
Solute carrier family 22 member 1	0	0	0	2
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	11
Solute carrier family 22 member 6	0	0	0	1
Bile salt export pump	0	4	0	4
Bile salt export pump	0	17	0	17
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	5
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	5	0	5
Cytochrome P450 2J2	0	5	0	6
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	11	0	11
Thymidine kinase	0	2	0	2
acetylcholinesterase	4	0	0	4
glp-1 receptor, partial	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	13	0	0	13
SMAD family member 2	4	0	0	4
Fumarate hydratase	3	0	0	3
USP1 protein, partial	4	0	0	4
SMAD family member 3	4	0	0	4
GLI family zinc finger 3	10	0	0	10
Microtubule-associated protein tau	5	0	0	5
AR protein	22	0	0	22
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
nonstructural protein 1	4	0	0	4
glucocorticoid receptor [Homo sapiens]	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	9	0	0	9
estrogen-related nuclear receptor alpha	15	0	0	15
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	22	0	0	22
cytochrome P450 2D6	5	0	0	5
polyprotein	3	0	0	3
67.9K protein	4	0	0	4
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
peroxisome proliferator-activated receptor delta	5	0	0	5
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
caspase-3	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
thyroid stimulating hormone receptor	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Caspase-7	2	0	0	2
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
cytochrome P450 2D6 isoform 1	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	5	0	0	5
huntingtin isoform 2	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	16	0	0	16
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	7	0	0	7
cytochrome P450 3A4 isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transmembrane protease serine 2	0	0	2	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	0	6
Polycomb protein EED	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Epidermal growth factor receptor	0	1	0	1
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	10	0	0	10
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Procathepsin L	0	0	2	2
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M4	0	6	0	6
ATP-dependent translocase ABCB1	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Cytochrome P450 3A4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	6	0	6
Alpha-2A adrenergic receptor	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	2	2
Muscarinic acetylcholine receptor M1	0	6	0	6
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Alpha-2C adrenergic receptor	0	2	0	2
Glutamate receptor 2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Muscarinic acetylcholine receptor M3	0	6	0	6
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Sodium-dependent noradrenaline transporter	0	6	0	6
Histamine H2 receptor	0	5	2	7
Alpha-1D adrenergic receptor	0	4	0	4
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 2C	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Melanocortin receptor 4	0	2	0	2
Somatostatin receptor type 3	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Somatostatin receptor type 5	0	1	0	1
Histamine H1 receptor	0	11	2	13
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Histamine H2 receptor	3	0	1	6
5-hydroxytryptamine receptor 6	0	3	0	3
Spike glycoprotein	4	0	2	6
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	5	1	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
GABA theta subunit	5	0	0	5
Multidrug and toxin extrusion protein 1	0	2	0	2
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	12	0	0	12
Sigma non-opioid intracellular receptor 1	0	4	0	4
Angiotensin-converting enzyme 2	0	0	2	2
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Histamine H4 receptor	0	4	2	6
Heparanase	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
interleukin 8	3	0	0	3
ATAD5 protein, partial	4	0	0	4
thioredoxin glutathione reductase	4	0	0	4
G	5	0	0	5
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Nuclear receptor ROR-gamma	5	0	0	5
Inositol hexakisphosphate kinase 1	5	0	0	5
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	5	0	0	5
pregnane X receptor	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
thyroid hormone receptor beta isoform a	1	0	0	1
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	3	22
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain A, Cruzipain	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Thymidine kinase	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Nuclear hormone receptor family member daf-12	0	0	1	1
chromobox protein homolog 1	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
flap endonuclease 1	2	0	0	2
MBT domain-containing protein 1	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
regulator of G-protein signaling 4	3	0	0	3
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Histamine H1 receptor	0	1	4	7
Histamine H3 receptor	0	1	0	3
Luciferase	3	0	0	3
Thrombopoietin	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
Angiotensin-converting enzyme	0	2	0	2
Histamine N-methyltransferase	0	0	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-3 adrenergic receptor	0	0	1	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	0	4
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	2	0	3
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carboxylic ester hydrolase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Histamine H3 receptor	0	1	2	3
Alpha-1D adrenergic receptor	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Vpr	1	0	0	1
PPM1D protein	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Albumin	0	0	1	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Chain A, NAD-dependent deacetylase	0	1	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Pyridoxal kinase	0	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
NFKB1 protein, partial	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Alpha-synuclein	1	0	0	1
Ileal sodium/bile acid cotransporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Solute carrier family 15 member 1	0	2	0	3
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
Adenosine deaminase	0	0	0	1
RNA-directed RNA polymerase	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

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Studies (103)

Protein Targets (454)

Gestational Pemphigoid

Synonyms(3)

Research Excerpts

Overview

Context

Actions

Research

Studies (103)

Drugs Studied (53)

Protein Targets (454)