Compounds > viridicatol
Page last updated: 2024-12-07

viridicatol

Viridicatol is a natural product isolated from the fungus *Penicillium viridicatum*. It exhibits a wide range of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Its unique chemical structure, characterized by a cyclopentenone ring and a spiro-fused lactone, has attracted significant interest in synthetic chemistry. Studies have focused on developing efficient synthetic routes to access viridicatol and its analogs, aiming to explore structure-activity relationships and identify potential therapeutic applications. Viridicatol's antiproliferative activity against various cancer cell lines has been particularly investigated, with potential applications in the treatment of leukemia and solid tumors. The compound's ability to inhibit the growth of bacteria and fungi has also been documented, making it a promising lead for developing new antimicrobial agents. Research on viridicatol is ongoing to understand its complex biological mechanisms and exploit its potential for drug development.'

Cross-References

ID SourceID
PubMed CID115033
MeSH IDM0282529

Synonyms (23)

Synonym
ACON0_001482
MEGXM0_000057
viridicatol
14484-44-7
3-hydroxy-4-(3-hydroxyphenyl)-1h-quinolin-2-one
2(1h)-quinolinone, 3-hydroxy-4-(3-hydroxyphenyl)-
45p12jne0l ,
3-hydroxy-4-(3-hydroxyphenyl)-2(1h)-quinolinone
unii-45p12jne0l
carbostyril, 3-hydroxy-4-(m-hydroxyphenyl)-
4-(3-hydroxyphenyl)-2,3-quinolinediol #
QIJIOTTYIGBOQA-UHFFFAOYSA-N
HY-116474
CS-0065593
3-hydroxy-4-(3-hydroxyphenyl)quinolin-2(1h)-one
nsc-794085
nsc794085
Q27258853
DTXSID60893995
3-hydroxy-4-(3-hydroxyphenyl) quinolin-2(1h)-one
F76730
3-hydroxy-4-(3-hydroxyphenyl)-1,2-dihydroquinolin-2-one
AKOS040740533

Research Excerpts

Overview

Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus.

ExcerptReferenceRelevance
"Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus "( Viridicatol Isolated from Deep-Sea
Cao, M; Liu, G; Liu, H; Liu, Q; Shu, Z; Xing, C; Yang, X; Zhang, J; Zhang, Y; Zhou, Y, 2020)		3.44
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		2.2510aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		1.9910glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		3.2760monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
cyclohexanol
Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.		1.9910cyclohexanols;
secondary alcohol		solvent
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		1.9910naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		1.9910
geosmin
geosmin: earthy smelling cpd from sediment in Lake Biwa; structure. (-)-geosmin : The (-)-stereoisomer of geosmin, having 4S,4aS,8aR configuration.		1.9910geosmin
viridicatin
viridicatin: structure. viridicatin : A hydroxyquinolone that is 3-hydroxyuinolin-2(1H)-one which is substituted at position 4 by a phenyl groups. Isolated from the mycelium of several Penicillium species, it exhibits strong antibiotic activity against M. tuberculosis and also against B. subtilis, S. aureus and S. cerevisiae.		1.9910hydroxyquinolineantibacterial agent;
Aspergillus metabolite;
marine metabolite;
Penicillium metabolite
cyclopenol
cyclopenol: RN given refers to cis-(-)-isomer		7.3620
chaetoglobosins
chaetoglobosins: like CYTOCHALASINS but with an indoyl in place of a phenyl ring at C10; chaetoglobosins A-J; metabolites of Chaetomium species; RN given refers to chaetoglobosin A; structure. chaetoglobosin A : A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.		1.9910
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.2510
roquefortine
roquefortine: metabolite of Penicillium roqueforti; structure		2.0210pyrroloindole
palitantin
palitantin: RN given refers to (2alpha,3beta(1E,3E),5alpha,6alpha)-isomer		1.9910
andrastin a
andrastin A: a farnesyltransferase inhibitor; structure given in first source. andrastin A : A 19-oxo steroid that is that is andrastin B in which the hydroxy group at position 19 has been oxidised to give the corresponding aldehyde. A farnesyltransferase inhibitor produced by Penicillium roqueforti, a filamentous fungus involved in the ripening of several kinds of blue cheeses.		2.0210
isoborneol
isoborneol: RN given refers to cpd without isomeric designation; structure		1.9910borneol
cyclopenin
cyclopenin: Penicillium metabolite; structure		1.9910
chiniofon
Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.		3.2760
ConditionIndicatedRelationship StrengthStudiesTrials
Anaphylactic Reaction
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Allergy, Food
[description not available]		02.2510
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		02.2510
Food Hypersensitivity
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.		02.2510
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