Compounds > tafluprost
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tafluprost

Description

tafluprost: structure in first source [MeSH]

tafluprost : A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. [CHeBI]

Cross-References

ID SourceID
PubMed CID9868491
CHEMBL ID1963683
SCHEMBL ID1286148
CHEBI ID66899
MeSH IDM0466141

Synonyms (73)

Synonym
209860-87-7
D06274
zioptan (tn)
tafluprost (jan/usan/inn)
tafluprost
zioptan
tapros
de-085
saflutan
afp-168
de-118
taflotan
mk-2452
unii-1o6wq6t7g3
1o6wq6t7g3 ,
1-methylethyl (5z)-7-{(1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5- dihydroxycyclopentyl}hept-5-enoate
5-heptenoic acid, 7-((1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxy-1-buten-1-yl)-3,5- dihydroxycyclopentyl)-, 1-methylethyl ester, (5z)-
1-methylethyl (5z)-7-((1r,2r, 3r,5s)-2-((1e)-3,3-difluoro-4-phenoxy -1-butenyl-3,5-dihydroxycyclopentyl)-5-heptenoate
isopropyl (5z)-7-{(1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl}hept-5-enoate
tafluprost [usan:inn:ban]
mk2452
CHEMBL1963683
chebi:66899 ,
isopropyl (5z)-7-{(1r,2r,3r,5s)-2-[(1e)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate
S4851
c25h34f2o5
AKOS025294885
tafluprost [usan]
tafluprost [inci]
5-heptenoic acid, 7-[(1r,2r,3r,5s)-2-[(1e)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5z)-
tafluprost [jan]
tafluprost [orange book]
tafluprost [mart.]
tafluprost [who-dd]
tafluprost [mi]
tafluprost [vandf]
tafluprost [inn]
isopropyl (z)-7-[(1r,2r,3r,5s)-2-[(e)-3,3-difluoro-4-phenoxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl]hept-5-enoate
DB08819
HY-B0600
propan-2-yl (z)-7-[(1r,2r,3r,5s)-2-[(e)-3,3-difluoro-4-(phenoxy)but-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
gtpl7451
(z)-isopropyl 7-((1r,2r,3r,5s)-2-((e)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate
J-502635
SCHEMBL1286148
(z)-isopropyl 7-((1r,2r,3r,5s)-2-((e)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxy cyclopentyl)hept-5-enoate
HMS3649F04
propan-2-yl (5z)-7-[(1r,2r,3r,5s)-2-[(1e)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoate
EX-A564
5-heptenoic acid, 7-[(1r,2r,3r,5s)-2-[(1e)-3,3-difluoro-4-phenoxy-1-butenyl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5z)-
AS-75193
sr-01000946707
SR-01000946707-1
Q2139543
1-methylethyl (5-z)-7-[(1r,2r,3r,5s)-2-[(1e)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoate
CCG-269257
propan-2-yl (z)-7-[(1r,2r,3r,5s)-2-[(e)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
mk2452afp-168
(z)-isopropyl7-((1r,2r,3r,5s)-2-((e)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate
DTXSID401021504
5-heptenoic acid, 7-((1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxy-1-buten-1-yl)-3,5-dihydroxycyclopentyl)-, 1-methylethyl ester, (5z)-
tafluprostum
1-methylethyl (5z)-7-((1r,2r, 3r,5s)-2-((1e)-3,3-difluoro-4-phenoxy-1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate
isopropyl (5z)-7-((1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate
isopropyl (5z)-7-((1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoate
tafluprost ophthalmic
tafluprost (mart.)
tafluprost opthalmic
1-methylethyl (5z)-7-((1r,2r, 3r,5s)-2-((1e)-3,3-difluoro-4-phenoxy-1-butenyl-3,5-dihydroxycyclopentyl)-5-heptenoate
1-methylethyl (5z)-7-((1r,2r,3r,5s)-2-((1e)-3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoate
s01ee05
EN300-21680961
Z2568721846

Roles (1)

RoleDescription
prostaglandin receptor agonistAn agonist that binds to and activates prostaglandin receptors.

Drug Classes (3)

ClassDescription
prostaglandins Falpha
organofluorine compoundAn organofluorine compound is a compound containing at least one carbon-fluorine bond.
isopropyl esterAny carboxylic ester resulting from the formal condensation of a carboxylic acid with the hydroxy group of propan-2-ol.

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1346394Human FP receptor (Prostanoid receptors)2004Experimental eye research, Apr, Volume: 78, Issue:4
ISSN: 0014-4835		Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug.

Research

Studies (144)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's18 (12.50)29.6817
2010's102 (70.83)24.3611
2020's24 (16.67)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials35 (23.18%)5.53%
Reviews18 (11.92%)6.00%
Case Studies1 (0.66%)4.05%
Observational9 (5.96%)0.25%
Other88 (58.28%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
dinoprost
0
monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite		00low000000
15-ketoprostaglandin f2alpha
0
prostaglandins Falpha00low000000
6-ketoprostaglandin f1 alpha
0
prostaglandins Falphahuman metabolite;
mouse metabolite		00low000000
prostaglandin f1
0
prostaglandins Falphahuman metabolite00low000000
prostaglandin f3alpha
0
prostaglandins Falpha00low000000
uf 021
0
isopropyl ester;
ketone;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
prodrug		00low000000
travoprost
0
(trifluoromethyl)benzenes;
isopropyl ester;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
ophthalmology drug;
prodrug;
prostaglandin receptor agonist		00low000000
15-keto-13,14-dihydroprostaglandin f2alpha
0
ketone;
prostaglandins Falpha		metabolite00low000000
fluprostenol
0
(trifluoromethyl)benzenes;
hydroxy monocarboxylic acid;
prostaglandins Falpha		abortifacient;
antiglaucoma drug;
antihypertensive agent;
female contraceptive drug;
prostaglandin receptor agonist		00low000000
latanoprost
0
isopropyl ester;
prostaglandins Falpha;
triol		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
prodrug		00low000000
phxa 85
0
hydroxy monocarboxylic acid;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor		00low000000
benefin
0
C-nitro compound;
organofluorine compound;
substituted aniline;
tertiary amino compound		agrochemical;
herbicide		00low000000
celecoxib
0
organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
cgs 12066
0
N-arylpiperazine;
organofluorine compound;
pyrroloquinoxaline		serotonergic agonist00low000000
citalopram
0
2-benzofurans;
cyclic ether;
nitrile;
organofluorine compound;
tertiary amino compound		00low000000
diflunisal
0
monohydroxybenzoic acid;
organofluorine compound		non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
droperidol
0
aromatic ketone;
benzimidazoles;
organofluorine compound		anaesthesia adjuvant;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic		00low000000
enflurane
0
ether;
organochlorine compound;
organofluorine compound		anaesthetic00low000000
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
0
aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore		00low000000
flecainide
0
aromatic ether;
monocarboxylic acid amide;
organofluorine compound;
piperidines		anti-arrhythmia drug00low000000
flucytosine
0
aminopyrimidine;
nucleoside analogue;
organofluorine compound;
pyrimidine antifungal drug;
pyrimidone		prodrug00low000000
fludiazepam
0
1,4-benzodiazepinone;
organochlorine compound;
organofluorine compound		anxiolytic drug00low000000
flufenamic acid
0
aromatic amino acid;
organofluorine compound		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
fluphenazine
0
N-alkylpiperazine;
organofluorine compound;
phenothiazines		anticoronaviral agent;
dopaminergic antagonist;
phenothiazine antipsychotic drug		00low000000
flumazenil
0
ethyl ester;
imidazobenzodiazepine;
organofluorine compound		antidote to benzodiazepine poisoning;
GABA antagonist		00low000000
flumequine
0
3-oxo monocarboxylic acid;
organofluorine compound;
pyridoquinoline;
quinolone antibiotic		00low000000
fluorouracil
0
nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic		00low000000
fluphenazine depot
0
decanoate ester;
N-alkylpiperazine;
organofluorine compound;
phenothiazines		dopaminergic antagonist;
phenothiazine antipsychotic drug;
prodrug		00low000000
vanoxerine
0
ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor00low000000
haloperidol
0
aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist		00low000000
halothane
0
haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound		inhalation anaesthetic00low000000
isoflurane
0
organofluorine compoundinhalation anaesthetic00low000000
ketanserin
0
aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist		00low000000
mefloquine hydrochloride
0
organofluorine compound;
piperidines;
quinolines;
secondary alcohol		00low000000
methoxyflurane
0
ether;
organochlorine compound;
organofluorine compound		hepatotoxic agent;
inhalation anaesthetic;
nephrotoxic agent;
non-narcotic analgesic		00low000000
ofloxacin
0
3-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline		00low000000
pantoprazole
0
aromatic ether;
benzimidazoles;
organofluorine compound;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
environmental contaminant;
xenobiotic		00low000000
pipamperone
0
aromatic ketone;
bipiperidines;
monocarboxylic acid amide;
organofluorine compound;
tertiary amino compound		dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist		00low000000
risperidone
0
1,2-benzoxazoles;
heteroarylpiperidine;
organofluorine compound;
pyridopyrimidine		alpha-adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
psychotropic drug;
second generation antipsychotic;
serotonergic antagonist		00low000000
ritanserin
0
organofluorine compound;
piperidines;
thiazolopyrimidine		antidepressant;
antipsychotic agent;
anxiolytic drug;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist		00low000000
sb 220025
0
aminopyrimidine;
imidazoles;
organofluorine compound;
piperidines		angiogenesis inhibitor;
anti-inflammatory agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
sb 202190
0
imidazoles;
organofluorine compound;
phenols;
pyridines		apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
sevoflurane
0
ether;
organofluorine compound		central nervous system depressant;
inhalation anaesthetic;
platelet aggregation inhibitor		00low000000
fluoroacetic acid
0
haloacetic acid;
organofluorine compound		EC 4.2.1.3 (aconitate hydratase) inhibitor00low000000
spiperone
0
aromatic ketone;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound		alpha-adrenergic antagonist;
antipsychotic agent;
dopaminergic antagonist;
psychotropic drug;
serotonergic antagonist		00low000000
gatifloxacin
0
N-arylpiperazine;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antiinfective agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor		00low000000
tosufloxacin
0
1,8-naphthyridine derivative;
amino acid;
aminopyrrolidine;
monocarboxylic acid;
organofluorine compound;
primary amino compound;
quinolone antibiotic;
tertiary amino compound		00low000000
trifluoperazine
0
N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines		antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug		00low000000
triflupromazine
0
organofluorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic		00low000000
zardaverine
0
organofluorine compound;
pyridazinone		anti-asthmatic drug;
bronchodilator agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
peripheral nervous system drug		00low000000
floxuridine
0
nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent		00low000000
trifluridine
0
nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor		00low000000
dinitrofluorobenzene
0
C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent		00low000000
1,1-difluoroethylene
0
olefinic compound;
organofluorine compound		00low000000
1,1,1-trifluoro-2-chloroethane
0
organofluorine compound00low000000
chloropentafluoroethane
0
organochlorine compound;
organofluorine compound		00low000000
2-fluoroadenosine
0
adenosines;
organofluorine compound		00low000000
perfluorotributylamine
0
organofluorine compoundblood substitute;
greenhouse gas;
solvent		00low000000
5-fluorouridine
0
organofluorine compound;
uridines		mutagen00low000000
5-fluorotryptophan
0
non-proteinogenic alpha-amino acid;
organofluorine compound;
tryptophan derivative		00low000000
bromochlorodifluoromethane
0
one-carbon compound;
organobromine compound;
organochlorine compound;
organofluorine compound		00low000000
difluoroacetic acid
0
monocarboxylic acid;
organofluorine compound		00low000000
fluroxene
0
organofluorine compound00low000000
2,3,4,5,6-pentafluorobenzyl alcohol
0
benzyl alcohols;
organofluorine compound		00low000000
2-fluoroadenine
0
organofluorine compound;
purines		antineoplastic agent00low000000
n-dichlorofluoromethylthio-n',n'-dimethyl-n-p-tolylsulfamide
0
organochlorine compound;
organofluorine compound;
phenylsulfamide fungicide;
sulfamides		antifungal agrochemical;
genotoxin		00low000000
hexafluoroisopropanol
0
organofluorine compound;
secondary alcohol		drug metabolite00low000000
dichlofluanid
0
organochlorine compound;
organofluorine compound;
phenylsulfamide fungicide;
sulfamides		acaricide;
antifungal agrochemical		00low000000
pimozide
0
benzimidazoles;
heteroarylpiperidine;
organofluorine compound		antidyskinesia agent;
dopaminergic antagonist;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist		00low000000
5-fluorocytidine
0
cytidines;
organofluorine compound		00low000000
doxifluridine
0
organofluorine compound;
pyrimidine 5'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
prodrug		00low000000
fludarabine phosphate
0
nucleoside analogue;
organofluorine compound;
purine arabinonucleoside monophosphate		antimetabolite;
antineoplastic agent;
antiviral agent;
DNA synthesis inhibitor;
immunosuppressive agent;
prodrug		00low000000
flubendazole
0
aromatic ketone;
benzimidazoles;
carbamate ester;
organofluorine compound		antinematodal drug;
teratogenic agent		00low000000
flunixin
0
aminopyridine;
organofluorine compound;
pyridinemonocarboxylic acid		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
desflurane
0
organofluorine compoundinhalation anaesthetic00low000000
paroxetine
0
aromatic ether;
benzodioxoles;
organofluorine compound;
piperidines		antidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor		00low000000
acifluorfen
0
aromatic ether;
benzoic acids;
C-nitro compound;
monocarboxylic acid;
organochlorine compound;
organofluorine compound		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
triflumuron
0
aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound		00low000000
4,5-amino-3,5-dichloro-6-fluoro-2-pyridinyloxyacetic acid
0
aminopyridine;
aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound		environmental contaminant;
herbicide;
xenobiotic		00low000000
haloxyfop
0
aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
pyridines		00low000000
fluazifop-butyl
0
aromatic ether;
carboxylic ester;
organofluorine compound;
pyridines		00low000000
fomesafen
0
aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
temafloxacin
0
amino acid;
monocarboxylic acid;
N-arylpiperazine;
organofluorine compound;
quinolone antibiotic;
quinolone;
secondary amino compound;
tertiary amino compound		00low000000
sertindole
0
heteroarylpiperidine;
imidazolidinone;
organochlorine compound;
organofluorine compound;
phenylindole		alpha-adrenergic antagonist;
H1-receptor antagonist;
second generation antipsychotic;
serotonergic antagonist		00low000000
gemcitabine hydrochloride
0
hydrochloride;
organofluorine compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral drug;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
immunosuppressive agent;
radiosensitizing agent		00low000000
gemcitabine
0
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic		00low000000
emtricitabine
0
monothioacetal;
nucleoside analogue;
organofluorine compound;
pyrimidone		antiviral drug;
HIV-1 reverse transcriptase inhibitor		00low000000
capecitabine
0
carbamate ester;
cytidines;
organofluorine compound		antimetabolite;
antineoplastic agent;
prodrug		00low000000
4-fluorofentanyl
0
monocarboxylic acid amide;
organofluorine compound;
piperidines		00low000000
efavirenz
0
acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor		00low000000
heptafluorobutyric anhydride
0
acyclic carboxylic anhydride;
organofluorine compound		chromatographic reagent00low000000
perfluorotripropylamine
0
organofluorine compoundblood substitute00low000000
3-fluoropyruvate
0
2-oxo monocarboxylic acid;
organofluorine compound		00low000000
spiramide
0
aromatic ether;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound		dopaminergic antagonist;
serotonergic antagonist		00low000000
flunoxaprofen
0
1,3-benzoxazoles;
monocarboxylic acid;
organofluorine compound		antirheumatic drug;
hepatotoxic agent;
non-steroidal anti-inflammatory drug;
protein kinase C agonist		00low000000
halopropane
0
organofluorine compound00low000000
enrofloxacin
0
cyclopropanes;
N-alkylpiperazine;
N-arylpiperazine;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone		antibacterial agent;
antimicrobial agent;
antineoplastic agent		00low000000
flurithromycin
0
cyclic ketone;
erythromycin derivative;
organofluorine compound;
semisynthetic derivative		antibacterial drug00low000000
nebivolol
0
chromanes;
diol;
organofluorine compound;
secondary alcohol;
secondary amino compound		00low000000
hp 873
0
1,2-benzoxazoles;
aromatic ether;
aromatic ketone;
methyl ketone;
monoamine;
organofluorine compound;
piperidines;
tertiary amino compound		dopaminergic antagonist;
second generation antipsychotic;
serotonergic antagonist		00low000000
fluphenacur
0
aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organofluorine compound		00low000000
nucleocidin
0
6-aminopurines;
adenosines;
diol;
organofluorine compound;
sulfamate ester		antibacterial agent;
bacterial metabolite;
nucleoside antibiotic;
protein synthesis inhibitor;
trypanocidal drug		00low000000
fluoroacetaldehyde
0
aldehyde;
organofluorine compound		cardiotoxic agent00low000000
fc 75
0
alkyltetrahydrofuran;
organofluorine compound		00low000000
tetraconazole
0
dichlorobenzene;
ether;
organofluorine compound;
triazoles		00low000000
hei 712
0
organofluorine compound;
quinolone		00low000000
n-(2,4-dichloro-5-(4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1h-1,2,4-triazol-1-yl)phenyl)methanesulfonamide
0
dichlorobenzene;
organofluorine compound;
sulfonamide;
triazoles		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
thifluzamide
0
1,3-thiazoles;
anilide fungicide;
aromatic amide;
aromatic ether;
dibromobenzene;
organofluorine compound		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor		00low000000
fludioxonil
0
benzodioxoles;
nitrile;
organofluorine compound;
pyrroles		androgen antagonist;
antifungal agrochemical;
estrogen receptor agonist		00low000000
fluquinconazole
0
conazole fungicide;
dichlorobenzene;
organofluorine compound;
quinazolines;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor		00low000000
cloransulam-methyl
0
methyl ester;
monochlorobenzenes;
organofluorine compound;
sulfonamide;
triazolopyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide		00low000000
fluazifop
0
aromatic ether;
monocarboxylic acid;
organofluorine compound;
pyridines		00low000000
dithiopyr
0
organofluorine compound;
pyridines;
thioester		00low000000
s 53482
0
benzoxazine;
dicarboximide;
organofluorine compound;
terminal acetylenic compound		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide;
teratogenic agent		00low000000
clodinafop-propargyl
0
aromatic ether;
carboxylic ester;
organochlorine compound;
organofluorine compound;
propyzamide;
pyridines		agrochemical;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
herbicide		00low000000
triflusulfuron-methyl
0
1,3,5-triazines;
aromatic ether;
benzoate ester;
methyl ester;
N-sulfonylurea;
organofluorine compound;
tertiary amino compound		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
proherbicide		00low000000
novaluron
0
aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound		00low000000
fulvestrant
0
17beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist		00low000000
cyfluthrin
0
aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound;
organofluorine compound		agrochemical;
pyrethroid ester insecticide		00low000000
fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether
0
organofluorine compound00low000000
florfenicol
0
organochlorine compound;
organofluorine compound;
secondary alcohol;
secondary carboxamide;
sulfone		antimicrobial agent00low000000
paliperidone
0
1,2-benzoxazoles;
heteroarylpiperidine;
organofluorine compound;
pyridopyrimidine;
secondary alcohol		00low000000
sc 58125
0
organofluorine compound;
pyrazoles;
sulfone		antineoplastic agent;
cyclooxygenase 2 inhibitor		00low000000
clofarabine
0
adenosines;
organofluorine compound		antimetabolite;
antineoplastic agent		00low000000
5-fluoromethylornithine
0
organofluorine compound;
ornithine derivative		EC 2.6.1.13 (ornithine aminotransferase) inhibitor00low000000
nitroflurbiprofen
0
biphenyls;
carboxylic ester;
nitrate ester;
organofluorine compound		cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector;
non-steroidal anti-inflammatory drug;
vasodilator agent		00low000000
ezogabine
0
carbamate ester;
organofluorine compound;
secondary amino compound;
substituted aniline		anticonvulsant;
potassium channel modulator		00low000000
garenoxacin
0
aromatic ether;
cyclopropanes;
isoindoles;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone antibiotic		antibacterial drug;
non-steroidal anti-inflammatory drug		00low000000
5-fluorowillardiine
0
L-alanine derivative;
non-proteinogenic L-alpha-amino acid;
organofluorine compound		AMPA receptor agonist00low000000
perfluoro-n-methyldecahydroisoquinoline
0
organofluorine compoundblood substitute00low000000
fc 80
0
alkyltetrahydrofuran;
organofluorine compound		00low000000
ezetimibe
0
azetidines;
beta-lactam;
organofluorine compound		anticholesteremic drug;
antilipemic drug;
antimetabolite		00low000000
5-fluorouridine 5'-phosphate
0
organofluorine compound;
pyrimidine ribonucleoside 5'-monophosphate		drug metabolite00low000000
cox 189
0
amino acid;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
secondary amino compound		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
canertinib
0
monochlorobenzenes;
morpholines;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
jte 522
0
1,3-oxazoles;
organofluorine compound;
sulfonamide		cyclooxygenase 2 inhibitor00low000000
trifluoromethionine
0
L-methionine derivative;
non-proteinogenic L-alpha-amino acid;
organofluorine compound		00low000000
lapatinib
0
furans;
organochlorine compound;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
cimicoxib
0
aromatic ether;
imidazoles;
organochlorine compound;
organofluorine compound;
sulfonamide		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
diflomotecan
0
epsilon-lactone;
organic heteropentacyclic compound;
organofluorine compound;
organonitrogen heterocyclic compound;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor		00low000000
5',5',5'-trifluoroleucine
0
leucine derivative;
non-proteinogenic alpha-amino acid;
organofluorine compound		00low000000
sorbinil
0
azaspiro compound;
chromanes;
imidazolidinone;
organofluorine compound;
oxaspiro compound		antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor		00low000000
linezolid
0
acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor		00low000000
2'-deoxy-2-fluoroadenosine
0
adenosines;
organofluorine compound		00low000000
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine
0
6-aminopurines;
acetylenic compound;
methoxybenzenes;
monochlorobenzenes;
organofluorine compound		antineoplastic agent;
Hsp90 inhibitor		00low000000
roflumilast
0
aromatic ether;
benzamides;
chloropyridine;
cyclopropanes;
organofluorine compound		anti-asthmatic drug;
phosphodiesterase IV inhibitor		00low000000
posaconazole
0
aromatic ether;
conazole antifungal drug;
N-arylpiperazine;
organofluorine compound;
oxolanes;
triazole antifungal drug;
triazoles		trypanocidal drug00low000000
efinaconazole
0
conazole antifungal drug;
olefinic compound;
organofluorine compound;
piperidines;
tertiary alcohol;
tertiary amino compound;
triazole antifungal drug		EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor00low000000
favipiravir
0
hydroxypyrazine;
organofluorine compound;
primary carboxamide		anticoronaviral agent;
antiviral drug;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor		00low000000
ck-0944666
0
benzamides;
indoles;
organofluorine compound		actin polymerisation inhibitor00low000000
2-(3-Chloro-2-fluorophenyl)-2,3-dihydroisothiazol-3-one
0
organofluorine compound00low000000
4-[(3-fluorophenyl)methyl-(3-pyridinylmethyl)amino]-4-oxobutanoic acid
0
organofluorine compound00low000000
transfluthrin
0
carboxylic ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester insecticide00low000000
4-(4-fluorophenyl)-3H-thiazole-2-thione
0
organofluorine compound00low000000
2-(4-chlorophenyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole
0
organofluorine compound00low000000
N-[(4-fluorophenyl)methyl]-2-thiophen-2-ylacetamide
0
organofluorine compound00low000000
1-(cycloheptylideneamino)-3-(4-fluorophenyl)thiourea
0
organofluorine compound00low000000
2-(2-fluorophenyl)-5-phenyl-4-thieno[2,3-d][1,3]oxazinone
0
organofluorine compound00low000000
sulindac
0
monocarboxylic acid;
organofluorine compound;
sulfoxide		analgesic;
antineoplastic agent;
antipyretic;
apoptosis inducer;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug;
tocolytic agent		00low000000
N-cyano-N'-(2-fluorophenyl)carbamimidothioic acid [2-(tert-butylamino)-2-oxoethyl] ester
0
organofluorine compound00low000000
N-(4-fluorobenzyl)urea
0
organofluorine compound00low000000
N1-(3-chloro-4-fluorophenyl)-2-(methylthio)acetamide
0
organofluorine compound00low000000
ethyl 1-[4-(4-chlorobenzenesulfonamido)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
0
ethyl ester;
monochlorobenzenes;
organofluorine compound;
pyrazoles;
sulfonamide		00low000000
S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate
0
acetylenic compound;
furans;
organofluorine compound;
thioester;
triazoles		00low000000
4-[1-(4-fluorophenyl)ethyl]-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione
0
organofluorine compound00low000000
1-(4-fluorophenyl)-1-cyclopentanecarboxylic acid [2-(2,6-dimethyl-4-morpholinyl)-2-oxoethyl] ester
0
organofluorine compound00low000000
deracoxib
0
organofluorine compound;
pyrazoles;
sulfonamide		cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
zd 6474
0
aromatic ether;
organobromine compound;
organofluorine compound;
piperidines;
quinazolines;
secondary amine		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
0
organic heterotricyclic compound;
organofluorine compound;
pyridines;
secondary amino compound		00low000000
1-(4-fluorophenyl)-N-methyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carbothioamide
0
organofluorine compound00low000000
2-[[2-[3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]thio]acetic acid butyl ester
0
organofluorine compound00low000000
sc 560
0
aromatic ether;
monochlorobenzenes;
organofluorine compound;
pyrazoles		angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 1 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
1-[(2-fluorophenyl)methyl]-4-pyrazolamine
0
organofluorine compound00low000000
3-[2,2-dichloro-1-(3-fluoro-4-methylphenyl)ethyl]-1,1-bis(phenylmethyl)urea
0
organofluorine compound00low000000
ro 60-0175
0
indoles;
organochlorine compound;
organofluorine compound;
primary amino compound		00low000000
jtk-303
0
aromatic ether;
monochlorobenzenes;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone		HIV-1 integrase inhibitor00low000000
arachidonyltrifluoromethane
0
fatty acid derivative;
ketone;
olefinic compound;
organofluorine compound		EC 3.1.1.4 (phospholipase A2) inhibitor00low000000
cyhalothrin
0
aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound;
organofluorine compound		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
sulindac sulfide
0
aryl sulfide;
monocarboxylic acid;
organofluorine compound		antineoplastic agent;
apoptosis inducer;
non-steroidal anti-inflammatory drug		00low000000
bw b70c
0
aromatic ether;
hydroxamic acid;
organofluorine compound;
ureas		EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor00low000000
(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
0
dihydroxy monocarboxylic acid;
indoles;
organofluorine compound		00low000000
sulindac sulfone
0
monocarboxylic acid;
organofluorine compound;
sulfone		apoptosis inducer;
cyclooxygenase 2 inhibitor;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor		00low000000
clodinafop
0
aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
pyridines		EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
phenoxy herbicide		00low000000
2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one
0
organic heterotetracyclic compound;
organofluorine compound		EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor00low000000
z-val-ala-asp(ome)-fluoromethylketone
0
carbamate ester;
organofluorine compound;
tripeptide		apoptosis inhibitor;
protease inhibitor		00low000000
robenacoxib
0
aromatic amino acid;
monocarboxylic acid;
organofluorine compound;
phenylacetic acids;
secondary amino compound		cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
acrinathrin
0
cyclopropanecarboxylate ester;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
bifenthrin
0
carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide		00low000000
netupitant
0
aminopyridine;
monocarboxylic acid amide;
N-alkylpiperazine;
N-arylpiperazine;
organofluorine compound;
toluenes		antiemetic;
neurokinin-1 receptor antagonist		00low000000
flibanserin
0
benzimidazoles;
N-alkylpiperazine;
N-arylpiperazine;
organofluorine compound		antidepressant;
serotonergic agonist;
serotonergic antagonist		00low000000
ru 58668
0
17beta-hydroxy steroid;
3-hydroxy steroid;
aromatic ether;
organofluorine compound;
sulfone		anti-estrogen;
antineoplastic agent;
estrogen receptor antagonist		00low000000
nepicastat
0
1,3-dihydroimidazole-2-thiones;
organofluorine compound;
primary amino compound;
tetralins		EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor00low000000
gw 501516
0
1,3-thiazoles;
aromatic ether;
aryl sulfide;
monocarboxylic acid;
organofluorine compound		carcinogenic agent;
PPARbeta/delta agonist		00low000000
noviflumuron
0
aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
organofluorine compound		00low000000
flonicamid
0
nitrile;
organofluorine compound;
pyridinecarboxamide		environmental contaminant;
insecticide;
xenobiotic		00low000000
4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl)benzenesulfonamide
0
organofluorine compound;
pyrazoles;
sulfonamide		cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug		00low000000
paliperidone palmitate
0
1,2-benzoxazoles;
fatty acid ester;
heteroarylpiperidine;
organofluorine compound;
pyridopyrimidine		00low000000
cangrelor
0
adenosine 5'-phosphate;
aryl sulfide;
nucleoside triphosphate analogue;
organochlorine compound;
organofluorine compound;
secondary amino compound		P2Y12 receptor antagonist;
platelet aggregation inhibitor		00low000000
ticagrelor
0
aryl sulfide;
hydroxyether;
organofluorine compound;
secondary amino compound;
triazolopyrimidines		P2Y12 receptor antagonist;
platelet aggregation inhibitor		00low000000
am 694
0
aromatic ketone;
indoles;
organofluorine compound;
organoiodine compound;
synthetic cannabinoid		cannabinoid receptor agonist00low000000
rucaparib
0
azepinoindole;
caprolactams;
organofluorine compound;
secondary amino compound		antineoplastic agent;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor		00low000000
NNC 55-0396 (free base)
0
benzimidazoles;
cyclopropanecarboxylate ester;
organofluorine compound;
tertiary amino compound;
tetralins		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker		00low000000
osu 03012
0
antibiotic antifungal drug;
aromatic amide;
glycine derivative;
organofluorine compound;
phenanthrenes;
pyrazoles		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor		00low000000
vorapaxar
0
carbamate ester;
lactone;
naphthofuran;
organofluorine compound;
pyridines		cardiovascular drug;
platelet aggregation inhibitor;
protease-activated receptor-1 antagonist		00low000000
azd 6244
0
benzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monochlorobenzenes;
organofluorine compound;
secondary amino compound		anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
bibw 2992
0
aromatic ether;
enamide;
furans;
monochlorobenzenes;
organofluorine compound;
quinazolines;
secondary carboxamide;
tertiary amino compound		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
rolapitant
0
azaspiro compound;
ether;
organofluorine compound;
piperidines;
pyrrolidin-2-ones		antiemetic;
neurokinin-1 receptor antagonist		00low000000
r-138727
0
organofluorine compound00low000000
fluoxastrobin
0
aromatic ether;
dioxazine;
monochlorobenzenes;
organofluorine compound;
oxime O-ether;
pyrimidines;
strobilurin antifungal agent		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor		00low000000
flumorph
0
aromatic ether;
enamide;
morpholines;
organofluorine compound;
tertiary carboxamide		00low000000
fluopicolide
0
benzamide fungicide;
benzamides;
dichlorobenzene;
monochloropyridine;
organofluorine compound		antifungal agrochemical00low000000
gamendazole
0
alpha,beta-unsaturated monocarboxylic acid;
dichlorobenzene;
indazoles;
olefinic compound;
organofluorine compound		antispermatogenic agent;
eukaryotic translation elongation factor 1alpha 1 inhibitor;
Hsp90 inhibitor;
synthetic oral contraceptive		00low000000
tedizolid
0
carbamate ester;
organofluorine compound;
oxazolidinone;
primary alcohol;
pyridines;
tetrazoles		antimicrobial agent;
drug metabolite;
protein synthesis inhibitor		00low000000
rx-3117
0
organofluorine compound;
primary allylic alcohol;
triol		antimetabolite;
antineoplastic agent;
apoptosis inducer;
DNA synthesis inhibitor;
prodrug		00low000000
picoxystrobin
0
aromatic ether;
enoate ester;
enol ether;
methoxyacrylate strobilurin antifungal agent;
organofluorine compound;
pyridines		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor		00low000000
bay 63-2521
0
aminopyrimidine;
carbamate ester;
organofluorine compound;
pyrazolopyridine		antihypertensive agent;
soluble guanylate cyclase activator		00low000000
penthiopyrad
0
aromatic amide;
organofluorine compound;
pyrazoles;
thiophenes		00low000000
tedizolid phosphate
0
carbamate ester;
organofluorine compound;
oxazolidinone;
phosphate monoester;
pyridines;
tetrazoles		antimicrobial agent;
prodrug;
protein synthesis inhibitor		00low000000
tavaborole
0
benzoxaborole;
organofluorine compound		antifungal agent;
EC 6.1.1.4 (leucine--tRNA ligase) inhibitor;
protein synthesis inhibitor		00low000000
tembotrione
0
aromatic ketone;
beta-triketone;
cyclic ketone;
ether;
monochlorobenzenes;
organofluorine compound;
sulfone		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor;
herbicide		00low000000
finafloxacin
0
cyclopropanes;
monocarboxylic acid;
nitrile;
organofluorine compound;
quinolone;
secondary amino compound;
tertiary amino compound		antibacterial drug;
antimicrobial agent		00low000000
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine
0
aminopyridine;
aromatic ether;
dichlorobenzene;
organofluorine compound;
pyrazolylpiperidine;
racemate		antineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor		00low000000
idelalisib
0
aromatic amine;
organofluorine compound;
purines;
quinazolines;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor		00low000000
zstk474
0
benzimidazoles;
morpholines;
organofluorine compound;
triamino-1,3,5-triazine		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor		00low000000
trifloxystrobin
0
methoxyiminoacetate strobilurin antifungal agent;
methyl ester;
organofluorine compound;
oxime O-ether		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor		00low000000
5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide
0
aromatic amide;
organofluorine compound;
pyrazoles		00low000000
n-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxamide
0
aromatic amide;
cyclopropanes;
organofluorine compound;
pyrazoles;
ring assembly		00low000000
trametinib
0
acetamides;
aromatic amine;
cyclopropanes;
organofluorine compound;
organoiodine compound;
pyridopyrimidine;
ring assembly		anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector		00low000000
butafenacil
0
benzoate ester;
diester;
monochlorobenzenes;
olefinic compound;
organofluorine compound		EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
bgt226
0
aromatic ether;
imidazoquinoline;
N-arylpiperazine;
organofluorine compound;
pyridines		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor		00low000000
buparlisib
0
aminopyridine;
aminopyrimidine;
morpholines;
organofluorine compound		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor		00low000000
lumacaftor
0
aromatic amide;
benzodioxoles;
benzoic acids;
cyclopropanes;
organofluorine compound;
pyridines		CFTR potentiator;
orphan drug		00low000000
ro5126766
0
aryloxypyrimidine;
coumarins;
organofluorine compound;
pyridines;
sulfamides		antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
sulfoxaflor
0
nitrile;
organofluorine compound;
pyridines;
sulfoximide		00low000000
azd 7545
0
benzamides;
monochlorobenzenes;
organofluorine compound;
secondary carboxamide;
sulfone;
tertiary alcohol;
tertiary carboxamide		EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor;
hypoglycemic agent		00low000000
ph 797804
0
aromatic ether;
benzamides;
organobromine compound;
organofluorine compound;
pyridone		anti-inflammatory agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
lde225
0
aminopyridine;
aromatic ether;
benzamides;
biphenyls;
morpholines;
organofluorine compound;
tertiary amino compound		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist		00low000000
dafadine D
0
aromatic amide;
aromatic ether;
isoxazoles;
N-acylpiperidine;
organofluorine compound;
pyridines		P450 inhibitor00low000000
canagliflozin
0
C-glycosyl compound;
organofluorine compound;
thiophenes		hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor		00low000000
florbetapir f 18
0
(18)F radiopharmaceutical;
aromatic ether;
organofluorine compound;
pyridines;
substituted aniline		radioactive imaging agent00low000000
navitoclax
0
aryl sulfide;
monochlorobenzenes;
morpholines;
N-sulfonylcarboxamide;
organofluorine compound;
piperazines;
secondary amino compound;
sulfone;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor		00low000000
dcc-2036
0
organofluorine compound;
phenylureas;
pyrazoles;
pyridinecarboxamide;
quinolines		tyrosine kinase inhibitor00low000000
cabozantinib
0
aromatic ether;
dicarboxylic acid diamide;
organofluorine compound;
quinolines		antineoplastic agent;
tyrosine kinase inhibitor		00low000000
pexidartinib
0
aminopyridine;
organochlorine compound;
organofluorine compound;
pyrrolopyridine;
secondary amino compound		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor		00low000000
TAK-580
0
1,3-thiazolecarboxamide;
aminopyrimidine;
chloropyridine;
organofluorine compound;
pyrimidinecarboxamide;
secondary carboxamide		antineoplastic agent;
apoptosis inducer;
B-Raf inhibitor		00low000000
dabrafenib
0
1,3-thiazoles;
aminopyrimidine;
organofluorine compound;
sulfonamide		anticoronaviral agent;
antineoplastic agent;
B-Raf inhibitor		00low000000
sofosbuvir
0
isopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester		antiviral drug;
hepatitis C protease inhibitor;
prodrug		00low000000
[5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid
0
organofluorine compoundnon-steroidal anti-inflammatory drug00low000000
torin 1
0
N-acylpiperazine;
N-arylpiperazine;
organofluorine compound;
pyridoquinoline;
quinolines		antineoplastic agent;
mTOR inhibitor		00low000000
ro 4929097
0
dibenzoazepine;
dicarboxylic acid diamide;
lactam;
organofluorine compound		EC 3.4.23.46 (memapsin 2) inhibitor00low000000
torin 2
0
aminopyridine;
organofluorine compound;
primary amino compound;
pyridoquinoline		antineoplastic agent;
mTOR inhibitor		00low000000
gsk2656157
0
biaryl;
indoles;
methylpyridines;
organofluorine compound;
pyrrolopyrimidine;
tertiary carboxamide		antineoplastic agent;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
PERK inhibitor		00low000000
N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide
0
aromatic amide;
bridged compound;
olefinic compound;
organochlorine compound;
organofluorine compound;
pyrazoles		00low000000
vericiguat
0
aminopyrimidine;
carbamate ester;
organofluorine compound;
pyrazolopyridine		antihypertensive agent;
soluble guanylate cyclase activator;
vasodilator agent		00low000000
pacific blue succinimidyl ester
0
hydroxycoumarin;
N-hydroxysuccinimide ester;
organofluorine compound		fluorochrome00low000000
3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)propan-2-yl]pyrazole-4-carboxamide
0
aromatic amide;
monocarboxylic acid amide;
organofluorine compound;
pyrazoles;
trichlorobenzene		00low000000
oxathiapiprolin
0
1,3-thiazoles;
isoxazoline;
N-acylpiperidine;
organofluorine compound;
pyrazoles;
tertiary carboxamide		00low000000
5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylidene]thiazolidine-2,4-dione
0
halophenol;
organofluorine compound		00low000000
LimKi 3
0
1,3-thiazoles;
dichlorobenzene;
organofluorine compound;
pyrazoles;
secondary carboxamide		LIM kinase inhibitor00low000000
ledipasvir
0
azaspiro compound;
benzimidazole;
bridged compound;
carbamate ester;
carboxamide;
fluorenes;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organofluorine compound		antiviral drug;
hepatitis C protease inhibitor		00low000000
ivosidenib
0
cyanopyridine;
monochlorobenzenes;
organofluorine compound;
pyrrolidin-2-ones;
secondary carboxamide;
tertiary carboxamide		antineoplastic agent;
EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor		00low000000
as 1842856
0
organofluorine compound;
primary amino compound;
quinolinemonocarboxylic acid;
quinolone;
secondary amino compound;
tertiary amino compound		anti-obesity agent;
antineoplastic agent;
apoptosis inducer;
autophagy inhibitor;
forkhead box protein O1 inhibitor;
hypoglycemic agent		00low000000
praliciguat
0
aminopyrimidine;
isoxazoles;
monofluorobenzenes;
organofluorine compound;
pyrazoles;
secondary amino compound;
tertiary alcohol		anti-inflammatory agent;
antihypertensive agent;
soluble guanylate cyclase activator;
vasodilator agent		00low000000
enasidenib
0
1,3,5-triazines;
aminopyridine;
aromatic amine;
organofluorine compound;
secondary amino compound;
tertiary alcohol		antineoplastic agent;
EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor		00low000000
MMP-9-IN-1
0
aromatic compound;
organic sulfide;
organofluorine compound;
pyrimidone;
secondary carboxamide		antineoplastic agent;
EC 3.4.24.35 (gelatinase B) inhibitor		00low000000
5-(2,5-difluorophenyl)-N-(2-oxolanylmethyl)-6H-1,3,4-thiadiazin-2-amine
0
organofluorine compound00low000000
nirmatrelvir
0
azabicyclohexane;
nitrile;
organofluorine compound;
pyrrolidin-2-ones;
pyrrolidinecarboxamide;
secondary carboxamide;
tertiary carboxamide		anticoronaviral agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor		00low000000
fenofibrate
0
aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic		00low000000
isradipine
0
benzoxadiazole;
dihydropyridine;
isopropyl ester;
methyl ester		00low000000
diisopropyl 1,3-dithiol-2-ylidenemalonate
0
isopropyl ester00low000000
nilvadipine
0
dihydropyridine;
isopropyl ester;
methyl ester;
nitrile		00low000000
nimodipine
0
2-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester		antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent		00low000000
isopropyl palmitate
0
fatty acid ester;
isopropyl ester		human metabolite00low000000
isofenphos
0
isopropyl ester;
organic phosphonate;
organothiophosphate insecticide;
phosphonic ester;
salicylates		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor		00low000000
isoprothiolane
0
dithiolanes;
isopropyl ester;
malonate ester		antifungal agrochemical;
environmental contaminant;
insecticide;
phospholipid biosynthesis inhibitor		00low000000
Nitrothal-isopropyl
0
diester;
isopropyl ester;
nitrobenzoic acid		00low000000
azelnidipine
0
isopropyl ester00low000000
npk 1886
0
dihydropyridine;
isopropyl ester;
methyl ester		00low000000
bay 93820
0
isopropyl ester;
organic phosphonate;
organothiophosphate insecticide;
phosphonic ester;
salicylates		agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor		00low000000
pn 202-791
0
benzoxadiazole;
isopropyl ester		00low000000
yh 439
0
aromatic amide;
isopropyl ester;
secondary carboxamide		00low000000
sandoz-21-009
0
indolyl carboxylate ester;
isopropyl ester		00low000000
2-[(5,5-dimethyl-6H-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)thio]acetic acid propan-2-yl ester
0
isopropyl ester;
triazolopyridine		00low000000
4-[(3-cyano-4,6-dimethyl-2-pyridinyl)thio]-3-oxobutanoic acid propan-2-yl ester
0
aryl sulfide;
isopropyl ester		00low000000
2-[[4-amino-5-(4-tert-butylphenyl)-1,2,4-triazol-3-yl]thio]acetic acid propan-2-yl ester
0
isopropyl ester;
triazoles		00low000000
2-[(3-methyl-6-oxo-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-1-yl)oxy]acetic acid propan-2-yl ester
0
coumarins;
isopropyl ester		00low000000
4-[[2-furanyl(oxo)methyl]amino]benzoic acid propan-2-yl ester
0
aromatic amide;
furans;
isopropyl ester;
secondary carboxamide		00low000000
2-amino-5-[diethylamino(oxo)methyl]-4-methyl-3-thiophenecarboxylic acid propan-2-yl ester
0
aromatic amine;
isopropyl ester;
tertiary carboxamide;
thiophenes		00low000000
2-[[oxo(thiophen-2-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester
0
aromatic amide;
isopropyl ester;
secondary carboxamide;
thiophenes		00low000000
4-[[(4-bromo-2-ethyl-3-pyrazolyl)-oxomethyl]amino]benzoic acid propan-2-yl ester
0
aromatic amide;
isopropyl ester;
secondary carboxamide		00low000000
4-[[[5-[(4-chloro-3,5-dimethyl-1-pyrazolyl)methyl]-2-furanyl]-oxomethyl]amino]benzoic acid propan-2-yl ester
0
aromatic amide;
furans;
isopropyl ester		00low000000
2-[3-oxo-1-[[[oxo(thiophen-2-yl)methyl]amino]-sulfanylidenemethyl]-2-piperazinyl]acetic acid propan-2-yl ester
0
isopropyl ester;
piperazines		00low000000
2-[1-[[[(4-methoxyphenyl)-oxomethyl]amino]-sulfanylidenemethyl]-3-oxo-2-piperazinyl]acetic acid propan-2-yl ester
0
isopropyl ester;
piperazines		00low000000
3,4-dimethyl-6-phenyl-2-sulfanylidene-1,6-dihydropyrimidine-5-carboxylic acid propan-2-yl ester
0
isopropyl ester;
pyrimidinethione		00low000000
1-methyl-4-[2-oxo-2-(N-(phenylmethyl)anilino)ethyl]-5-pyrrolo[3,2-b]pyrrolecarboxylic acid propan-2-yl ester
0
isopropyl ester;
tertiary carboxamide		00low000000
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester
0
aryl sulfide;
azole;
isopropyl ester;
oxadiazole;
pyridines		00low000000
2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-pyridinecarboxylic acid propan-2-yl ester
0
isopropyl ester;
pyridopyrimidine		00low000000
2-[4-(3-chlorophenyl)-1-piperazinyl]-3-pyridinecarboxylic acid propan-2-yl ester
0
isopropyl ester;
piperazines;
pyridines		00low000000
2-[[2-(3,4-dimethoxyanilino)-2-oxoethyl]thio]-3-pyridinecarboxylic acid propan-2-yl ester
0
dimethoxybenzene;
isopropyl ester;
secondary carboxamide		00low000000
2-(benzenesulfonamido)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester
0
isopropyl ester;
sulfonamide		00low000000
methoprene
0
isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate;
isopropyl ester		juvenile hormone mimic00low000000
propetamphos
0
isopropyl ester;
organophosphate insecticide;
phosphoramidate ester		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor		00low000000
l 744832
0
benzenes;
ether;
isopropyl ester;
secondary carboxamide;
sulfone;
thiol		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
geroprotector		00low000000
gs-7340
0
6-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester		antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug		00low000000
t 98475
0
isopropyl ester;
thienopyridine		00low000000
molnupiravir
0
isopropyl ester;
ketoxime;
nucleoside analogue		anticoronaviral agent;
antiviral drug;
prodrug		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
travoprost
0
(trifluoromethyl)benzenes;
isopropyl ester;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
ophthalmology drug;
prodrug;
prostaglandin receptor agonist		00low000000
17-phenyltrinorprostaglandin e2
0
alicyclic ketone;
beta-hydroxy ketone;
hydroxy monocarboxylic acid;
olefinic compound;
oxo monocarboxylic acid;
prostanoid;
secondary alcohol		human metabolite;
prostaglandin receptor agonist		00low000000
fluprostenol
0
(trifluoromethyl)benzenes;
hydroxy monocarboxylic acid;
prostaglandins Falpha		abortifacient;
antiglaucoma drug;
antihypertensive agent;
female contraceptive drug;
prostaglandin receptor agonist		00low000000
beraprost
0
enyne;
monocarboxylic acid;
organic heterotricyclic compound;
secondary alcohol;
secondary allylic alcohol		anti-inflammatory agent;
antihypertensive agent;
platelet aggregation inhibitor;
prostaglandin receptor agonist;
vasodilator agent		00low000000
beraprost sodium
0
organic sodium saltanti-inflammatory agent;
antihypertensive agent;
platelet aggregation inhibitor;
prostaglandin receptor agonist;
vasodilator agent		00low000000
cay 10580
0
hydroxy monocarboxylic acid;
pyrrolidin-2-ones;
secondary alcohol		prostaglandin receptor agonist00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
travoprost
0
(trifluoromethyl)benzenes;
isopropyl ester;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
ophthalmology drug;
prodrug;
prostaglandin receptor agonist		00low000000
fluprostenol
0
(trifluoromethyl)benzenes;
hydroxy monocarboxylic acid;
prostaglandins Falpha		abortifacient;
antiglaucoma drug;
antihypertensive agent;
female contraceptive drug;
prostaglandin receptor agonist		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
carbamates
1
amino-acid anion2013201311.0low000010
glycine
1
alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical		202020204.0low000010
histamine
1
aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter		2008200816.0low000100
acetazolamide
1
monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor		2013201311.0low000010
betaxolol
1
propanolamineantihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent		202020204.0low000010
carteolol
1
quinolone;
secondary alcohol		anti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent		201920195.0low000010
clobazam
1
1,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
GABA modulator		2013201311.0low000010
diclofenac
1
amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic		2007200717.0low000100
indomethacin
1
aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic		2013201311.0low000010
pilocarpine
1
pilocarpineantiglaucoma drug2013201311.0low000010
carbostyril
1
monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite2013201311.0low000010
phenylephrine
1
phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent		2010201014.0low000100
quinoxalines
1
mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene		2013201311.0low000010
thiophenes
4
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent201320188.2low100040
indazoles
1
indazole2013201311.0low000010
thiazoles
2
1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		2013201510.0low000020
cresyl violet
1
2008200816.0low000100
glutamic acid
1
glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical		2009200915.0low000100
timolol
31
timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist		201220236.8medium8000256
7-ethoxycoumarin
1
aromatic ether;
coumarins		2012201212.0low000010
diltiazem
1
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent		2008200816.0low000100
ng-nitroarginine methyl ester
1
alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor2013201311.0low000010
thiazolyl blue
1
organic bromide saltcolorimetric reagent;
dye		201520159.0low000010
brinzolamide
1
sulfonamide;
thienothiazine		antiglaucoma drug;
EC 4.2.1.1 (carbonic anhydrase) inhibitor		201920195.0low000010
kt 5823
1
gamma-lactam;
hemiaminal;
indolocarbazole;
methyl ester;
organic heterooctacyclic compound		EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor2009200915.0low000100
ezogabine
1
carbamate ester;
organofluorine compound;
secondary amino compound;
substituted aniline		anticonvulsant;
potassium channel modulator		2013201311.0low000010
atropine
1
202020204.0low000010
dinoprost
10
monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite		2003201912.8low100460
uf 021
3
isopropyl ester;
ketone;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
prodrug		2005201314.0low000120
travoprost
31
(trifluoromethyl)benzenes;
isopropyl ester;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
ophthalmology drug;
prodrug;
prostaglandin receptor agonist		200520229.8high5008194
dorzolamide
2
sulfonamide;
thiophenes		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor		2013201510.0low000020
bimatoprost
22
monocarboxylic acid amideantiglaucoma drug;
antihypertensive agent		200820228.5medium3002173
cloprostenol
22
prostanoid2005202111.8medium4008122
latanoprost
49
isopropyl ester;
prostaglandins Falpha;
triol		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
prodrug		2003202210.7high130017284
axitinib
1
aryl sulfide;
benzamides;
indazoles;
pyridines		antineoplastic agent;
tyrosine kinase inhibitor;
vascular endothelial growth factor receptor antagonist		2013201311.0low000010
indacaterol
1
indanes;
monohydroxyquinoline;
quinolone;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent		2013201311.0low000010
pep005
1
2013201311.0low000010
mirabegron
1
1,3-thiazoles;
aromatic amide;
ethanolamines;
monocarboxylic acid amide		beta-adrenergic agonist2013201311.0low000010
brimonidine tartrate
2
201320198.0low000020
duotrav
1
2014201410.0high000010
endothelin-1
2
2010201412.0low000110
vx-770
1
aromatic amide;
monocarboxylic acid amide;
phenols;
quinolone		CFTR potentiator;
orphan drug		2013201311.0low000010
gdc 0449
1
benzamides;
monochlorobenzenes;
pyridines;
sulfone		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent		2013201311.0low000010
warfarin
1
benzenes;
hydroxycoumarin;
methyl ketone		2012201212.0low000010
dorzolamide-timolol combination
3
201520187.3low100030
ganfort
1
2014201410.0medium000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Active Hyperemia0
5
2007202211.6low200311
Adverse Drug Event0
2
2010201412.0low000110
Allergic Reaction0
2
2010201113.5low000110
Amaurosis0
1
2010201014.0low000100
Axonal Injury, Diffuse0
1
202020204.0low000010
Bladder, Overactive0
1
2013201311.0low000010
Blepharitis0
1
2010201014.0low000100
Blindness0
1
2010201014.0low000100
Blood Pressure, High0
1
2013201311.0low000010
Chloasma0
1
2004200420.0low000100
Chronic Primary Open Angle Glaucoma0
54
200820238.4medium20005409
Colonic Inertia0
1
2013201311.0low000010
Conjunctival Diseases0
4
2010201510.5low100130
Constipation0
1
2013201311.0low000010
Constricted Pupil0
2
2003202012.5low000110
Cornea Injuries0
1
201620168.0low000010
Corneal Angiogenesis0
1
2013201311.0low000010
Corneal Diseases0
2
201420188.0low000020
Corneal Injuries0
1
201620168.0low000010
Corneal Neovascularization0
1
2013201311.0low000010
Cranial Nerve II Injuries0
2
202020242.0low000011
Degenerative Diseases, Central Nervous System0
1
202020204.0low000010
Disease Models, Animal0
5
2005201612.2low000230
Drug-Related Side Effects and Adverse Reactions0
2
2010201412.0low000110
Dry Eye0
2
201320188.5low000020
Dry Eye Syndromes0
2
201320188.5low000020
Equine Diseases0
1
202220222.0low000001
Exfoliation Glaucoma0
2
2010201014.0low100200
Exfoliation Syndrome0
2
2010201014.0low100200
Eyelid Diseases0
3
201220208.7low000030
Glaucoma1
50
200420239.1medium90011318
Glaucoma, Open-Angle1
54
200820238.4medium20005409
Glaucoma, Suspect0
54
200820238.8medium170073710
Hyperemia0
5
2007202211.6low200311
Hypersensitivity0
2
2010201113.5low000110
Hypertension0
1
2013201311.0low000010
Hypertrichosis0
1
2013201311.0low000010
Intraocular Pressure0
92
200320239.5high2900206111
Keratitis0
2
2013201510.0low000020
Keratoconjunctivitis0
1
2008200816.0low000100
Light Sensitivity0
1
2007200717.0low100100
Low Tension Glaucoma0
7
2010201710.3low300160
Melanosis0
1
2004200420.0low000100
Miosis0
2
2003202012.5low000110
Mydriasis0
1
2013201311.0low000010
Neurodegenerative Diseases0
1
202020204.0low000010
Ocular Hypertension1
54
200820238.8medium170073710
Ocular Hypotension0
2
201220227.0low100011
Orbital Diseases0
3
201420215.7low000021
Pregnancy0
1
2009200915.0low000100
Recrudescence0
1
201720177.0low000010
Retinal Diseases0
1
2014201410.0low000010
Symptom Cluster0
2
201320207.5low000020
Syndrome0
2
201320207.5low000020
Urinary Bladder, Overactive0
1
2013201311.0low000010

Safety/Toxicity (22)

ArticleYear
Reviewing the evidence surrounding preservative-free tafluprost/timolol fixed-dose combination therapy in open-angle glaucoma and ocular hypertension management: a focus on efficacy, safety, and tolerability.
Expert opinion on drug safety, , Volume: 21, Issue:10		2022
Effectiveness and safety of tafluprost in primary open-angle glaucoma and ocular hypertension: a post-marketing phase IV study in China.
BMC ophthalmology, , Aug-05, Volume: 22, Issue:1		2022
Efficacy and safety of the fixed combinations of tafluprost/timolol and latanoprost/carteolol.
Scientific reports, , 05-16, Volume: 9, Issue:1		2019
Long term safety and tolerability of Tafluprost 0.0015% vs Timolol 0.1% preservative-free in ocular hypertensive and in primary open-angle glaucoma patients: a cross sectional study.
BMC ophthalmology, , Aug-03, Volume: 17, Issue:1		2017
Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination.
PloS one, , Volume: 11, Issue:7		2016
Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies.
Clinical pharmacokinetics, , Volume: 55, Issue:4		2016
Comparison of the toxicity profile of benzalkonium chloride-preserved tafluprost and SofZia-preserved travoprost applied to the ocular surface.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 31, Issue:3		2015
Safety and tolerability of the tafluprost/timolol fixed combination for the treatment of glaucoma.
Expert opinion on drug safety, , Volume: 14, Issue:4		2015
A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components.
Advances in therapy, , Volume: 31, Issue:12		2014
Efficacy and safety of tafluprost 0.0015% and timolol maleate 0.5% fixed combination in patients with ocular hypertension or open-angle glaucoma.
Expert opinion on pharmacotherapy, , Volume: 15, Issue:15		2014
Mechanisms of benzalkonium chloride toxicity in a human trabecular meshwork cell line and the protective role of preservative-free tafluprost.
Clinical & experimental ophthalmology, , Volume: 43, Issue:2		2015
Efficacy, safety, and tolerability of preservative-free fixed combination of tafluprost 0.0015%/timolol 0.5% versus concomitant use of the ingredients.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 30, Issue:6		2014
Prospective observational post-marketing study of tafluprost for glaucoma and ocular hypertension: short-term efficacy and safety.
Advances in therapy, , Volume: 31, Issue:4		2014
Comparison of corneal safety and intraocular pressure-lowering effect of tafluprost ophthalmic solution with other prostaglandin ophthalmic solutions.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 30, Issue:4		2014
Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients With Existing Superficial Punctate Keratitis.
Journal of glaucoma, , Volume: 24, Issue:6		2015
Randomized clinical trial of the efficacy and safety of preservative-free tafluprost and timolol in patients with open-angle glaucoma or ocular hypertension.
American journal of ophthalmology, , Volume: 153, Issue:6		2012
Efficacy and safety of tafluprost in normal-tension glaucoma with intraocular pressure of 16 mmHg or less.
Japanese journal of ophthalmology, , Volume: 55, Issue:6		2011
In vitro toxicity of topical ocular prostaglandin analogs and preservatives on corneal epithelial cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 26, Issue:3		2010
[Optimization of benzalkonium chloride concentration in 0.0015% tafluprost ophthalmic solution from the points of ocular surface safety and preservative efficacy].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 130, Issue:6		2010
Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study.
Acta ophthalmologica, , Volume: 88, Issue:1		2010
Efficacy and safety levels of preserved and preservative-free tafluprost are equivalent in patients with glaucoma or ocular hypertension: results from a pharmacodynamics analysis.
Acta ophthalmologica. Supplement, , Volume: 242		2008
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers.
Acta ophthalmologica. Supplement, , Volume: 242		2008

Long-term Use (2)

ArticleYear
[Tafluprost--a novel prostaglandin F2alpha analogue].
Vestnik oftalmologii, , Volume: 130, Issue:5
Effect of tafluprost 0.0015% on central corneal thickness in patients with primary open-angle glaucoma.
Current eye research, , Volume: 38, Issue:9		2013

Pharmacokinetics (5)

ArticleYear
Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies.
Clinical pharmacokinetics, , Volume: 55, Issue:4		2016
Tear clearance and ocular symptoms in patients treated with preservative-free prostaglandins.
Archivos de la Sociedad Espanola de Oftalmologia, , Volume: 88, Issue:3		2013
Tafluprost, a new potent prostanoid receptor agonist: a dose-response study on pharmacodynamics and tolerability in healthy volunteers.
International journal of clinical pharmacology and therapeutics, , Volume: 46, Issue:8		2008
Efficacy and safety levels of preserved and preservative-free tafluprost are equivalent in patients with glaucoma or ocular hypertension: results from a pharmacodynamics analysis.
Acta ophthalmologica. Supplement, , Volume: 242		2008
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers.
Acta ophthalmologica. Supplement, , Volume: 242		2008

Bioavailability (1)

ArticleYear
Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 27, Issue:3		2011

Dosage (7)

ArticleYear
A comparison of country-level data from the VISIONARY study examining treatment outcomes with preservative-free tafluprost/timolol fixed-dose combination therapy.
Current medical research and opinion, , Volume: 38, Issue:7		2022
Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies.
Clinical pharmacokinetics, , Volume: 55, Issue:4		2016
Benefits of Tafluprost and Timolol Fixed-Dose Combination for the Treatment of Glaucoma Are Confirmed by Studies on Experimental Animal Models.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 31, Issue:9		2015
Therapeutic uses of prostaglandin F(2α) analogues in ocular disease and novel synthetic strategies.
Prostaglandins & other lipid mediators, , Volume: 104-105
Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, , Volume: 27, Issue:3		2011
Tafluprost, a new potent prostanoid receptor agonist: a dose-response study on pharmacodynamics and tolerability in healthy volunteers.
International journal of clinical pharmacology and therapeutics, , Volume: 46, Issue:8		2008
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers.
Acta ophthalmologica. Supplement, , Volume: 242		2008