| Assay ID | Title | Year | Journal | Article |
|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID315086 | Displacement of [3H]tiotidine from human H2 receptor expressed in monkey COS7 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID465708 | Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells after 60 mins by scintillation counting | 2010 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
| Acidic elements in histamine H(3) receptor antagonists. |
| AID1115514 | Binding affinity to Homo sapiens (human) H3 receptor | 2013 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Aug, Volume: 22, Issue:8
| Non-imidazole histamine H |
| AID290795 | Binding affinity to human histamine H3 receptor | 2007 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13
| A new class of histamine H3 receptor antagonists derived from ligand based design. |
| AID315084 | Displacement of [3H]histamine from human H4 receptor expressed in monkey COS7 cells at 1 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID86475 | Histamine-induced inhibition of forskolin- stimulated cAMP accumulation in SK-N-MC cells overexpressing the human Histamine H3 receptor | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID260989 | Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Aplysamine-1 and related analogs as histamine H3 receptor antagonists. |
| AID349186 | Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21
| 2-Aryloxymethylmorpholine histamine H(3) antagonists. |
| AID715208 | Binding affinity to rat histamine H3 receptor | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation. |
| AID315082 | Displacement of [3H]pyrilamine from human H1 receptor expressed in monkey COS7 cells at 1 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID478551 | Binding affinity to human histamine H3 receptor | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists. |
| AID28405 | Apparent permeability in Caco-2 cells was determined | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID1140781 | Binding affinity to rat histamine H3 receptor | 2014 | Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10
| Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness. |
| AID353209 | In vivo histamine H3 receptor potency in po dosed Swiss mouse assessed as N'-methylhistamine level | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
| Fluorinated non-imidazole histamine H3 receptor antagonists. |
| AID315083 | Displacement of [3H]tiotidine from human H2 receptor expressed in monkey COS7 cells at 1 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID315076 | Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID1833219 | Antagonist activity at human histamine H3 receptor | 2021 | Bioorganic & medicinal chemistry, 11-15, Volume: 50 | Histamine H |
| AID616616 | Tmax in Swiss mouse brain at 10 mg/kg, po by LC-MS/MS | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
| Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. |
| AID1140780 | Binding affinity to human histamine H3 receptor | 2014 | Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10
| Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness. |
| AID1729009 | Binding affinity to human H3R | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Structural modifications in the distal, regulatory region of histamine H |
| AID692499 | Half life in rat | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Histamine H3 receptor as a drug discovery target. |
| AID315075 | Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID599205 | Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as inhibition of forskolin stimulated cAMP accumulation after 6 hrs | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. |
| AID692494 | Binding affinity to human histamine H3 receptor | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Histamine H3 receptor as a drug discovery target. |
| AID715202 | Binding affinity to human recombinant histamine H3 receptor | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation. |
| AID616618 | Tmax in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
| Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. |
| AID300627 | Binding affinity to human histamine H3 receptor | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
| Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors. |
| AID526118 | Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by fluid scintillation counting | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Indole- and benzothiophene-based histamine H3 antagonists. |
| AID1829881 | Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID260990 | Displacement of N-[3H]methylhistamine from rat histamine H3 receptor in rat cortical hemispheres | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Aplysamine-1 and related analogs as histamine H3 receptor antagonists. |
| AID616621 | Ratio of AUC (0 to 3 hrs) in Swiss mouse brain to AUC (0 to 3 hrs) in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
| Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. |
| AID1829887 | Displacement of [3H]UR-DE25 from human H2R receptor expressed in HEK293 cells by radioligand competition binding assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID1829899 | Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID238933 | Antagonist potency against human H3 receptor in GTPgamma-S-Assay | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
| 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. |
| AID599203 | Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. |
| AID86618 | In vitro binding affinity for human Histamine H3 receptor by displacing N-[3H]-methylhistamine in SK-N-MC cells was determined | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID7595 | Human plasma protein binding activity was determined | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID353208 | Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cells | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
| Fluorinated non-imidazole histamine H3 receptor antagonists. |
| AID315087 | Displacement of [3H]histamine from human H4 receptor expressed in monkey COS7 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID616620 | Inverse agonist activity at human histamine H3 receptor expressed in SK-N-MC cells | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
| Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. |
| AID1829888 | Displacement of [3H]UR-P1294 from human H3R receptor expressed in HEK293 cells by radioligand competition binding assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID315085 | Displacement of [3H]pyrilamine from human H1 receptor expressed in monkey COS7 cells at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 18, Issue:7
| Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I. |
| AID1829890 | Inhibition of human H3R expressed in HEK293-A cells assessed as inhibition of imetit-induced Gi2 activation by BRET assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID323564 | Inhibition of AChE | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
| Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. |
| AID375418 | Binding affinity to histamine H3 receptor | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
| 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. |
| AID323565 | Inhibition of histamine H3 receptor | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
| Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. |
| AID616615 | AUC (0 to 3 hrs) in Swiss mouse brain at 10 mg/kg, po by LC-MS/MS | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
| Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. |
| AID89869 | In vitro binding affinity for rat Histamine H3 receptor by displacing N-[3H]-methylhistamine in SK-N-MC cells was determined | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID1829886 | Displacement of [3H]mepyramine from human H1R receptor expressed in HEK293 cells by radioligand competition binding assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID305748 | Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
| 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration. |
| AID692509 | Volume of distribution in rat | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Histamine H3 receptor as a drug discovery target. |
| AID616617 | AUC (0 to 3 hrs) in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
| Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. |
| AID30949 | stabilit in human liver microsome expressed as Half life | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID715201 | Binding affinity to rat cerebral cortex histamine H3 receptor assessed as per mg of protein | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation. |
| AID1829889 | Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells by radioligand competition binding assay | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H |
| AID239867 | Mean functional activity against human H3 receptor | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| 4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists. |
| AID290797 | Antagonist activity at human histamine H3 receptor | 2007 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13
| A new class of histamine H3 receptor antagonists derived from ligand based design. |
| AID260991 | Activity against human histamine H3 receptor by histamine induced inhibition of forskolin stimulated cAMP accumulation in SK-N-MC cells | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
| Aplysamine-1 and related analogs as histamine H3 receptor antagonists. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346107 | Human H3 receptor (Histamine receptors) | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| AID493017 | Wombat Data for BeliefDocking | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |