Page last updated: 2024-09-28

Slow Virus Diseases

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.

Synonyms(1)

Synonym
Slow Virus Diseases

Research

Studies (68)

TimeframeStudies, This Condition (%)All Conditions %
pre-199040 (58.82)23.3326
1990's26 (38.24)12.5806
2000's2 (2.94)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
5-hydroxytryptophan0low10
phosphonoacetic acid0low10
lactic acid0low10
formaldehyde0low20
histamine0low10
dihydroxyphenylalanine0low20
urea0low10
vanilmandelic acid0low10
homovanillic acid0low10
amantadine0low20
aspirin0low10
etidronate0low10
hydroxyurea0low10
pamidronate0low10
pentoxifylline0low10
prednisolone0low10
thymidine0low10
idoxuridine0low20
biguanides0low10
cyanides0low10
kanamycin a0low10
bromodeoxyuridine0low20
leucine0low10
histidine0low10
arginine0low10
dimethoxyphenylethylamine0low10
cuprizone0low10
deoxyuridine0low10
sodium hydroxide0low10
streptomycin0low10
trolamine salicylate0low20
substance p0low10
tromantadine0low10
moroxydine0low10
proline0low10
naproxen0low10
glycogen0low10
dactinomycin0low10
myelin basic protein0low30
phenylephrine hydrochloride0low10
aluminum0low40
triethyltin0low10
oligonucleotides0low10
glycolipids0low10
thymosin0low10
hydroxocobalamin0low10
vitamin b 120low10
rifampin0low10
inosine pranobex0low10
eye0low10
phosphorus radioisotopes0low10

Protein Targets (506)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
TDP1 protein100010
glucocorticoid receptor [Homo sapiens]120012
estrogen-related nuclear receptor alpha130013
thyroid hormone receptor beta isoform 28008
lamin isoform A-delta10130013
acetylcholinesterase4004
thioredoxin reductase8008
RAR-related orphan receptor gamma120012
NFKB1 protein, partial5005
GLI family zinc finger 38008
AR protein170017
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor110011
regulator of G-protein signaling 44004
EWS/FLI fusion protein6006
estrogen nuclear receptor alpha180018
putative alpha-glucosidase1001
euchromatic histone-lysine N-methyltransferase 2160016
heat shock protein beta-11001
peripheral myelin protein 227007
histone acetyltransferase KAT2A isoform 16006
Solute carrier family 22 member 20103
Solute carrier family 22 member 1 0002
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0204
Spike glycoprotein6017
Glutamate receptor ionotropic, NMDA 2A 0103
Glutamate receptor ionotropic, NMDA 2B0103
Glutamate receptor ionotropic, NMDA 2C0103
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0103
Solute carrier family 22 member 10203
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0103
Multidrug and toxin extrusion protein 10101
Solute carrier family 22 member 20203
Glutamate receptor ionotropic, NMDA 3A0103
ATP-dependent phosphofructokinase4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
phosphopantetheinyl transferase2002
GLS protein6006
alpha-galactosidase1001
cytochrome P450 2C19 precursor1001
chromobox protein homolog 16006
flap endonuclease 13003
DNA polymerase iota isoform a (long)8008
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)6006
Cytochrome P450 3A40001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase4004
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 86006
aldehyde dehydrogenase 1 family, member A19009
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 46006
retinoic acid nuclear receptor alpha variant 1120012
cytochrome P450 2D62002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta7007
Rac1 protein0011
IDH15005
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 17007
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase kappa isoform 14004
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0101
Bile salt export pump011011
Epidermal growth factor receptor0202
Carbonic anhydrase 10306
Carbonic anhydrase 20409
Fatty acid-binding protein, liver0202
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10204
Adenosine receptor A2a0204
Substance-P receptor0202
Prostaglandin G/H synthase 20404
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma5005
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-14105
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10808
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
pregnane X receptor2002
ATAD5 protein, partial5005
Microtubule-associated protein tau5005
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor6006
retinoid X nuclear receptor alpha7007
pregnane X nuclear receptor7007
bromodomain adjacent to zinc finger domain 2B3003
arylsulfatase A3003
nuclear receptor subfamily 1, group I, member 22002
cellular tumor antigen p53 isoform a3003
Nuclear hormone receptor family member daf-120011
nuclear factor erythroid 2-related factor 2 isoform 23003
serine/threonine-protein kinase mTOR isoform 11001
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin9009
survival motor neuron protein isoform d4004
Voltage-dependent calcium channel gamma-2 subunit7007
Thymidine kinase, cytosolic0407
Glutamate receptor 28008
Thymidine phosphorylase0004
Thymidylate kinase0202
Thymidine kinase0003
Thymidylate kinase0202
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Luciferase3003
hypoxia-inducible factor 1 alpha subunit3003
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x6006
Cellular tumor antigen p536006
Carbonic anhydrase 40204
Carbonic anhydrase0103
Carbonic anhydrase 150103
glp-1 receptor, partial2002
Fumarate hydratase4004
USP1 protein, partial3003
PPM1D protein1001
Smad32002
estrogen receptor 2 (ER beta)4004
farnesoid X nuclear receptor4004
polyprotein4004
67.9K protein2002
P532002
peroxisome proliferator activated receptor gamma4004
RPL19A0011
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 62002
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
thyroid hormone receptor beta isoform a2002
nuclear factor NF-kappa-B p105 subunit isoform 11001
ras-related protein Rab-9A1001
heat shock protein HSP 90-alpha isoform 20001
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
cytochrome P450 3A4 isoform 14004
COUP transcription factor 2 isoform a0101
Gamma-aminobutyric acid receptor subunit pi4004
Transmembrane protease serine 20011
Glucose transporter0101
Hexose transporter 1 0101
Interferon beta4004
Procathepsin L0011
Polyunsaturated fatty acid 5-lipoxygenase0202
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Solute carrier family 2, facilitated glucose transporter member 10101
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Alpha-synuclein1102
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0202
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
TAR DNA-binding protein 432002
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0101
GABA theta subunit4004
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0011
Gamma-aminobutyric acid receptor subunit epsilon4004
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0001
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain2002
Chain A, Cruzipain3003
15-lipoxygenase, partial3003
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
caspase-32002
RAD510101
Caspase-71001
vitamin D3 receptor isoform VDRA3003
caspase-31001
huntingtin isoform 21001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
caspase-1 isoform alpha precursor1001
ATP-dependent translocase ABCB10001
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-72002
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Chain A, Dutpase0011
Chain A, Dutpase0011
Chain B, Dutpase0011
Chain A, Dutpase0011
Chain B, Dutpase0011
endonuclease IV3003
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
mitogen-activated protein kinase 11001
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
serine-protein kinase ATM isoform a1001
5-hydroxytryptamine receptor 2C0011
5-hydroxytryptamine receptor 2A0011
5-hydroxytryptamine receptor 1A0011
5-hydroxytryptamine receptor 1B0011
5-hydroxytryptamine receptor 1D0011
5-hydroxytryptamine receptor 1F0011
5-hydroxytryptamine receptor 2B0011
5-hydroxytryptamine receptor 60011
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
Chain A, JmjC domain-containing histone demethylation protein 3A2002
acid sphingomyelinase1001
apical membrane antigen 1, AMA12002
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase2002
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
transforming acidic coiled-coil-containing protein 30001
Carbonic anhydrase 120002
Solute carrier family 22 member 30102
Plasma kallikrein0002
Carbonic anhydrase 30002
Macrophage migration inhibitory factor0202
Carbonic anhydrase 60002
Histamine H2 receptor0123
5-hydroxytryptamine receptor 1D0002
Histamine H1 receptor0134
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0103
Histamine H1 receptor0224
Carbonic anhydrase 70002
Histamine H2 receptor1012
Carbonic anhydrase0003
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0202
Carbonic anhydrase 90104
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0003
Carbonic anhydrase0003
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40002
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
Histamine H3 receptor0123
Chain A, HISTIDINE-BINDING PROTEIN0011
Histidine-binding periplasmic protein0011
Large neutral amino acids transporter small subunit 10202
ClpP1001
lysosomal alpha-glucosidase preproprotein2002
M-phase phosphoprotein 82002
Solute carrier family 22 member 80001
peripheral myelin protein 22 isoform 12002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0202
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0202
Gamma-aminobutyric acid receptor subunit epsilon0101
Inositol monophosphatase 12002
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Thymidine kinase 0203
importin subunit beta-1 isoform 12002
snurportin-12002
Vpr2002
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
thyroid stimulating hormone receptor3003
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Proton-coupled amino acid transporter 10203
Phospholipase A-2-activating protein0101
SMAD family member 21001
SMAD family member 31001
Dihydrofolate reductase0101
Cytochrome P450 2C9 0202
Polyunsaturated fatty acid 5-lipoxygenase0103
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Caspase-10202
Prostaglandin G/H synthase 2 0102
Aldo-keto reductase family 1 member C30101
Caspase-30101
Caspase-40101
Cytochrome P450 2J20202
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Aldo-keto reductase family 1 member C10101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
dopamine D1 receptor1001
vasopressin V1b receptor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
relaxin receptor 1 isoform 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Tumor necrosis factor0101
Cholinesterase0101
Acetylcholinesterase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A2b0101
Disintegrin and metalloproteinase domain-containing protein 171001
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chitotriosidase-10213
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Endochitinase B10213
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Chain A, Alkaline Phosphatase0101
Chain A, ALKALINE PHOSPHATASE0101
DNA polymerase III, partial1001
nonstructural protein 11001
GTP-binding nuclear protein Ran isoform 11001
Fe(3+)-Zn(2+) purple acid phosphatase0101
luciferase0001
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nociceptin receptor0011
Estrogen receptor beta0202
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Bile salt export pump0303
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
Albumin0011
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
10 kDa heat shock protein, mitochondrial0101
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B30203
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10203
Protein-arginine deiminase type-40202
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-K receptor0101
D(2) dopamine receptor0011
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
Thymidine kinase0102
Thymidylate synthase0001
Thymidine phosphorylase0001
Glucose-6-phosphate 1-dehydrogenase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
cystic fibrosis transmembrane conductance regulator0101
Neuronal acetylcholine receptor subunit beta-20011
Neuronal acetylcholine receptor subunit beta-40011
Neuronal acetylcholine receptor subunit alpha-30011
Neuronal acetylcholine receptor subunit alpha-70011
Neuronal acetylcholine receptor subunit alpha-40011
DNA primase0101
Neuronal acetylcholine receptor subunit alpha-70011
Rap guanine nucleotide exchange factor 31001
Olfactory receptor 51E20011
thioredoxin glutathione reductase1001
atrial natriuretic peptide receptor 1 precursor1001
neuropeptide S receptor isoform A1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]