Megacolon

Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.

Synonym
Megacolon

Excerpt	Reference
"Myxedema megacolon is rare; usually, it manifests with abdominal distention, flatulence, and constipation."	( Hughes, RW; Patel, R, 1992)
"Idiopathic megacolon is a generalized dysfunction of colonic smooth muscle in cats."	( Stalis, IH; Washabau, RJ, 1996)
"Chagasic megacolon is one of the most important forms of Chagas disease."	( Correa-Oliveira, R; da Silveira, AB; de Oliveira, EC; Freitas, MA; Furness, JB; Luquetti, AO; Neto, SG; Reis, Dd, 2008)
"Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter."	( Acosta, A; Bharucha, AE; Burton, D; Busciglio, I; Camilleri, M; O'Dwyer, RH, 2015)
"Chronic megacolon is a severe colonic dysmotility, manifesting radiologically with increased colonic diameter; it can be proven by measuring colonic compliance and typically requires colectomy because of failed medical therapy."	( Acosta, A; Bharucha, AE; Burton, D; Busciglio, I; Camilleri, M; O'Dwyer, RH, 2015)
"The etiology of Megacolon is multiple."	( Acosta Canedo, A; Saravia Burgos, J, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	251 (79.68)	23.3326
1990's	24 (7.62)	12.5806
2000's	17 (5.40)	18.1394
2010's	21 (6.67)	28.8240
2020's	2 (0.63)	9.53

Drug	Relationship Strength	Studies	Trials
choline	low	1	0
chlorine	low	2	0
salicylic acid	low	1	0
creatine	low	1	0
glycine	low	2	0
glycerol	low	2	0
histamine	low	2	0
hydrogen	low	1	0
iodine	low	1	0
inositol	low	1	0
taurine	low	1	0
1,2-dimethylhydrazine	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
phenytoin	low	1	0
diatrizoic acid	low	5	0
bisacodyl	low	1	0
bupivacaine	low	1	0
chlorpromazine	low	2	0
cisapride	low	1	0
dibutyl phthalate	low	1	0
diclofenac	low	1	0
doxapram	low	1	0
fluorouracil	low	1	0
guaifenesin	low	2	0
halothane	low	2	0
2-propanol	low	1	0
isoproterenol	low	3	0
ketamine	low	1	0
loperamide	low	1	0
meperidine	low	2	0
neostigmine	low	4	0
phenobarbital	low	1	0
phthalylsulfathiazole	low	1	0
potassium chloride	low	1	0
propranolol	low	2	0
risperidone	low	1	0
sennoside a&b	low	1	0
sulfadiazine	low	1	0
sulfasalazine	low	4	0
temazepam	low	1	0
thalidomide	low	3	0
thioridazine	low	1	0
trihexyphenidyl	low	1	0
phentolamine	low	2	0
thyroxine	low	2	0
prednisone	low	1	0
dimethylphenylpiperazinium iodide	low	1	0
isoflurophate	low	1	0
alanine	low	1	0
chloramphenicol	low	3	0
physostigmine	low	2	0
sucrose	low	1	0
kanamycin a	low	2	0
galactose	low	1	0
methacholine chloride	low	1	0
lactose	low	1	0
methionine	low	2	0
egtazic acid	low	1	0
ampicillin	low	2	0
threonine	low	1	0
isoprene	low	1	0
methylprednisolone	low	1	0
n-vinyl-2-pyrrolidinone	low	1	0
pyridostigmine bromide	low	1	0
thiophenes	low	1	0
ergotamine	low	2	0
diatrizoate meglumine	low	1	0
copper phthalocyanine	low	1	0
chenodeoxycholic acid	low	1	0
azomycin	low	1	0
erythromycin	low	1	0
vancomycin	low	1	0
acetylthiocholine	low	1	0
enbucrilate	low	1	0
titanium	low	1	0
magnesium sulfate	low	2	0
barium sulfate	medium	65	1
silver nitrate	low	1	0
deuterium	low	1	0
barium chloride	low	1	0
trolamine salicylate	low	3	0
benzonidazole	low	1	0
4-methoxyamphetamine	low	2	0
substance p	low	14	0
ng-nitroarginine methyl ester	low	2	0
enkephalin, methionine	low	1	0
fomesafen	low	25	0
dimethylhydrazines	low	1	0
venlafaxine hydrochloride	low	1	0
nicotine	low	4	0
atropine	low	4	0
deoxycholic acid	low	1	0
cortisone	low	4	0
glycogen	low	1	0
bradykinin	low	1	0
elastin	low	1	0
inositol 3-phosphate	low	2	0
cocaine	low	1	0
dactinomycin	low	1	0
enkephalin, leucine	low	3	0
arginine vasopressin	low	1	0
benztropine	low	1	0
tamoxifen	low	1	0
alpha-chymotrypsin	low	1	0
codeine	low	1	0
morphine	low	43	0
barium	low	7	0
aluminum	low	1	0
bismuth	low	1	0
silicon	low	1	0
phosphorus	low	1	0
tetrodotoxin	low	1	0
nifurtimox	low	1	0
sincalide	low	2	0
pentagastrin	medium	2	1
struvite	low	1	0
lactulose	low	4	0
s-tetradecanoyl-coenzyme a	low	1	0
pituitrin	low	1	0
enerbol	low	2	0
acid phosphatase	low	1	0
cholecystokinin	low	4	0
ceruletide	medium	2	1
motilin	low	1	0
gastrins	low	2	0
glucagon	low	1	0
neuropeptide y	low	2	0
cellulose	low	1	0
sodium ethylxanthate	low	2	0
neurotensin	low	3	0
piperidines	low	2	0
vasoactive intestinal peptide	low	16	0
oxyntomodulin	low	1	0
cyclosporine	low	1	0
muramidase	low	1	0
exudates	low	1	0
folic acid	low	1	0
ganciclovir	low	1	0
tegaserod	low	1	0
alcian blue	low	1	0
cholestyramine resin	low	1	0
ego	low	1	0

Protein Targets (1,122)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	20	0	0	20
USP1 protein, partial	14	0	0	14
TDP1 protein	32	0	0	32
vitamin D3 receptor isoform VDRA	9	0	0	9
importin subunit beta-1 isoform 1	2	0	0	2
flap endonuclease 1	7	0	0	7
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	11	0	0	11
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	33	0	0	33
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	2	3	8
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	13	0	0	13
RAR-related orphan receptor gamma	29	0	0	29
GLI family zinc finger 3	36	0	0	36
AR protein	37	0	0	37
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	27	0	0	27
retinoid X nuclear receptor alpha	26	0	0	26
estrogen nuclear receptor alpha	40	0	0	40
peroxisome proliferator-activated receptor delta	19	0	0	19
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
activating transcription factor 6	15	0	0	15
v-jun sarcoma virus 17 oncogene homolog (avian)	19	0	0	19
Histone H2A.x	14	0	0	14
thyroid hormone receptor beta isoform a	10	0	0	10
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
lamin isoform A-delta10	24	0	0	24
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Glutamate receptor 2	13	0	0	13
5-hydroxytryptamine receptor 2C	0	8	1	9
5-hydroxytryptamine receptor 2A	0	8	2	10
5-hydroxytryptamine receptor 1A	0	17	2	20
5-hydroxytryptamine receptor 1B	0	16	1	17
5-hydroxytryptamine receptor 1D	0	4	1	5
5-hydroxytryptamine receptor 1F	0	4	1	5
5-hydroxytryptamine receptor 2B	0	8	1	9
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	17	1	18
Sodium-dependent serotonin transporter	0	7	0	8
5-hydroxytryptamine receptor 7	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	3	1	4
5-hydroxytryptamine receptor 4	0	1	2	4
5-hydroxytryptamine receptor 3B	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
regulator of G-protein signaling 4	12	0	0	12
cytochrome P450 2C19 precursor	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Carbonic anhydrase 1	0	10	0	12
Carbonic anhydrase 2	0	11	1	15
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	2	0	4
Glutamate receptor ionotropic, NMDA 1	0	7	2	10
Proton-coupled amino acid transporter 1	0	4	0	4
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	1	0	3
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	5	0	0	5
Beta-lactamase	0	0	0	1
GLS protein	13	0	0	13
apical membrane antigen 1, AMA1	4	0	0	4
farnesoid X nuclear receptor	16	0	0	16
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	28	0	0	28
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
chromobox protein homolog 1	18	0	0	18
thyroid hormone receptor beta isoform 2	22	0	0	22
DNA polymerase beta	4	0	0	4
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	13	1	4	18
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	2	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	1	0	2
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	9	0	0	9
peripheral myelin protein 22	15	0	0	15
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	22
Bile salt export pump	0	39	0	39
Translocator protein	0	1	2	3
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	3	3
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	1	2
Vasopressin V2 receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	19	0	19
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
glucocorticoid receptor [Homo sapiens]	22	0	0	22
pregnane X nuclear receptor	27	0	0	27
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	7	0	11
5-hydroxytryptamine receptor 4	0	21	2	23
Muscarinic acetylcholine receptor M2	0	14	2	19
Muscarinic acetylcholine receptor M4	0	13	1	16
Muscarinic acetylcholine receptor M1	0	9	1	12
Muscarinic acetylcholine receptor M3	0	7	1	10
Muscarinic acetylcholine receptor M4	0	8	1	11
Muscarinic acetylcholine receptor M5	0	7	1	10
Muscarinic acetylcholine receptor M5	0	13	1	16
Muscarinic acetylcholine receptor M2	0	9	1	13
Muscarinic acetylcholine receptor M1	0	14	2	19
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	15	2	19
Alpha-1D adrenergic receptor	0	18	3	22
5-hydroxytryptamine receptor 2C	0	21	1	22
Muscarinic acetylcholine receptor M4	0	2	0	2
Histamine H2 receptor	8	0	2	12
5-hydroxytryptamine receptor 7	0	5	0	5
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	1	1	2
EWS/FLI fusion protein	13	0	0	13
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Cytochrome P450 1A2	0	4	1	5
Cytochrome P450 3A4	0	11	1	12
Cytochrome P450 2D6	0	12	1	13
Cytochrome P450 2C9	0	8	0	9
Cytochrome P450 2C19	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	24	0	24
Aurora kinase B	0	1	0	1
Spike glycoprotein	0	1	4	5
Replicase polyprotein 1ab	0	1	5	6
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Transmembrane protease serine 2	0	1	4	5
Cellular tumor antigen p53	21	0	0	21
Procathepsin L	0	1	4	5
Aldo-keto reductase family 1 member B1	0	8	0	8
Alpha-2A adrenergic receptor	0	18	5	25
Replicase polyprotein 1a	0	1	4	5
Replicase polyprotein 1ab	0	1	4	5
Replicase polyprotein 1ab	0	2	4	6
Replicase polyprotein 1ab	0	4	4	8
Alpha-2B adrenergic receptor	0	16	3	21
Alpha-2C adrenergic receptor	0	15	4	21
Sodium-dependent noradrenaline transporter	0	11	0	11
Sodium-dependent dopamine transporter	0	10	0	10
Histamine H2 receptor	0	13	2	15
5-hydroxytryptamine receptor 2A	0	19	1	20
Histamine H1 receptor	0	11	2	13
D(3) dopamine receptor	0	17	0	18
5-hydroxytryptamine receptor 2B	0	21	1	22
5-hydroxytryptamine receptor 6	0	13	1	14
Sodium-dependent dopamine transporter	0	13	0	13
Sigma non-opioid intracellular receptor 1	0	20	0	20
Angiotensin-converting enzyme 2	0	1	4	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
phosphopantetheinyl transferase	6	0	0	6
Microtubule-associated protein tau	14	0	0	14
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	4	0	6
Solute carrier organic anion transporter family member 1B1	0	4	0	6
acetylcholinesterase	14	0	0	14
Mcl-1	0	1	0	1
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
thioredoxin glutathione reductase	2	0	0	2
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
thyroid stimulating hormone receptor	11	0	0	11
estrogen receptor 2 (ER beta)	11	0	0	11
progesterone receptor	16	0	0	16
estrogen-related nuclear receptor alpha	28	0	0	28
G	9	0	0	9
cytochrome P450 2D6	15	0	0	15
glucocerebrosidase	4	0	0	4
peroxisome proliferator activated receptor gamma	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
IDH1	11	0	0	11
thyroid stimulating hormone receptor	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
cytochrome P450 2C9 precursor	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
G-protein coupled receptor 35 isoform a	0	1	0	1
G-protein coupled receptor 55	0	1	0	1
cytochrome P450 3A4 isoform 1	9	0	0	9
lethal factor (plasmid)	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	9	3	1	13
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit delta	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-2	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-5	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-2	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-4	9	3	1	13
Gamma-aminobutyric acid receptor subunit gamma-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit alpha-6	9	3	1	13
Aryl hydrocarbon receptor	0	0	1	1
Kappa-type opioid receptor	0	17	3	21
Nuclear receptor ROR-gamma	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	9	3	1	13
Gamma-aminobutyric acid receptor subunit beta-3	9	3	1	13
Gamma-aminobutyric acid receptor subunit beta-2	9	3	1	13
GABA theta subunit	9	3	1	13
Inositol hexakisphosphate kinase 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	9	3	1	13
cytochrome P450 2C9, partial	9	0	0	9
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	4	1	7
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	3	3
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	2	1	3
Potassium channel subfamily K member 9	0	2	0	2
Luciferase	10	0	0	10
caspase 7, apoptosis-related cysteine protease	9	0	0	9
caspase-3	9	0	0	9
Caspase-7	7	0	0	7
caspase-3	7	0	0	7
Vitamin D3 receptor	0	2	2	4
Retinoic acid receptor RXR-alpha	0	0	1	1
Ileal sodium/bile acid cotransporter	0	2	0	2
TAR DNA-binding protein 43	6	0	0	6
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	1	2	3
interleukin 8	5	0	0	5
aryl hydrocarbon receptor	11	0	0	11
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
50S ribosomal protein L36 2	0	2	1	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 15	0	3	0	4
Proteasome subunit beta type-11	0	0	0	1
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	6	0	0	6
NFKB1 protein, partial	2	0	0	2
Thrombopoietin	3	0	0	3
Smad3	4	0	0	4
NADPH oxidase 1	0	1	0	1
polyprotein	6	0	0	6
67.9K protein	4	0	0	4
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	2	0	2
cytochrome P450 2D6 isoform 1	6	0	0	6
cellular tumor antigen p53 isoform a	4	0	0	4
D(1A) dopamine receptor	7	0	0	7
histone deacetylase 9 isoform 3	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
ras-related protein Rab-9A	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
survival motor neuron protein isoform d	12	0	0	12
M-phase phosphoprotein 8	7	0	0	7
muscarinic acetylcholine receptor M1	9	0	0	9
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Bile salt export pump	0	5	0	5
Epidermal growth factor receptor	0	4	0	4
Albumin	0	4	5	9
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Integrin beta-3	3	0	0	3
Tyrosine-protein kinase Fyn	0	4	0	4
ATP-dependent translocase ABCB1	0	10	2	16
Integrin alpha-IIb	3	0	0	3
5-hydroxytryptamine receptor 1A	0	4	2	6
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	12	0	12
D(2) dopamine receptor	0	15	1	17
Alpha-1B adrenergic receptor	0	14	3	17
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	7	0	7
D(3) dopamine receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	12	3	15
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	13	1	15
D(4) dopamine receptor	0	9	0	10
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	12	3	15
UDP-glucuronosyltransferase 1A4	0	1	0	3
Alpha-2A adrenergic receptor	0	12	3	15
Alpha-1D adrenergic receptor	0	12	3	16
D(1B) dopamine receptor	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	3	0	3
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	3	2	5
Melanocortin receptor 4	0	4	0	4
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	6	1	7
Mu-type opioid receptor	0	14	5	20
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	4	0	5
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	13	5	19
Melanocortin receptor 3	0	4	0	4
Alpha-1A adrenergic receptor	0	14	3	17
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	4	0	0	4
Cytochrome P450 2J2	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	2	3
D(2) dopamine receptor	0	9	1	11
Calmodulin	0	2	2	4
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	6	2	9
Glutamate receptor ionotropic, NMDA 2B	0	6	2	9
Glutamate receptor ionotropic, NMDA 2C	0	6	2	9
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	2	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Sodium channel protein type 5 subunit alpha	0	8	0	8
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	6	2	9
Nuclear receptor subfamily 3 group C member 3	0	12	0	12
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	6	2	9
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	12	0	0	12
Sodium channel protein type 3 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	6	2	9
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	3	2	5
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-4	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-2	0	4	2	7
Neuronal acetylcholine receptor subunit beta-2	0	4	2	7
Neuronal acetylcholine receptor subunit beta-3	0	4	2	7
Neuronal acetylcholine receptor subunit beta-4	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-5	0	4	2	7
Acetylcholinesterase	0	8	1	10
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-9	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	7
Solute carrier family 22 member 1	0	3	0	5
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	4	2	7
Solute carrier family 22 member 2	0	3	0	5
5-hydroxytryptamine receptor 3E	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Beta-2 adrenergic receptor	0	9	3	13
Beta-1 adrenergic receptor	0	9	2	11
Beta-3 adrenergic receptor	0	6	2	8
Dipeptidyl peptidase 4	0	1	0	1
Insulin receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	2	2	4
Alpha-1A adrenergic receptor	0	6	4	11
Prostaglandin G/H synthase 2	0	3	0	3
Alpha-1B adrenergic receptor	0	4	3	8
5-hydroxytryptamine receptor 3A	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	2	4
Neutral alpha-glucosidase AB	0	1	0	1
5-hydroxytryptamine receptor 3D	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	0	2
Heparanase	0	0	1	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	1	2	0	3
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Liver carboxylesterase 1	0	0	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	5	1	7
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Delta-type opioid receptor	0	7	1	10
Kappa-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	5	1	8
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
endonuclease IV	7	0	0	7
dopamine D1 receptor	1	0	0	1
pregnane X receptor	4	0	0	4
peripheral myelin protein 22 isoform 1	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
Glucocorticoid receptor	0	6	1	7
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	5	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Chain A, Ferritin light chain	5	0	0	5
15-lipoxygenase, partial	2	0	0	2
RAD51	0	1	0	1
Bloom syndrome protein isoform 1	9	0	0	9
huntingtin isoform 2	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
ATPase family AAA domain-containing protein 5	8	0	0	8
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Hsf1 protein	0	0	2	2
glp-1 receptor, partial	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Cathepsin B	0	1	0	1
Cathepsin B	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	4	1	6
Solute carrier family 22 member 6	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3A isoform a	0	1	0	1
arylsulfatase A	15	0	0	15
Opioid receptor, delta 1b	0	2	0	2
Opioid receptor homologue	0	2	0	2
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	6	1	7
Mu-type opioid receptor	0	2	0	2
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	4	0	4
Thromboxane-A synthase	0	3	0	3
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
Vpr	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	2	0	2
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Alpha-synuclein	3	0	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	4	0	0	4
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	1	0	2
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	1	0	2
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	2	0	3
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	1	2
Histamine H1 receptor	0	3	1	4
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	1	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Acetylcholinesterase	0	6	0	7
Acetylcholinesterase	0	1	1	2
Lysosomal protective protein	0	1	0	1
Fatty acid synthase	0	1	0	1
Liver carboxylesterase	0	1	0	1
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	1	2	5
beta-2 adrenergic receptor	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-2 adrenergic receptor	0	4	1	6
Beta-1 adrenergic receptor	0	5	2	9
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	2	3	6
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	2
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Cholinesterase	0	4	0	5
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
PPM1D protein	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Menin	0	1	0	1
Cocaine esterase	0	2	0	2
Nociceptin receptor	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
galanin receptor type 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Cholinesterase	0	4	0	4
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	3	6
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
Adenosine receptor A3	0	3	1	4
Cytochrome P450 2C8	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Adenosine receptor A2a	0	3	1	4
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	3	3	6
Sodium/bile acid cotransporter	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Transporter	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	4	1	5
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Aurora kinase A	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Cystine/glutamate transporter	0	1	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Progesterone receptor	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Protein kinase C eta type	0	1	0	1
Adenosine receptor A1	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Protein kinase C iota type	0	1	0	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Estrogen receptor beta	0	2	1	3
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Translocator protein	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Parkin	2	0	0	2
Cathepsin D	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
PINK1	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (315)

Protein Targets (1,122)

Megacolon

Synonyms(1)

Research Excerpts

Overview

Research

Studies (315)

Drugs Studied (172)

Protein Targets (1,122)