histamine and Dysesthesia studies

Research Excerpts

Excerpt	Relevance	Reference
" After the capsaicin-induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25-40 spicules)."	7.85	Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N, 2017)
"In control subjects, but not in atopic eczema (AE) patients, capsaicin pretreatment significantly reduced the flare area."	6.69	Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. ( Forster, C; Handwerker, HO; Heyer, G; Weisshaar, E, 1998)
"We investigated the effects of tactile allodynia on the itch and mechanically evoked dysesthesiae produced by an intradermal injection of histamine in human volunteers."	5.09	Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. ( Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J, 1999)
" After the capsaicin-induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25-40 spicules)."	3.85	Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N, 2017)
"In control subjects, but not in atopic eczema (AE) patients, capsaicin pretreatment significantly reduced the flare area."	2.69	Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. ( Forster, C; Handwerker, HO; Heyer, G; Weisshaar, E, 1998)
"Histamine 10 microl was injected into each bleb, and the resulting magnitude of itch estimated."	2.69	Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. ( Atanassoff, PG; Brull, SJ; Greenquist, K; Lamotte, RH; Silverman, DG; Zhang, J, 1999)

Research

Studies (11)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (36.36)	18.7374
1990's	4 (36.36)	18.2507
2000's	1 (9.09)	29.6817
2010's	2 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Vierow, V	1
Forster, C	2
Vogelgsang, R	1
Dörfler, A	1
Handwerker, HO	2
Andersen, HH	1
Elberling, J	1
Sharma, N	1
Hauberg, LE	1
Gazerani, P	1
Arendt-Nielsen, L	1
Sikand, P	1
Shimada, SG	1
Green, BG	1
LaMotte, RH	3
Saxena, RC	1
Das, M	1
Dixit, KS	1
Bhargava, KP	1
Weisshaar, E	1
Heyer, G	1
Atanassoff, PG	2
Brull, SJ	2
Zhang, J	2
Greenquist, K	1
Silverman, DG	2
Aoki, T	1
Fruhstorfer, H	1
Hermanns, M	1
Latzke, L	1
Straube, G	1
Forette, B	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]	Phase 2	13 participants (Actual)	Interventional	2017-05-23	Terminated (stopped due to Efficacy was not seen after interim analysis)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

Mechanical Thresholds (Mechanical Detection and Pain).

Intervention	Intensity score (Mean)
Topical KeAmLi Combo	62.7
Topical Ketamine	63.1
Topical Amitriptyline	69.2
Topical Lidocaine	65.8
Topical Vehicle	61.9

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

Thermal Threshold Detection (Warmth and Heat Pain)

Intervention	mN (Mean)
	Mechanical Detection Threshold	Mechanical Pain Threshold
Topical Amitriptyline	3.573423965	152.4768146
Topical KeAmLi Combo	3.519376956	152.3293608
Topical Ketamine	3.464204768	135.9
Topical Lidocaine	3.546037659	126.9
Topical Vehicle	3.525692637	148.7138273

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

Intervention	Degrees celsius (Mean)
	Warm Detection Threshold	Heat Pain Threshold
Topical Amitriptyline	33.9	40.0
Topical KeAmLi Combo	33.6	39.8
Topical Ketamine	34.0	40.0
Topical Lidocaine	33.7	39.4
Topical Vehicle	33.8	39.7

Article	Year
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage. Pain, 2009, Volume: 144, Issue:1-2 Topics: Area Under Curve; Capsaicin; Dose-Response Relationship, Drug; Female; Histamine; Humans; Incidence;	2009
Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. Archives of dermatological research, 1998, Volume: 290, Issue:6 Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Dermatitis, Allergic Contact; Dermatitis, Ato	1998
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & motor research, 1999, Volume: 16, Issue:4 Topics: Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Forearm; Histamine; Humans; Hy	1999
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosensory & motor research, 1999, Volume: 16, Issue:4 Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Ag	1999

Article	Year
Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin. Acta dermato-venereologica, 2015, Volume: 95, Issue:6 Topics: Adolescent; Adult; Amygdala; Brain Mapping; Capsaicin; Caudate Nucleus; Cerebral Cortex; Cross-Over	2015
Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. European journal of pain (London, England), 2017, Volume: 21, Issue:6 Topics: Adult; Capsaicin; Female; Healthy Volunteers; Histamine; Humans; Hyperalgesia; Male; Nociceptors; Pa	2017
Involvement of H1 & H2 receptors in histamine-induced skin response in human. The Indian journal of medical research, 1983, Volume: 78 Topics: Adult; Burimamide; Histamine; Humans; Male; Paresthesia; Premedication; Pyrilamine; Receptors, Hista	1983
The effects of thermal stimulation on clinical and experimental itch. Pain, 1986, Volume: 24, Issue:2 Topics: Adult; Cold Temperature; Dermatitis, Atopic; Female; Forearm; Histamine; Hot Temperature; Humans; Im	1986
[Treatment of sensation disturbances of different etiology with Dermotherma]. Medizinische Monatsschrift, 1967, Volume: 21, Issue:10 Topics: Fatty Acids, Essential; Histamine; Humans; Hypesthesia; Nicotinic Acids; Ointments; Paresthesia; Sal	1967
[Diagnosis of pheochromocytomas]. La Presse medicale, 1968, Dec-07, Volume: 76, Issue:48 Topics: Angiography; Catecholamines; Diabetes Complications; Glucagon; Histamine; Humans; Hypertension; Hype	1968

histamine and Dysesthesia