1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline profile

1-Methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (1-MPT) is a synthetic compound that is structurally similar to the naturally occurring neurotransmitter dopamine.

**Here's what makes it important in research:**

* **Dopamine Agonist:** 1-MPT acts as a dopamine agonist, meaning it can bind to and activate dopamine receptors in the brain. This makes it a valuable tool for studying dopamine signaling pathways and the role of dopamine in various neurological and psychiatric conditions.
* **Animal Model for Parkinson's Disease:** 1-MPT is neurotoxic and can induce a Parkinson's-like syndrome in rodents. By studying the effects of 1-MPT in animal models, researchers can gain insights into the mechanisms of neurodegeneration in Parkinson's disease and develop potential therapeutic strategies.
* **Addiction Research:** 1-MPT's dopamine agonist properties make it relevant to addiction research. It has been used to investigate the role of dopamine in reward pathways and the development of addictive behaviors.
* **Drug Development:** 1-MPT has been used as a starting point for the development of new drugs targeting dopamine receptors, such as potential treatments for Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and other conditions.
* **Understanding the Brain:** 1-MPT is a tool to explore the complex workings of the brain, particularly dopamine signaling and its implications for various neurological and behavioral processes.

**Important Considerations:**

* **Toxicity:** 1-MPT is neurotoxic and can cause Parkinson's-like symptoms in animals. It should be handled with caution and used only in controlled research settings.
* **Ethical Concerns:** Animal studies involving neurotoxins like 1-MPT raise ethical considerations. Researchers must ensure the humane treatment of animals and minimize any potential suffering.

Overall, 1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline is a valuable research tool with potential for contributing to our understanding of neurodegenerative diseases, addiction, and other important areas of neuroscience.

1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline: structure given in first source; a non-competitive NMDA receptor antagonist; RN refers to (+)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	130852
SCHEMBL ID	6021932
MeSH ID	M0224360

Synonym
(+)-1,2,3,4-tetrahydro-1-methyl-1-phenylisoquinoline hydrochloride
1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
fr-115427
isoquinoline, 1,2,3,4-tetrahydro-1-methyl-1-phenyl-, hydrochloride, (+)-
126114-66-7
SCHEMBL6021932
(+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
1-methyl-1-phenyl-3,4-dihydro-2h-isoquinoline;hydrochloride
1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)
DTXSID10925417

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	9 (81.82)	18.2507
2000's	1 (9.09)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	2.38	2	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
histamine [no description available]	1.99	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist	1.98	1
dimethylphenylpiperazinium iodide Dimethylphenylpiperazinium Iodide: A selective nicotinic cholinergic agonist used as a research tool. DMPP activates nicotinic receptors in autonomic ganglia but has little effect at the neuromuscular junction.	1.99	1	N-arylpiperazine; organic iodide salt; piperazinium salt; quaternary ammonium salt	nicotinic acetylcholine receptor agonist
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	2.4	2	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
n-methylaspartate N-Methylaspartate: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).. N-methyl-D-aspartic acid : An aspartic acid derivative having an N-methyl substituent and D-configuration.	2.7	3	amino dicarboxylic acid; D-alpha-amino acid; D-aspartic acid derivative; secondary amino compound	neurotransmitter agent
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.11	1	cobalt group element atom
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.39	2	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
tenocyclidine tenocyclidine : A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and thiophen-2-yl groups attached at position 1. A dissociative anaesthetic drug with halluccinogenic and stimulant effects. Its effects are similar to those of phencyclidine (PCP, an analogue with the thienyl group replaced by phenyl), but it is rather more potent.	1.98	1	piperidines; tertiary amino compound; thiophenes	central nervous system stimulant; hallucinogen; neuroprotective agent; NMDA receptor antagonist
selfotel selfotel: a N-methyl-D-aspartate (NMDA) antagonist; used to treat stroke-induced impairment	1.99	1	non-proteinogenic alpha-amino acid
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	1.99	1
tetrodotoxin Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.	1.99	1	azatetracycloalkane; oxatetracycloalkane; quinazoline alkaloid	animal metabolite; bacterial metabolite; marine metabolite; neurotoxin; voltage-gated sodium channel blocker
dizocilpine maleate Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.	3.49	8	maleate salt; tetracyclic antidepressant	anaesthetic; anticonvulsant; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist
sodium glutamate Sodium Glutamate: One of the FLAVORING AGENTS used to impart a meat-like flavor.. monosodium glutamate : An organic sodium salt that is the monosodium salt of glutamic acid.	1.99	1	monosodium glutamate	flavouring agent

Condition	Relationship Strength	Studies
Brain Disorders [description not available]	1.98	1
Cerebral Ischemia [description not available]	2.68	3
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	1.98	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.68	3
Anoxemia [description not available]	1.99	1
Absence Seizure [description not available]	1.99	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	1.99	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	1.99	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	1.99	1

1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Description

Cross-References

Synonyms (10)

Research

Studies (11)

Market Indicators

Research Demand Index: 11.86

Study Types