Page last updated: 2024-08-05 15:46:19
CB1 receptor agonist
A cannabinoid receptor agonist that binds to and activates type 1 cannabinoid receptors.
ChEBI ID: 192269
Members (1)
| Member | Definition | Class |
|---|---|---|
| arachidonyl-2-chloroethylamide | A fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). | arachidonyl-2'-chloroethylamide |
Research
Studies (150)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.33) | 18.2507 |
| 2000's | 54 (36.00) | 29.6817 |
| 2010's | 84 (56.00) | 24.3611 |
| 2020's | 10 (6.67) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (2.60%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 150 (97.40%) | 84.16% |
Protein Targets (19)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 31.6228 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 0.0053 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.0950 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.3162 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.3162 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 0.3162 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 0.3162 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 0.3162 | 1 | 1 |