Page last updated: 2024-09-27

Carcinoid Heart Disease

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.

Synonyms(1)

Synonym
Carcinoid Heart Disease

Research Excerpts

Overview

ExcerptReference
"Carcinoid heart disease is not as common in our patients as in patients selected on a cardiological basis described in earlier studies."( Eskilsson, J; Nobin, A; Törnebrandt, K, 1986)
"In Japan, carcinoid heart disease is rare and we can find only four reported cases (33% of reported carcinoid syndrome)."( Kasuga, T; Kawaoi, A; Matsubara, O; Okano, T; Suzuki, K; Takemura, T; Tanaka, M; Watanabe, S, 1984)
"Carcinoid heart disease is a complication of a neuroendocrine carcinoid tumor."( Funa, K; Heldin, CH; Lundin, L; Miyazono, K; Oberg, K; Waltenberger, J; Wilander, E, 1993)
"Carcinoid heart disease is caused by increased levels of circulating serotonin."( Boomsma, F; De Vries, EG; Kema, IP; Meijer, WC; Van den Berg, MP; van Veldhuisen, DJ; Willemse, PH, 2002)
"Carcinoid heart disease is a rare disease, and its prevalence is uncertain."( Bachet, JB; Dubourg, O; Mansencal, N; Mitry, E; Rougier, P, 2010)
"Management of carcinoid heart disease is complex, and multidisciplinary assessment of cardiac status, hormonal syndrome, and tumor burden is critical in guiding optimal timing of surgery."( Caplin, ME; Davar, J; Hayes, AR, 2018)

Research

Studies (102)

TimeframeStudies, This Condition (%)All Conditions %
pre-199028 (27.45)23.3326
1990's12 (11.76)12.5806
2000's27 (26.47)18.1394
2010's26 (25.49)28.8240
2020's9 (8.82)9.53
DrugIndicatedRelationship StrengthStudiesTrials
5-hydroxytryptophan0low10
histamine0low30
dihydroxyphenylalanine0low30
niacin0low20
3,4-methylenedioxyamphetamine0low10
hydroxyindoleacetic acid0low360
citalopram0low10
cyproheptadine0low20
fenfluramine0low10
fentanyl0low10
flunitrazepam0low10
fluorouracil0low10
iproniazid0low10
ketanserin0low20
methiothepin0low10
midazolam0low10
activins0low10
nifedipine0low10
nitroglycerin0low10
fenclonine0low10
phentermine0low10
prazosin0low10
ritanserin0low10
temozolomide0low10
phentolamine0low10
aldosterone0low10
methylene blue0low10
tryptophan0low10
methylprednisolone0low10
ergotamine0low10
pyrazines0low10
methysergide0low30
pizotyline0low10
lisuride0low10
etoposide0low20
substance p0low20
fluorodopa f 180low20
dexfenfluramine0low10
fluorodeoxyglucose f180low20
yttrium radioisotopes0low10
bosentan anhydrous0low10
docetaxel anhydrous0low10
carboplatin0low10
fibrin0low20
bradykinin0low30
elastin0low10
dironyl0low10
osteoprotegerin0low10
sirolimus0low10
kallidin0low10
neurokinin a0low10
everolimus0low30
pituitrin0low20
atrial natriuretic factor0low30
glucagon0low10
cardiovascular agents0low10
piperidines0low10
natriuretic peptide, brain0low60
transforming growth factor beta0low20
cc-2230low10
lutetium lu 177 dotatate0low30
dacarbazine0low10

Protein Targets (925)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C08311
5-hydroxytryptamine receptor 2A010313
5-hydroxytryptamine receptor 1A015116
Sodium-dependent noradrenaline transporter 0718
Sodium-dependent dopamine transporter0314
5-hydroxytryptamine receptor 1B012113
5-hydroxytryptamine receptor 1D0113
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B07310
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter0628
Sodium-dependent serotonin transporter0224
5-hydroxytryptamine receptor 7 0415
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
Sodium-dependent dopamine transporter 0303
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
AR protein200020
glucocorticoid receptor [Homo sapiens]150015
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 25005
geminin130013
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0123
Androgen receptor0303
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G3003
Atrial natriuretic peptide receptor 10112
Atrial natriuretic peptide receptor 1 0011
phosphopantetheinyl transferase9009
RAR-related orphan receptor gamma100010
GLI family zinc finger 3150015
estrogen receptor 2 (ER beta)7007
progesterone receptor9009
cytochrome P450 family 3 subfamily A polypeptide 4140014
retinoic acid nuclear receptor alpha variant 1120012
estrogen-related nuclear receptor alpha160016
pregnane X nuclear receptor130013
G100010
peroxisome proliferator activated receptor gamma110011
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
activating transcription factor 67007
v-jun sarcoma virus 17 oncogene homolog (avian)100010
vitamin D3 receptor isoform VDRA8008
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 19009
nuclear receptor ROR-gamma isoform 16006
ATP-binding cassette sub-family C member 3013013
Multidrug resistance-associated protein 4013013
Bile salt export pump0404
Nuclear receptor subfamily 1 group I member 20044
Bile salt export pump017017
Interferon beta150015
HLA class I histocompatibility antigen, B alpha chain 100010
Endothelin receptor type B0303
Endothelin receptor type B0415
Endothelin-1 receptor0202
Endothelin-1 receptor0213
Endothelin receptor type B0011
Deoxyhypusine synthase0101
Sodium/bile acid cotransporter0101
Endothelin-1 receptor0101
Inositol hexakisphosphate kinase 1100010
cytochrome P450 2C9, partial100010
histone acetyltransferase KAT2A isoform 17007
Angiotensin-converting enzyme 0001
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
acetylcholinesterase100010
cytochrome P450 2D6130013
euchromatic histone-lysine N-methyltransferase 2190019
histone-lysine N-methyltransferase 2A isoform 2 precursor5005
DNA polymerase kappa isoform 16006
ATP-dependent phosphofructokinase110011
PPM1D protein6006
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0011
Macrophage colony-stimulating factor 1 receptor0101
Vascular endothelial growth factor receptor 30101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0011
Serine/threonine-protein kinase mTOR0336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0011
Potassium voltage-gated channel subfamily H member 2012012
Regulatory-associated protein of mTOR0303
Phosphatidylinositol 3-kinase catalytic subunit type 30011
Target of rapamycin complex subunit LST80303
Phosphatidylinositol 4-kinase beta0011
thioredoxin reductase9009
aldehyde dehydrogenase 1 family, member A1130013
EWS/FLI fusion protein8008
NPC intracellular cholesterol transporter 1 precursor4004
D(1A) dopamine receptor8008
survival motor neuron protein isoform d7007
Solute carrier family 22 member 1 0405
Sodium-dependent noradrenaline transporter0202
5-hydroxytryptamine receptor 4014014
Aldo-keto reductase family 1 member B10404
Tryptophan 5-hydroxylase 10101
Angiotensin-converting enzyme0909
Aldo-keto reductase family 1 member B10101
Acetylcholinesterase0101
Aromatase0101
Alpha-1D adrenergic receptor013217
5-hydroxytryptamine receptor 2C019222
Histamine H1 receptor011314
5-hydroxytryptamine receptor 2B018019
5-hydroxytryptamine receptor 70303
Spike glycoprotein100010
Sigma intracellular receptor 20202
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0808
Canalicular multispecific organic anion transporter 1012013
Ataxin-2130013
Sigma non-opioid intracellular receptor 10808
Sigma non-opioid intracellular receptor 10202
Transporter0303
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
ATAD5 protein, partial9009
Fumarate hydratase7007
TDP1 protein160016
thyroid stimulating hormone receptor8008
nuclear receptor subfamily 1, group I, member 3100010
regulator of G-protein signaling 48008
farnesoid X nuclear receptor7007
estrogen nuclear receptor alpha180018
polyprotein7007
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a4004
cytochrome P450 2C19 precursor3003
chromobox protein homolog 1110011
potassium voltage-gated channel subfamily H member 2 isoform d100010
thyroid hormone receptor beta isoform 2150015
huntingtin isoform 24004
atrial natriuretic peptide receptor 2 precursor3003
serine/threonine-protein kinase mTOR isoform 16006
peripheral myelin protein 228008
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)3003
chaperonin GroEL1001
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Voltage-dependent calcium channel gamma-2 subunit7007
Cellular tumor antigen p53130013
Prostaglandin G/H synthase 10101
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50203
Alpha-2A adrenergic receptor012115
Muscarinic acetylcholine receptor M20101
Glycogen phosphorylase, brain form0123
Glycogen phosphorylase, muscle form0101
Muscarinic acetylcholine receptor M10304
D(2) dopamine receptor011112
Alpha-2B adrenergic receptor012115
Alpha-2C adrenergic receptor010113
D0505
D(3) dopamine receptor0101
Glutamate receptor 28008
Muscarinic acetylcholine receptor M30203
D(1A) dopamine receptor0808
UDP-glucuronosyltransferase 1A40102
Histamine H2 receptor0527
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A016220
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 2C 0202
5-hydroxytryptamine receptor 70618
D(3) dopamine receptor010010
UDP-glucuronosyltransferase 1A30001
Histamine H2 receptor6018
5-hydroxytryptamine receptor 6011012
D(2) dopamine receptor0101
D(2) dopamine receptor010212
Histone-lysine N-methyltransferase SETD70202
Chain A, 2-oxoglutarate Oxygenase6006
interleukin 82002
hypoxia-inducible factor 1 alpha subunit6006
thyroid stimulating hormone receptor8008
lamin isoform A-delta10120012
Matrix metalloproteinase-90202
Inositol monophosphatase 15005
Isocitrate lyase0101
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
endonuclease IV5005
15-lipoxygenase, partial2002
Microtubule-associated protein tau100010
Bloom syndrome protein isoform 16006
polyunsaturated fatty acid lipoxygenase ALOX122002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
mitogen-activated protein kinase 14004
Epidermal growth factor receptor0224
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Caspase-71001
Chain A, JmjC domain-containing histone demethylation protein 3A6006
apical membrane antigen 1, AMA12002
aryl hydrocarbon receptor6006
mu-type opioid receptor isoform MOR-10011
importin subunit beta-1 isoform 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
DNA polymerase iota isoform a (long)8008
Vpr3003
D(3) dopamine receptor isoform e1001
5-hydroxytryptamine receptor 2A0011
caspase 7, apoptosis-related cysteine protease4004
67.9K protein6006
caspase-34004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear receptor subfamily 1, group I, member 22002
Serum paraoxonase/arylesterase 10202
Kinesin-like protein KIF110101
ATPase family AAA domain-containing protein 59009
Nucleotide-binding oligomerization domain-containing protein 20101
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0123
Tyrosine-protein kinase Fyn0123
ATP-dependent translocase ABCB10303
Beta-2 adrenergic receptor0404
ATP-dependent translocase ABCB10709
Beta-1 adrenergic receptor0404
Cytochrome P450 3A40606
ATP-dependent translocase ABCB10303
Thromboxane-A synthase 0202
5-hydroxytryptamine receptor 1D0304
5-hydroxytryptamine receptor 1B0303
5-hydroxytryptamine receptor 5A0303
glp-1 receptor, partial5005
SMAD family member 24004
SMAD family member 34004
retinoid X nuclear receptor alpha7007
peroxisome proliferator-activated receptor delta6006
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
Histone H2A.x6006
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Prothrombin0001
Regulatory protein E20011
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0139
Cytochrome P450 2C9 0415
Polyunsaturated fatty acid lipoxygenase ALOX150202
DNA topoisomerase 20001
UDP-glucuronosyltransferase 1A1 0102
Glutamate receptor ionotropic, NMDA 1 0003
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0003
Glutamate receptor ionotropic, NMDA 2B0003
Glutamate receptor ionotropic, NMDA 2C0003
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta01310
Glutamate receptor ionotropic, NMDA 2D0003
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0003
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0003
USP1 protein, partial100010
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0022
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10123
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Protein kinase C beta type0022
Insulin receptor0022
Cyclin-dependent kinase 10022
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Platelet-derived growth factor receptor beta0022
Tyrosine-protein kinase Fgr0022
Serine/threonine-protein kinase A-Raf0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0022
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0123
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0022
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20022
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40022
Myosin-100022
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20123
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Sodium channel protein type 5 subunit alpha0202
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0123
Mitogen-activated protein kinase 110022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140022
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30022
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase Nek70011
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Dual specificity testis-specific protein kinase 20022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10022
Septin-90022
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Long-chain-fatty-acid--CoA ligase 50011
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
GLS protein9009
arylsulfatase A6006
peripheral myelin protein 22 isoform 16006
flap endonuclease 15005
Luciferase4004
Amine oxidase [flavin-containing] A0303
D(4) dopamine receptor0314
Amine oxidase [flavin-containing] B0202
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Mu-type opioid receptor0213
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi4307
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-10224
Gamma-aminobutyric acid receptor subunit beta-14307
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit delta4307
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit gamma-24307
Gamma-aminobutyric acid receptor subunit alpha-54307
Gamma-aminobutyric acid receptor subunit alpha-34307
Gamma-aminobutyric acid receptor subunit gamma-14307
Gamma-aminobutyric acid receptor subunit alpha-24307
Gamma-aminobutyric acid receptor subunit alpha-44307
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit gamma-34307
Gamma-aminobutyric acid receptor subunit alpha-64307
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-14307
Gamma-aminobutyric acid receptor subunit beta-34307
Gamma-aminobutyric acid receptor subunit beta-24307
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10101
GABA theta subunit4307
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit epsilon4307
Gamma-aminobutyric acid receptor subunit theta0101
Chain A, Uracil Phosphoribosyltransferase0101
Skn7p0001
pregnane X receptor2002
Thrombopoietin2002
nonstructural protein 14004
IDH16006
hemoglobin subunit beta1001
muscleblind-like protein 1 isoform 15005
Solute carrier family 22 member 80001
Amyloid-beta precursor protein1203
Thymidylate synthase0101
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase3003
aryl hydrocarbon receptor nuclear translocator0001
GALC protein2002
bromodomain adjacent to zinc finger domain 2B8008
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20102
Carbonic anhydrase 120103
Solute carrier family 22 member 30203
Carbonic anhydrase 10103
Carbonic anhydrase 20104
Plasma kallikrein0002
Carbonic anhydrase 30002
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40002
Carbonic anhydrase 60002
Adenosine receptor A10001
Adenosine receptor A2a0113
Histamine H1 receptor0325
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0002
Carbonic anhydrase0002
Carbonic anhydrase 70002
Carbonic anhydrase0003
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90103
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0003
Carbonic anhydrase0003
Solute carrier family 22 member 10102
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150002
Carbonic anhydrase 130002
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
Histamine H3 receptor0123
NFKB1 protein, partial3003
Smad35005
hypothetical protein, conserved3003
alpha-galactosidase4004
cytochrome P450 2C9 precursor5005
M-phase phosphoprotein 85005
neuropeptide S receptor isoform A3003
Uracil nucleotide/cysteinyl leukotriene receptor0202
Cytochrome P450 2D60303
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
C-X-C chemokine receptor type 30101
dopamine D1 receptor2002
cytochrome P450 3A4 isoform 14004
5-hydroxytryptamine receptor 1A0437
Alpha-1B adrenergic receptor011516
Alpha-1D adrenergic receptor09515
Alpha-1A adrenergic receptor012517
Synaptic vesicular amine transporter0202
Vesicular acetylcholine transporter0101
glucocerebrosidase2002
Parkin2002
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
ras-related protein Rab-9A3003
G-protein coupled receptor homolog US280011
G protein-coupled receptor0011
Chain E, Fibrin beta chain0101
Chain A, Ferritin light chain2002
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase2002
isocitrate dehydrogenase 1, partial1001
luciferase1001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 32002
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
DNA polymerase eta isoform 11001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glutathione reductase0101
Glutathione reductase, mitochondrial0304
Glycoprotein hormones alpha chain1001
Albumin0001
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Cruzipain0101
Alpha-synuclein2002
TAR DNA-binding protein 431001
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor subfamily 1 group I member 20011
DNA polymerase III, partial2002
Translocator protein0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 2B10 0101
Polyunsaturated fatty acid 5-lipoxygenase0001
Neuromedin-K receptor0022
Substance-K receptor0123
Substance-K receptor0405
Substance-P receptor0314
Neuromedin-K receptor0224
Substance-K receptor0202
Substance-K receptor0202
Substance-K receptor0101
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein2002
Polyphenol oxidase 20101
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
Multidrug and toxin extrusion protein 10202
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
beta-2 adrenergic receptor1001
tumor necrosis factor1001
perilipin-50101
perilipin-10101
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Potassium channel subfamily K member 20011
Integrin beta-33003
Cytochrome P450 1A20101
Integrin alpha-IIb3003
Adenosine receptor A30202
Phospholipase A2, membrane associated0001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Potassium voltage-gated channel subfamily A member 50101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Indoleamine 2,3-dioxygenase 10101
Adenosine receptor A2a0101
Adenosine receptor A10202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
C-C chemokine receptor type 20202
Nuclear receptor ROR-gamma1001
Cytochrome P450 2J20101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0203
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Leukotriene B4 receptor 10001
Sodium channel protein type 9 subunit alpha0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Beta-2 adrenergic receptor0001
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Sodium channel protein type 2 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Trace amine-associated receptor 10011
ClpP1001
Hsf1 protein0011
estrogen receptor beta isoform 10101
Alpha-1A adrenergic receptor0123
Alpha-1A adrenergic receptor0202
Alpha-1B adrenergic receptor0202
Alpha-2B adrenergic receptor0336
Alpha-2C adrenergic receptor0336
Alpha-2A adrenergic receptor0336
Alpha-1A adrenergic receptor05211
Alpha-1B adrenergic receptor0529
Nischarin0101
interferon gamma precursor0001
Beta-casein0101
Interstitial collagenase0101
Alpha-2A adrenergic receptor0101
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
Alpha-2B adrenergic receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Type-1 angiotensin II receptor0101
D(1A) dopamine receptor2002
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Multidrug and toxin extrusion protein 20101
ubiquitin-conjugating enzyme E2 N0101
pyruvate kinase PKM isoform b1001
Ornithine decarboxylase1001
Diacylglycerol kinase alpha0101
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2B0101
Rap guanine nucleotide exchange factor 41001
Tyrosine-protein kinase JAK20011
Cyclin-dependent kinase-like 50011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Cytochrome P450 2C190101
Serine/threonine-protein kinase receptor R30011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Protein kinase C zeta type0011
Cyclin-dependent kinase 180011
Tyrosine-protein kinase Mer0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
MAP kinase-activated protein kinase 50011
Misshapen-like kinase 10011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase mTOR 0101
Isoleucine--tRNA ligase, mitochondrial0011
Serine/threonine-protein kinase ICK0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Serine/threonine-protein kinase 240011
Solute carrier organic anion transporter family member 1B10101
Substance-P receptor0202
Substance-P receptor0202
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
polyadenylate-binding protein 10101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]