Page last updated: 2024-10-18

histamine and Epilepsy

histamine has been researched along with Epilepsy in 29 studies

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
" We evaluated the effect of intra-amygdala injection of pitolisant the H3R inverse agonist on seizures induced by the electrical kindling model of epilepsy."8.12Anticonvulsant activity of the histamine H3 receptor inverse agonist pitolisant in an electrical kindling model of epilepsy. ( Beheshti, S; Wesal, MW, 2022)
"Wuling mycelia can delay the kindling and ameliorate the ability of learning in rats with pentylenetetrazole-induced epilepsy and the enhancement of neuronal histamine activity may be one of possible mechanisms."7.78[Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats]. ( Chen, GF; Hu, XY; Ren, GL; Zhang, LS, 2012)
"To investigate the mechanisms of memory impairment induced by pentylenetetrazole (PTZ)-kindled epilepsy in rats and the effects of endogenous histamine."7.73[Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats]. ( Li, Q; Ma, YY; Zhang, LS, 2006)
"To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)."7.72[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004)
"The effects of the histamine precursor, L-histidine, were examined in the rat kindling model of epilepsy."7.69Biphasic action of the histamine precursor L-histidine in the rat kindling model of epilepsy. ( Koshino, Y; Nakamura, M; Shiraishi, J; Wada, Y, 1996)
"Epilepsy is a common neurological disorder characterized by repeated and spontaneous epileptic seizures and is not well controlled by current medication."6.82Central histaminergic signalling, neural excitability and epilepsy. ( Chen, Z; Wang, Y; Yang, L, 2022)
"Histamine-induced flare was quantified using laser-Doppler flowmetry."6.70Influence of vagus nerve stimulation on histamine-induced itching. ( Birklein, F; Haslbeck, KM; Kirchner, A; Schmelz, M; Stefan, H, 2002)
" We evaluated the effect of intra-amygdala injection of pitolisant the H3R inverse agonist on seizures induced by the electrical kindling model of epilepsy."4.12Anticonvulsant activity of the histamine H3 receptor inverse agonist pitolisant in an electrical kindling model of epilepsy. ( Beheshti, S; Wesal, MW, 2022)
"The effects of metoprine, an inhibitor of histamine N-methyltransferase, on open field activity and brain regional histamine (HA) content were examined in rats with mixed, absence and audiogenic, epilepsy (WAG/Rij-AGS), rats with audiogenic epilepsy (Wistar-AGS) and in non-epileptic control rats (Wistar-nAGS)."3.78Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats. ( Bazyan, AS; Birioukova, LM; Kuznetsova, GD; Midzyanovskaya, IS; Samotaeva, IS; Tuomisto, L, 2012)
"Wuling mycelia can delay the kindling and ameliorate the ability of learning in rats with pentylenetetrazole-induced epilepsy and the enhancement of neuronal histamine activity may be one of possible mechanisms."3.78[Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats]. ( Chen, GF; Hu, XY; Ren, GL; Zhang, LS, 2012)
" Since increased brain histamine appears to have an antiepileptic effect through the H(1) receptor activity, kainic acid (KA)-induced status epilepticus in rat was used to study modulation of H(1) and H(3) receptors in the thalamus following seizures."3.73Histamine H(1) and H(3) receptors in the rat thalamus and their modulation after systemic kainic acid administration. ( Jin, C; Lintunen, M; Panula, P, 2005)
" We used systemic kainic acid (KA) administration to study possible changes of the histaminergic system in rat brain in status epilepticus (SE)."3.73Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures. ( Karlstedt, K; Lintunen, M; Panula, P; Sallmen, T, 2005)
"To investigate the mechanisms of memory impairment induced by pentylenetetrazole (PTZ)-kindled epilepsy in rats and the effects of endogenous histamine."3.73[Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats]. ( Li, Q; Ma, YY; Zhang, LS, 2006)
"To investigate the mechanisms of histamine on chronic epilepsy induced by pentylenetetrazole (PTZ)."3.72[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. ( Chen, Z; Hu, WW; Jin, CL; Shen, HQ; Zhang, LS; Zhao, MH, 2004)
"The effects of the histamine precursor, L-histidine, were examined in the rat kindling model of epilepsy."3.69Biphasic action of the histamine precursor L-histidine in the rat kindling model of epilepsy. ( Koshino, Y; Nakamura, M; Shiraishi, J; Wada, Y, 1996)
"Epilepsy is a common neurological disorder characterized by repeated and spontaneous epileptic seizures and is not well controlled by current medication."2.82Central histaminergic signalling, neural excitability and epilepsy. ( Chen, Z; Wang, Y; Yang, L, 2022)
"Histamine-induced flare was quantified using laser-Doppler flowmetry."2.70Influence of vagus nerve stimulation on histamine-induced itching. ( Birklein, F; Haslbeck, KM; Kirchner, A; Schmelz, M; Stefan, H, 2002)
"Epilepsy is a common neurological disease characterized by recurrent unpredictable seizures."2.61Use and Future Prospects of in Vivo Microdialysis for Epilepsy Studies. ( Kennedy, RT; Luna-Munguia, H; Stacey, WC; Zestos, AG, 2019)
"gamma-Aminobutyric acid (GABA) is a major neurotransmitter in AMG, and histamine receptor activation is also reported to stimulate GABA release."1.31Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala. ( Faingold, CL; Feng, HJ; Naritoku, DK; Randall, ME, 2001)
"Psoriasis was also seen in combination with segulae of brain injuries, neuroinfections, hypothalamic syndrome, vascular brain lesions, epilepsy."1.26[State of the nervous system in psoriasis patients]. ( Fedorov, SM; Fedorova, ML, 1976)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199010 (34.48)18.7374
1990's1 (3.45)18.2507
2000's12 (41.38)29.6817
2010's4 (13.79)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Yang, L1
Wang, Y1
Chen, Z4
Beheshti, S1
Wesal, MW1
Zestos, AG1
Luna-Munguia, H1
Stacey, WC1
Kennedy, RT1
Bañuelos-Cabrera, I1
Valle-Dorado, MG1
Aldana, BI1
Orozco-Suárez, SA1
Rocha, L1
Samotaeva, IS1
Birioukova, LM1
Midzyanovskaya, IS1
Kuznetsova, GD1
Bazyan, AS1
Tuomisto, L1
Chen, GF1
Ren, GL1
Zhang, LS3
Hu, XY1
KLOUDA, M1
BENDA, P1
BENDA, R1
GOLD, SC1
Meador, KJ1
Loring, DW1
Ray, PG1
Helman, SW1
Vazquez, BR1
Neveu, PJ1
Hu, WW2
Shen, HQ1
Jin, CL1
Zhao, MH1
Yawata, I1
Tanaka, K1
Nakagawa, Y1
Watanabe, Y1
Murashima, YL1
Nakano, K1
Inoue, E1
Shimizu, Y1
Shoji, M1
Tsuchida, H1
Sano, Y1
Ito, C1
Jin, C1
Lintunen, M2
Panula, P2
Sallmen, T1
Karlstedt, K1
Ma, YY1
Li, Q1
Sigidinenko, LV1
Sellinger, OZ1
Schatz, RA1
Porta, R1
Wilens, TE1
Wada, Y1
Shiraishi, J1
Nakamura, M1
Koshino, Y1
Vohora, D1
Pal, SN1
Pillai, KK1
Feng, HJ1
Naritoku, DK1
Randall, ME1
Faingold, CL1
Li, WD1
Zhu, LJ1
Shen, YJ1
Wei, EQ1
Kirchner, A1
Stefan, H1
Schmelz, M1
Haslbeck, KM1
Birklein, F1
Fedorova, ML1
Fedorov, SM1
Kostopoulos, G1
Psarropoulou, C1
Haas, HL1
Helwig, H1
Engel, D2

Reviews

5 reviews available for histamine and Epilepsy

ArticleYear
Central histaminergic signalling, neural excitability and epilepsy.
    British journal of pharmacology, 2022, Volume: 179, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Epilepsy; Histamine; Histamine Antagonists; Receptors, Histamine H3

2022
Use and Future Prospects of in Vivo Microdialysis for Epilepsy Studies.
    ACS chemical neuroscience, 2019, 04-17, Volume: 10, Issue:4

    Topics: Animals; Brain; Chromatography, Liquid; Electrophoresis, Capillary; Epilepsy; Forecasting; gamma-Ami

2019
Role of histaminergic system in blood-brain barrier dysfunction associated with neurological disorders.
    Archives of medical research, 2014, Volume: 45, Issue:8

    Topics: Alzheimer Disease; Blood-Brain Barrier; Epilepsy; Histamine; Humans; Inflammation; Mast Cells; Parki

2014
[Histamine and diseases of central nervous system].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:3

    Topics: Alzheimer Disease; Brain Ischemia; Epilepsy; Histamine; Humans; Parkinson Disease

2004
[Psychopharmacological agents in children].
    Monatsschrift fur Kinderheilkunde, 1973, Volume: 121, Issue:3

    Topics: Acetylcholine; Aminobutyrates; Antipsychotic Agents; Cerebral Palsy; Child; Chlordiazepoxide; Diazep

1973

Trials

1 trial available for histamine and Epilepsy

ArticleYear
Influence of vagus nerve stimulation on histamine-induced itching.
    Neurology, 2002, Jul-09, Volume: 59, Issue:1

    Topics: Adult; Electric Stimulation Therapy; Epilepsy; Female; Histamine; Humans; Iontophoresis; Male; Pruri

2002

Other Studies

23 other studies available for histamine and Epilepsy

ArticleYear
Anticonvulsant activity of the histamine H3 receptor inverse agonist pitolisant in an electrical kindling model of epilepsy.
    Neuroscience letters, 2022, 06-21, Volume: 782

    Topics: Animals; Anticonvulsants; Epilepsy; Histamine; Histamine Agonists; Histamine Antagonists; Kindling,

2022
Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.
    Epilepsy research, 2012, Volume: 101, Issue:1-2

    Topics: Animals; Behavior, Animal; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Epilepsy; Epi

2012
[Effects of Wuling mycelia on pentylenetetrazole-induced epilepsy in rats].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2012, Volume: 41, Issue:6

    Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Histamine; Kindling,

2012
[Histamine skin tests in epileptic children].
    Ceskoslovenska psychiatrie, 1960, Volume: 56

    Topics: Child; Epilepsy; Histamine; Humans; Skin Tests

1960
[The histamine-protection test in epilepsy and in various psychiatric syndromes].
    Annales medico-psychologiques, 1960, Volume: 118(1)

    Topics: Epilepsy; Histamine; Humans; Immune Sera; Mental Disorders; Psychotic Disorders; Syndrome

1960
DISCOID LUPUS ERYTHEMATOSUS ERUPTION WITH DIGITAL ARTERIAL OCCLUSION.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Brachial Artery; Epilepsy; Epilepsy, Tonic-Cloni

1964
Role of cerebral lateralization in control of immune processes in humans.
    Annals of neurology, 2004, Volume: 55, Issue:6

    Topics: Adult; Cerebral Cortex; Dominance, Cerebral; Epilepsy; Female; Histamine; Humans; Immune System; Lan

2004
[Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:3

    Topics: Animals; Brain; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; Histamine; Histidine; I

2004
Role of histaminergic neurons in development of epileptic seizures in EL mice.
    Brain research. Molecular brain research, 2004, Dec-06, Volume: 132, Issue:1

    Topics: Animals; Brain; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epilepsy; Epil

2004
Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood.
    The American journal of Chinese medicine, 2005, Volume: 33, Issue:1

    Topics: Animals; Behavior, Animal; Carrageenan; Convulsants; Crocus; Drugs, Chinese Herbal; Edema; Epilepsy;

2005
Histamine H(1) and H(3) receptors in the rat thalamus and their modulation after systemic kainic acid administration.
    Experimental neurology, 2005, Volume: 194, Issue:1

    Topics: Animals; Binding, Competitive; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Histamine;

2005
Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures.
    Neurobiology of disease, 2005, Volume: 20, Issue:1

    Topics: Amygdala; Animals; Axons; Epilepsy; Hippocampus; Histamine; Kainic Acid; Limbic System; Male; MAP Ki

2005
[Effects of endogenous histamine on memory impairment induced by pentylenetetrazole-kindled epilepsy in rats].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2006, Volume: 35, Issue:6

    Topics: Animals; Epilepsy; Hippocampus; Histamine; Kindling, Neurologic; Male; Memory Disorders; Neurons; Pe

2006
[Various principles of therapeutic tactics in epilepsy patients during pregnancy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1984, Volume: 84, Issue:6

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Epinephrine; Female; Histamine; Humans;

1984
Brain methylation and epileptogenesis: the case of methionine sulfoximine.
    Annals of neurology, 1984, Volume: 16 Suppl

    Topics: Adenosine; Animals; Brain; Epilepsy; Histamine; Homocysteine; Methionine; Methionine Sulfoximine; Me

1984
Biphasic action of the histamine precursor L-histidine in the rat kindling model of epilepsy.
    Neuroscience letters, 1996, Feb-09, Volume: 204, Issue:3

    Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Histamine; Histidine; Kin

1996
Histamine and selective H3-receptor ligands: a possible role in the mechanism and management of epilepsy.
    Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; Epilepsy; Histamine; Histamine Agonist

2001
Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala.
    Experimental neurology, 2001, Volume: 172, Issue:2

    Topics: Acoustic Stimulation; Amygdala; Animals; Epilepsy; GABA Agonists; gamma-Aminobutyric Acid; Genetic P

2001
Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:4

    Topics: Animals; Drug Synergism; Epilepsy; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histi

2002
[State of the nervous system in psoriasis patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:11

    Topics: Adolescent; Adult; Aged; Autonomic Nervous System; Brain Injuries; Cerebrovascular Circulation; Elec

1976
Membrane properties, response to amines and to tetanic stimulation of hippocampal neurons in the genetically epileptic mutant mouse tottering.
    Experimental brain research, 1988, Volume: 72, Issue:1

    Topics: Action Potentials; Animals; Calcium; Electric Stimulation; Epilepsy; Hippocampus; Histamine; Isoprot

1988
Studies on headache produced by carbon dioxide, histamine and adrenalin.
    Acta neurochirurgica, 1969, Volume: 21, Issue:4

    Topics: Blood Pressure; Brain Concussion; Carbon Dioxide; Craniocerebral Trauma; Epilepsy; Headache; Histami

1969
Cerebral blood vessel reaction to carbon dioxide, histamine and adrenalin.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Blood Pressure; Brain Concussion; Carbon Dioxide; Cerebrovascular Circulation; Cr

1970