Page last updated: 2024-10-18

histamine and Bladder Pain Syndrome

histamine has been researched along with Bladder Pain Syndrome in 6 studies

Research Excerpts

ExcerptRelevanceReference
"Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by overexpression of monocyte chemoattractant protein-1 (MCP-1) in bladder tissues and induction of mast cell (MC) degranulation."5.38MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models. ( Bo, J; Huang, Y; Leng, J; Liu, D; Lv, J; Yang, G; Zhang, Y; Zhu, S, 2012)
"The topic of interstitial cystitis (IC), also known as painful bladder syndrome (PBS), and folate/one carbon metabolism has previously been unaddressed in research."2.61The potential role of folate metabolism in interstitial cystitis. ( Keagy, CD, 2019)
"Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by overexpression of monocyte chemoattractant protein-1 (MCP-1) in bladder tissues and induction of mast cell (MC) degranulation."1.38MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models. ( Bo, J; Huang, Y; Leng, J; Liu, D; Lv, J; Yang, G; Zhang, Y; Zhu, S, 2012)
"A total of 40 women with interstitial cystitis and 29 healthy controls collected 24-hour urine samples."1.33Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis. ( Kreder, KJ; Lamale, LM; Lutgendorf, SK; Zimmerman, MB, 2006)
"Many patients with interstitial cystitis (IC) also have irritable bowel syndrome (IBS), both of which occur overwhelmingly in women, are characterized by pain, and worsen under stress."1.29Mast cell and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis. ( Boucher, W; Pang, X; Sant, GR; Theoharides, TC; Triadafilopoulos, G, 1996)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Grundy, L1
Caldwell, A1
Garcia Caraballo, S1
Erickson, A1
Schober, G1
Castro, J1
Harrington, AM1
Brierley, SM1
Keagy, CD1
Lv, J1
Huang, Y1
Zhu, S1
Yang, G1
Zhang, Y1
Leng, J1
Bo, J1
Liu, D1
Lamale, LM1
Lutgendorf, SK1
Zimmerman, MB1
Kreder, KJ1
Pang, X1
Boucher, W1
Triadafilopoulos, G1
Sant, GR1
Theoharides, TC1
Bouchelouche, K1
Horn, T1
Nordling, J1
Larsen, S1
Hald, T1
Bouchelouche, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acupuncture for Female Interstitial Cystitis/Painful Bladder Syndrome and Its Effect on the Urinary Microbiome: A Randomized Controlled Trial[NCT02232282]22 participants (Actual)Interventional2014-10-31Completed
Mediators of Neurogenic Inflammation in the Urinary Tract as Key Factors in the Painful Bladder Syndrome / Interstitial Cystitis and Bladder Dysfunction[NCT00775281]45 participants (Anticipated)Observational2006-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy of Acupuncture to Reduce Pain in Women With Interstitial Cystitis/Painful Bladder Syndrome

Change in worst pain as measured by the Brief Pain Inventory-Short Form. Scores range from 0 to 10 and higher scores indicate more pain. Change is calculated as the 6 weeks score minus the baseline score. (NCT02232282)
Timeframe: 0 weeks, 6 weeks

Interventionscore on a scale (Least Squares Mean)
Minimal Acupuncture-2.08
Standard Acupuncture Treatment-2.91

Safety of Acupuncture in Women With Interstitial Cystitis/Painful Bladder Syndrome

The total number of adverse events experienced by women receiving acupuncture (NCT02232282)
Timeframe: 0 weeks, 12 weeks

Interventiontotal number of adverse events (Number)
Minimal Acupuncture0
Standard Acupuncture Treatment0

Tolerability of Acupuncture in Women With Interstitial Cystitis/Painful Bladder Syndrom

The total number of acupuncture sessions stopped due to poor tolerability of acupuncture (NCT02232282)
Timeframe: 0 weeks, 6 weeks

Interventiontotal number of sessions (Number)
Minimal Acupuncture0
Standard Acupuncture Treatment0

Reviews

1 review available for histamine and Bladder Pain Syndrome

ArticleYear
The potential role of folate metabolism in interstitial cystitis.
    International urogynecology journal, 2019, Volume: 30, Issue:3

    Topics: Cystitis, Interstitial; Endothelium; Female; Folic Acid; Histamine; Humans; Hypersensitivity; Mast C

2019

Other Studies

5 other studies available for histamine and Bladder Pain Syndrome

ArticleYear
Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H
    American journal of physiology. Renal physiology, 2020, 02-01, Volume: 318, Issue:2

    Topics: Administration, Intravesical; Animals; Calcium Signaling; Cells, Cultured; Cystitis, Interstitial; F

2020
MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models.
    Mediators of inflammation, 2012, Volume: 2012

    Topics: Animals; Cell Line; Chemokine CCL2; Cystitis, Interstitial; Female; Flow Cytometry; Histamine; Hista

2012
Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis.
    Urology, 2006, Volume: 68, Issue:4

    Topics: Adult; Aged; Biomarkers; Cystitis, Interstitial; Female; Histamine; Humans; Interleukin-6; Methylhis

2006
Mast cell and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis.
    Urology, 1996, Volume: 47, Issue:3

    Topics: Chymases; Colon; Colonic Diseases, Functional; Cystitis, Interstitial; Female; Histamine; Humans; Ma

1996
Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis.
    Urology, 2001, Volume: 57, Issue:6 Suppl 1

    Topics: Calcium; Cell Division; Cystitis, Interstitial; Female; Histamine; Humans; Leukotriene D4; Muscle, S

2001