histamine has been researched along with Acute Pain in 2 studies
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
Excerpt | Relevance | Reference |
---|---|---|
"Yet, hyperalgesia was typically accompanied by hyperknesis." | 2.76 | Sensory responses to injection and punctate application of capsaicin and histamine to the skin. ( Green, BG; LaMotte, RH; Shimada, SG; Sikand, P, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Sikand, P | 1 |
Shimada, SG | 1 |
Green, BG | 1 |
LaMotte, RH | 1 |
Steinhoff, M | 1 |
Ikoma, A | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
Intervention | Intensity score (Mean) |
---|---|
Topical KeAmLi Combo | 62.7 |
Topical Ketamine | 63.1 |
Topical Amitriptyline | 69.2 |
Topical Lidocaine | 65.8 |
Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
Intervention | mN (Mean) | |
---|---|---|
Mechanical Detection Threshold | Mechanical Pain Threshold | |
Topical Amitriptyline | 3.573423965 | 152.4768146 |
Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
Topical Ketamine | 3.464204768 | 135.9 |
Topical Lidocaine | 3.546037659 | 126.9 |
Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
Intervention | Degrees celsius (Mean) | |
---|---|---|
Warm Detection Threshold | Heat Pain Threshold | |
Topical Amitriptyline | 33.9 | 40.0 |
Topical KeAmLi Combo | 33.6 | 39.8 |
Topical Ketamine | 34.0 | 40.0 |
Topical Lidocaine | 33.7 | 39.4 |
Topical Vehicle | 33.8 | 39.7 |
1 trial available for histamine and Acute Pain
Article | Year |
---|---|
Sensory responses to injection and punctate application of capsaicin and histamine to the skin.
Topics: Acute Pain; Capsaicin; Female; Histamine; Histamine Agonists; Humans; Hyperalgesia; Injections, Intr | 2011 |
1 other study available for histamine and Acute Pain
Article | Year |
---|---|
Dissecting itch and pain sensations in human skin.
Topics: Acute Pain; Capsaicin; Female; Histamine; Humans; Hyperalgesia; Male; Skin | 2011 |