1,7-diaminoheptane profile

## 1,7-Diaminoheptane: A Key Building Block

1,7-diaminoheptane is a **diamine** - a molecule containing two amine (-NH₂) functional groups. It's a seven-carbon chain with an amine group at each end.

**Why is it important in research?**

1,7-diaminoheptane is a valuable building block for various research areas, particularly in the synthesis of:

* **Polyamides**: This diamine is used to synthesize polymers like nylon, which have diverse applications in textiles, plastics, and engineering.
* **Pharmaceuticals**: Its structure can be modified to create molecules with specific biological activities. This diamine is used in the development of drugs for conditions like cancer, Alzheimer's disease, and bacterial infections.
* **Biomaterials**: Its properties make it suitable for creating biocompatible materials used in implants, tissue engineering, and drug delivery systems.
* **Surfactants**: By attaching hydrophobic groups to 1,7-diaminoheptane, researchers can create surfactants with specific properties for applications in detergents, cosmetics, and pharmaceuticals.
* **Metal-organic frameworks (MOFs)**: 1,7-diaminoheptane can act as a linker to assemble MOFs with specific properties for gas storage, separation, and catalysis.

**Beyond its applications, 1,7-diaminoheptane also offers:**

* **Versatility**: Its structure allows for various modifications, making it adaptable to different synthetic strategies and diverse applications.
* **Biocompatibility**: Its amine groups can be modified to improve biocompatibility, crucial for biomedical applications.
* **Tailorable properties**: By changing the functional groups attached to the diamine, researchers can adjust its physical and chemical properties to match specific needs.

**In summary, 1,7-diaminoheptane is a versatile and crucial molecule for various research areas, contributing to the development of new materials, pharmaceuticals, and technologies.**

ID Source	ID
PubMed CID	69533
CHEMBL ID	28242
SCHEMBL ID	36258
MeSH ID	M0064173

Synonym
1,7-diaminoheptane
h2n(ch2)7nh2
nsc-45777
1,7-heptanediamine
nsc45777
646-19-5
1,7-diaminoheptane, 98%
D0094
heptamethylenediamine
heptane-1,7-diamine
CHEMBL28242 ,
bdbm50216787
AKOS003789317
einecs 211-468-2
nsc 45777
1,7-heptadiamine
unii-3011l9b20c
3011l9b20c ,
STL175683
FT-0607021
SCHEMBL36258
1,7-diamino-n-heptane
1,9-diazanonane
1,7-heptamethylenediamine
STR02318
DTXSID60214848
mfcd00008246
EN300-106743
Q27255888
1,7-heptanediamine; diaminoheptane; 98%; heptamethylenediamine~1,7-heptanediamine
A867850
O11823
Z275166586

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Deoxyhypusine synthase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	50.0000	0.1000	0.1000	0.1000	AID289237
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID448532	Cytotoxicity against Mycobacterium bovis Bacillus Calmette-Guerin infected mouse J774 macrophage assessed as cell viability at 1 ug/mL after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
AID448530	Cytotoxicity against mouse J774 macrophage assessed as cell viability at 10 ug/mL after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
AID448380	Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as minimum inhibitory concentration after 24 hrs by micro plate Alamar blue assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
AID100047	Tested for the T/C (survival time treated/survival time control x 100) after intraperitoneal administration of 50 mg/Kg in 10 E 5 L1210 cells on day 0; not active	1990	Journal of medicinal chemistry, May, Volume: 33, Issue:5	Polyamine analogues with antitumor activity.
AID448533	Cytotoxicity against Mycobacterium bovis Bacillus Calmette-Guerin infected mouse J774 macrophage assessed as cell viability at 10 ug/mL after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
AID448534	Cytotoxicity against Mycobacterium bovis Bacillus Calmette-Guerin infected mouse J774 macrophage assessed as cell viability at 100 ug/mL after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
AID289237	Inhibition of recombinant deoxyhypusine synthase in Plasmodium falciparum NF54	2007	Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18	Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties.
AID448531	Cytotoxicity against mouse J774 macrophage assessed as cell viability at 100 ug/mL after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
AID448381	Cytotoxicity against mouse J774 macrophage assessed as cell viability at 1 ug/mL after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)nNH2.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (29.41)	18.2507
2000's	7 (41.18)	29.6817
2010's	5 (29.41)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
agmatine Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.	2	1	guanidines; primary amino compound	Escherichia coli metabolite; mouse metabolite
cadaverine [no description available]	2.43	2	alkane-alpha,omega-diamine	Daphnia magna metabolite; Escherichia coli metabolite; mouse metabolite; plant metabolite
trimethylenediamine trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.	2.05	1	alkane-alpha,omega-diamine	human metabolite; mouse metabolite; reagent
histamine [no description available]	2.01	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
propionic acid propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.	2.05	1	saturated fatty acid; short-chain fatty acid	antifungal drug
putrescine [no description available]	3.11	5	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite
spermidine [no description available]	2.69	3	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
spermine [no description available]	1.98	1	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent
1,10-diaminodecane [no description available]	2.48	2
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
eflornithine Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.	1.99	1	alpha-amino acid; fluoroamino acid	trypanocidal drug
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	2.05	1	alkane-alpha,omega-diamine	GABA agonist
dipropylenetriame N-(3-aminopropyl)-1,3-propanediamine: structure in first source	1.97	1	polyazaalkane	algal metabolite; plant metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.94	4	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
benzylamine aminotoluene : Any member of the class of toluenes carrying one or more amino groups.	2.01	1	aralkylamine; primary amine	allergen; EC 3.5.5.1 (nitrilase) inhibitor; plant metabolite
dicyclohexylamine dicyclohexylamine: potent inhibitor of spermidine synthase; RN given refers to parent cpd	2	1	primary aliphatic amine
perfluorobutyric acid perfluorobutyric acid: ion pairing reagent; RN given refers to parent cpd. perfluorobutyric acid : A monocarboxylic acid that is perfluorinated butyric acid.	2.05	1	fluoroalkanoic acid	chromatographic reagent; environmental contaminant; xenobiotic
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.01	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
ethambutol Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.	2.05	1	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic
zinc oxide Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	2.07	1	zinc molecular entity
1,6-diaminohexane 1,6-diaminohexane: Russian drug; RN given refers to parent cpd; structure. hexane-1,6-diamine : A C6 alkane-alpha,omega-diamine.	2.43	2	alkane-alpha,omega-diamine	human xenobiotic metabolite
disperse orange 1 [no description available]	2.11	1
1,12-dodecamethylenediamine 1,12-dodecamethylenediamine: RN given refers to parent cpd. dodecane-1,12-diamine : An alkane-alpha,omega-diamine that is dodecane substituted by amino groups at positions 1 and 12.	2.48	2	alkane-alpha,omega-diamine
octamethylenediamine octamethylenediamine: RN given refers to parent cpd. 1,8-diaminooctane : An alkane-alpha,omega-diamine in which the two amino groups are separated by eight methylene groups.	2.71	3	alkane-alpha,omega-diamine
hypusine hypusine: N-terminal amino alcohol deriv of Lys occurring in bovine brain & in the urine of children with familial hyperlysinemia; minor descriptor (75-82); online & Index Medicus search LYSINE/AA (75-82). hypusine : An L-lysine derivative that is L-lysine bearing a (2R)-4-amino-2-hydroxybutyl substituent at position N(6).	2.94	4
isocoumarins Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.	2.07	1	isocoumarins
leupeptins Leupeptins: A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.	2.01	1
n(1)-guanyl-1,7-diaminoheptane N(1)-guanyl-1,7-diaminoheptane: inhibits deoxyhypusine synthase. 2-(7-aminoheptyl)guanidine : A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038).	2.03	1	guanidines; primary amino compound	antineoplastic agent; EC 2.5.1.46 (deoxyhypusine synthase) inhibitor
benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.	2.01	1	amino aldehyde; carbamate ester; tripeptide	proteasome inhibitor
lactacystin [no description available]	2.01	1	lactam; S-substituted L-cysteine

Condition	Relationship Strength	Studies
Leukemia L 1210 [description not available]	1.97	1
Breast Cancer [description not available]	7.11	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.11	1
Disease Exacerbation [description not available]	2.13	1
Esophageal Squamous Cell Carcinoma A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.	2.13	1
Carcinoma, Epidermoid [description not available]	2.13	1
Cancer of Esophagus [description not available]	2.13	1
Metastase [description not available]	2.13	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	2.13	1
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	2.13	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.13	1
Leukemia, Megakaryocytic [description not available]	2.01	1
Leukemia, Megakaryoblastic, Acute An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone marrow RETICULIN is common.	2.01	1
Adrenal Cancer [description not available]	1.98	1
Pheochromocytoma, Extra-Adrenal [description not available]	1.98	1
Pheochromocytoma A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)	1.98	1
Parasitemia The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)	2	1

1,7-diaminoheptane

Cross-References

Synonyms (33)

Protein Targets (1)

Inhibition Measurements

Bioassays (9)

Research

Studies (17)

Market Indicators

Research Demand Index: 26.29

Study Types

1,7-diaminoheptane

Cross-References

Synonyms (33)

Protein Targets (1)

Inhibition Measurements

Bioassays (9)

Research

Studies (17)

Market Indicators

Research Demand Index: 26.29

Study Types

Related Drugs (30)

Related Conditions (17)