Page last updated: 2024-10-18

histamine and Pemphigoid

histamine has been researched along with Pemphigoid in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, Y1
Hwang, BJ1
Liu, Z2
Li, N1
Lough, K1
Williams, SE1
Chen, J1
Burette, SW1
Diaz, LA1
Su, MA1
Xiao, S1
Dimson, OG1
Giudice, GJ2
Fu, CL2
Van den Bergh, F1
Warren, SJ1
Janson, MM1
Fairley, JA2
Katayama, I1
Doi, T1
Nishioka, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open Label Case Series on the Effects of Xolair (Omalizumab) in Bullous Pemphigoid[NCT00472030]Phase 42 participants (Actual)Interventional2007-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Decrease in Anti-BP180 IgG (Immunoglobulin G Anti-Bullous Pemphigoid 180 Antibody) Following Treatment With Omalizumab.

Anti-BP180 IgG levels were completed using an Elisa assay. Anti-BP180 IgG levels were obtained prior to baseline and at week 16 (NCT00472030)
Timeframe: Up to 24 weeks

Interventionunits per milliliter (Number)
Omalizumab Treatment Arm92.06

Decrease in Anti-BP230 Antibody IgG (Anti-bullous Pemphigoid 230 Antibody Immunoglobulin G) At Baseline and Week 16

(NCT00472030)
Timeframe: Up to 24 weeks

Interventionunits per milliliter (Number)
Omalizumab Treatment Arm62.6

Decrease in Eosinophil Levels Following Treatment With Omalizumab.

The subject's eosinophil count measured at baseline was compared to the eosinophil count at week 8. A normal eosinophil count at the University of Iowa Hospital lab is 0-0.4 cells per microliter (NCT00472030)
Timeframe: Baseline, 24 weeks.

Interventioncells/microliter (Number)
Omalizumab Treatment Arm2.16

Median Time From First Dose of Omalizumab Treatment to Cessation of New Blisters.

The study subject underwent physical examination and was assessed for cessation of new blister formation via physical examination and photography. (NCT00472030)
Timeframe: Up to 24 weeks

Interventionweeks (Number)
Omalizumab Treatment Arm6

Percent Decrease in the Total Body Surface Area Affected By Active Bullous Pemphigoid Skin Disease From Day 0 to Week 24.

Measurement of total body surface area affected by bullous pemphigoid active skin disease(active erosions, blisters, and/or lesions) was measured at Day 0 (prior to treatment with Omalizumab) and at 24 weeks (24 weeks is end of study). (NCT00472030)
Timeframe: Up to 24 weeks

Interventionpercentage of active skin disease (Number)
Omalizumab Treatment Arm22.5

Other Studies

4 other studies available for histamine and Pemphigoid

ArticleYear
BP180 dysfunction triggers spontaneous skin inflammation in mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 06-19, Volume: 115, Issue:25

    Topics: Adaptive Immunity; Animals; Autoantigens; Collagen Type XVII; Cytokines; Histamine; Humans; Immunogl

2018
Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid.
    The Journal of investigative dermatology, 2003, Volume: 120, Issue:5

    Topics: Autoantibodies; Autoantigens; Basophils; Carrier Proteins; Collagen; Collagen Type XVII; Cytoskeleta

2003
Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:3

    Topics: Antibody Specificity; Autoantibodies; Autoantigens; Basophils; Binding Sites, Antibody; Collagen Typ

2005
High histamine level in the blister fluid of bullous pemphigoid.
    Archives of dermatological research, 1984, Volume: 276, Issue:2

    Topics: Aged; Eosinophils; Female; Histamine; Humans; Male; Mast Cells; Middle Aged; Pemphigoid, Bullous; Sk

1984