Osteoma

A benign tumor composed of bone tissue or a hard tumor of bonelike structure developing on a bone (homoplastic osteoma) or on other structures (heteroplastic osteoma). (From Dorland, 27th ed)

Synonym
Osteoma

Excerpt	Reference
"The true osteoma is a benign tumour, which mainly occurs in the bones and cavities of the middle third of the face."	( Giannoulopoulos, A; Iatrou, J, 1979)
"These osteomas are not infrequently found completely or partially within the frontal sinus or adjacent ethmoid complex."	( Chapnik, JS; Kirsh, JC; Noyek, AM, 1989)
"Fronto ethmoidal osteoma are rare slow growth benign tumors."	( Constans, JP; Fredy, D; Justiniano, P; Meder, JF; Michalski, M, 1984)
"Choroidal osteoma is a rare choroidal tumor; knowledge of its indocyanine green characteristics is limited."	( De Laey, JJ; Gaudric, A; Kohno, T; Lafaut, BA; Mestdagh, C, 1997)
"The choroidal osteoma is a benign, ossifying tumor of the choroid that typically is found in young, healthy women in the second or third decade of life."	( Kadrmas, EF; Weiter, JJ, 1997)
"Osteomas are uncommon, slow-growing, benign osteogenic neoplasms that arise most frequently in the craniofacial skeleton."	( Foster, JA; Kim, AW; Papay, FA; Wright, KW, 2000)
"Osteomas are the most frequent benign tumors of the paranasal sinuses."	( Assaker, R; Bourgeois, P; Fichten, A; Louis, E; Pertuzon, B; Vincent, C, 2002)
"Osteoid osteomas are often located in the foot, mainly in the talus."	( Hajri, R; Hendaoui, L; Mestiri, M; Rezgui-Marhoul, L; Saïd, W; Zakraoui, L; Zlitni, M, 2003)
"Osteoma is a rare, osteogenic tumour that usually grows slowly and asymptomatically."	( Narne, S; Saetti, R; Silvestrini, M, 2005)
"An osteoma is a benign tumor essentially restricted to the craniofacial skeleton."	( Catapano, S; Mobilio, N; Zanetti, U, 2010)
"Multiple cutaneous osteomas are a rare complication of chronic inflammatory acne that often goes unrecognized."	( Celerier, P; Fenot, M; Maillard, H; Rivet, J; Sierra-Fortuny, S, 2011)
"Osteomas are the most common benign tumors of the paranasal sinuses."	( Benech, A; Brucoli, M; Grivetto, F; Nicolotti, M, 2012)
"Nasal sinus osteoma are common."	( Dong, J; Dong, W; Li, Y; Lu, M; Zhang, W; Zhou, H, 2015)
"Osteomas are benign bone-forming tumours with slow growth."	( Blanco Domínguez, I; Franco Iglesias, G; Martínez González, LM; Moreno García-Rubio, B; Oteiza Álvarez, AV; Riba García, J, 2016)
"Osteomas are the most frequent benign tumor of the paranasal sinuses."	( Ata, N; Erdur, Ö; Koç, E; Övet, G; Tezer, MS, 2017)
"Osteomas are generally benign tumors of the skull that affect all age groups and are diagnosed in the fourth or fifth decade of life, and are rare in childhood."	( Binatli, AO; Karadag, A; Kinali, B; Ozer, FD; Senoglu, M, 2018)
"Subdural osteomas are benign neoplasms that are rarely encountered."	( Dai, J; Duan, L; Jia, J; Li, Q; Niu, L; Pan, Y; Yang, H; Zhang, Y, 2018)
"Osteoma is a benign, usually asymptomatic bone tumour, frequently arising in the nose and paranasal sinuses."	( Cartry, F; Fanchette, J; Faucon, B; Ratajczak, M, 2019)
"Osteoma is the most frequent benign tumor in the craniomaxillofacial region."	( Carvalho, PHA; Guerra, RC; Hochuli-Vieira, E; Junior, JCR; Passetto, MT; Pulino, BFB, 2020)
"Although osteoma is a common benign tumor of the paranasal sinuses, its orbital extension is not common."	( Bagheri, A; Feizi, M; Jafari, R; Kanavi, MR; Raad, N, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	153 (57.95)	23.3326
1990's	30 (11.36)	12.5806
2000's	38 (14.39)	18.1394
2010's	33 (12.50)	28.8240
2020's	10 (3.79)	9.53

Drug	Relationship Strength	Studies
alpha-hydroxyglutarate	low	1
salicylic acid	low	14
histamine	low	1
hydroquinone	low	1
nickel	low	1
carprofen	low	1
ciprofloxacin	low	1
ddt	low	1
pentetic acid	low	1
etidronate	low	2
fenofibrate	low	1
2-propanol	low	1
sodium fluoride	low	1
urethane	low	1
hydroxyproline	low	1
thyroxine	low	1
aldosterone	low	1
penicillin g	low	1
chloramphenicol	low	1
glutamine	low	1
histidine	low	1
dichlorodiphenyldichloroethane	low	1
trichloroacetic acid	low	1
methylmethacrylate	low	2
benzoyl peroxide	low	1
betamethasone	low	1
luminol	low	1
ethylnitrosourea	low	1
testolactone	low	1
durapatite	low	3
technetium	low	7
titanium	low	5
erbium	low	1
gadolinium	low	3
gold	low	1
yttrium	low	1
tricalcium phosphate	low	2
fluorine	low	1
trolamine salicylate	low	9
propiconazole	low	77
fomesafen	low	2
fluorodeoxyglucose f18	low	2
fibrinogen	low	1
delta-hydroxylysylnorleucine	low	1
5,5'-dihydroxylysylnorleucine	low	1
methotrexate	low	1
histidinohydroxymerodesmosine	low	1
organophosphonates	low	1
glycogen	low	2
fibrin	low	1
tretinoin	low	2
bromochloroacetic acid	low	1
pyrophosphate	low	2
thiourea	low	1
hydroxylysine	low	1
freedom	low	1
calcitriol	low	1
isotretinoin	low	2
phenylephrine hydrochloride	low	15
desonide	low	1
strontium	low	1
sulfur	low	1
phosphorus	low	4
strontium radioisotopes	low	2
radium	low	1
technetium tc 99m pyrophosphate	low	2
gadolinium dtpa	low	1
amoxicillin-potassium clavulanate combination	low	1
indocyanine green	low	10
acid phosphatase	low	1
jaw	low	17
desmosine	low	1
sodium ethylxanthate	low	1
oxytetracycline, anhydrous	low	1
minocycline	low	2
salicylates	low	1
demeclocycline	low	1
rome	low	1
hyaluronoglucosaminidase	low	1
technetium tc 99m medronate	low	3
eye	low	6

Protein Targets (731)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
RAR-related orphan receptor gamma	16	0	0	16
GLI family zinc finger 3	18	0	0	18
AR protein	27	0	0	27
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	32	0	0	32
peroxisome proliferator-activated receptor delta	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	10	0	0	10
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
lamin isoform A-delta10	13	0	0	13
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Glutamate receptor 2	12	0	0	12
glucocorticoid receptor [Homo sapiens]	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
geminin	16	0	0	16
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	6	0	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	3	0	3
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Methylcytosine dioxygenase TET2	0	1	1	2
acetylcholinesterase	1	0	0	1
Spike glycoprotein	4	0	0	4
pregnane X receptor	6	0	0	6
progesterone receptor	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
estrogen-related nuclear receptor alpha	21	0	0	21
farnesoid X nuclear receptor	12	0	0	12
pregnane X nuclear receptor	19	0	0	19
vitamin D (1,25- dihydroxyvitamin D3) receptor	17	0	0	17
IDH1	4	0	0	4
aryl hydrocarbon receptor	14	0	0	14
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
galanin receptor type 3	0	1	0	1
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	12
Bile salt export pump	0	17	0	17
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	9	0	9
ORF73	0	0	1	1
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
thyroid stimulating hormone receptor	10	0	0	10
Cellular tumor antigen p53	15	0	0	15
Nuclear receptor ROR-gamma	5	1	1	7
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, Ferritin light chain	6	0	0	6
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	8	0	0	8
PPM1D protein	1	0	0	1
Microtubule-associated protein tau	9	0	0	9
thioredoxin glutathione reductase	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	17	0	0	17
mitogen-activated protein kinase 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	8	0	0	8
Interferon beta	10	0	0	10
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	1	3
Cytochrome P450 3A4	0	5	1	7
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	2	1	3
Vitamin D3 receptor	0	1	2	5
Cytochrome P450 2C9	0	3	1	5
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Cytochrome P450 2C19	0	2	1	3
Kappa-type opioid receptor	0	0	1	2
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Luciferase	7	0	0	7
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
nonstructural protein 1	5	0	0	5
67.9K protein	3	0	0	3
peroxisome proliferator activated receptor gamma	14	0	0	14
vitamin D3 receptor isoform VDRA	7	0	0	7
histone deacetylase 9 isoform 3	1	0	0	1
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Complement C5	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
interleukin 8	4	0	0	4
TDP1 protein	20	0	0	20
EWS/FLI fusion protein	7	0	0	7
G	8	0	0	8
cytochrome P450 2D6	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
thyroid hormone receptor beta isoform 2	16	0	0	16
DNA polymerase iota isoform a (long)	7	0	0	7
streptokinase A precursor	0	0	2	2
lethal factor (plasmid)	5	0	0	5
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	8	0	0	8
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	8	0	0	8
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Chain A, Cruzipain	4	0	0	4
cytochrome P450 2C9 precursor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	4	3	1	8
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
Gamma-aminobutyric acid receptor subunit beta-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit delta	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-2	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-3	4	3	1	8
DNA gyrase subunit A	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-2	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	4	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit alpha-6	4	3	1	8
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-1	4	3	1	8
Gamma-aminobutyric acid receptor subunit beta-3	4	3	1	8
Gamma-aminobutyric acid receptor subunit beta-2	4	3	1	8
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
GABA theta subunit	4	3	1	8
Gamma-aminobutyric acid receptor subunit epsilon	4	3	1	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	7	0	0	7
estrogen receptor 2 (ER beta)	12	0	0	12
Caspase-7	6	0	0	6
cellular tumor antigen p53 isoform a	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
caspase-3	6	0	0	6
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	12	0	0	12
GLS protein	7	0	0	7
regulator of G-protein signaling 4	6	0	0	6
arylsulfatase A	5	0	0	5
hexokinase-4 isoform 1	1	0	0	1
chromobox protein homolog 1	10	0	0	10
glucokinase regulatory protein	1	0	0	1
flap endonuclease 1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
DNA polymerase kappa isoform 1	5	0	0	5
M-phase phosphoprotein 8	6	0	0	6
ATP-dependent phosphofructokinase	8	0	0	8
Gamma-aminobutyric acid	0	1	0	1
glp-1 receptor, partial	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Fatty acid-binding protein, liver	0	2	1	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	1	2	4
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
5-hydroxytryptamine receptor 1A	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Peroxisome proliferator-activated receptor alpha	1	1	1	3
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
acid sphingomyelinase	2	0	0	2
apical membrane antigen 1, AMA1	4	0	0	4
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
endonuclease IV	3	0	0	3
phosphopantetheinyl transferase	7	0	0	7
ATAD5 protein, partial	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
serine-protein kinase ATM isoform a	2	0	0	2
Bloom syndrome protein isoform 1	8	0	0	8
peripheral myelin protein 22 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	1	3
Fatty acid-binding protein, liver	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Adenosine receptor A3	0	6	0	6
Muscarinic acetylcholine receptor M2	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	6	0	6
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Cruzipain	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	3	4
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-1A adrenergic receptor	0	6	0	6
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Carbonic anhydrase 1	0	5	0	9
Carbonic anhydrase 2	0	5	1	11
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	2	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Carbonic anhydrase 12	0	2	0	4
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	2	0	4
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 6	0	2	0	4
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	2
5-hydroxytryptamine receptor 1D	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	4
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 7	0	2	0	4
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase 9	0	2	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	2
Carbonic anhydrase 15	0	2	0	4
Carbonic anhydrase 13	0	2	0	4
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
Histamine H3 receptor	0	1	2	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Nrf2	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
DNA polymerase III, partial	1	0	0	1
Parkin	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
hemoglobin subunit beta	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Acetylcholinesterase	0	1	0	1
Polyphenol oxidase 2	0	2	0	4
Tyrosinase	0	1	0	1
Tyrosinase	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Carbonic anhydrase	0	2	0	2
large T antigen	0	1	0	1
Glutamine synthetase	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
serine/threonine-protein kinase PLK1	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Alpha-2B adrenergic receptor	0	2	0	2
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Cellular retinoic acid-binding protein 1	0	0	2	2
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
Chymotrypsinogen A	0	1	0	1
tumor necrosis factor	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Queuine tRNA-ribosyltransferase	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Estrogen receptor	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	2	0	2
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Aromatase	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease	0	2	0	3
Urease subunit alpha	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	2	0	2
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Alpha-synuclein	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (264)

Protein Targets (731)

Osteoma

Synonyms(1)

Research Excerpts

Overview

Research

Studies (264)

Drugs Studied (98)

Protein Targets (731)