histamine has been researched along with Middle Ear Effusion in 30 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-four children with secretory otitis media awaiting operation for removal of adenoids were studied to investigate the effects of an antihistamine/nasal decongestant combination ('Dimotapp') and sodium cromoglycate nasal drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions." | 9.05 | The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media. ( Church, MK; Collins, MP, 1983) |
| "The aims of our study were to assess whether the increased oxidative stress in experimental otitis media with effusion (OME) induced by histamine was reflected erythrocytes and middle ear effusion fluid by lipid peroxidation; to survey the alterations in antioxidant enzyme activities in experimental OME; and to determine the effect of dantrolene on this oxidative stress." | 7.73 | Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs. ( Aktan, B; Buyukokuroglu, ME; Elmastas, M; Taysi, S; Ucuncu, H, 2005) |
| "In this study, the anti-inflammatory effect of erythromycin was investigated in a model of histamine-induced otitis media with effusion (OME)." | 7.72 | Anti-inflammatory effect of erythromycin on histamine-induced otitis media with effusion in guinea pigs. ( Aktan, B; Altas, S; Gundogdu, C; Sütbeyaz, Y; Ucuncu, H; Unal, B, 2004) |
| "The aims of this study were: (a) to assess whether the increased oxidative stress in otitis media with effusion (OME) induced in guinea pigs by histamine injection into the middle ear cavity is reflected by lipid peroxidation in erythrocytes, plasma, and middle ear effusion fluid; (b) to survey the alterations of oxidant and antioxidant enzyme activities in experimental OME; and (c) to determine the effects of melatonin and methylprednisolone on this oxidative stress." | 7.72 | Protective effect of melatonin on experimental otitis media with effusion in guinea pigs. ( Aktan, B; Akyuz, M; Altas, E; Buyukokuroglu, ME; Ozabacigil, F; Ucuncu, H, 2004) |
| "Histamine, which has been found in middle ear effusions, is a potent pharmacological mediator released at an early stage of allergic reactions or general inflammatory process, increasing permeability of small blood vessels." | 7.68 | Histamine-induced mucociliary dysfunction and otitis media with effusion. ( Esaki, Y; Furuya, H; Nakai, Y; Ohashi, Y; Ohno, Y; Okamoto, H; Sugiura, Y, 1991) |
| "Histamine, both free and cell associated, has been demonstrated in middle ear fluid from patients with secretory otitis media (SOM)." | 7.67 | Histamine and secretory otitis media. ( Bakhshi, K; Church, MK; Collins, MP; Wareham, CA, 1984) |
| "Otitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa." | 5.48 | The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. ( Aktan, B; Ersoy, B; Kilic, K; Sakat, MS; Sipal, S, 2018) |
| " The results indicate that in those children treated with hydroxyzine, the rate of relapse was significantly reduced and so was the amount of histamine present in middle ear effusions." | 5.07 | Treatment of secretory otitis media with local instillation of hydroxyzine. ( Manolidis, LS; Manolidis, SS; Theoharides, TC; Vliagoftis, H, 1994) |
| "Twenty-four children with secretory otitis media awaiting operation for removal of adenoids were studied to investigate the effects of an antihistamine/nasal decongestant combination ('Dimotapp') and sodium cromoglycate nasal drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions." | 5.05 | The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media. ( Church, MK; Collins, MP, 1983) |
| " Experimental otitis media with effusion was created by intratympanic histamine injection." | 3.96 | Effect of probiotics in experimental otitis media with effusion. ( Arslan, N; Celik, H; Ibas, M; Kaytez, SK; Ocal, R; Yumusak, N, 2020) |
| "The aims of our study were to assess whether the increased oxidative stress in experimental otitis media with effusion (OME) induced by histamine was reflected erythrocytes and middle ear effusion fluid by lipid peroxidation; to survey the alterations in antioxidant enzyme activities in experimental OME; and to determine the effect of dantrolene on this oxidative stress." | 3.73 | Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs. ( Aktan, B; Buyukokuroglu, ME; Elmastas, M; Taysi, S; Ucuncu, H, 2005) |
| "In this study, the anti-inflammatory effect of erythromycin was investigated in a model of histamine-induced otitis media with effusion (OME)." | 3.72 | Anti-inflammatory effect of erythromycin on histamine-induced otitis media with effusion in guinea pigs. ( Aktan, B; Altas, S; Gundogdu, C; Sütbeyaz, Y; Ucuncu, H; Unal, B, 2004) |
| "The aims of this study were: (a) to assess whether the increased oxidative stress in otitis media with effusion (OME) induced in guinea pigs by histamine injection into the middle ear cavity is reflected by lipid peroxidation in erythrocytes, plasma, and middle ear effusion fluid; (b) to survey the alterations of oxidant and antioxidant enzyme activities in experimental OME; and (c) to determine the effects of melatonin and methylprednisolone on this oxidative stress." | 3.72 | Protective effect of melatonin on experimental otitis media with effusion in guinea pigs. ( Aktan, B; Akyuz, M; Altas, E; Buyukokuroglu, ME; Ozabacigil, F; Ucuncu, H, 2004) |
| "To show a relationship between intranasal histamine challenge, the development of middle ear effusion and Eustachian tube (ET) dysfunction in a rat model." | 3.71 | Effect of intranasal histamine challenge on Eustachian tube function. ( Dubin, MG; Ebert, CS; McQueen, CT; Pillsbury, HC; Pollock, HW; Prazma, J; Scharer, SS, 2002) |
| " Histamine, leukotriene C4(LTC4) and D4(LTD4), and platelet activating factor (PAF) were perfused through the Eustachian tube of anesthetized dogs at concentrations detected in human middle ear effusion of patients with otitis media." | 3.68 | Effects of various inflammatory mediators on eustachian tube patency. ( Kubo, N; Kumazawa, T; Minami, T; Tomoda, K, 1992) |
| " Middle ear effusion was induced by intravenous administration or local application in the tympanic bulla of substance P (SP), acetylcholine, and histamine." | 3.68 | Identification and characterization of middle ear vascular leakage sites in experimental otitis media. ( Goldie, P; Hellström, S, 1990) |
| "Histamine, which has been found in middle ear effusions, is a potent pharmacological mediator released at an early stage of allergic reactions or general inflammatory process, increasing permeability of small blood vessels." | 3.68 | Histamine-induced mucociliary dysfunction and otitis media with effusion. ( Esaki, Y; Furuya, H; Nakai, Y; Ohashi, Y; Ohno, Y; Okamoto, H; Sugiura, Y, 1991) |
| "Histamine, both free and cell associated, has been demonstrated in middle ear fluid from patients with secretory otitis media (SOM)." | 3.67 | Histamine and secretory otitis media. ( Bakhshi, K; Church, MK; Collins, MP; Wareham, CA, 1984) |
| " The presence of histamine in most middle ear effusions is thought to be generated from inflammatory and not allergic provocation." | 3.67 | The role of histamine in secretory otitis media. ( Berger, G; Hawke, M; Proops, DW; Ranadive, NS, 1984) |
| " Nasal challenges were performed with histamine and Substance P in order to create an edema of the nasal mucosa." | 3.67 | [Animal experiment concerning the relationship between tubal function and nasal resistance]. ( Van Cauwenberge, P, 1989) |
| "Otitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa." | 1.48 | The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. ( Aktan, B; Ersoy, B; Kilic, K; Sakat, MS; Sipal, S, 2018) |
| "Histamine was found to induce a dose-response related increase, whereas blood flow volume tended to decrease in each concentration range in the series of PAF administration." | 1.29 | Regional blood flow volume in the eustachian tube. ( Kubo, N; Kumazawa, T; Minami, T; Tomoda, K; Yamashita, T, 1993) |
| "However, middle ear effusions, when compared with the corresponding sera, were proven to contain higher amounts of histamine and prostaglandin E2." | 1.28 | Experimental otitis media with effusion induced by middle ear effusion. ( Kawauchi, H; Mogi, G; Nakata, J; Suzuki, M, 1992) |
| "To investigate the influence of middle ear effusion (MEE) on perilymph (PL), an experimental otitis media with effusion (OME) was manufactured in chinchillas by injecting the tympanic cavity with immune complexes." | 1.28 | Round window membrane and perilymph in experimental otitis media with effusion. ( Fujiyoshi, T; Kawauchi, H; Mogi, G; Suzuki, M, 1989) |
| "Histamine was assayed radioisotopically, 13,14-dihydro-15-keto-prostaglandin F2 alpha (stable PGF2 alpha metabolite) by radioimmunoassay, and neutrophil chemotactic factor of anaphylaxis by modified Boyden chamber." | 1.27 | Inflammatory mediators in chronic otitis media with effusion. ( Casselbrandt, ML; Doyle, WJ; Fireman, P; Skoner, DP; Stillwagon, PK; Tanner, EP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (33.33) | 18.7374 |
| 1990's | 10 (33.33) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kaytez, SK | 1 |
| Ocal, R | 1 |
| Yumusak, N | 1 |
| Celik, H | 1 |
| Arslan, N | 1 |
| Ibas, M | 1 |
| Ersoy, B | 1 |
| Aktan, B | 5 |
| Kilic, K | 1 |
| Sakat, MS | 2 |
| Sipal, S | 1 |
| Kozan, G | 1 |
| Kurt, S | 1 |
| Öner, F | 1 |
| Kara, A | 1 |
| Aycicek, A | 1 |
| Çetinkaya, Z | 1 |
| Kıyıcı, H | 1 |
| Bukulmez, A | 1 |
| Yucedag, F | 1 |
| McCormick, DP | 1 |
| Saeed, K | 1 |
| Uchida, T | 1 |
| Baldwin, CD | 1 |
| Deskin, R | 1 |
| Lett-Brown, MA | 1 |
| Heikkinen, T | 1 |
| Chonmaitree, T | 1 |
| Gundogdu, C | 1 |
| Ucuncu, H | 3 |
| Unal, B | 1 |
| Sütbeyaz, Y | 1 |
| Altas, S | 1 |
| Ozabacigil, F | 1 |
| Buyukokuroglu, ME | 2 |
| Akyuz, M | 1 |
| Altas, E | 1 |
| Sankovic, S | 1 |
| Dergenc, R | 1 |
| Bojic, P | 1 |
| Taysi, S | 1 |
| Elmastas, M | 1 |
| Collins, MP | 3 |
| Bakhshi, K | 1 |
| Wareham, CA | 1 |
| Church, MK | 3 |
| Berger, G | 1 |
| Hawke, M | 1 |
| Proops, DW | 1 |
| Ranadive, NS | 1 |
| Hori, F | 1 |
| Kawauchi, H | 3 |
| Mogi, G | 5 |
| Theoharides, TC | 1 |
| Manolidis, SS | 1 |
| Vliagoftis, H | 1 |
| Manolidis, LS | 1 |
| Minami, T | 2 |
| Kubo, N | 2 |
| Tomoda, K | 2 |
| Yamashita, T | 1 |
| Kumazawa, T | 2 |
| Ebert, CS | 1 |
| Pollock, HW | 1 |
| Dubin, MG | 1 |
| Scharer, SS | 1 |
| Prazma, J | 1 |
| McQueen, CT | 1 |
| Pillsbury, HC | 1 |
| Nakata, J | 1 |
| Suzuki, M | 2 |
| Goldie, P | 1 |
| Hellström, S | 1 |
| Palva, T | 1 |
| Taskinen, E | 1 |
| Lehtinen, T | 1 |
| Ramsay, H | 1 |
| Björksten, F | 1 |
| Hackman, P | 1 |
| Esaki, Y | 1 |
| Ohashi, Y | 1 |
| Furuya, H | 1 |
| Sugiura, Y | 1 |
| Ohno, Y | 1 |
| Okamoto, H | 1 |
| Nakai, Y | 1 |
| Borges Dinis, P | 1 |
| Gomes, A | 1 |
| Jeep, S | 1 |
| Van Cauwenberge, P | 1 |
| Fujiyoshi, T | 1 |
| Skoner, DP | 1 |
| Stillwagon, PK | 1 |
| Casselbrandt, ML | 1 |
| Tanner, EP | 1 |
| Doyle, WJ | 1 |
| Fireman, P | 1 |
| Tomonaga, K | 2 |
| Kurono, Y | 2 |
| Endo, S | 1 |
| Awataguchi, T | 1 |
| Suzuki, S | 1 |
| Shibuya, M | 1 |
| Takasaka, T | 1 |
| Kawamoto, K | 1 |
| Bakhshi, KN | 1 |
| Osborne, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000363] | Phase 3 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for histamine and Middle Ear Effusion
| Article | Year |
|---|---|
Immunologic mechanisms in secretory otitis media-recent concepts (Part II).
Topics: Agammaglobulinemia; Antigen-Antibody Complex; Arachidonic Acid; Arachidonic Acids; Child; Child, Pre | 1991 |
3 trials available for histamine and Middle Ear Effusion
| Article | Year |
|---|---|
Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment.
Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ceftriaxone; Child; Child, Preschool | 2003 |
The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media.
Topics: Adenoids; Child; Chlorpheniramine; Cromolyn Sodium; Drug Combinations; Ear, Middle; Exudates and Tra | 1983 |
Treatment of secretory otitis media with local instillation of hydroxyzine.
Topics: Child; Child, Preschool; Female; Histamine; Humans; Hydroxyzine; Injections; Male; Mast Cells; Otiti | 1994 |
26 other studies available for histamine and Middle Ear Effusion
| Article | Year |
|---|---|
Effect of probiotics in experimental otitis media with effusion.
Topics: Animals; Disease Models, Animal; Ear, Middle; Histamine; Male; Neutrophils; Otitis Media with Effusi | 2020 |
The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Azithromycin; Clarithromycin; Disease Mode | 2018 |
Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs.
Topics: Animals; Anti-Bacterial Agents; Clarithromycin; Cytokines; Disease Models, Animal; Dose-Response Rel | 2015 |
Can Helicobacter pylori cause inflammation in the middle ear?
Topics: Animals; Ear, Middle; Helicobacter pylori; Histamine; Otitis Media with Effusion; Rabbits | 2012 |
Anti-inflammatory effect of erythromycin on histamine-induced otitis media with effusion in guinea pigs.
Topics: Animals; Anti-Inflammatory Agents; Erythromycin; Glucocorticoids; Guinea Pigs; Histamine; Methylpred | 2004 |
Protective effect of melatonin on experimental otitis media with effusion in guinea pigs.
Topics: Animals; Antioxidants; Disease Models, Animal; Erythrocytes; Guinea Pigs; Histamine; Lipid Peroxidat | 2004 |
Mast cells in chronic inflammation of the middle ear mucosa.
Topics: Adult; Biopsy; Cell Count; Cell Degranulation; Child; Child, Preschool; Chronic Disease; Coloring Ag | 2005 |
Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs.
Topics: Animals; Dantrolene; Disease Models, Animal; Erythrocytes; Glutathione; Glutathione Peroxidase; Glut | 2005 |
Histamine and secretory otitis media.
Topics: Adenoids; Adolescent; Child; Child, Preschool; Histamine; Histamine Release; Humans; Otitis Media; O | 1984 |
The role of histamine in secretory otitis media.
Topics: Adolescent; Adult; Female; Histamine; Humans; Hypersensitivity; Infant; Male; Middle Aged; Otitis Me | 1984 |
Effect of S-carboxymethylcysteine on the clearance of middle ear effusion. An experimental study.
Topics: Animals; Carbocysteine; Chinchilla; Dinoprostone; Ear, Middle; Histamine; Male; Mucous Membrane; Oti | 1994 |
Regional blood flow volume in the eustachian tube.
Topics: Animals; Blood Volume; Dogs; Dose-Response Relationship, Drug; Eustachian Tube; Histamine; Otitis Me | 1993 |
Effect of intranasal histamine challenge on Eustachian tube function.
Topics: Administration, Intranasal; Animals; Disease Models, Animal; Eustachian Tube; Histamine; Male; Otiti | 2002 |
Effects of various inflammatory mediators on eustachian tube patency.
Topics: Animals; Constriction, Pathologic; Dogs; Ear, Middle; Eustachian Tube; Female; Histamine; Male; Otit | 1992 |
Experimental otitis media with effusion induced by middle ear effusion.
Topics: Animals; Antigen-Antibody Complex; Capillaries; Chinchilla; Connective Tissue; Dinoprostone; Ear Dis | 1992 |
Identification and characterization of middle ear vascular leakage sites in experimental otitis media.
Topics: Acetylcholine; Air; Animals; Capillaries; Capillary Permeability; Carbon; Ear Canal; Ear, Middle; Hi | 1990 |
Mast cells and histamine in adenoid tissue and middle ear.
Topics: Adenoids; Chronic Disease; Ear, Middle; Epithelium; Histamine; Humans; Mast Cells; Mucous Membrane; | 1991 |
Histamine-induced mucociliary dysfunction and otitis media with effusion.
Topics: Animals; Cilia; Cimetidine; Diphenhydramine; Ear, Middle; Eustachian Tube; Guinea Pigs; Histamine; M | 1991 |
[Correlation of immunoglobulins, the complement system and inflammatory mediators with reference to the pathogenesis of serous otitis media].
Topics: Adolescent; Child; Child, Preschool; Complement C3c; Dinoprostone; Female; Histamine; Humans; Immuno | 1990 |
[Animal experiment concerning the relationship between tubal function and nasal resistance].
Topics: Airway Resistance; Animals; Edema; Eustachian Tube; Histamine; Macaca mulatta; Manometry; Nose; Otit | 1989 |
Round window membrane and perilymph in experimental otitis media with effusion.
Topics: Albumins; Animals; Chinchilla; Cochlea; Dinoprostone; Disease Models, Animal; Histamine; Immunoglobu | 1989 |
Inflammatory mediators in chronic otitis media with effusion.
Topics: Adolescent; Adult; Chemotactic Factors; Child; Child, Preschool; Chronic Disease; Dinoprost; Haemoph | 1988 |
The role of nasal allergy in otitis media with effusion. A clinical study.
Topics: Acoustic Impedance Tests; Child; Child, Preschool; Eustachian Tube; Histamine; Humans; Otitis Media | 1988 |
[The role of type I allergy in otitis media with effusion].
Topics: Acoustic Impedance Tests; Child; Child, Preschool; Eustachian Tube; Histamine; Humans; Nasal Provoca | 1987 |
[Fluorometric assay of histamine levels in middle ear effusions of secretory otitis media].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Exudates and Transudates; Fluorometry; Histamine; | 1985 |
Adenoid histamine and its possible relationship to secretory otitis media.
Topics: Adenoidectomy; Adenoids; Adolescent; Child; Child, Preschool; Female; Histamine; Humans; Male; Nasop | 1985 |