Compounds > gt 2016
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gt 2016

Description

4-(1-cyclohexylpentanoyl-4-piperidyl)-1H-imidazole: structure given in first source [MeSH]

Cross-References

ID SourceID
PubMed CID9839975
CHEMBL ID14812
SCHEMBL ID3395544
MeSH IDM0254454

Synonyms (18)

Synonym
PDSP2_001477
PDSP1_001493
L009653
CHEMBL14812 ,
gt-2016
SCHEMBL3395544
gt 2016
bdbm86490
5-cyclohexyl-1-[4-(1h-imidazol-5-yl)-1-piperidinyl]-1-pentanone
152241-24-2
AKOS024457088
NCGC00371075-01
5-cyclohexyl-1-[4-(1h-imidazol-5-yl)piperidin-1-yl]pentan-1-one
1-(4-(1h-imidazol-5-yl)piperidin-1-yl)-5-cyclohexylpentan-1-one
CS-0028874
HY-107559
Z3301404517
4-(1-cyclohexylpentanoyl-4-piperidyl)-1h-imidazole

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency6.7412AID1645841
GVesicular stomatitis virusPotency26.8370AID1645842
cytochrome P450 2D6Homo sapiens (human)Potency5.3547AID1645840
Interferon betaHomo sapiens (human)Potency26.8370AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency26.8370AID1645842
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency26.8370AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency26.8370AID1645842

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Histamine H3 receptorRattus norvegicus (Norway rat)Ki0.0400AID89558

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
ISSN: 2472-5560		Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111		A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111		A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID89558Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor1998Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10
ISSN: 0960-894X		New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine.

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's2 (25.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
clobenpropit
1
imidazoles;
imidothiocarbamic ester;
organochlorine compound		H3-receptor antagonist;
H4-receptor agonist		1998199826.0low001000
3-methylhistamine
1
1998199826.0low001000
thioperamide
1
primary aliphatic amine1998199826.0low001000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
histamine
2
aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter		1999200124.0medium001100
astemizole
1
benzimidazoles;
piperidines		anti-allergic agent;
anticoronaviral agent;
H1-receptor antagonist		1998199826.0low001000
betahistine
1
aminoalkylpyridine;
secondary amino compound		H1-receptor agonist;
vasodilator agent		1999199925.0low001000
clobenpropit
1
imidazoles;
imidothiocarbamic ester;
organochlorine compound		H3-receptor antagonist;
H4-receptor agonist		2001200123.0low000100
tele-methylhistamine
1
imidazoles;
primary amino compound		human metabolite;
mouse metabolite		2001200123.0low000100
pargyline
1
aromatic amine2001200123.0low000100
kainic acid
1
dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist		1999199925.0low001000
thiourea
1
one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore		2001200123.0low000100
thioperamide
1
primary aliphatic amine2001200123.0low000100
piperidines
1
2001200123.0low000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Central Nervous System Origin Vertigo0
1
1998199826.0medium001000
Congenital Zika Syndrome0
1
202020204.0medium000010
Disease Models, Animal0
2
1999202014.5high001010
Vertigo0
1
1998199826.0medium001000
Vestibular Diseases0
1
1999199925.0medium001000
Zika Virus Infection0
1
202020204.0medium000010

Bioavailability (1)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, , Volume: 96, Issue:5		2019