tetrachlorophthalic anhydride profile

tetrachlorophthalic anhydride: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tetrachlorophthalic anhydride : A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	8326
CHEMBL ID	1567912
CHEBI ID	59097
SCHEMBL ID	21861
MeSH ID	M0054065

Synonyms (66)

Synonym
etrachlorophthalic acid anhydride
CHEBI:59097 ,
phthalic anhydride, tetrachloro-
tetrachlorophthalic anhydride
nsc-1484
niagathal
117-08-8
1,5,6,7-tetrachloroisobenzofuran
nsc1484
1, 4,5,6,7-tetrachloro-
4,5,6,7-tetrachloro-2-benzofuran-1,3-dione
inchi=1/c8cl4o3/c9-3-1-2(8(14)15-7(1)13)4(10)6(12)5(3)1
1,3-isobenzofurandione, 4,5,6,7-tetrachloro-
NCGC00091300-01
1,3-dioxy-4,5,6,7-tetrachloroisobenzofuran
ai3-09048
brn 0211560
4,5,6,7-tetrachloro-1,3-isobenzofurandione
einecs 204-171-4
ccris 6202
nsc 1484
nci-c61585
hsdb 2922
cp 626
tetrathal
tetrachlorophthalic anhydride, 96%
NCGC00091300-02
STK256922
AC-11123
FT-0657077
T0071
AKOS003239988
4,5,6,7-tetrakis(chloranyl)-2-benzofuran-1,3-dione
A803707
4,5,6,7-tetrachloroisobenzofuran-1,3-dione
NCGC00091300-03
BBL000527
unii-76glw0lbek
76glw0lbek ,
5-17-11-00260 (beilstein handbook reference)
ec 204-171-4
dtxcid606102
dtxsid7026102 ,
NCGC00256940-01
tox21_303212
cas-117-08-8
tox21_201740
NCGC00259289-01
EPITOPE ID:122674
tetrachlorophthalic anhydride [hsdb]
tetrachlorophthalic acid anhydride
tetrachloro-phthalic acid anhydride
tetrachloro phthalic anhydride
3,4,5,6-tetrachlorophthalic anhydride
SCHEMBL21861
CHEMBL1567912
4,5,6,7-tetrachloro-2-benzofuran-1,3-dione #
1,3-isobenzofurandione, tetrachloro-
1,3-dioxo-4,5,6,7-tetrachloroisobenzofuran
4,5,6,7-tetrachloro-isobenzofuran-1,3-dione
tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione
J-514038
mfcd00005920
VS-00637
Q21045245
EN300-211008

Excerpt	Relevance	Reference
" The rats were orally dosed for 7 d with TCPA suspended in corn oil at 25, 100, 250, or 500 mg/kg."	( Effect of tetrachlorophthalic anhydride on hepatic microsomal metabolism in rats and mice. Nair, RS; Ridley, WP; Warren, J, 1988)	0.68

Role	Description
cross-linking reagent	A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified.
allergen	A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
cyclic dicarboxylic anhydride	An acid anhydride derived by loss of water between two carboxylic groups in the same molecule so as to close a ring.
tetrachlorobenzene	Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	39.8107	0.0112	12.4002	100.0000	AID1030
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	39.8107	0.0013	18.0743	39.8107	AID926; AID938
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	76.9588	0.0030	41.6115	22,387.1992	AID1159553
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	54.4827	0.0015	30.6073	15,848.9004	AID1224848; AID1224849
pregnane X nuclear receptor	Homo sapiens (human)	Potency	61.7528	0.0054	28.0263	1,258.9301	AID1346982
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	50.1187	0.0010	19.4141	70.9645	AID588537
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	0.0016	0.0100	39.5371	1,122.0200	AID588545
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	48.5577	0.0006	27.2152	1,122.0200	AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (53.85)	18.7374
1990's	6 (46.15)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.69%)	6.00%
Case Studies	2 (15.38%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (76.92%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
histamine [no description available]	1.97	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	3.06	1	metal allergen; nickel group element atom	epitope; micronutrient
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	3.06	1	alkane-alpha,omega-diamine	GABA agonist
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	1.98	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
zoxazolamine Zoxazolamine: A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.	1.97	1	benzoxazole
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	1.97	1	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	3.06	1	alkadiene; hemiterpene; volatile organic compound	plant metabolite
phthalic anhydride phthalic anhydride : The cyclic dicarboxylic anhydride that is the anhydride of phthalic acid.	2.67	3	2-benzofurans; cyclic dicarboxylic anhydride	allergen
maleic anhydride Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.	1.98	1	cyclic dicarboxylic anhydride; furans	allergen
trimellitic anhydride trimellitic anhydride: structure. trimellitic anhydride : A 2-benzofuran compound having oxo groups at the 1- and 3-positions and a carboxy substituent at the 5-position; the cyclic anhydride formed from the carboxy groups at the 1- and 2-positions of trimellitic acid.	3.76	3	2-benzofurans; cyclic dicarboxylic anhydride; dioxo monocarboxylic acid	allergen; epitope; hapten
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	3.06	1	elemental platinum; nickel group element atom; platinum group metal atom
nickel sulfate nickel sulfate: RN given refers to cpd with MF of Ni(2+)-H2SO4. nickel sulfate : A metal sulfate having nickel(2+) as the metal ion.	3.06	1	metal sulfate	allergen
cyanates Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).	3.06	1
araldite araldite: induces experimental asthma in immunized guinea pigs; RN given refers to araldite; see also record for araldite B	1.98	1

Condition	Relationship Strength	Studies
Asthma, Bronchial [description not available]	4.14	6
Eczema, Atopic [description not available]	2.88	1
Delayed Hypersensitivity [description not available]	2.88	1
Atopic Hypersensitivity [description not available]	3.28	2
Diseases, Occupational [description not available]	4.49	9
Airway Hyper-Responsiveness [description not available]	2.88	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	4.14	6
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	2.88	1
Allergy, Drug [description not available]	1.98	1
Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	1.98	1
Palsy [description not available]	1.97	1
Paralysis A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	1.97	1
Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM.	1.97	1

tetrachlorophthalic anhydride

Description

Cross-References

Synonyms (66)

Research Excerpts

Dosage Studied

Roles (2)

Drug Classes (2)

Protein Targets (8)

Potency Measurements

Research

Studies (13)

Market Indicators

Research Demand Index: 30.92

Study Types

tetrachlorophthalic anhydride

Description

Cross-References

Synonyms (66)

Research Excerpts

Dosage Studied

Roles (2)

Drug Classes (2)

Protein Targets (8)

Potency Measurements

Research

Studies (13)

Market Indicators

Research Demand Index: 30.92

Study Types

Related Drugs (14)

Related Conditions (13)