Page last updated: 2024-09-27

Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

Synonyms(6)

Synonym
Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration
Cerebellar Degeneration, Paraneoplastic
Paraneoplastic Cerebellar Degeneration
Cerebellar Syndrome, Paraneoplastic
Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated
Paraneoplastic Cerebellar Syndrome

Research Excerpts

Treatment

ExcerptReference
"As a debilitating syndrome, paraneoplastic cerebellar degeneration (PCD) remains challenging to treat."( Ariizumi, Y; Hiruma, K; Imai, T; Maki, F; Okuma, H; Shinohara, K; Uchino, K; Yamano, Y, 2022)

Research

Studies (43)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's20 (46.51)18.1394
2010's16 (37.21)28.8240
2020's7 (16.28)9.53
DrugIndicatedRelationship StrengthStudiesTrials
creatine0low10
histamine0low10
imipramine0low10
prednisolone0low10
thyroxine0low10
prednisone0low40
aspartic acid0low10
methylprednisolone0low30
lithium carbonate0low10
paclitaxel0low20
etoposide0low10
epirubicin0low10
n-acetylaspartic acid0low10
fluorodeoxyglucose f180low190
carboplatin0low10
tamoxifen0low10
calpain0low10
snx 2300low10
dacarbazine0low20
leptin0low10

Protein Targets (492)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Ferritin light chain2002
phosphopantetheinyl transferase5005
aldehyde dehydrogenase 1 family, member A14004
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 26006
Bloom syndrome protein isoform 11001
cytochrome P450 2C19 precursor1001
lethal factor (plasmid)2002
lamin isoform A-delta106006
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
Carbonic anhydrase 10002
Carbonic anhydrase 20003
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0204
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0204
Glutamate receptor ionotropic, NMDA 2B0204
Glutamate receptor ionotropic, NMDA 2C0204
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0204
Glutamate receptor ionotropic, NMDA 3B0204
Carbonic anhydrase 40002
Glutamate receptor ionotropic, NMDA 3A0204
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
acetylcholinesterase3003
RAR-related orphan receptor gamma6006
estrogen receptor 2 (ER beta)3003
G3003
cytochrome P450 2D63003
vitamin D3 receptor isoform VDRA3003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 16006
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 11001
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 3003
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase3003
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10101
Chain A, 2-oxoglutarate Oxygenase1001
interleukin 81001
hypoxia-inducible factor 1 alpha subunit5005
AR protein100010
thyroid stimulating hormone receptor2002
glucocorticoid receptor [Homo sapiens]9009
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha8008
estrogen nuclear receptor alpha100010
peroxisome proliferator activated receptor gamma7007
thyroid stimulating hormone receptor4004
activating transcription factor 64004
geminin6006
survival motor neuron protein isoform d1001
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Bile salt export pump0909
Matrix metalloproteinase-90101
Inositol monophosphatase 11001
Isocitrate lyase0101
Canalicular multispecific organic anion transporter 109010
PPM1D protein4004
TDP1 protein8008
GLI family zinc finger 37007
caspase 7, apoptosis-related cysteine protease3003
nuclear receptor subfamily 1, group I, member 35005
cytochrome P450 family 3 subfamily A polypeptide 44004
farnesoid X nuclear receptor2002
pregnane X nuclear receptor8008
67.9K protein5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-33003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear receptor subfamily 1, group I, member 24004
thyroid hormone receptor beta isoform 28008
Cellular tumor antigen p538008
Serum paraoxonase/arylesterase 10303
Kinesin-like protein KIF110101
Spike glycoprotein3014
ATPase family AAA domain-containing protein 55005
Ataxin-26006
Nucleotide-binding oligomerization domain-containing protein 20202
Genome polyprotein 0202
Fumarate hydratase2002
EWS/FLI fusion protein3003
polyprotein2002
Tyrosine-protein kinase Fyn0303
UDP-glucuronosyltransferase 2B70102
glp-1 receptor, partial1001
SMAD family member 22002
SMAD family member 32002
progesterone receptor5005
retinoid X nuclear receptor alpha4004
peroxisome proliferator-activated receptor delta4004
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x2002
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 25005
heat shock protein beta-12002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase iota isoform a (long)2002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Voltage-dependent calcium channel gamma-2 subunit3003
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10519
Cytochrome P450 3A40203
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Cytochrome P450 2C9 0303
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
Glutamate receptor 23003
ATP-dependent translocase ABCB10202
UDP-glucuronosyltransferase 1A1 0203
Caspase-30101
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Tubulin beta-2B chain0114
Integrase 0101
Similar to alpha-tubulin isoform 1 0114
Similar to alpha-tubulin isoform 1 0103
Solute carrier organic anion transporter family member 1B30404
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase3003
aryl hydrocarbon receptor nuclear translocator0001
thioredoxin reductase2002
USP1 protein, partial4004
GALC protein1001
GLS protein1001
apical membrane antigen 1, AMA13003
regulator of G-protein signaling 43003
bromodomain adjacent to zinc finger domain 2B3003
potassium voltage-gated channel subfamily H member 2 isoform d2002
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0102
Carbonic anhydrase 120001
Solute carrier family 22 member 30203
Plasma kallikrein0001
Carbonic anhydrase 30001
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Histamine H2 receptor0325
Adenosine receptor A10001
Adenosine receptor A2a0001
Histamine H1 receptor0134
Histamine H1 receptor0314
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0001
Histamine H1 receptor0426
Carbonic anhydrase0001
Carbonic anhydrase 70001
Histamine H2 receptor2114
Carbonic anhydrase0002
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Solute carrier family 22 member 10203
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20203
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Histamine H3 receptor0123
Microtubule-associated protein tau2002
Snq2p0001
cytochrome P450 2D6 isoform 12002
D(1A) dopamine receptor2002
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
peripheral myelin protein 222002
muscarinic acetylcholine receptor M11001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium-dependent noradrenaline transporter0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Major prion protein0011
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Cytochrome P450 2D60101
D(2) dopamine receptor0404
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0404
Sphingomyelin phosphodiesterase0101
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0303
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40103
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0404
Sodium-dependent dopamine transporter0101
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0303
5-hydroxytryptamine receptor 1B0303
5-hydroxytryptamine receptor 1D0101
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
Sodium-dependent serotonin transporter0404
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0101
Cytochrome P450 2C190001
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 3A0101
Alpha-1A adrenergic receptor0404
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60303
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20202
D(2) dopamine receptor0101
D(2) dopamine receptor0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0303
Envelope glycoprotein0011
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 4 0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Sodium channel protein type 2 subunit alpha0101
5-hydroxytryptamine receptor 3B0101
Sodium channel protein type 3 subunit alpha0101
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transporter0202
Sodium channel protein type 10 subunit alpha0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
IDH13003
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0505
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
transcriptional regulator ERG isoform 32002
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Rap guanine nucleotide exchange factor 41001
Luciferase1001
pregnane X receptor2002
NPC intracellular cholesterol transporter 1 precursor2002
Tyrosine-protein kinase ABL10101
Epidermal growth factor receptor0202
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20202
Integrin beta-31102
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 1-60101
Substance-K receptor0404
Cholecystokinin receptor type A0202
Melanocortin receptor 50404
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0404
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Solute carrier organic anion transporter family member 1B10203
luciferase0001
aryl hydrocarbon receptor2002
Fatty acid-binding protein, liver0101
Estrogen receptor0416
Progesterone receptor0304
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0415
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
thioredoxin glutathione reductase1001
nuclear receptor ROR-gamma isoform 12002
Nuclear receptor ROR-gamma1001
Chain A, CES1 protein0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
DNA polymerase III, partial1001
glucocerebrosidase1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
caspase-31001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
streptokinase A precursor0011
Gamma-aminobutyric acid receptor subunit pi1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit beta-11001
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Adenosine receptor A2a0202
Gamma-aminobutyric acid receptor subunit alpha-61001
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Alpha-synuclein1001
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Estrogen-related receptor gamma0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
GABA theta subunit1001
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
Gamma-aminobutyric acid receptor subunit epsilon1001
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
thyroid hormone receptor beta isoform a1001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]