Dirofilariasis

Infection with nematodes of the genus DIROFILARIA, usually in animals, especially dogs, but occasionally in man.

Synonym
Dirofilariasis
Heartworm Disease

Excerpt	Reference
"Human dirofilariasis is a rare infection in Malaysia."	( Krishnan, R; Pathmanathan, R; Shekhar, KC, 1996)
"Pulmonary dirofilariasis is essentially an asymptomatic disease."	( Chitkara, RK; Sarinas, PS, 1997)
"Cutaneous nodular dirofilariasis is occasionally reported in dogs but is rare in cats."	( Bo, S; Colombo, S; Cornegliani, L; Vercelli, A, 2003)
"Human dirofilariasis is a rare zoonotic infection caused by various filarial species of the genus Dirofilaria."	( Hearne, RH; Polk, AC; Warthan, ML; Warthan, MM; Warthan, TL, 2007)
"Canine heartworm disease is caused by infection with Dirofilaria immitis, a filarial nematode that resides in the pulmonary arteries and occasionally in the right heart chambers of infected dogs."	( Bertoni, G; Genchi, M; Gnudi, G; Grandi, G; Kramer, L; Mavropoulou, A; Quintavalla, C, 2010)
"Dirofilariasis is a zoonosis affecting dogs and cats."	( Amara, K; Ben Ghachem, M; Bouchoucha, S; Khaled, S; Mrad, K; Nessib, MN; Saied, W; Smida, M, 2011)
"Dirofilariasis is a worldwide zoonotic filariasis with over 782 cases reported so far from different parts of the world."	( Bhavsar, S; Patel, R; Singh, S, 2014)
"Human subcutaneous dirofilariasis is an emerging mosquitoborne zoonosis."	( Giese, M; Huebl, L; Jochum, J; Kreuels, B; Mempel, S; Ramharter, M; Tannich, E; Tappe, D; Veletzky, L, 2021)
"Dirofilariasis is an emerging zoonosis caused by nematodes of the genus Dirofilaria, most often D."	( Ćwikłowska, A; Czaplewski, A; Grzanka, D; Kulawiak-Wasielak, N; Marek-Józefowicz, L; Sulima, M; Szostakowska, B, 2022)
"Dirofilariasis is an emerging zoonosis in India."	( Murthy, PR; Shambhu, SK, 2022)
"Dirofilariasis is an endemic infestation in tropical and subtropical countries caused by about 40 different species."	( Brailo, V; Bukovski, S; Juras, DV; Loncar Brzak, B; Lozic Erent, J; Skrinjar, I, 2022)

Excerpt	Reference
"In 7 dogs with ascitic pulmonary heartworm disease, plasma benazeprilat concentrations tended to be higher than in 7 control dogs both on the 1st and 7th administration days."	( Kitagawa, H; Kitoh, K; Kondo, M; Kuwahara, Y; Nakano, M; Ohba, Y; Ohne, R; Sasaki, Y, 2003)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	211 (38.50)	23.3326
1990's	84 (15.33)	12.5806
2000's	85 (15.51)	18.1394
2010's	113 (20.62)	28.8240
2020's	55 (10.04)	9.53

Drug	Relationship Strength	Studies	Trials
2,3-diphosphoglycerate	low	1	0
acetic acid	low	2	0
acetone	low	1	0
adenine	low	1	0
carbamates	low	2	0
chlorine	low	1	0
salicylic acid	low	1	0
lactic acid	low	1	0
dimethyl sulfoxide	low	1	0
formaldehyde	low	6	0
glycine	low	1	0
hydrogen carbonate	low	2	0
histamine	low	7	0
oxamic acid	low	1	0
phosphorylcholine	low	1	0
phosphorylethanolamine	low	1	0
urea	low	3	0
mercaptoethanol	low	2	0
albendazole	low	2	0
aspirin	low	13	0
azathioprine	low	1	0
bupivacaine	low	1	0
chloroquine	low	1	0
chlorothiazide	low	1	0
chlorpromazine	low	1	0
cimetidine	low	2	0
diazepam	low	1	0
dichlorvos	low	3	0
diethylcarbamazine	low	40	0
diphenhydramine	low	1	0
dipyridamole	low	1	0
erythrosine	low	1	0
fenthion	low	4	0
fipronil	low	1	0
furosemide	low	3	0
halothane	low	1	0
homochlorocyclizine	low	1	0
hydralazine	low	1	0
lidocaine	low	1	0
indomethacin	low	3	0
isoproterenol	low	2	0
ketoconazole	low	1	0
tetramisole	low	1	0
malathion	low	1	0
mebendazole	low	4	0
mefenamic acid	low	2	0
metoprolol	low	1	0
mirtazapine	low	1	0
apnea	low	2	0
neostigmine	low	1	0
nitroglycerin	low	6	0
ofloxacin	low	1	0
oxibendazole	low	1	0
pimobendan	low	2	0
potassium chloride	low	1	0
praziquantel	medium	4	1
prazosin	low	2	0
sevoflurane	low	1	0
sulfadiazine	low	1	0
sulfobromophthalein	low	1	0
thiabendazole	low	2	0
ticlopidine	low	1	0
trimethoprim	low	1	0
tripelennamine	low	1	0
prednisolone	low	12	0
hydroxyproline	low	1	0
carbachol	low	4	0
prednisolone acetate	low	1	0
adenosine diphosphate	low	4	0
phenylephrine	low	1	0
edetic acid	low	2	0
methylene blue	low	5	0
methacholine chloride	low	4	0
methionine	low	1	0
arginine	low	3	0
tromethamine	low	1	0
cyclizine	low	1	0
thiophenes	low	1	0
meglumine	low	1	0
quinazolines	low	1	0
isoxazoles	low	3	0
oxazoles	low	1	0
thiazoles	low	5	0
evans blue	low	1	0
melarsoprol	low	1	0
dithiazanine	low	5	0
arsenamide	low	41	0
fluorescein-5-isothiocyanate	low	1	0
ecdysone	low	1	0
streptomycin	low	1	0
carbonates	low	1	0
gold	low	1	0
mercuric chloride	low	1	0
levamisole	low	19	0
clonixin	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
flubendazole	low	1	0
substance p	low	1	0
flunixin meglumine	low	1	0
ng-nitroarginine methyl ester	low	3	0
1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril	low	1	0
permethrin	low	2	0
lodoxamide ethyl	low	1	0
propiconazole	low	11	0
itazigrel	low	1	0
fomesafen	low	1	0
sulfadiazine, trimethoprim drug combination	low	1	0
meglumine antimoniate	low	1	0
histamine phosphate	low	1	0
melarsomine	medium	27	2
medetomidine	medium	2	1
fluorodeoxyglucose f18	low	2	0
tricine	low	1	0
fibrinogen	low	2	0
pyriproxyfen	low	1	0
n-succinimidyl-3-(4-hydroxyphenyl)propionate	low	1	0
foxes	low	28	0
alphaxalone	low	1	0
beauvericin	low	1	0
enniatin b	low	1	0
symmetric dimethylarginine	low	1	0
angiotensin ii	low	1	0
atropine	low	1	0
cortisone	low	1	0
inositol 3-phosphate	low	2	0
quinidine	low	1	0
arachidonic acid	low	1	0
oleic acid	low	1	0
prostaglandin d2	low	1	0
pyrantel	medium	5	3
digoxin	low	3	0
thiamylal	low	1	0
deracoxib	low	1	0
sodium dodecyl sulfate	low	1	0
bilirubin	low	1	0
dinoprost	low	1	0
leukotriene b4	low	1	0
thromboxane a2	low	1	0
pyrantel pamoate	medium	4	1
thromboxane b2	low	2	0
phenylephrine hydrochloride	low	1	0
dexmedetomidine	low	1	0
u 44069	low	1	0
antimony	low	1	0
arsenic	medium	49	2
butorphanol	low	1	0
benazepril	medium	1	1
methoprene	low	1	0
ecdysterone	low	1	0
benazeprilat	medium	1	1
tinopal	low	1	0
c.i. fluorescent brightening agent 28	low	1	0
avermectin b(1)a	low	1	0
piriprost	low	1	0
beta-escin	low	4	0
loa	low	3	0
doramectin	medium	3	1
calcimycin	low	1	0
dextrothyroxine	medium	107	17
indocyanine green	low	1	0
acid phosphatase	low	9	0
nad	low	1	0
atrial natriuretic factor	low	2	0
endothelin-1	low	2	0
afoxolaner	low	2	0
interleukin-8	low	1	0
natriuretic peptide, brain	low	1	0
tetracycline	low	3	0
minocycline	low	3	0
transforming growth factor beta	low	1	0
dafachronic acid	low	1	0
moxidectin	medium	77	23
selamectin	medium	17	7
exudates	low	11	0
guanine	low	1	0
sildenafil citrate	low	1	0
imidacloprid	medium	30	10
avermectin	medium	5	2
eye	low	9	0

Protein Targets (1,289)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	59	0	0	59
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
TDP1 protein	44	0	0	44
glucocorticoid receptor [Homo sapiens]	36	0	0	36
estrogen-related nuclear receptor alpha	47	0	0	47
thyroid hormone receptor beta isoform 2	35	0	0	35
lamin isoform A-delta10	36	0	0	36
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	25	0	0	25
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	37	0	0	37
AR protein	53	0	0	53
nuclear receptor subfamily 1, group I, member 3	31	0	0	31
cytochrome P450 family 3 subfamily A polypeptide 4	28	0	0	28
pregnane X nuclear receptor	36	0	0	36
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	12
heat shock protein beta-1	15	0	0	15
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Bile salt export pump	0	42	0	42
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	2	1	4
Glutamate receptor 2	19	0	0	19
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	8	0	0	8
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	17	0	0	17
Ataxin-2	22	0	0	22
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	11	0	0	11
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	4	1	5
Delta-type opioid receptor	0	5	1	6
Kappa-type opioid receptor	0	3	2	5
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	7	0	0	7
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	1	1	2
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, Beta-lactamase	13	0	0	13
Luciferase	20	0	0	20
glp-1 receptor, partial	14	0	0	14
hypoxia-inducible factor 1 alpha subunit	15	0	0	15
ATAD5 protein, partial	18	0	0	18
Fumarate hydratase	13	0	0	13
GLI family zinc finger 3	33	0	0	33
caspase 7, apoptosis-related cysteine protease	8	0	0	8
progesterone receptor	28	0	0	28
retinoic acid nuclear receptor alpha variant 1	38	0	0	38
retinoid X nuclear receptor alpha	33	0	0	33
farnesoid X nuclear receptor	26	0	0	26
polyprotein	13	0	0	13
67.9K protein	11	0	0	11
peroxisome proliferator activated receptor gamma	27	0	0	27
vitamin D (1,25- dihydroxyvitamin D3) receptor	30	0	0	30
caspase-3	8	0	0	8
IDH1	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	38	0	0	38
aryl hydrocarbon receptor	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	25	0	0	25
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
Histone H2A.x	18	0	0	18
cellular tumor antigen p53 isoform a	11	0	0	11
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
chromobox protein homolog 1	21	0	0	21
transcriptional regulator ERG isoform 3	4	0	0	4
histone deacetylase 9 isoform 3	9	0	0	9
mitogen-activated protein kinase 1	13	0	0	13
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
geminin	33	0	0	33
Vif	0	0	0	1
peripheral myelin protein 22	21	0	0	21
survival motor neuron protein isoform d	17	0	0	17
muscleblind-like protein 1 isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
neuropeptide S receptor isoform A	9	0	0	9
ATP-binding cassette sub-family C member 3	0	28	0	28
Multidrug resistance-associated protein 4	0	28	0	28
Interferon beta	28	0	0	28
Cellular tumor antigen p53	32	0	0	32
Integrin beta-3	7	1	0	8
Integrin alpha-IIb	7	1	0	8
Methionine aminopeptidase	0	3	0	3
Fatty-acid amide hydrolase 1	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	26	0	26
endonuclease IV	5	0	0	5
thioredoxin reductase	26	0	0	26
nonstructural protein 1	8	0	0	8
G	19	0	0	19
alpha-galactosidase	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	37	0	0	37
cytochrome P450 3A4 isoform 1	24	0	0	24
muscarinic acetylcholine receptor M1	15	0	0	15
Gamma-aminobutyric acid receptor subunit pi	24	4	2	30
HLA class I histocompatibility antigen, B alpha chain	19	0	0	19
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	4	7
Gamma-aminobutyric acid receptor subunit beta-1	24	4	2	30
Gamma-aminobutyric acid receptor subunit delta	24	4	2	30
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit gamma-2	24	4	2	30
Gamma-aminobutyric acid receptor subunit alpha-5	24	4	2	30
Gamma-aminobutyric acid receptor subunit alpha-3	24	4	2	30
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	24	4	2	30
Gamma-aminobutyric acid receptor subunit alpha-2	24	4	2	30
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	24	4	2	30
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-3	24	4	2	30
Gamma-aminobutyric acid receptor subunit alpha-6	24	4	2	30
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Alpha-synuclein	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-2	0	3	3	6
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	24	5	2	31
Gamma-aminobutyric acid receptor subunit beta-3	24	4	2	30
Gamma-aminobutyric acid receptor subunit beta-2	24	4	2	30
GABA theta subunit	24	4	2	30
Inositol hexakisphosphate kinase 1	19	0	0	19
Gamma-aminobutyric acid receptor subunit epsilon	24	4	2	30
cytochrome P450 2C9, partial	19	0	0	19
glucocerebrosidase	7	0	0	7
DNA polymerase kappa isoform 1	15	0	0	15
histone acetyltransferase KAT2A isoform 1	13	0	0	13
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Microtubule-associated protein tau	19	0	0	19
arylsulfatase A	10	0	0	10
Bloom syndrome protein isoform 1	16	0	0	16
D(1A) dopamine receptor	5	0	0	5
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	17	0	0	17
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Chain A, Cruzipain	8	0	0	8
15-lipoxygenase, partial	4	0	0	4
phosphopantetheinyl transferase	14	0	0	14
USP1 protein, partial	18	0	0	18
thioredoxin glutathione reductase	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	29	0	0	29
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
vitamin D3 receptor isoform VDRA	19	0	0	19
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
nuclear receptor ROR-gamma isoform 1	14	0	0	14
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
caspase-1 isoform alpha precursor	3	0	0	3
Fatty-acid amide hydrolase 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Prostaglandin G/H synthase 1	0	5	0	7
Trypsin	0	2	0	3
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Aromatase	0	4	0	4
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	3	1	4
Prostaglandin G/H synthase 2	0	9	2	12
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
Histamine H2 receptor	13	2	3	20
10 kDa heat shock protein, mitochondrial	0	3	0	3
Calmodulin	0	1	1	3
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Prostaglandin G/H synthase 2	0	4	0	5
Solute carrier organic anion transporter family member 2A1	0	3	0	6
Fatty acid-binding protein 5	0	2	0	2
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	3	0	3
Lanosterol 14-alpha demethylase	0	3	1	4
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	7	0	8
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	7	0	8
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	6	0	0	6
GLS protein	16	0	0	16
thyroid stimulating hormone receptor	18	0	0	18
cytochrome P450 2C19 precursor	8	0	0	8
flap endonuclease 1	9	0	0	9
DNA polymerase iota isoform a (long)	14	0	0	14
lethal factor (plasmid)	11	0	0	11
Cytochrome P450 3A4	0	7	0	9
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	13	0	0	13
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	9	0	0	9
hypothetical protein, conserved	3	0	0	3
EWS/FLI fusion protein	23	0	0	23
cytochrome P450 2D6	21	0	0	21
peroxisome proliferator-activated receptor delta	20	0	0	20
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	6	0	6
Prostaglandin G/H synthase 2	0	4	0	5
Epidermal growth factor receptor	0	4	0	4
Carbonic anhydrase 1	0	12	0	15
Carbonic anhydrase 2	0	12	0	16
Fatty acid-binding protein, liver	0	4	0	4
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	4
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Adenosine receptor A1	0	3	0	4
Adenosine receptor A2a	0	3	0	4
Substance-P receptor	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	9	1	1	11
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	4	0	4
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	10	0	13
5-hydroxytryptamine receptor 4	0	8	0	8
Muscarinic acetylcholine receptor M2	0	14	3	21
Muscarinic acetylcholine receptor M4	0	11	3	17
Muscarinic acetylcholine receptor M1	0	5	2	11
Muscarinic acetylcholine receptor M3	0	5	2	10
Muscarinic acetylcholine receptor M4	0	5	1	9
Muscarinic acetylcholine receptor M5	0	5	1	9
Muscarinic acetylcholine receptor M5	0	11	3	17
Muscarinic acetylcholine receptor M2	0	5	1	10
Muscarinic acetylcholine receptor M1	0	11	3	18
Muscarinic acetylcholine receptor M1	0	1	1	3
Muscarinic acetylcholine receptor M3	0	11	3	17
Alpha-1D adrenergic receptor	0	9	2	13
5-hydroxytryptamine receptor 2C	0	9	0	9
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	6	0	6
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	3	1	4
pregnane X receptor	8	0	0	8
SMAD family member 2	16	0	0	16
SMAD family member 3	16	0	0	16
estrogen receptor 2 (ER beta)	21	0	0	21
activating transcription factor 6	12	0	0	12
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
thyroid hormone receptor beta isoform a	13	0	0	13
potassium voltage-gated channel subfamily H member 2 isoform d	13	0	0	13
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
Chain A, Ferritin light chain	11	0	0	11
acetylcholinesterase	15	0	0	15
P53	2	0	0	2
thyroid stimulating hormone receptor	19	0	0	19
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
M-phase phosphoprotein 8	7	0	0	7
Bile salt export pump	0	9	0	9
Protein-arginine deiminase type-4	0	7	0	7
Angiotensin-converting enzyme	0	2	0	2
Angiotensin-converting enzyme	0	8	0	8
Liver carboxylesterase 1	0	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Caspase-7	2	0	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	1	3
Potassium channel subfamily K member 9	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
acid sphingomyelinase	2	0	0	2
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TSHR protein	2	0	0	2
Smad3	6	0	0	6
apical membrane antigen 1, AMA1	3	0	0	3
Parkin	4	0	0	4
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
serine-protein kinase ATM isoform a	6	0	0	6
lysosomal alpha-glucosidase preproprotein	4	0	0	4
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
type-1 angiotensin II receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	8	0	0	8
glucokinase regulatory protein	2	0	0	2
huntingtin isoform 2	5	0	0	5
ras-related protein Rab-9A	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
serine/threonine-protein kinase PLK1	4	0	0	4
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	2	0	4
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	3	0	0	3
streptokinase A precursor	0	0	2	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
Amyloid-beta precursor protein	1	3	0	4
D(1A) dopamine receptor	4	0	0	4
Guanine nucleotide-binding protein G	6	0	0	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	2
GALC protein	5	0	0	5
thyrotropin-releasing hormone receptor	7	0	0	7
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	3	0	5
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	3	0	5
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Carbonic anhydrase 4	0	7	0	10
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 15	0	5	0	6
Caspase-2	0	0	1	1
PPM1D protein	8	0	0	8
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	2	2	4
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	2	2
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	3	2	5
Alpha-2A adrenergic receptor	0	16	2	19
Replicase polyprotein 1a	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Alpha-2B adrenergic receptor	0	11	0	12
Alpha-2C adrenergic receptor	0	11	2	14
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	21	2	2	25
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	14	0	14
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	2	4
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
ORF73	0	0	1	1
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	4	0	0	4
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
Adenylate cyclase type 1	0	2	0	2
Caspase-7	1	0	0	1
cytochrome P450 2D6 isoform 1	10	0	0	10
caspase-3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Albumin	0	4	6	11
Albumin	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	1	1	2
Aldo-keto reductase family 1 member B1	0	6	0	6
ATP-dependent translocase ABCB1	0	11	0	18
5-hydroxytryptamine receptor 1A	0	3	1	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Cytochrome P450 2D6	0	7	1	8
Cytochrome P450 2C9	0	12	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
D(2) dopamine receptor	0	4	0	5
5-hydroxytryptamine receptor 2A	0	5	0	5
Alpha-1B adrenergic receptor	0	13	2	15
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	4	0	4
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	6	2	8
Alpha-2B adrenergic receptor	0	8	1	9
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	3	0	4
D(4) dopamine receptor	0	5	0	6
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	8	1	9
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	8	1	9
Alpha-1D adrenergic receptor	0	13	2	15
Sodium-dependent noradrenaline transporter	0	6	1	7
Sodium-dependent dopamine transporter	0	4	0	4
Histamine H2 receptor	0	7	2	9
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 1B	0	3	0	3
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Histamine H1 receptor	0	2	4	7
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	11	2	13
Glutamate receptor ionotropic, NMDA 1	0	3	2	6
D(3) dopamine receptor	0	7	0	8
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	8	0	8
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	13	2	15
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Cytochrome P450 2J2	0	10	0	10
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	5	1	7
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	2	6
Glutamate receptor ionotropic, NMDA 2B	0	3	2	6
Glutamate receptor ionotropic, NMDA 2C	0	3	2	6
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Sodium-dependent dopamine transporter	0	6	0	6
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	2	6
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	2	6
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	2	6
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	2	4
Sodium channel protein type 10 subunit alpha	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	7
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
ATP-dependent translocase ABCB1	0	5	0	5
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Potassium-transporting ATPase subunit beta	0	1	0	1
Solute carrier family 22 member 6	0	3	0	4
Solute carrier family 22 member 1	0	6	0	8
Multidrug and toxin extrusion protein 2	0	3	0	3
Solute carrier family 22 member 8	0	4	0	7
Multidrug and toxin extrusion protein 1	0	9	0	9
Histamine H4 receptor	0	3	2	5
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 2	0	6	0	7
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
dopamine D1 receptor	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Glucocorticoid receptor	0	4	1	10
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	7	0	0	7
Alpha-1A adrenergic receptor	0	2	2	4
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Translocator protein	0	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Acetylcholinesterase	0	4	0	4
Acetylcholinesterase	0	1	0	1
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
tumor necrosis factor	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	3
Solute carrier organic anion transporter family member 2A1	0	2	0	5
Solute carrier organic anion transporter family member 2A1	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	2
Solute carrier family 22 member 7	0	0	0	2
Histamine N-methyltransferase	0	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H3 receptor	0	1	0	2
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
isocitrate dehydrogenase 1, partial	2	0	0	2
LANA	0	0	0	1
NPYLR7B	0	0	2	2
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	3	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Ultraspiracle	0	4	0	4
20-hydroxy-ecdysone receptor	0	4	0	4
Ecdysone receptor	0	2	0	2
Ecdysone receptor	0	1	0	1
Protein ultraspiracle	0	1	0	1
Ultraspiracle	0	1	0	1
20-hydroxy-ecdysone receptor	0	1	0	1
Ultraspiracle protein	0	1	0	1
20-hydroxy-ecdysone receptor	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Endothelin-1 receptor	0	1	0	1
PINK1	1	0	0	1
heat shock protein 90	0	0	1	1
Glycoprotein hormones alpha chain	2	0	0	2
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
relaxin receptor 1 isoform 1	2	0	0	2
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	5
Nuclear factor NF-kappa-B p105 subunit	0	0	0	1
Tyrosine-protein phosphatase 1	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Vesicular glutamate transporter 3	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
Carbonic anhydrase 12	0	3	0	6
Carbonic anhydrase 3	0	3	0	5
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Carbonic anhydrase 6	0	5	0	8
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	4	0	7
Carbonic anhydrase 7	0	3	0	6
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 9	0	4	0	7
Carbonic anhydrase 13	0	3	0	6
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	3	0	6
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	2
Histamine H1 receptor	0	4	1	5
Metabotropic glutamate receptor 5	0	2	1	3
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carboxylic ester hydrolase	0	0	0	1
pyruvate kinase	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	2	0	2
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	4	0	4
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	3	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Beta-1 adrenergic receptor	0	0	2	3
beta-2 adrenergic receptor	2	0	0	2
Beta-2 adrenergic receptor	0	4	4	9
Beta-1 adrenergic receptor	0	4	3	7
Beta-2 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	1	3	4
Beta-1 adrenergic receptor	0	4	2	7
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	4	3	11
Alpha-1B adrenergic receptor	0	3	3	8
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	0	3	3
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	2
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	2	0	2
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Vitamin D3 receptor	0	1	1	2
G-protein coupled bile acid receptor 1	0	0	1	1
Carboxylic ester hydrolase	0	1	0	1
Tyrosine-protein kinase ABL1	0	2	0	2
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Calmodulin-domain protein kinase 1	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Myc proto-oncogene protein	0	1	0	1
Peroxisome proliferator-activated receptor alpha	3	0	1	4
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Adenosine transporter 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
galanin receptor type 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
luciferase	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	0	1
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Transporter	0	2	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	3	0	3
Cholinesterase	0	2	0	2
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	2	0	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Fatty acid-binding protein, liver	0	0	1	1
DNA topoisomerase 1	0	1	0	1
Protein kinase C alpha type	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
L-lactate dehydrogenase A chain	0	2	0	2
L-lactate dehydrogenase C chain	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
L-lactate dehydrogenase B chain	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Polyphenol oxidase 2	0	1	0	3
Endolysin	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	2
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b	0	0	1	1
interferon gamma precursor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
galactokinase	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Aurora kinase A	0	1	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
BRCA1	1	0	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	0	1	1
Cytochrome P450 2B6	0	2	0	2
Cytochrome P450 2C19	0	2	0	2
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (548)

Protein Targets (1,289)

Dirofilariasis

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (548)

Drugs Studied (209)

Protein Targets (1,289)