Compounds > dictamnine
Page last updated: 2024-11-06

dictamnine

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Description

Dictamnine is a furoquinoline alkaloid found in a variety of plants, including Dictamnus albus (burning bush) and Ruta graveolens (rue). It has been shown to possess various pharmacological activities, including antioxidant, anti-inflammatory, anti-cancer, and anti-microbial properties. Dictamnine is synthesized through a complex biosynthetic pathway involving several enzymes and intermediates. Its effects are attributed to its ability to interact with various cellular targets, such as DNA, enzymes, and receptors. Dictamnine is studied for its potential therapeutic applications in treating a range of diseases, including cancer, infections, and inflammatory conditions. Its unique chemical structure and biological activities make it an interesting target for further research.'

dictamnine: furanoquinoline alkaloid; crosslinks DNA in presence of ultraviolet light [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID68085
CHEMBL ID22533
CHEBI ID4512
SCHEMBL ID1760700
MeSH IDM0086729

Synonyms (64)

Synonym
SPECTRUM5_000086
DIVK1C_006140
KBIO1_001084
SDCCGMLS-0066336.P001
SPECTRUM_000597
ccris 1583
brn 0176932
furo(2,3-b)quinoline, 4-methoxy-
dictamine
OPREA1_134081
BSPBIO_001682
484-29-7
dictamnine
NCGC00095429-01
KBIO2_003645
KBIOGR_001706
KBIO2_006213
KBIO3_000802
KBIO2_001077
KBIOSS_001077
SPECTRUM3_000101
SPBIO_000417
SPECPLUS_000044
SPECTRUM2_000349
SPECTRUM4_001383
SPECTRUM100541
OPREA1_294767
NCGC00095429-02
4-methoxyfuro[2,3-b]quinoline
chebi:4512 ,
CHEMBL22533
VU0243862-3
AKOS006274709
4-methoxy-furo[2,3-b]quinoline
hqz3798d0a ,
unii-hqz3798d0a
4-27-00-02030 (beilstein handbook reference)
S9292
CCG-38624
FT-0686595
dictamnine [mi]
4-methoxyfuro(2,3-b)quinoline
c12h9no2
BRD-K29178788-001-01-2
HY-N0849
CS-3267
SCHEMBL1760700
AC-34014
Q-100537
HMS3561L11
furo[2,3-b]quinoline, 4-methoxy-
diktaminin
4-methoxyfuro[2,3-b]quinoline #
DTXSID0041012
sr-05000002442
SR-05000002442-1
mfcd00221742
dictamnine,(s)
Q27106403
A14857
dictamnine;dectamine
AS-56194
dectamine
A871921

Research Excerpts

Overview

Dictamnine (DTM) is a natural alkaloid isolated from the root of Dictamnus dasycarpus Turcz. It has been shown to exhibit multiple biological functions, including anti-inflammatory, antifungal, anti-angiogenic and anticancer activity.

ExcerptReferenceRelevance
"Dictamnine is an active pharmaceutical ingredient in Dictamnus dasycarpus, a Chinese herbal medicine widely used for the treatment of skin inflammations such as atopic dermatitis (AD). "( Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model.
Chan, LY; Chang, TM; Hsieh, YT; Huang, HC; Lin, CY; Maeda, T; Yang, TY, 2021)		3.51
"Dictamnine (DTM) is a natural alkaloid isolated from the root of Dictamnus dasycarpus Turcz and has been shown to exhibit multiple biological functions, including anti-inflammatory, antifungal, anti-angiogenic and anticancer activity. "( Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways.
Jin, X; Li, MY; Lian, LH; Ma, J; Mi, C; Piao, LX; Wang, JY; Wang, Z; Wu, YL; Xing, Y; Xu, GH; Zhang, Z; Zuo, HX, 2018)		3.37
"Dictamnine is an herbal ingredient isolated from the root bark of Dictamnus dasycarpus Turcz. "( Pharmacokinetics, tissue distribution and excretion study of dictamnine, a major bioactive component from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae).
Gao, E; Qu, W; Sun, J; Wang, P; Xu, J; Yan, Q; Yu, Z; Zhao, Y, 2013)		2.07

Effects

ExcerptReferenceRelevance
"Dictamnine (Dic) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells and dihydroartemisinin (DHA) also has potent anticancer activity on various tumour cell lines. "( Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells.
An, FF; Liang, L; Liu, YC; Zhang, WW, 2013)		2.12

Toxicity

ExcerptReferenceRelevance
" In order to determine the toxic components, we investigated the cytotoxicity of extracts and chosen components using CCK-8 assay in HepG2 cells."( Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro.
Fan, Q; Wang, C; Wang, T; Wu, J; Xu, A; Zhang, J; Zhao, B, 2018)		0.48

Pharmacokinetics

ExcerptReferenceRelevance
" This rapid and sensitive method was fully validated and successfully applied to the pharmacokinetic study of limonin, dictamnine, obacunone and fraxinellone in the rat plasma after oral administration of Cortex Dictamni extract."( Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract.
Gao, E; Qu, W; Sun, J; Wang, P; Yu, Z; Zhao, Y, 2013)		0.87
"This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent."( Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
Bui, D; Duan, S; Hu, M; Singh, R; Wei, B; Wong, SJ; Yang, P; Yin, T; You, M, 2021)		0.62

Bioavailability

ExcerptReferenceRelevance
"This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent."( Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
Bui, D; Duan, S; Hu, M; Singh, R; Wei, B; Wong, SJ; Yang, P; Yin, T; You, M, 2021)		0.62
"The pharmacological activities of dictamnine and fraxinellone have been well reported; however, only a few studies have focused on the pharmacokinetics and bioavailability of concomitant delivery of these drugs in vivo."( A Methodology for Quantitation of Dictamnine and Fraxinellone and its Application to Study Pharmacokinetics and Bioavailability in Rats Via Oral and Intravenous Administration.
Chen, M; Chen, Y; Li, L; Lu, C; Shen, X; Tian, D; Wang, F; Yan, L; Yang, X; Ye, CJ; Yin, Q, 2023)		1.47

Dosage Studied

ExcerptRelevanceReference
" The dose-response curves were linear in the range 10-40 micrograms."( Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).
Kanamori, H; Mizuta, M, 1985)		0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
oxacycleAny organic heterocyclic compound containing at least one ring oxygen atom.
organonitrogen heterocyclic compoundAny organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
organic heterotricyclic compoundAn organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
alkaloid antibioticAny alkaloid that has significant antibiotic properties.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency22.38720.00798.23321,122.0200AID2551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (144)

Assay IDTitleYearJournalArticle
AID1815103Volume of distribution in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101707Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) after 3 days2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID333904Genotoxicity in CHO cells assessed as mitotic inhibition at 5 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
AID1101768Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815108Cmax in C57BL/6 mouse at 500 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101725Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101718Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID376570Antibacterial activity against Staphylococcus aureus by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New quinoline alkaloids from Ruta chalepensis.
AID1815100Cmax in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101753Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID376571Antibacterial activity against Candida albicans by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New quinoline alkaloids from Ruta chalepensis.
AID1101766Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101711Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377570Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 32 nmol relative to TPA2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1815098Stability in mouse blood assessed as compound remaining measured at - 80 degC for 4 months2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101714Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101769Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815117Half life in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815124AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101728Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101744Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101774Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815093Antiproliferative activity against human CAL-27 cells assessed as cell viability measured after 72 hrs by MTT assay2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101722Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101708Antifeedant activity against adult of Sitophilus zeamais after 3 days2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101731Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID634796Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation.
AID1815101AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID144216Blockade of peak steady-state K+ currents of neuroblastoma cells N1E-115 at 50 uM concentration2001Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.
AID1101720Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101709Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101755Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID333909Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.3 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
AID333907Genotoxicity in CHO cells assessed as chromosomal aberrations at 1.3 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
AID1101752Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815099Half life in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101729Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1101716Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101779Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815113Tmax in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101726Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101770Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101775Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377577Cytotoxicity against human Raji cells assessed as cell viability at 0.32 nmol by trypan blue assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1101756Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815122Cmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID344043Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks2008Journal of natural products, Jul, Volume: 71, Issue:7
Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.
AID1101771Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815107Tmax in C57BL/6 mouse at 500 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101776Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377576Cytotoxicity against human Raji cells assessed as cell viability at 3.2 nmol by trypan blue assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1815118MRT (0 to 24 hrs) in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101739Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815120Tmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815130MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101748Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101721Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101781Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101742Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815128Half life in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101712Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101758Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101759Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815104Clearance in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101735Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID333905Genotoxicity in CHO cells assessed as chromosomal aberrations at 5 ppm after 90 mins in dark
AID1101740Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID328636Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release2008Journal of natural products, Feb, Volume: 71, Issue:2
Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae.
AID1815129MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101737Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID328635Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation2008Journal of natural products, Feb, Volume: 71, Issue:2
Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae.
AID1101724Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101713Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID333908Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.6 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
AID1101733Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101736Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101743Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101757Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101719Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815119Tmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101777Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101717Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101763Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101727Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101760Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101706Antifeedant activity against adult of Tribolium castaneum (red flour beetle) after 3 days2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID99820Blockade of peak steady-state K+ currents of Kv1.3 channels in mice fibroblasts L929 at 50 uM concentration2001Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.
AID1101734Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID376569Antibacterial activity against Bacillus subtilis by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New quinoline alkaloids from Ruta chalepensis.
AID333906Genotoxicity in CHO cells assessed as chromosomal aberrations at 2.5 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
AID1101767Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101773Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377571Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 16 nmol relative to TPA2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID144222Blockade of peak steady-state Na+ currents of neuroblastoma cells N1E-115 at 50 uM concentration2001Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8
Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.
AID1101730Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377575Cytotoxicity against human Raji cells assessed as cell viability at 16 nmol by trypan blue assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1815095Antiinflammatory activity against human SCC-9 cells assessed as inhibition of LPS-induced PGE2 production at 10 ug/ml preincubated for 30 mins followed by stimulation with LPS and measured after 12 hrs by LC-MS/MS analysis2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101750Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101772Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815116AUC (0 to infinity) in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101746Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101754Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101780Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101747Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815096Stability in mouse blood assessed as compound recovery measured at 25 degC for 4 hrs2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101751Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377572Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 3.2 nmol relative to TPA2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1815121Cmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID377573Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 0.32 mol relative to TPA2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1101783Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815123AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815112MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815126AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101732Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101741Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815105MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101749Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101782Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101761Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815106Oral bioavailability in C57BL/6 mouse at 4000 mg/kg2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101715Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID376568Antibacterial activity against Mycobacterium smegmatis by microtiter plate assay2000Journal of natural products, Jul, Volume: 63, Issue:7
New quinoline alkaloids from Ruta chalepensis.
AID1815109AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID333903Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.2 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
AID1101738Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101723Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815094Antiproliferative activity against human SCC-9 cells assessed as cell viability measured after 72 hrs by MTT assay2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101762Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815102AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815115AUC (0 to 24 hrs) in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101745Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101765Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101710Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101778Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815097Stability in mouse blood assessed as compound remaining measured at 20 degC for 8 hrs2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815114Cmax in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1101764Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID377574Cytotoxicity against human Raji cells assessed as cell viability at 32 nmol by trypan blue assay2000Journal of natural products, Oct, Volume: 63, Issue:10
Constituents of Boronia pinnata.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (63)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (17.46)18.7374
1990's6 (9.52)18.2507
2000's13 (20.63)29.6817
2010's19 (30.16)24.3611
2020's14 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.99 (24.57)
Research Supply Index4.19 (2.92)
Research Growth Index4.85 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (4.62%)6.00%
Case Studies2 (3.08%)4.05%
Observational0 (0.00%)0.25%
Other60 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		2.610aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
2,4,6-tribromophenol
[no description available]		3.110bromophenolenvironmental contaminant;
fungicide;
marine metabolite
bay-k-8644
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.. Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644. methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.		1.9810(trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester
berberine
[no description available]		2.1710alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound		antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker
5-methoxypsoralen
5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.		9.01405-methoxyfurocoumarin;
organic heterotricyclic compound;
psoralens		hepatoprotective agent;
plant metabolite
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9810aromatic ether;
nitrile;
polyether;
tertiary amino compound
diphenyleneiodonium
diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor. dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.		2.0410organic cation
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.3110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
glyburide
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide. glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.		1.9810monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.2110dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
khellin
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024). khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.		3.4720furanochromone;
organic heterotricyclic compound;
oxacycle		anti-asthmatic agent;
bronchodilator agent;
cardiovascular drug;
vasodilator agent
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.		4.9770aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
nitidine
nitidine: RN given refers to parent cpd; synonym NSC 146397 refers to chloride; structure		2.0610phenanthridines
phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl Fluoride: An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.. phenylmethanesulfonyl fluoride : An acyl fluoride with phenylmethanesulfonyl as the acyl group.		2.0410acyl fluorideserine proteinase inhibitor
potassium chloride
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.		1.9810inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
sanguinarine
benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.		2.0610alkaloid antibiotic;
benzophenanthridine alkaloid;
botanical anti-fungal agent
dinitrofluorobenzene
Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.. 1-fluoro-2,4-dinitrobenzene : The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.		2.610C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.610erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
visnagin
visnagin: from Musineon divaricatum. visnagin : A furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga.		3.4720aromatic ether;
furanochromone;
polyketide		anti-inflammatory agent;
antihypertensive agent;
EC 1.1.1.37 (malate dehydrogenase) inhibitor;
phytotoxin;
plant metabolite;
vasodilator agent
skimmianine
skimmianine: furanoquinoline alkaloid from Teclea (RUTACEAE)		8.3770alkaloid antibiotic;
organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		1.9810pyrrole;
secondary amine
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		3.0710mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
scoparone
scoparone: structure. scoparone : A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.		2.0410aromatic ether;
coumarins		anti-allergic agent;
anti-inflammatory agent;
antihypertensive agent;
antilipemic drug;
immunosuppressive agent;
plant metabolite
syringaldehyde
syringaldehyde: isolated from nonfermented fiber fractions of oat hulls and cottonseed hulls. syringaldehyde : A hydroxybenzaldehyde that is 4-hydroxybenzaldehyde substituted by methoxy groups at positions 3 and 5. Isolated from Pisonia aculeata and Panax japonicus var. major, it exhibits hypoglycemic activity.		210dimethoxybenzene;
hydroxybenzaldehyde		hypoglycemic agent;
plant metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.0510azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
kokusaginine
kokusaginine: antimalarial alkaloid from Teclea afzelii; structure in first source		210organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
angelicin
angelicin: used as tranquillizer; sedative; or anticonvulsant; structure		3.4720furanocoumarin
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.3110dialdehydebiomarker
paeonol
paeonol: structure		7.4620methoxybenzenes;
phenols		metabolite
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.610acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		2.0410ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		3.0310D-glucopyranoseepitope;
mouse metabolite
rutecarpine
rutacarpine: from Evodia rutaecarpa; an ingredient in zhuyu hewei zhitong capsules		2.0510beta-carbolines
flindersiamine
flindersiamine: from Helietta parvifolia; structure		2.0210organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
cromakalim
Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)		1.9810
matrine
[no description available]		2.3110alkaloid
inermin
inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.		3.520maackiain
girinimbine
girinimbine: carbazole alkaloid		2.0710carbazolesmetabolite
gamma-fagarine
gamma-fagarine: active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae); structure given in first source		8.2560organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
trans-1,2-dihydro-1,2-naphthalenediol
trans-1,2-dihydro-1,2-naphthalenediol: structure in first source. (1S,2S)-1,2-dihydronaphthalene-1,2-diol : The (1S,2S)-isomer of trans-1,2-dihydronaphthalene-1,2-diol.		2.0210trans-1,2-dihydronaphthalene-1,2-diol
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane		8.7330limonoid
fraxinellone
fraxinellone: structure given in first source; RN given for (3R-cis)-isomer		4.59902-benzofurans
planinin
planinin: from Zanthoxylum planispinum; structure given in first source		2.110lignan
limonin
[no description available]		8.4220epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound		inhibitor;
metabolite;
volatile oil component
eudesmin
eudesmin: RN refers to (1R-(1alpha,3aalpha,4alpha,6aalpha))-isomer; structure given in first source; very similar to pinoresinol		2.1710
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		4.4780
maackiain
[no description available]		2.3110phenols;
pterocarpans
rutaevin
rutaevin: from root bark of Dictamnus daycarpus Turcz.		3.0310steroid lactone
trifolirhizin
trifolirhizin: from Sophora flavescens; has inhibitory effect on tyrosinase and melanin synthesis; structure in first source		3.0310pterocarpans
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.5320
e-z cinnamic acid
cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.. trans-cinnamic acid : The E (trans) isomer of cinnamic acid		2.0510cinnamic acidplant metabolite
methyl carbazole-3-carboxylate
methyl carbazole-3-carboxylate: structure in first source		2.0710carbazoles
trans-4-coumaric acid
hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.		2104-coumaric acidfood component;
mouse metabolite;
plant metabolite
uk 78282
[no description available]		210diarylmethane
oxazolone
Oxazolone: Immunologic adjuvant and sensitizing agent.		7.3110
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.110
6,7,8-trimethoxycoumarin
6,7,8-trimethoxycoumarin: structure in first source		2.0410coumarins
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.610
scopoletin
[no description available]		2.0410hydroxycoumarinplant growth regulator;
plant metabolite
rottlerin
rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.		2.0710aromatic ketone;
benzenetriol;
chromenol;
enone;
methyl ketone		anti-allergic agent;
antihypertensive agent;
antineoplastic agent;
apoptosis inducer;
K-ATP channel agonist;
metabolite
clausine e
clausine E: structure in first source		2.0710carbazolesmetabolite
toosendanin
[no description available]		2.0110limonoid
artenimol
artenimol: derivative of antimalarial drug artemisinin (quinghaosu)		2.0810
syringaresinol, (1r-(1alpha, 3aalpha,4alpha,6aalpha))-isomer
(-)-syringaresinol : The (7beta,7'beta,8beta,8'beta)-stereoisomer of syringaresinol.		2.0410syringaresinol
cleomiscosin d
cleomiscosin D: from the root bark of Hibiscus syriacus (Malvaceae); structure in first source		2.0410
trans-avicennol
trans-avicennol: from Zanthoxylum chiloperone var. angustifolium; structure in first source		2.0410
chiniofon
Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.		2.110
edetic acid
solasodine: RN given refers to (3beta,22alpha,25R)-isomer; structure. solasodine : An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills.		210
cyclic gmp
Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.		1.98103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110
Benign Neoplasms
[description not available]		03.4620
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.4620
Anemia, Fanconi
[description not available]		02.1310
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)		02.1310
Cancer of Mouth
[description not available]		02.3110
Mouth Neoplasms
Tumors or cancer of the MOUTH.		02.3110
Cancer of Lung
[description not available]		02.5720
Lung Neoplasms
Tumors or cancer of the LUNG.		02.5720
E coli Infections
[description not available]		02.4110
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		02.4110
Urinary Tract Infections
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.		02.4110
Cancer of Pancreas
[description not available]		03.3340
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		03.3340
Chemical and Drug Induced Liver Injury, Chronic
Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.		02.610
Eczema, Atopic
[description not available]		03.6150
Itching
[description not available]		03.5240
Dermatitis, Atopic
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.		03.6150
Pruritus
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.		03.5240
Allergic Rhinitis
[description not available]		07.610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.8220
Rhinitis, Allergic
An inflammation of the NASAL MUCOSA triggered by ALLERGENS.		02.610
Liver Steatosis
[description not available]		02.610
Fatty Liver
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.		02.610
Acute Liver Injury, Drug-Induced
[description not available]		03.1440
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		03.1440
Innate Inflammatory Response
[description not available]		02.3110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.3110
Experimental Neoplasms
[description not available]		02.1710
Invasiveness, Neoplasm
[description not available]		02.1710
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0810
Lung Adenocarcinoma
[description not available]		07.0810
Adenocarcinoma, Basal Cell
[description not available]		02.0810
Adenocarcinoma of Lung
A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.		02.0810
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		07.0810
Breast Cancer
[description not available]		02.110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.110
Actinic Reticuloid Syndrome
[description not available]		01.9510
Dermatitis, Contact, Photoallergic
[description not available]		01.9910
Diseases, Occupational
[description not available]		01.9910
Dermatitis, Contact, Phototoxic
[description not available]		02.9110
Bullous Dermatoses
[description not available]		02.9110
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9810
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9810
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		01.9610