Compounds > cellulose sulfate
Page last updated: 2024-09-24

cellulose sulfate

Description

cellulose sulfate: RN given refers to cpd with unknown MF; vaginal gel being developed as both a contraceptive and blockage to STD somewhat like nonoxynol-9 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID98941
CHEMBL ID154126
CHEBI ID135742
SCHEMBL ID6394045
MeSH IDM0073824

Synonyms (17)

Synonym
brn 6075091
pyrrolidine, 1-(2-(4-(3,4-dihydro-7-methoxy-2,2-dimethyl-3-phenyl-2h-1-benzopyran-4-yl)phenoxy)ethyl)-, cis-
nsc 147956
cellulose sulfate
51423-20-2
nsc147956
nsc-147956
CHEBI:135742
CHEMBL154126
1-[2-[4-(7-methoxy-2,2-dimethyl-3-phenyl-3,4-dihydrochromen-4-yl)phenoxy]ethyl]pyrrolidine
FT-0664458
SCHEMBL6394045
1-[2-[4-(2,2-dimethyl-7-methoxy-3-phenylchroman-4-yl)phenoxy]ethyl]pyrrolidine
levormeloxifene;centchroman;78994-24-8
BCP15758
DTXSID60860460
1-{2-[4-(7-methoxy-2,2-dimethyl-3-phenyl-3,4-dihydro-2h-1-benzopyran-4-yl)phenoxy]ethyl}pyrrolidine

Research Excerpts

Overview

ExcerptReference
"Cellulose sulfate (CelS), which is a GAG mimetic, was evaluated for its use in promoting neurite extension."( Arinzeh, TL; Collins, G; Foston, M; Hashemi, S; Menezes, R; Meyer, J; Vincent, R, 2019)
"Cellulose sulfate is a semi-synthesized polysaccharide sulfate with a relatively simple chain structure and unique biological properties and its biological applications have been explored in research and clinical trials."( Lin, D; Yao, S; Zhang, Q, 2015)
"Cellulose sulfate (CS) is a noncytotoxic antifertility agent that exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV."( Ballagh, SA; Brache, V; Callahan, M; Creinin, MD; Fichorova, RN; Hillier, SL; Lai, JJ; Mauck, C; Schwartz, JL; Weiner, DH, 2006)
"Cellulose sulfate (CS) is a promising vaginal microbicide. "( Buvé, A; Jespers, V; Van Damme, L, 2007)
"Cellulose sulfate (CS) is an antimicrobial and contraceptive agent. "( Cheng, H; Chipato, T; Depineres, T; Dhlakama, P; Hammond, N; Mauck, C; Napierala, S; Padian, N; Thompson, M; van der Straten, A, 2007)
"Cellulose sulfate (CS) is a non-cytotoxic antifertility agent that also exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV."( Archer, DF; Ballagh, S; Callahan, M; Creinin, M; Lai, JJ; Mauck, C; Pymar, H; Schwartz, J; Weiner, DH, 2001)

Drug Classes (2)

ClassDescription
flavonoidsAny organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
phosphopantetheinyl transferaseBacillus subtilisPotency50.11870.141337.9142100.0000AID1490
USP1 protein, partialHomo sapiens (human)Potency50.11870.031637.5844354.8130AID504865
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.99530.035520.977089.1251AID504332
huntingtin isoform 2Homo sapiens (human)Potency35.48130.000618.41981,122.0200AID1688
gemininHomo sapiens (human)Potency22.69190.004611.374133.4983AID624296; AID624297
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency28.69540.005612.367736.1254AID624032
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID451833Displacement of [3H]estradiol from rat estrogen receptor by radiometric assay relative to estradiol2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer.
AID173474Estrogenic activity as percent of control at 100 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID184492Antiimplantation activity in sperm-positive female albino rats mated to coeval males of proven fertility1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID194107Anti-uterotrophic activity in immature rats at 5 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID196351Antiuterotrophic activity in immature rats at 5 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID197051Estrogenic activity in immature rats and assayed as uterine weight gain at 50 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID197049Estrogenic activity in immature rats and assayed as uterine weight gain at 100 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID194105Anti-uterotrophic activity in immature rats at 100 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID173605Effective dose for antiimplantation activity in male albino rats1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Antifertility agents. 38. Effect of the side chain and its position on the activity of 3,4-diarylchromans.
AID451834Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer.
AID173477Estrogenic activity as percent of control at 500 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID195685Uterotrophic activity in rats relative to estradiol (E2 = 100%)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID189169Relative binding affinity for uterine cytosolic estrogen receptors of immature rats1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID197043Estrogenic activity in immature rats and assayed as uterine weight gain at 0.05 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID196350Antiuterotrophic activity in immature rats at 50 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID197040Anti-uterotrophic activity in immature rats at 50 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID197041Anti-uterotrophic activity in immature rats at 5 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID173472Estrogenic activity as percent of control at 0.5 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID173475Estrogenic activity as percent of control at 5 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID69538Relative binding affinity for uterine cytosol 17-beta-estradiol receptor obtained from immature Charles Foster rats1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Antifertility agents. 38. Effect of the side chain and its position on the activity of 3,4-diarylchromans.
AID197050Estrogenic activity in immature rats and assayed as uterine weight gain at 5 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID173476Estrogenic activity as percent of control at 50 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID196349Antiuterotrophic activity in immature rats at 100 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID197047Estrogenic activity in immature rats and assayed as uterine weight gain at 0.05 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID343883Antiimplantation activity against Sprague-Dawley albino rat at 1 mg/kg, po administered for 1-5 days measured on day 10 of pregnancy relative to control2008Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
Synthesis and in vivo evaluation of 11-substituted estradiol derivatives as anti-implantation agents.
AID197039Anti-uterotrophic activity in immature rats at 100 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID194106Anti-uterotrophic activity in immature rats at 50 ug1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID173469Estrogenic activity as percent of control at 0.05 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID451832Estrogenic antagonistic activity in bilaterally ovariectomized Sprague-Dawley rat assessed as inhibition of ethynylesterol-induced uterine weight at 10 mg/kg, po once daily for 3 days measured on day 31 of age2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer.
AID343882Antiimplantation activity against Sprague-Dawley albino rat at 10 mg/kg, po administered for 1-5 days measured on day 10 of pregnancy relative to control2008Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
Synthesis and in vivo evaluation of 11-substituted estradiol derivatives as anti-implantation agents.
AID180231Effect on uterine weight gain in immature rats by subcutaneous dose; N-Nil1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Antifertility agents. 38. Effect of the side chain and its position on the activity of 3,4-diarylchromans.
AID451835Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer.
AID197052Estrogenic activity in immature rats and assayed as uterine weight gain at 500 ug subcutaneous dose1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Studies in antifertility agents. 50. Stereoselective binding of d- and l-centchromans to estrogen receptors and their antifertility activity.
AID180230Compound was evaluated in immature rats as assessed by uterine weight gain (subcutaneously)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Antifertility agents. 38. Effect of the side chain and its position on the activity of 3,4-diarylchromans.
AID451831Estrogenic agonistic activity in bilaterally ovariectomized Sprague-Dawley rat assessed as uterine weight gain at 10 mg/kg, po once daily for three days measured on day 31 of age2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (152)

TimeframeStudies, This Drug (%)All Drugs %
pre-199023 (15.13)18.7374
1990's12 (7.89)18.2507
2000's59 (38.82)29.6817
2010's47 (30.92)24.3611
2020's11 (7.24)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials16 (9.70%)5.53%
Reviews5 (3.03%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other144 (87.27%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
nafoxidine[no description available]medium10benzenes;
naphthalenes;
ring assembly
tamoxifen[no description available]medium10stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
cellulose[no description available]medium16016glycoside
chitosan[no description available]medium120
chondroitin sulfates[no description available]medium60
transforming growth factor beta[no description available]medium10
palladium[no description available]medium10metal allergen;
nickel group element atom;
platinum group metal atom
chromium[no description available]medium20chromium cation;
monoatomic hexacation
chromium[no description available]medium20chromium group element atom;
metal allergen		micronutrient
pyrroles[no description available]medium10pyrrole;
secondary amine
cellulase[no description available]medium30cellotriose
lead[no description available]medium10carbon group element atom;
elemental lead;
metal atom		neurotoxin
dapivirine[no description available]medium10
tenofovir[no description available]medium30nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
adenine[no description available]medium306-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydrogen[no description available]medium30elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
naproxen[no description available]medium10methoxynaphthalene;
monocarboxylic acid		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
mannans[no description available]medium10
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
sq-23377[no description available]medium10cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid		calcium ionophore;
metabolite
mesalamine[no description available]medium20amino acid;
aromatic amine;
monocarboxylic acid;
monohydroxybenzoic acid;
phenols		non-steroidal anti-inflammatory drug
sodium sulfate[no description available]medium30inorganic sodium salt
sulfuric acid[no description available]medium10sulfur oxoacidcatalyst
nonoxynol[no description available]medium63
lactoferrin[no description available]medium10
dimethylacetamide[no description available]medium10acetamides;
monocarboxylic acid amide		human metabolite
lithium chloride[no description available]medium10inorganic chloride;
lithium salt		antimanic drug;
geroprotector
sulfur trioxide[no description available]medium10sulfur oxide
pyridine[no description available]medium10azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
pectins[no description available]medium20D-galactopyranuronic acid
zoledronic acid[no description available]medium101,1-bis(phosphonic acid);
imidazoles		bone density conservation agent
acebutolol[no description available]medium20alpha-D-glucosyl-(1->4)-D-mannopyranose
tricalcium phosphate[no description available]medium10calcium phosphate
bortezomib[no description available]medium10amino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
glucuronic acid[no description available]medium90D-glucuronic acidalgal metabolite
muramidase[no description available]medium10
poly-n,n-dimethyl-n,n-diallylammonium chloride[no description available]medium10
organophosphonates[no description available]medium30divalent inorganic anion;
phosphite ion
copper gluconate[no description available]medium10organic molecular entity
beta-glucono-1,5-lactone[no description available]medium10aldono-1,5-lactone;
gluconolactone		animal metabolite;
mouse metabolite
manganese dioxide[no description available]medium10manganese molecular entity;
metal oxide
gluconic acid[no description available]medium10gluconic acidchelator;
Penicillium metabolite
perfluorodecalin[no description available]medium10fluorocarbonblood substitute;
solvent
n-dodecane[no description available]medium10alkaneplant metabolite
guanine[no description available]medium102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
interleukin-8[no description available]medium10
betaine[no description available]medium10amino-acid betaine;
glycine derivative		fundamental metabolite
c 31g[no description available]medium10
pamidronate[no description available]medium10phosphonoacetic acid
dimethylformamide[no description available]medium10formamides;
volatile organic compound		geroprotector;
hepatotoxic agent;
polar aprotic solvent
minocycline[no description available]medium10
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
barium sulfate[no description available]medium10barium salt;
inorganic barium salt;
metal sulfate		radioopaque medium
sulfur[no description available]medium20chalcogen;
nonmetal atom		macronutrient
losartan potassium[no description available]medium10
orabase[no description available]medium10
glycerol[no description available]medium22alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
uc-781[no description available]medium10
ifosfamide[no description available]medium10ifosfamidesalkylating agent;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
xenobiotic
heparitin sulfate[no description available]medium10
dermatan sulfate[no description available]medium10amino disaccharide;
glycosylgalactose derivative;
iduronic acids;
oligosaccharide sulfate
bradykinin[no description available]medium60oligopeptidehuman blood serum metabolite;
vasodilator agent
unithiol[no description available]medium20
pyridinolcarbamate[no description available]medium30pyridines
aminocaproic acid[no description available]medium10amino acid zwitterion;
epsilon-amino acid;
omega-amino fatty acid		antifibrinolytic drug;
hematologic agent;
metabolite
cysteine[no description available]medium10cysteiniumfundamental metabolite
penicillamine[no description available]medium20non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
carbamates[no description available]medium20amino-acid anion
p-methoxy-n-methylphenethylamine[no description available]medium10aromatic ether;
secondary amino compound		metabolite
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
histamine[no description available]medium20aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
verapamil[no description available]medium10aromatic ether;
nitrile;
polyether;
tertiary amino compound
ginkgolide b[no description available]medium10
1-hexadecyl-2-acetyl-glycero-3-phosphocholine[no description available]medium102-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
urea[no description available]medium10isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
methylene blue[no description available]medium10organic chloride saltacid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer
ammonium chloride[no description available]medium10ammonium salt;
inorganic chloride		ferroptosis inhibitor
hyaluronoglucosaminidase[no description available]medium10
dimethyl sulfide[no description available]medium10aliphatic sulfidealgal metabolite;
bacterial xenobiotic metabolite;
EC 3.5.1.4 (amidase) inhibitor;
Escherichia coli metabolite;
marine metabolite
dimethyl disulfide[no description available]medium10organic disulfidexenobiotic metabolite
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
reserpine[no description available]medium10alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
diclofenac[no description available]medium10amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
captopril[no description available]medium20alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
paraquat[no description available]medium10organic cationgeroprotector;
herbicide
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
glucose 6-(hydrogen sulfate)[no description available]medium10monosaccharide sulfate
thyroxine[no description available]medium102-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
dimercaprol[no description available]medium10dithiol;
primary alcohol		chelator
dimefline[no description available]low00ether;
flavonoids
hesperetin[no description available]low00ether;
flavonoids
4'-methoxyflavone[no description available]low00ether;
flavonoids
5,7,4'-trimethylapigenin[no description available]low00ether;
flavonoids
5-Methoxyflavone[no description available]low00ether;
flavonoids
nepitrin[no description available]low00flavonoids;
glycoside
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone[no description available]low00ether;
flavonoids
2'-methoxyflavone[no description available]low00ether;
flavonoids
6-methoxyflavone[no description available]low00ether;
flavonoids
3,3',4',5,6,7,8-heptamethoxyflavone[no description available]low00ether;
flavonoids
sideritoflavone[no description available]low00ether;
flavonoids
cirsimarin[no description available]low00flavonoids;
glycoside
3'-demethylnobiletin[no description available]low00ether;
flavonoids
3',4',5'-trimethoxyflavone[no description available]low00ether;
flavonoids
5-demethylnobiletin[no description available]low00ether;
flavonoids
5-Hydroxy-7-methoxy-6-methylflavone[no description available]low00ether;
flavonoids
5,7-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one[no description available]low00ether;
flavonoids
7-methoxyflavone[no description available]low00ether;
flavonoids
negletein[no description available]low00ether;
flavonoids
5-hydroxy-6,7-dimethoxyflavone[no description available]low00ether;
flavonoids
zapotin[no description available]low00ether;
flavonoids
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one[no description available]low00ether;
flavonoids
6-methoxy-2-(3-methoxyphenyl)-1-benzopyran-4-one[no description available]low00ether;
flavonoids
3,7-dimethoxyflavone[no description available]low00ether;
flavonoids
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one[no description available]low00ether;
flavonoids
N-(2-ethylphenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-1-benzopyran-6-yl]oxy]acetamide[no description available]low00ether;
flavonoids
6,3',4'-Trimethoxyflavanone[no description available]low00ether;
flavonoids
demethoxysudachitin[no description available]low00ether;
flavonoids
hidrosmin[no description available]low00flavonoids;
glycoside
2-[[2-(4-methoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]-4-methylpentanoic acid[no description available]low00ether;
flavonoids
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-8-(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)-4H-chromen-4-one[no description available]low00C-glycosyl compound;
flavonoids
2-[[2-(3,4-dimethoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]butanoic acid[no description available]low00ether;
flavonoids
6-(5,6-Dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid[no description available]low00flavonoids;
glucosiduronic acid
alpinetin[no description available]low00ether;
flavonoids
isovitexin[no description available]low00C-glycosyl compound;
flavonoids
7-methoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one[no description available]low00ether;
flavonoids
rutin[no description available]low00flavonoids;
glycoside
hydroxygenkwanin[no description available]low00ether;
flavonoids
juglanin[no description available]low00flavonoids;
glycoside
kaempferol 3-o-neohesperidoside[no description available]low00flavonoids;
glycoside
Kumatakenin[no description available]low00ether;
flavonoids
apigenin-7-o-beta-d-glucuronide[no description available]low00flavonoids;
glucosiduronic acid
neoisoliquiritin[no description available]low00flavonoids;
glycoside
artemetin[no description available]low00ether;
flavonoids
Diosmetin rutinoside[no description available]low00flavonoids;
glycoside
apigenin-7-o-glucuronide[no description available]low00flavonoids;
glucosiduronic acid
ternatin (flavonoid)[no description available]low00ether;
flavonoids
icarrin[no description available]low00flavonoids;
glycoside
vitexin rhamnoside[no description available]low00flavonoids;
glycoside
epimedin b[no description available]low00flavonoids;
glycoside
epimedin c[no description available]low00flavonoids;
glycoside
hesperidin[no description available]low00flavonoids;
glycoside
1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]hexitol[no description available]low00C-glycosyl compound;
flavonoids
marein[no description available]low00flavonoids;
glycoside
isoliquiritin apioside[no description available]low00flavonoids;
glycoside
2''-galloylhyperin[no description available]low00flavonoids;
glycoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one[no description available]low00C-glycosyl compound;
flavonoids
pinostrobin[no description available]low00ether;
flavonoids
7-monohydroxyethylrutoside[no description available]low00flavonoids;
glycoside
sagittatoside b[no description available]low00flavonoids;
glycoside
calycopterin[no description available]low00ether;
flavonoids
Diosmetin 7-O-beta-D-glucopyranoside[no description available]low00flavonoids;
glycoside
5-Hydroxyauranetin[no description available]low00ether;
flavonoids
Asebotin[no description available]low00flavonoids;
glycoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside[no description available]low00flavonoids;
glycoside
sudachitin[no description available]low00ether;
flavonoids
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 2-O-hexopyranosylhexopyranoside[no description available]low00flavonoids;
glycoside
3'',4''-Diacetylafzelin[no description available]low00flavonoids;
glycoside
didymin[no description available]low00flavonoids;
glycoside
4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone[no description available]low00ether;
flavonoids
multiflorin a[no description available]low00flavonoids;
glycoside
typhaneoside[no description available]low00flavonoids;
glycoside
acebutolol[no description available]low00aromatic amide;
ethanolamines;
ether;
monocarboxylic acid amide;
propanolamine;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent
cetirizine[no description available]low00ether;
monocarboxylic acid;
monochlorobenzenes;
piperazines		anti-allergic agent;
environmental contaminant;
H1-receptor antagonist;
xenobiotic
diphenhydramine[no description available]low00ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
econazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
enflurane[no description available]low00ether;
organochlorine compound;
organofluorine compound		anaesthetic
eprazinone[no description available]low00aromatic ketone;
ether;
N-alkylpiperazine		mucolytic
ether[no description available]low00ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
vanoxerine[no description available]low00ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor
gbr 12935[no description available]low00ether;
N-alkylpiperazine;
tertiary amino compound		dopamine uptake inhibitor
isoconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
ketoconazole[no description available]low00dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
methoxyflurane[no description available]low00ether;
organochlorine compound;
organofluorine compound		hepatotoxic agent;
inhalation anaesthetic;
nephrotoxic agent;
non-narcotic analgesic
metolachlor[no description available]low00aromatic amide;
benzenes;
ether;
organochlorine compound
miconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
orphenadrine[no description available]low00ether;
tertiary amino compound		antidyskinesia agent;
antiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist;
muscle relaxant;
NMDA receptor antagonist;
parasympatholytic
salmeterol xinafoate[no description available]low00ether;
phenols;
primary alcohol;
secondary alcohol;
secondary amino compound
sevoflurane[no description available]low00ether;
organofluorine compound		central nervous system depressant;
inhalation anaesthetic;
platelet aggregation inhibitor
tioconazole[no description available]low00dichlorobenzene;
ether;
imidazoles;
thiophenes
chloromethyl methyl ether[no description available]low00ether
bis(2-chloro-1-methylethyl) ether[no description available]low00ether
vinyl ether[no description available]low00ether
bis(2-chloroethyl)ether[no description available]low00ether
butyl carbitol[no description available]low00ether
dimethyl ether[no description available]low00ether
flurothyl[no description available]low00ether
bis(chloromethyl) ether[no description available]low00ether;
organochlorine compound		alkylating agent;
carcinogenic agent
methoxyacetic acid[no description available]low00ether;
monocarboxylic acid		antineoplastic agent;
apoptosis inducer;
human xenobiotic metabolite;
mutagen
ethyl tert-butyl ether[no description available]low00ether;
volatile organic compound		fuel additive
methyl tert-butyl ether[no description available]low00etherfuel additive;
metabolite;
non-polar solvent
mitomycin a[no description available]low00ether;
mitomycin		alkylating agent;
antimicrobial agent;
antineoplastic agent;
toxin
ethofumesate[no description available]low001-benzofurans;
ether;
methanesulfonate ester
enilconazole[no description available]low00dichlorobenzene;
ether;
imidazoles
sufentanil[no description available]low00anilide;
ether;
piperidines;
thiophenes		anaesthesia adjuvant;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic
metalaxyl[no description available]low00alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester
fenticonazole[no description available]low00aryl sulfide;
dichlorobenzene;
ether;
imidazoles
oxadixyl[no description available]low00anilide fungicide;
aromatic amide;
carbohydrazide;
ether;
oxazolidinone		agrochemical
adefovir[no description available]low006-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
adefovir dipivoxil[no description available]low006-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug
sertaconazole[no description available]low001-benzothiophenes;
dichlorobenzene;
ether;
imidazoles
tetraconazole[no description available]low00dichlorobenzene;
ether;
organofluorine compound;
triazoles
raptors[no description available]low00ether;
imidazolines;
imidazolone;
pyridinemonocarboxylic acid
dimethenamid[no description available]low00aromatic amide;
ether;
organochlorine compound;
thiophenes
2'-o-methyladenosine[no description available]low00adenosines;
ether		fungal metabolite
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole[no description available]low00ether;
imidazoles;
monomethoxybenzene		TRP channel blocker
o-methyl threonine[no description available]low00ether;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid		antibacterial agent;
bleaching agent
mycophenolate mofetil[no description available]low00carboxylic ester;
ether;
gamma-lactone;
phenols;
tertiary amino compound		anticoronaviral agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
immunosuppressive agent;
prodrug
soraphen a[no description available]low00cyclic hemiketal;
ether;
macrolide;
olefinic compound		bacterial metabolite;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
teratogenic agent
l 683590[no description available]low00ether;
lactol;
macrolide;
secondary alcohol		antifungal agent;
bacterial metabolite;
immunosuppressive agent
acetylspiramycin[no description available]low00acetate ester;
aldehyde;
disaccharide derivative;
ether;
macrolide;
tertiary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite
sirolimus[no description available]low00antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
oripavine[no description available]low00ether;
morphinane alkaloid;
organic heteropentacyclic compound;
organic hydroxy compound;
tertiary amino compound		bacterial xenobiotic metabolite;
opioid analgesic
bongkrekic acid[no description available]low00ether;
olefinic compound;
tricarboxylic acid		apoptosis inhibitor;
ATP/ADP translocase inhibitor;
bacterial metabolite;
EC 2.5.1.18 (glutathione transferase) inhibitor;
toxin
demycarosylturimycin h[no description available]low00aldehyde;
disaccharide derivative;
ether;
macrolide;
tertiary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite
everolimus[no description available]low00cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
primary alcohol;
secondary alcohol		anticoronaviral agent;
antineoplastic agent;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
l 744832[no description available]low00benzenes;
ether;
isopropyl ester;
secondary carboxamide;
sulfone;
thiol		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
geroprotector
gs-7340[no description available]low006-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester		antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug
estin[no description available]low001-benzofurans;
ether;
methyl ester;
organochlorine compound;
oxaspiro compound;
phenols		Aspergillus metabolite;
Penicillium metabolite
selexipag[no description available]low00aromatic amine;
ether;
monocarboxylic acid amide;
N-sulfonylcarboxamide;
pyrazines;
tertiary amino compound		orphan drug;
platelet aggregation inhibitor;
prodrug;
prostacyclin receptor agonist;
vasodilator agent
mre 269[no description available]low00aromatic amine;
ether;
monocarboxylic acid;
pyrazines;
sulfonamide;
tertiary amino compound		drug metabolite;
orphan drug;
platelet aggregation inhibitor;
prostacyclin receptor agonist;
vasodilator agent
vilanterol[no description available]low00benzyl alcohols;
dichlorobenzene;
ether;
phenols;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent
rolapitant[no description available]low00azaspiro compound;
ether;
organofluorine compound;
piperidines;
pyrrolidin-2-ones		antiemetic;
neurokinin-1 receptor antagonist
iejimalide b[no description available]low00ether;
formamides;
macrolide		antineoplastic agent;
marine metabolite
migrastatin[no description available]low00ether;
macrolide antibiotic;
piperidones;
secondary alcohol		antineoplastic agent;
metabolite
episilvestrol[no description available]low00dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite
tembotrione[no description available]low00aromatic ketone;
beta-triketone;
cyclic ketone;
ether;
monochlorobenzenes;
organofluorine compound;
sulfone		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor;
herbicide
silvestrol[no description available]low00dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite
cytotrienin a[no description available]low00cyclopropanecarboxylate ester;
ether;
hydroquinones;
lactam;
macrocycle;
secondary alcohol		antibacterial agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
metabolite
nodularin[no description available]low00ether
debromoaplysiatoxin[no description available]low00aplysiatoxins;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
phenols;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist
aplysiatoxin[no description available]low00aplysiatoxins;
bromophenol;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist
novobiocin[no description available]low00carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent
gs-5816[no description available]low00carbamate ester;
ether;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heteropentacyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor
althiomycin[no description available]low001,3-thiazoles;
aldoxime;
ether;
gamma-lactam;
pentapeptide;
peptide antibiotic;
primary alcohol;
pyrroline;
secondary carboxamide;
tertiary carboxamide		antibacterial agent;
bacterial metabolite;
protein synthesis inhibitor
marineosin a[no description available]low00azaspiro compound;
ether;
macrocycle;
oxaspiro compound;
pyrroles		antineoplastic agent;
metabolite
marineosin b[no description available]low00azaspiro compound;
ether;
macrocycle;
oxaspiro compound;
pyrroles		antineoplastic agent;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
2019 Novel Coronavirus Disease0low10
2019 Novel Coronavirus Infection0low10
2019-nCoV Disease0low10
2019-nCoV Infection0low10
Abdominal Pain0medium11
Acquired Immune Deficiency Syndrome0low10
Acquired Immuno-Deficiency Syndrome0low10
Acquired Immunodeficiency Syndrome0low10
AIDS0low10
AIDS Seroconversion0low10
AIDS Seropositivity0low10
Anasarca0low30
Angiogenesis, Pathologic0low10
Angiogenesis, Pathological0low10
Anti-HIV Positivity0low10
Bacterial Vaginitides0medium31
Bacterial Vaginitis0medium31
Bacterial Vaginoses0medium31
Bacterial Vaginosis0medium31
Bleeding Between Periods0medium11
Body Weight0low10
Breakthrough Bleeding0medium11
Breast Cancer0low10
Breast Carcinoma0low10
Breast Neoplasms0low10
Breast Tumors0low10
Cancer of Breast0low10
Cancer of Lung0low10
Cancer of the Breast0low10
Cancer of the Lung0low10
Candidiasis, Genital0medium11
Candidiasis, Vulvovaginal0medium11
Carcinoma0low10
Carcinoma, Anaplastic0low10
Carcinoma, Spindle-Cell0low10
Carcinoma, Undifferentiated0low10
Carcinomatosis0low10
Central Hypothyroidism0low10
Chlamydia Infections0medium33
Colicky Pain0medium11
Complications, Infectious Pregnancy0low10
Coronavirus Disease 20190low10
Coronavirus Disease-190low10
COVID-190low10
COVID-19 Pandemic0low10
COVID-19 Pandemics0low10
COVID-19 Virus Disease0low10
COVID-19 Virus Infection0low10
COVID190low10
Cytomegalovirus0low10
Diathesis0low10
Disease Models, Animal0low10
Disease Susceptibility0low10
Diseases, Occupational0low10
Dropsy0low30
Dysfunctional Uterine Bleeding0medium11
Edema0low30
Electrolytes0low40
Endotoxin Shock0low10
Epithelial Neoplasms, Malignant0low10
Epithelial Tumors, Malignant0low10
Epithelioma0low10
Female Genital Diseases0medium11
Female Genitourinary Diseases0medium11
Female Urogenital Diseases0medium11
Genital Diseases, Female0medium11
Genital Herpes0low10
Genital Vulvovaginal Candidiasis0medium11
Gonorrhea0medium33
Gynecologic Diseases0medium11
Herpes Genitalis0low10
Herpes Simplex Virus Genital Infection0low10
Herpes Simplex, Genital0low10
HIV0low20
HIV Antibody Positivity0low10
HIV Coinfection0medium267
HIV Infections0medium267
HIV Seroconversion0low10
HIV Seropositivity0low10
HPV Infection0low10
HTLV-III Infections0medium267
HTLV-III Seroconversion0low10
HTLV-III Seropositivity0low10
HTLV-III-LAV Infections0medium267
Human Mammary Carcinoma0low10
Human Papillomavirus Infection0low10
Hydrops0low30
Hypothyroidism0low10
Immunodeficiency Syndrome, Acquired0low10
Immunologic Deficiency Syndrome, Acquired0low10
Infections, Chlamydia0medium33
Infectious Pregnancy Complications0low10
Inflammation0low20
Innate Inflammatory Response0low20
Intermenstrual Bleeding0medium11
Lung Cancer0low10
Lung Neoplasms0low10
Malaria, Falciparum0low10
Malignant Epithelial Neoplasms0low10
Malignant Neoplasm of Breast0low10
Malignant Tumor of Breast0low10
Mammary Cancer0low10
Mammary Carcinoma, Human0low10
Mammary Neoplasm, Human0low10
Mammary Neoplasms, Human0low10
Maternal Sepsis0low10
Metastase0low10
Metastases, Neoplasm0low10
Metastasis0low10
Metastasis, Neoplasm0low10
Metrorrhagia0medium11
Moniliasis, Vulvovaginal0medium11
Muscle Contraction0low10
Neisseria gonorrhoeae Infection0medium33
Neoplasm Metastases0low10
Neoplasm Metastasis0low10
Neoplasms, Breast0low10
Neoplasms, Lung0low10
Neoplasms, Malignant Epithelial0low10
Neoplasms, Pulmonary0low10
Neovascularization, Pathologic0low10
Neovascularization, Pathological0low10
Occupational Diseases0low10
Occupational Illnesses0low10
Papillomavirus Infections0low10
Pathologic Angiogenesis0low10
Pathologic Neovascularization0low10
Peritoneal Carcinomatosis0low10
Peritoneal Neoplasms0low10
Peritoneal Surface Malignancy0low10
Plasmodium falciparum Malaria0low10
Pleurisy0low10
Pleuritis0low10
Pregnancy0medium32
Pregnancy Complications, Infectious0low10
Pregnancy, Infectious Complications0low10
Primary Hypothyroidism0low10
Pulmonary Cancer0low10
Pulmonary Neoplasms0low10
SARS Coronavirus 2 Infection0low10
SARS-CoV-2 Infection0low10
Secondary Hypothyroidism0low10
Sensitivity and Specificity0medium11
Sepsis during Pregnancy0low10
Sepsis in Pregnancy0low10
Septic Shock0low10
Sexually Transmitted Diseases0medium96
Sexually Transmitted Infections0medium96
Shock, Endotoxic0low10
Shock, Septic0low10
Shock, Toxic0low10
Spotting0medium11
STDs0medium96
STIs0medium96
Susceptibility, Disease0low10
T-Lymphotropic Virus Type III Infections, Human0medium267
Thyroid-Stimulating Hormone Deficiency0low10
Toxic Shock0low10
Toxic Shock Syndrome0low10
TSH Deficiency0low10
Tumors, Breast0low10
Vaginal Yeast Infection0medium11
Vaginal Yeast Infections0medium11
Vaginitides, Bacterial0medium31
Vaginitis0medium11
Vaginitis, Bacterial0medium31
Vaginitis, Monilial0medium11
Vaginitis, Nonspecific0medium31
Vaginoses, Bacterial0medium31
Vaginosis, Bacterial0medium31
Venereal Diseases0medium96
Viral Diseases0low10
Viral Infections0low10
Virus Diseases0low10
Virus Infections0low10

Research Highlights

Safety/Toxicity (14)

ArticleYear
New candidate biomarkers in the female genital tract to evaluate microbicide toxicity.
PloS one, Volume: 9, Issue: 10		2014
Toward early safety alert endpoints: exploring biomarkers suggestive of microbicide failure.
AIDS research and human retroviruses, Volume: 29, Issue: 11		2013
Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety.
PloS one, Volume: 6, Issue: 11		2011
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety.
The Journal of infectious diseases, Aug-15, Volume: 200, Issue: 4		2009
A randomized controlled safety trial of the diaphragm and cellulose sulfate microbicide gel in sexually active women in Zimbabwe.
Contraception, Volume: 76, Issue: 5		2007
Safety and acceptability of 6% cellulose sulfate vaginal gel applied four times per day for 14 days.
Contraception, Volume: 76, Issue: 3		2007
Safety trial of the vaginal microbicide cellulose sulfate gel in HIV-positive men.
Sexually transmitted diseases, Volume: 34, Issue: 7		2007
Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety study.
Contraception, Volume: 74, Issue: 2		2006
Safety and acceptability of cellulose sulfate as a vaginal microbicide in HIV-infected women.
AIDS (London, England), May-12, Volume: 20, Issue: 8		2006
Expanded Phase I safety and acceptability study of 6% cellulose sulfate vaginal gel.
AIDS (London, England), Dec-02, Volume: 19, Issue: 18		2005
Single and multiple exposure tolerance study of cellulose sulfate gel: a Phase I safety and colposcopy study.
Contraception, Volume: 64, Issue: 6		2001
Prevention of complement-mediated cytotoxicity against rat islets by encapsulation in a cellulose sulphate membrane.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, Volume: 19, Issue: 8		1987
Effectiveness of sodium sugar sulfates on acute toxicity of paraquat in mice.
Journal of pharmacobio-dynamics, Volume: 12, Issue: 8		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL).
Contraception, Volume: 72, Issue: 1		2005
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior.
Journal of biomaterials applications, Volume: 33, Issue: 1		2018
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Natural Sources (1)

ArticleYear
Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior.
Journal of biomaterials applications, Volume: 33, Issue: 1		2018
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]