Compounds > tetraglyme
Page last updated: 2024-12-05

tetraglyme

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Tetraglyme, also known as tetraethylene glycol dimethyl ether, is a colorless, odorless liquid that serves as an aprotic polar solvent. It is a high-boiling, stable, and non-flammable compound. Its synthesis involves the reaction of ethylene glycol with dimethyl sulfate in the presence of a base. Tetraglyme exhibits excellent solvating properties for various inorganic salts and organometallic compounds. Its unique coordination properties with metal cations have made it a crucial component in a variety of applications, including lithium battery electrolytes, extraction processes, and polymer science. Research on tetraglyme focuses on its ability to stabilize metal cations in solution, its use as a non-aqueous electrolyte for lithium batteries, its applications in organic synthesis, and its potential in CO2 capture and utilization. The study of tetraglyme is driven by its promising properties and potential for advancements in various technological fields.'

Cross-References

ID SourceID
PubMed CID8925
CHEMBL ID3182543
CHEBI ID46785
SCHEMBL ID14920
MeSH IDM0408167

Synonyms (64)

Synonym
wln: 1o2o2o2o2o1
ether, bis[2-(2-methoxyethoxy)ethyl]
glyme 5
nsc65624
nsc-65624
tetraglyme
glyme-5
dimethoxytetraglycol
2,8,11,14-pentaoxapentadecane
dimethoxytetraethylene glycol
bis[2-(2-methoxyethoxy)ethyl] ether
tetraethylene glycol dimethyl ether
ansul ether 181at
143-24-8
brn 1760005
e181 (ether)
methyltetraglyme200
bis(2-(2-methoxyethoxy)ethyl) ether
nsc 65624
einecs 205-594-7
ai3-01596
ether, bis(2-(2-methoxyethoxy)ethyl)
nissan uniox mm 200
2,5,8,11,14-pentaoxapentadecane
tetraethylene glycol dimethyl ether, >=99%
CHEBI:46785 ,
ch3o[ch2ch2o]4ch3
B0497
1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane
unii-78l136flz9
78l136flz9 ,
ec 205-594-7
cas-143-24-8
dtxcid5024396
dtxsid7044396 ,
tox21_302147
NCGC00255794-01
AKOS015950630
STL280528
FT-0674962
SCHEMBL14920
tetraethyleneglycol dimethylether
tetraethylene glycol dimethylether
tetraglyme [mi]
peg-4 dimethyl ether
e 181 (ether)
CHEMBL3182543
c10h22o5
mfcd00008505
tetraethyleneglycol dimethyl ether
tetraethylene glycol dimethyl ether, analytical standard
AS-60434
J-007779
F0001-0510
tetraethylene glycol dimethyl ether (tetraglyme)
Q3788669
DB14000
methyl-peg4-methyl
me-peg4-me
2,5,8,11,14-pentaoxapentadecane;bis(2-(2-methoxyethoxy)ethyl) ether;2,5,8,11,14-pentaoxapentadecane bis(2-(2-methoxyethoxy)ethyl) ether
D70429
A884998
CS-W014238
HY-W013522
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
polyetherAny ether that contains more than one ether linkage.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency48.94233.189029.884159.4836AID1224846
progesterone receptorHomo sapiens (human)Potency30.60670.000417.946075.1148AID1346795
retinoid X nuclear receptor alphaHomo sapiens (human)Potency48.94230.000817.505159.3239AID1159527
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (50.00)29.6817
2010's13 (46.43)24.3611
2020's1 (3.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 42.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index42.01 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index59.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (42.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
histamine
[no description available]		210aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
sulfur dioxide
Sulfur Dioxide: A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.		7.2110sulfur oxideEscherichia coli metabolite;
food bleaching agent;
refrigerant
acrylic acid
acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.		2.4620alpha,beta-unsaturated monocarboxylic acidmetabolite
glycidyl methacrylate
glycidyl methacrylate: RN given refers to monomer. glycidyl methacrylate : An enoate ester obtained by formal condensation of the carboxy group of methacrylic acid with the hydroxy group of glycidol.		2.0510enoate ester;
epoxide
allylamine
Allylamine: Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.		2.4620alkylamine
maleic anhydride
Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.		2.0510cyclic dicarboxylic anhydride;
furans		allergen
diglyme
diglyme : A polyether that is the dimethyl ether derivative of diethylene glycol.		2.110polyetherenvironmental contaminant;
solvent;
xenobiotic
triglyme
triglyme : A polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms.		2.110polyethersolvent
propylene
propylene: structure		2.0510alkene;
gas molecular entity		refrigerant;
xenobiotic
hydroxyethyl methacrylate
hydroxyethyl methacrylate: many of cited refs are for gel which refers to polymeric form of above cpd: POLYHYDROXYETHYL METHACRYLATE. 2-hydroxyethyl methacrylate : An enoate ester that is the monomethacryloyl derivative of ethylene glycol.		2.0610enoate esterallergen;
polymerisation monomer
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.0610copper group element atom;
elemental gold
alkenes
[no description available]		2.0510
fibrinogen
Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.		3.5380iditolfungal metabolite
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		2.7730alkali metal atom
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		2.4920chalcogen;
nonmetal atom		macronutrient
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		02.4820
Hypermobility, Joint
[description not available]		02.0510
Prosthesis Durability
[description not available]		02.0510
Innate Inflammatory Response
[description not available]		02.0610
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0610
Blood Clot
[description not available]		02.0310
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.		02.0310