Page last updated: 2024-11-06

copper histidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Copper histidine is a coordination complex formed between copper ions (Cu2+) and the amino acid histidine. It is a naturally occurring compound found in various biological systems and has been studied for its potential therapeutic applications. Its synthesis involves the reaction of copper salts with histidine in aqueous solution. The resulting complex exhibits a characteristic blue color. Copper histidine is known to have antioxidant properties, protecting cells from oxidative damage. It has also been shown to have anti-inflammatory effects and may play a role in the regulation of immune responses. This compound is of interest due to its potential applications in treating conditions such as rheumatoid arthritis, Alzheimer's disease, and cancer. Research focuses on understanding its mechanisms of action, optimizing its synthesis and delivery, and exploring its therapeutic potential.'

Cross-References

ID SourceID
PubMed CID71083
CHEMBL ID104875
CHEBI ID27947
SCHEMBL ID59365
MeSH IDM0258657

Synonyms (62)

Synonym
d-histidin
CHEBI:27947 ,
(2r)-2-amino-3-(1h-imidazol-4-yl)propanoic acid
d-his
C06419
(r)-alpha-amino-1h-imidazole-4-propionic acid
351-50-8
d-histidine ,
d-histidine, >=98% (tlc)
2EZ7
NCGC00142611-01
NCGC00142611-02
E13FF66C-6B46-4431-AE14-82A8D0C9DD56
d-histamine
CHEMBL104875
(2r)-2-amino-3-(1h-imidazol-5-yl)propanoic acid
h-d-his-oh
H0998
(2r)-2-ammonio-3-(1h-imidazol-4-yl)propanoate
3-(1h-imidazole-4-yl)-2-aminopropanoic acid;
A836759
histidine, monohydrochloride, d-
niosh/ms3116000
MS31160000
A822610
(2r)-2-azanyl-3-(1h-imidazol-5-yl)propanoic acid
BBL009711
d-histidine; d-his-oh
AKOS005716904
unii-4je5hrm5ch
einecs 206-513-8
4je5hrm5ch ,
STL141076
AKOS015854102
(r)-2-amino-3-(4-imidazolyl)propionic acid
(r)-2-amino-3-(1h-imidazol-4-yl)propanoic acid
gtpl4679
FD3017
SCHEMBL59365
AM81800
HNDVDQJCIGZPNO-RXMQYKEDSA-N
Q-101530
mfcd00065963
d-histidine (h-d-his-oh)
M02972
d-a-amino-ss-(4-imidazolyl)propionic acid
AC-8655
d-histidine, puriss., >=99.0% (t)
d-histidine, vetec(tm) reagent grade, 98%
CS-W013288
AKOS032949750
Q27077043
AS-13490
histidine, d-
(r)-histidine
copper-histidine
DTXSID70889344
HY-W012572
bdbm50463187
EN300-67346
(2r)-2-amino-3-(3h-imidazol-4-yl)propanoic acid
Z1079168982
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
Saccharomyces cerevisiae metaboliteAny fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
D-alpha-amino acid
histidineAn alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.
polar amino acid zwitterion
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (35)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency14.12540.011212.4002100.0000AID1030
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency17.78280.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Carbonic anhydrase 2Homo sapiens (human)Kd43.500043.500043.500043.5000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)KA24.85000.24000.81921.6700AID1815483; AID318346
Carbonic anhydrase 1Homo sapiens (human)KA0.09000.02001.72197.4000AID1331203; AID1397319; AID1815474; AID268620; AID291061; AID307896; AID318343; AID365827; AID409984; AID462829; AID691713; AID725228
Carbonic anhydrase 2Homo sapiens (human)KA43.00000.01101.42737.8000AID1331204; AID1397320; AID1815475; AID268621; AID291063; AID307897; AID318344; AID365828; AID409986; AID414329; AID462830; AID464319; AID691714; AID725229
Plasma kallikreinHomo sapiens (human)KA4.38000.04401.39744.3800AID305777
Carbonic anhydrase 3Homo sapiens (human)KA1.11330.09100.72851.1200AID1815476; AID365829; AID409993
Carbonic anhydrase 4Homo sapiens (human)KA12.30000.07904.45607.3000AID1815477; AID365830; AID375786
Carbonic anhydrase 6Homo sapiens (human)KA13.00001.20005.82769.5400AID1815480; AID307898; AID462831
Adenosine receptor A1Rattus norvegicus (Norway rat)KA43.00000.01101.32337.8000AID691714
Adenosine receptor A2aRattus norvegicus (Norway rat)KA43.00000.01101.32337.8000AID691714
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)KA0.12000.01002.79269.8100AID1815478; AID305776
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Carbonic anhydrase 7Homo sapiens (human)KA0.71000.71003.875610.0000AID1815481; AID291065
Carbonic anhydraseSaccharomyces cerevisiae S288CKa85.00000.95005.12509.3000AID414331; AID464321
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Carbonic anhydrase 9Homo sapiens (human)KA12.50000.00904.24939.7100AID1815482; AID318345
Carbonic anhydrase-like protein, putativeTrypanosoma cruzi strain CL BrenerKA7.54000.14002.80507.5400AID1397322
Carbonic anhydraseCandida albicans SC5314KA19.50000.96003.95338.4000AID458784
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka21.20007.10008.30009.5000AID464322
Carbonic anhydrase 13Homo sapiens (human)KA0.09000.05001.11334.6000AID1815484
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Carbonic anhydrase 15Mus musculus (house mouse)KA14.10004.00007.68579.5000AID375787
Carbonic anhydrase 13Mus musculus (house mouse)KA0.09000.01301.51404.6000AID268622
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA0.71000.71003.79009.7400AID291065
Carbonic anhydrase 14Homo sapiens (human)KA2.38500.01002.28947.2100AID1815485; AID291067
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)KA4.39000.04402.120510.0000AID1815479; AID305777
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (60)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
Factor XII activationPlasma kallikreinHomo sapiens (human)
proteolysisPlasma kallikreinHomo sapiens (human)
blood coagulationPlasma kallikreinHomo sapiens (human)
zymogen activationPlasma kallikreinHomo sapiens (human)
plasminogen activationPlasma kallikreinHomo sapiens (human)
fibrinolysisPlasma kallikreinHomo sapiens (human)
positive regulation of fibrinolysisPlasma kallikreinHomo sapiens (human)
response to bacteriumCarbonic anhydrase 3Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 3Homo sapiens (human)
bicarbonate transportCarbonic anhydrase 4Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 4Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter tasteCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 7Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 7Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 7Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 7Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cytokine production involved in immune responseLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
negative regulation of gene expressionLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
positive regulation of type II interferon productionLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
positive regulation of interleukin-17 productionLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
positive regulation of interleukin-4 productionLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
negative regulation of autophagyLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
response to muscle activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
neutral amino acid transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
isoleucine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-leucine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
methionine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
phenylalanine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
proline transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
tryptophan transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
tyrosine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
valine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
alanine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
cellular response to glucose starvationLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
xenobiotic transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
response to hyperoxiaLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
positive regulation of glial cell proliferationLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
thyroid hormone transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
cellular response to lipopolysaccharideLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
amino acid import across plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
liver regenerationLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
transport across blood-brain barrierLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-histidine transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
cellular response to L-arginineLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-leucine import across plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-tryptophan transmembrane transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell apoptotic processLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
positive regulation of L-leucine import across plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
amino acid transmembrane transportLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 13Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 14Homo sapiens (human)
response to bacteriumCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (19)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
serine-type endopeptidase activityPlasma kallikreinHomo sapiens (human)
protein bindingPlasma kallikreinHomo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 3Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 3Homo sapiens (human)
nickel cation bindingCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 4Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 6Homo sapiens (human)
G protein-coupled adenosine receptor activityAdenosine receptor A2aRattus norvegicus (Norway rat)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 7Homo sapiens (human)
protein bindingLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
amino acid transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
aromatic amino acid transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
neutral L-amino acid transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-leucine transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-tryptophan transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
antiporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
thyroid hormone transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
peptide antigen bindingLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
L-amino acid transmembrane transporter activityLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 13Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 13Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 13Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (33)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular regionPlasma kallikreinHomo sapiens (human)
extracellular spacePlasma kallikreinHomo sapiens (human)
plasma membranePlasma kallikreinHomo sapiens (human)
extracellular exosomePlasma kallikreinHomo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytoplasmCarbonic anhydrase 3Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 4Homo sapiens (human)
rough endoplasmic reticulumCarbonic anhydrase 4Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentCarbonic anhydrase 4Homo sapiens (human)
Golgi apparatusCarbonic anhydrase 4Homo sapiens (human)
trans-Golgi networkCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
external side of plasma membraneCarbonic anhydrase 4Homo sapiens (human)
cell surfaceCarbonic anhydrase 4Homo sapiens (human)
membraneCarbonic anhydrase 4Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 4Homo sapiens (human)
transport vesicle membraneCarbonic anhydrase 4Homo sapiens (human)
secretory granule membraneCarbonic anhydrase 4Homo sapiens (human)
brush border membraneCarbonic anhydrase 4Homo sapiens (human)
perinuclear region of cytoplasmCarbonic anhydrase 4Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
extracellular regionCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
cytosolCarbonic anhydrase 6Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
Golgi membraneAdenosine receptor A2aRattus norvegicus (Norway rat)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
cytosolCarbonic anhydrase 7Homo sapiens (human)
cytoplasmCarbonic anhydrase 7Homo sapiens (human)
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
lysosomal membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
cytosolLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
basal plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
basolateral plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
apical plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
microvillus membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
intracellular membrane-bounded organelleLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
extracellular exosomeLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
external side of apical plasma membraneLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
amino acid transport complexLarge neutral amino acids transporter small subunit 1Homo sapiens (human)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
cytosolCarbonic anhydrase 13Homo sapiens (human)
myelin sheathCarbonic anhydrase 13Homo sapiens (human)
intracellular membrane-bounded organelleCarbonic anhydrase 13Homo sapiens (human)
cytoplasmCarbonic anhydrase 13Homo sapiens (human)
cytosolCarbonic anhydrase 13Homo sapiens (human)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
membraneCarbonic anhydrase 14Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 14Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 14Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (85)

Assay IDTitleYearJournalArticle
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1815474Activation of human carbonic anhydrase 1 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID691713Activity of human recombinant CA1 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID1815484Activation of human carbonic anhydrase 13 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID365577Activity of human recombinant CA2 at 10 uM stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID1815485Activation of human carbonic anhydrase 14 by stopped flow CO2 hydrase assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID1815483Activation of human carbonic anhydrase 12 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID1331204Activation of recombinant human carbonic anhydrase 2 at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID1815479Activation of human carbonic anhydrase 5B by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID318345Activation of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID1397322Activation of Trypanosoma cruzi CA preincubated for 15 mins followed by CO2 addition by stopped-flow assay
AID365829Activation of human recombinant CA3 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID458787Activation of Cryptococcus neoformans beta-carbonic anhydrase Can2 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID725227Activation of Sulfurihydrogenibium yellowstonense recombinant CA by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID1815475Activation of human carbonic anhydrase 2 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID1397319Activation of human CA1 by stopped-flow CO2 hydration assay
AID1398360Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake at 200 uM preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting 2018Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
AID691715Activity of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant CA expressed in Escherichia coli BL21(DE3) after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID365578Activity of human recombinant CA3 at 10 uM stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID365576Activity of human recombinant CA1 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID458784Activation of Candida albicans beta-carbonic anhydrase Nce103 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.
AID291067Activation of of human recombinant CA14 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID365828Activation of human recombinant CA2 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID409992Activation of Methanosarcina thermophila cobalt(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID318343Activation of human recombinant CA1 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID725226Activation of Sulfurihydrogenibium azorense recombinant alpha carbonic anhydrase by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID307897Activation of human recombinant CA2 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID1815478Activation of human carbonic anhydrase 5A by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID1398361Trans-stimulation of human LAT1 expressed in TREx HEK293 cells assessed as induction of [3H]-gabapentin efflux at 200 uM after 3 mins by scintillation counting analysis relative to L-phenylalanine2018Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
AID414330Activation of Methanothermobacter thermautotrophicus recombinant Cab by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID1397320Activation of human CA2 by stopped-flow CO2 hydration assay
AID462832Activation of Stylophora pistillata carbonic anhydrase STPCA by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID198301Cleavage rate against hairpin ribozyme at 2 mM, in presence of 0.5 uM magnesium ions2001Bioorganic & medicinal chemistry letters, Dec-03, Volume: 11, Issue:23
Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration.
AID375785Activity of membrane associated mouse recombinant carbonic anhydrase 15 isoform2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID462831Activation of human full length CA6 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID1331206Activation of Burkholderia pseudomallei gamma carbonic anhydrase at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID1281543Activation of Malassezia globosa beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped flow CO2 hydrase method2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids.
AID375786Activation of human recombinant carbonic anhydrase 4 lacking 20 amino terminal residues by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID307896Activation of human recombinant CA1 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID464319Activation of human recombinant carbonic anhydrase isoenzyme 2 by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID414331Activation of yeast recombinant CA by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID409984Activation of human recombinant CA1 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID1397321Activation of Leishmania donovani chagasi CA preincubated for 15 mins followed by CO2 addition by stopped-flow assay
AID305777Activation of human recombinant carbonic anhydrase 5B by stopped-flow CO2 hydrase method2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
AID1815477Activation of human carbonic anhydrase 4 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID365830Activation of human recombinant truncated CA4 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID268622Activation of mouse recombinant CA13 by CO2 hydrase method2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID409990Activation of Methanosarcina thermophila Zinc(2)-derived gamma-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID318346Activation of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID365826Activity of human recombinant truncated CA4 at 10 uM stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID268620Activation of human recombinant CA1 by CO2 hydrase assay2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID464322Activation of Candida glabrata recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID1331203Activation of recombinant human carbonic anhydrase 1 at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID1815481Activation of human carbonic anhydrase 7 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID464321Activation of Saccharomyces cerevisiae recombinant Nce103p by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID691714Activity of human recombinant CA2 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.
AID1815476Activation of human carbonic anhydrase 3 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID409988Activation of Methanobacterium thermoautotrophicum beta-class CA by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID307898Activation of human recombinant CA6 by stopped flow CO2 hydrase method2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
AID291063Activation of human recombinant CA2 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID291061Activation of human recombinant CA1 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID291065Activation of human recombinant CA7 by CO2 hydrase assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
AID268621Activation of human recombinant CA2 by CO2 hydrase assay2006Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
AID725229Activation of human recombinant CA2 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID725228Activation of human recombinant CA1 by stopped flow CO2 hydrase method2013Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.
AID1331205Activation of recombinant Methanosarcina thermophila gamma carbonic anhydrase at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID462830Activation of human recombinant CA2by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID1398359Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis r2018Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
AID375784Activity of human recombinant carbonic anhydrase 4 lacking 20 amino terminal residues2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID462829Activation of human recombinant CA1 by stopped flow CO2 hydration assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.
AID305776Activation of human recombinant carbonic anhydrase 5A by stopped-flow CO2 hydrase method2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
AID1815482Activation of human carbonic anhydrase 9 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID1331210Activation of Burkholderia pseudomallei gamma carbonic anhydrase assessed as Kcat at 10 uM incubated for 15 mins prior to testing by stopped flow CO2 hydration assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.
AID409986Activation of human recombinant CA2 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID464320Activation of archaea Methanobacterium thermoautotrophicum recombinant carbonic anhydrase by stopped flow CO2 hydration method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.
AID365827Activation of human recombinant CA1 at 10 uM by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
AID318344Activation of human recombinant CA2 by stopped-flow CO2 hydration method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
AID375787Activation of membrane associated mouse recombinant carbonic anhydrase 15 isoform by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
AID409993Activation of human recombinant CA3 by stopped-flow CO2 hydrase assay2008Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
AID414329Activation of human recombinant CA2 by stopped-flow CO2 hydrase method2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
AID1815480Activation of human carbonic anhydrase 6 by stopped flow assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.
AID198302Cleavage rate against hairpin ribozyme at 5 mM with 0.5 uM magnesium ions2001Bioorganic & medicinal chemistry letters, Dec-03, Volume: 11, Issue:23
Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2006Chemistry (Weinheim an der Bergstrasse, Germany), Sep-18, Volume: 12, Issue:27
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
AID1811Experimentally measured binding affinity data derived from PDB2006Chemistry (Weinheim an der Bergstrasse, Germany), Sep-18, Volume: 12, Issue:27
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (47.83)29.6817
2010's9 (39.13)24.3611
2020's3 (13.04)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.05 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.48 (4.65)
Search Engine Demand Index48.33 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (37.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]