Page last updated: 2024-11-13
allatotropin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Market Indicators
Description
allatotropin: from cerebral or corpora cardiaca of locusts & moths [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 101591393 |
| MeSH ID | M0144558 |
Synonyms (3)
| Synonym |
|---|
| 120928-88-3 |
| allatotropin |
| h-gly-phe-lys-asn-val-glu-met-met-thr-ala-arg-gly-phe-nh(2) |
Research Excerpts
Overview
Allatotropin (AT) is a neuropeptide originally described as a regulator of Juvenile Hormone synthesis. It plays multiple neural, endocrine and myoactive roles in insects and other organisms. Allatotropins stimulate the biosynthesis of juvenile hormone in certain insect species.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Allatotropin is a pleiotropic peptide originally characterized in insects. " | ( G protein-coupled receptor signal transduction and Ca Alzugaray, ME; Gavazzi, MV; Ronderos, JR, 2021) | 2.06 |
| "Allatotropin (AT) is a neuropeptide originally described as a regulator of Juvenile Hormone synthesis, which plays multiple neural, endocrine and myoactive roles in insects and other organisms." | ( Allatotropin: an ancestral myotropic neuropeptide involved in feeding. Adami, ML; Alzugaray, ME; Damborenea, C; Diambra, LA; Hernandez-Martinez, S; Noriega, FG; Ronderos, JR, 2013) | 2.55 |
| "Allatotropins (ATs) are a family of neuropeptides that have been shown to stimulate the biosynthesis of juvenile hormone in certain insect species, and to have stimulatory activity on some visceral muscles. " | ( Molecular characterization and possible biological roles of allatotropin in Rhodnius prolixus. Masood, M; Orchard, I, 2014) | 2.09 |
| "Allatotropin (AT) is a neuropeptide originally isolated from the brain of Manduca sexta and then characterized in several insect species. " | ( Allatotropin expression during the development of the fourth instar larvae of the kissing-bug Triatoma infestans (Klüg). Riccillo, FL; Ronderos, JR, 2010) | 3.25 |
| "Allatotropin is an insect neuropeptide with pleiotropic actions on a variety of different tissues. " | ( Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes. Brockhoff, A; Goodwin, M; Mayoral, JG; Meyerhof, W; Noriega, FG; Nouzova, M, 2012) | 2.1 |
| "Allatotropin is a 13-residue amidated neuropeptide isolated from pharate adult heads of the tobacco hornworm, Manduca sexta and strongly stimulates biosynthesis of juvenile hormones in adults, but not larval, lepidopteran corpora allata. " | ( Molecular characterization of a cDNA from the silk moth Bombyx mori encoding Manduca sexta allatotropin peptide. Hwang, JS; Kang, SW; Lee, BH; Park, C, 2002) | 1.98 |
| "Allatotropin (AT) is a 13-residue amidated neuropeptide, first isolated from pharate adult heads of the tobacco hornworm, Manduca sexta (Manse-AT), which strongly stimulates the biosynthesis of juvenile hormones (JH) in the corpora allata (CA) of adult moths. " | ( Molecular characterisation of cDNAs from the fall armyworm Spodoptera frugiperda encoding Manduca sexta allatotropin and allatostatin preprohormone peptides. Abdel-latief, M; Hoffmann, KH; Meyering-Vos, M, 2003) | 1.98 |
| "Allatotropin (AT) is an insect neuropeptide isolated from the tobacco hornworm, Manduca sexta, stimulates juvenile hormone (JH) biosynthesis by the corpora allata. " | ( Molecular characterization of a cDNA from the true armyworm Pseudaletia unipuncta encoding Manduca sexta allatotropin peptide(1). Bendena, WG; Kataoka, H; Koladich, PM; Mizoguchi, A; N McNeil, J; Suzuki, A; Tobe, SS; Truesdell, PF, ) | 1.79 |
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Allatotropin induced an increase in frequency and intensity of peristaltic contractions at the level of the HG." | ( Allatotropin-like peptide released by Malpighian tubules induces hindgut activity associated with diuresis in the Chagas disease vector Triatoma infestans (Klug). Ronderos, JR; Santini, MS, 2007) | 2.5 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " Physiological assays using AT and AT- antibodies revealed that while AT stimulated the extrusion of the hypostome in a dose-response fashion in starved hydroids, the activity of hypostome in hydroids challenged with food was blocked by treatments with different doses of AT-antibodies." | ( Allatotropin: an ancestral myotropic neuropeptide involved in feeding. Adami, ML; Alzugaray, ME; Damborenea, C; Diambra, LA; Hernandez-Martinez, S; Noriega, FG; Ronderos, JR, 2013) | 1.83 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (105)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.95) | 18.7374 |
| 1990's | 11 (10.48) | 18.2507 |
| 2000's | 47 (44.76) | 29.6817 |
| 2010's | 41 (39.05) | 24.3611 |
| 2020's | 5 (4.76) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 22.71
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (22.71) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 5 (4.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 106 (95.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||