Page last updated: 2024-10-18

histamine and Brain Ischemia

histamine has been researched along with Brain Ischemia in 30 studies

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Histamine is recognized as a neurotransmitter or neuromodulator in the brain, and it plays a major role in the pathogenic progression after cerebral ischemia."8.88Role of histamine and its receptors in cerebral ischemia. ( Chen, Z; Hu, WW, 2012)
" Since cerebral edema is a major cause of brain damage, we studied effects on brain edema of postischemic administration of L-histidine, a precursor of histamine, and thioperamide, a histamine H(3)-receptor antagonist, both of which enhance central histaminergic activity."7.74Alleviation of ischemia-induced brain edema by activation of the central histaminergic system in rats. ( Adachi, N; Arai, T; Irisawa, Y; Liu, K; Nagaro, T, 2008)
"Histamine plays a role as a neurotransmitter in the mammalian brain, and histamine release from nerve endings is enhanced in ischemia by facilitation of histaminergic activity."6.43Cerebral ischemia and brain histamine. ( Adachi, N, 2005)
"Histamine plays the role of neurotransmitter in the central nervous system, and histaminergic fibers are widely distributed in the brain."6.41[Cerebral ischemia and histamine]. ( Adachi, N, 2002)
"Histamine is recognized as a neurotransmitter or neuromodulator in the brain, and it plays a major role in the pathogenic progression after cerebral ischemia."4.88Role of histamine and its receptors in cerebral ischemia. ( Chen, Z; Hu, WW, 2012)
" We examined the effects of pharmacological manipulations of the histaminergic neuron system on various kinds of invasive stimuli, such as methamphetamine behavioral sensitization (reverse tolerance), neuronal cell death caused by brain ischemia and electroconvulsive shock."4.79[Histaminergic neuron system and neural plasticity]. ( Watanabe, T, 1997)
" Since cerebral edema is a major cause of brain damage, we studied effects on brain edema of postischemic administration of L-histidine, a precursor of histamine, and thioperamide, a histamine H(3)-receptor antagonist, both of which enhance central histaminergic activity."3.74Alleviation of ischemia-induced brain edema by activation of the central histaminergic system in rats. ( Adachi, N; Arai, T; Irisawa, Y; Liu, K; Nagaro, T, 2008)
"The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia."3.69Histamine depletion in brain caused by treatment with (S)alpha-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons. ( Abe, K; Itoyama, Y; Kogure, K; Lee, TH; Sakurai, E; Sugimoto, K; Watanabe, T; Yanai, K, 1994)
"Histamine plays a role as a neurotransmitter in the mammalian brain, and histamine release from nerve endings is enhanced in ischemia by facilitation of histaminergic activity."2.43Cerebral ischemia and brain histamine. ( Adachi, N, 2005)
"Histamine plays the role of neurotransmitter in the central nervous system, and histaminergic fibers are widely distributed in the brain."2.41[Cerebral ischemia and histamine]. ( Adachi, N, 2002)
"Histamine treatment decreased the extracellular glutamate content and alleviated neuronal cell death induced by exogenous glutamate challenge."1.40Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury. ( Chen, Z; Fang, Q; Hu, WW; Jin, MM; Lou, GD; Shen, Y; Wang, XF; Xu, TL; Yan, HJ; Yang, Y; Zeng, WZ; Zhang, SH, 2014)
"The histamine output was markedly reduced by intraperitoneal injection of alpha-fluoromethylhistidine (100 mg/kg), an irreversible inhibitor of histidine decarboxylase, or (R)-alpha-methylhistamine (5 mg/kg), a potent and specific H3-receptor agonist."1.28Direct evidence for increased continuous histamine release in the striatum of conscious freely moving rats produced by middle cerebral artery occlusion. ( Adachi, N; Itoh, Y; Oishi, R; Saeki, K, 1992)
"The histamine levels were elevated already in the precrisis period and remained high throughout the acute period of cerebral circulatory impairment."1.27[Dynamics of the histamine content and diamine oxidase activity of the blood in patients with ischemic stroke and transient disorders of cerebral blood circulation]. ( Khrapova, EV, 1988)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19908 (26.67)18.7374
1990's5 (16.67)18.2507
2000's10 (33.33)29.6817
2010's5 (16.67)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Fan, LS1
Chen, YC1
Liao, RJ1
Zhao, YY1
Zhang, XN1
Chen, Z8
Jiang, L1
Hu, WW5
d'Adesky, N1
Diaz, F1
Zhao, W1
Bramlett, HM1
Perez-Pinzon, MA1
Dave, KR1
Raval, AP1
Fang, Q1
Wang, XF1
Yang, Y2
Lou, GD1
Jin, MM1
Yan, HJ1
Zeng, WZ1
Shen, Y3
Zhang, SH1
Xu, TL1
Bae, ON1
Majid, A1
Yan, H1
Zhang, X2
Hu, W3
Ma, J1
Hou, W1
Wang, X1
Gao, J1
Lv, J1
Ohtsu, H1
Han, F1
Wang, G1
Kaur, I1
Kumar, A1
Jaggi, AS1
Singh, N1
Irisawa, Y2
Adachi, N7
Liu, K3
Arai, T4
Nagaro, T2
Ionov, ID1
He, P1
Fan, YY1
Zhang, LY1
FAZEKAS, JF2
ALMAN, RW2
TICKTIN, HE1
EHRMANTRAUT, WR1
SAVARESE, CJ1
Hamami, G1
Xu, L1
Pan, J1
Zheng, X1
Motoki, A1
Hiraga, N1
Semba, K1
Fan, Y1
Dai, H1
Fu, Q1
Il'icheva, RF1
Burd, GS1
Sheliakina, LA1
Sergeeva, NA1
Karnushina, I1
Suzuki, R1
Padgett, W1
Daly, JW1
Sugimoto, K1
Abe, K1
Lee, TH1
Sakurai, E1
Yanai, K1
Kogure, K1
Itoyama, Y1
Watanabe, T2
Joó, F1
Kovács, J1
Szerdahelyi, P1
Temesvári, P1
Tósaki, A1
Fujitani, T1
Miyazaki, H1
Nakamura, Y1
Kataoka, K1
Stepanian, AV1
Mirzoian, GI1
Itoh, Y1
Oishi, R1
Saeki, K1
Waskiewicz, J1
Molchanova, L1
Wałajtys-Rode, E1
Rafałowska, U1
Khrapova, EV1
Messick, JM1
Newberg, LA1
Nugent, M1
Faust, RJ1

Reviews

8 reviews available for histamine and Brain Ischemia

ArticleYear
Self-amplification of nigral degeneration in Parkinson's disease: a hypothesis.
    The International journal of neuroscience, 2008, Volume: 118, Issue:12

    Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Histamine;

2008
Role of histamine and its receptors in cerebral ischemia.
    ACS chemical neuroscience, 2012, Apr-18, Volume: 3, Issue:4

    Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Histamine; Humans; Receptors, Histamine H1; Re

2012
[Cerebral ischemia and histamine].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:4

    Topics: Animals; Brain Ischemia; Histamine; Histamine Release; Humans; Neurotransmitter Agents

2002
CURRENT THERAPEUTIC CONCEPTS OF CEREBRAL AND MYOCARDIAL VASCULAR DISEASE.
    Angiology, 1964, Volume: 15

    Topics: Acetazolamide; Anticoagulants; Brain Ischemia; Cerebrovascular Disorders; Coronary Disease; Histamin

1964
[Histamine and diseases of central nervous system].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:3

    Topics: Alzheimer Disease; Brain Ischemia; Epilepsy; Histamine; Humans; Parkinson Disease

2004
Cerebral ischemia and brain histamine.
    Brain research. Brain research reviews, 2005, Dec-15, Volume: 50, Issue:2

    Topics: Animals; Brain Ischemia; Histamine; Histidine; Humans; Models, Neurological; Neurotransmitter Agents

2005
[Histaminergic neuron system and neural plasticity].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1997, Volume: 17, Issue:4

    Topics: Animals; Brain Ischemia; Cell Death; Histamine; Homeostasis; Hypothalamus; Methamphetamine; Mice; Mi

1997
Principles of neuroanesthesia for the nonneurosurgical patient with CNS pathophysiology.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:2

    Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Aortic A

1985

Other Studies

22 other studies available for histamine and Brain Ischemia

ArticleYear
Antagonism of histamine H
    Acta pharmacologica Sinica, 2022, Volume: 43, Issue:11

    Topics: Animals; Annexin A2; Brain Ischemia; Cerebral Infarction; Endothelial Cells; Histamine; Histidine De

2022
Nicotine Exposure Along with Oral Contraceptive Treatment in Female Rats Exacerbates Post-cerebral Ischemic Hypoperfusion Potentially via Altered Histamine Metabolism.
    Translational stroke research, 2021, Volume: 12, Issue:5

    Topics: Animals; Brain Ischemia; Contraceptives, Oral; Female; Histamine; Humans; Nicotine; Rats; Rats, Spra

2021
Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury.
    Neuropharmacology, 2014, Volume: 77

    Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Excitatory Amino Acid Transporter 2; Hippocampus; H

2014
Role of histidine/histamine in carnosine-induced neuroprotection during ischemic brain damage.
    Brain research, 2013, Aug-21, Volume: 1527

    Topics: Animals; Astrocytes; Brain Ischemia; Carnosine; Disease Models, Animal; Histamine; Histidine; Male;

2013
Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms.
    Nature communications, 2014, Feb-25, Volume: 5

    Topics: Animals; Autophagy-Related Protein 5; Brain Ischemia; Chloride Channels; Histamine; Histamine Agonis

2014
Evidence for the role of histaminergic pathways in neuroprotective mechanism of ischemic postconditioning in mice.
    Fundamental & clinical pharmacology, 2017, Volume: 31, Issue:4

    Topics: Animals; Brain Ischemia; Female; Histamine; Ischemic Postconditioning; Male; Maze Learning; Mice; Ne

2017
Alleviation of ischemia-induced brain edema by activation of the central histaminergic system in rats.
    Journal of pharmacological sciences, 2008, Volume: 108, Issue:1

    Topics: Animals; Blood Cell Count; Body Water; Brain Chemistry; Brain Edema; Brain Ischemia; Cerebral Cortex

2008
[Effect of endogenous histamine on ischemic preconditioning induced cerebral ischemic tolerance].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2009, Volume: 38, Issue:6

    Topics: Animals; Brain Ischemia; Histamine; Ischemic Preconditioning; Male; Mice; Mice, Inbred C57BL; Mice,

2009
THERAPEUTIC MODALITIES IN THE MANAGEMENT OF CEREBRAL VASCULAR INSUFFICIENCY.
    American heart journal, 1963, Volume: 66

    Topics: Anticoagulants; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; Classification; Hist

1963
Alleviation of ischemic neuronal damage by histamine H2 receptor stimulation in the rat striatum.
    European journal of pharmacology, 2004, Jan-26, Volume: 484, Issue:2-3

    Topics: Animals; Brain Ischemia; Corpus Striatum; Dopamine; Histamine; Male; Neurons; Rats; Rats, Wistar; Re

2004
Effect of cerebral ischemia on brain mast cells in rats.
    Brain research, 2004, Sep-03, Volume: 1019, Issue:1-2

    Topics: Animals; Brain; Brain Ischemia; Cell Count; Histamine; Male; Mast Cells; Rats; Rats, Sprague-Dawley

2004
A comparison of protective effects between L-histidine and hypothermia against ischemia-induced neuronal damage in gerbil hippocampus.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Animals; Brain Ischemia; Drug Therapy, Combination; Gerbillinae; Hippocampus; Histamine; Histamine A

2006
Mast cell-derived mediators protect against oxygen-glucose deprivation-induced injury in PC12 cells and neurons.
    Neuroscience letters, 2007, Aug-09, Volume: 423, Issue:1

    Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Culture M

2007
[State of serotonin--monoamine oxidase and histamine--diamine oxidase systems in circulating blood in ischemic strokes].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1980, Volume: 80, Issue:8

    Topics: Adrenocorticotropic Hormone; Amine Oxidase (Copper-Containing); Brain Ischemia; Brain Stem; Cerebral

1980
Degeneration of CA1 neurons in hippocampus after ischemia in Mongolian gerbils: cyclic AMP-systems.
    Brain research, 1983, May-23, Volume: 268, Issue:1

    Topics: Adenylyl Cyclases; Animals; Brain; Brain Chemistry; Brain Ischemia; Cyclic AMP; Female; Gerbillinae;

1983
Histamine depletion in brain caused by treatment with (S)alpha-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons.
    Brain research, 1994, Dec-15, Volume: 666, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Gerbillinae; Hippocampus; Histamine; Histamine Antagonists; Male; Me

1994
The role of histamine in brain oedema formation.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Dose-Response Relations

1994
Histaminergic H2 action protects hippocampal CA1 neurons by prolonging the onset of the anoxic depolarization in gerbils.
    Journal of neurochemistry, 1996, Volume: 67, Issue:6

    Topics: Animals; Brain Ischemia; Cell Hypoxia; Dose-Response Relationship, Drug; Gerbillinae; Hippocampus; H

1996
[Changes in the histamine concentration, histaminase activity and histaminopexic index of the blood in acute cerebral circulatory disorders].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:9

    Topics: Acute Disease; Adult; Amine Oxidase (Copper-Containing); Brain Ischemia; Cerebral Hemorrhage; Diagno

1978
Direct evidence for increased continuous histamine release in the striatum of conscious freely moving rats produced by middle cerebral artery occlusion.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:3

    Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebral Infarction; Corpus Striatum; Disease Models, Anim

1992
Hypoxia and ischemia modifies histamine metabolism and transport in brain synaptosomes.
    Resuscitation, 1988, Volume: 16, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Histamine; Histamine N-Methyltransferase; Histidine Decarboxylase; H

1988
[Dynamics of the histamine content and diamine oxidase activity of the blood in patients with ischemic stroke and transient disorders of cerebral blood circulation].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1988, Volume: 88, Issue:12

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amine Oxidase (Copper-Containing); Brain Ischemia; Ce

1988