| Assay ID | Title | Year | Journal | Article |
|---|
| AID86427 | Concentration required for agonistic activity against Histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86924 | Effective concentration for agonism activity in endothelium-denuded guinea pig aortic segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87535 | Relative potency against H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86895 | Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86921 | Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86925 | Effective concentration for agonist activity in guinea pig ileum whole segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID28749 | Concentration of the compound | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID141205 | Compound was evaluated for its antagonist affinity towards Muscarinic acetylcholine receptor M3 of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87215 | Relative potency was recorded in endothelium-denuded guinea pig aortic segment; value ranges from 399 to 526, significantly more potent than histamine (P<0.01). | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87075 | Negative logarithm of receptor dissociation constant Kp was reported in guinea pig ileum whole segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID79480 | Apparent pA2 value of compound at 100 nM concentration of mepyramine in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87210 | Relative potency was recorded in Endothelium-Denuded guinea pig aortic segment(pre contracted with PGF-2 alpha); value ranges from 296 to 569, significantly more potent than histamine | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86271 | Maximum response (E max) against Histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87390 | The compound was evaluated for intrinsic activity i.e. maximum histamine controls relative to contraction evoked by 10 uM PGF2-alpha in in relaxed rat aortic rings | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID5600 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 2A receptor of rat | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86435 | Intrinsic activity was reported in guinea pig ileum whole segment; mean significantly different from 100 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86430 | Intrinsic activity was reported in endothelium-denuded guinea pig aortic segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86922 | Effective concentration against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86272 | concentration of mepyramine was determined | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87071 | Equilibrium dissociation constant (pKp) against histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87544 | Effective concentration for agonism activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87546 | Relative potency was recorded in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619; value ranges from 1854 to 4305 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87080 | Relative potency in guinea pig ileum whole segment; value ranges from 308 to 382 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86578 | The compound was evaluated for intrinsic activity i.e. maximum histamine controls relative to contraction evoked by 10 uM PGF2-alpha in Endothelium-Denuded guinea pig aortic segment(pre contracted with PGF-2 alpha) | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86923 | Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID28748 | Mepyramine concentration required to antagonise histaprodifens compound induced effects in guinea pig or rat assays | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86761 | Relative potency against Histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID5965 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 3 receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86758 | Maximum response (E max) against Histamine H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID86898 | Antagonism of guinea pig ileum contraction at 100 nM mepyramine | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87539 | Maximum response (E max) against Histamine H1 receptor in guinea pig ileum | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID87389 | Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID35610 | Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86285 | Compound was evaluated for its antagonist affinity towards Histamine H3 receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86267 | Antagonist effects was studied on contraction of guinea-pig ileum preparation. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87538 | Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID42212 | Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID88149 | Compound was evaluated for its antagonist affinity towards Histamine H2 receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87392 | The compound was evaluated for intrinsic activity in relaxed rat aortic rings with intact endothelium, submaximally precontracted with 15.8 nM U-46,619 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID87543 | Effective concentration against histamine H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID4489 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 1B receptor of guinea pig | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID6248 | Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 4 receptor of rat | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID86576 | Relative potency against Histamine H1 receptor in rat aorta | 2003 | Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
| N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. |
| AID28753 | concentration; value ranges from 3 to 30 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1346037 | Human H1 receptor (Histamine receptors) | 2003 | The Journal of pharmacology and experimental therapeutics, Jun, Volume: 305, Issue:3
| Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |