A histamine agonist that binds to and activates H1-receptors.
ChEBI ID: 71173
| Member | Definition | Class |
|---|---|---|
| betahistine | An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease. | betahistine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 107 (25.48) | 18.7374 |
| 1990's | 43 (10.24) | 18.2507 |
| 2000's | 105 (25.00) | 29.6817 |
| 2010's | 120 (28.57) | 24.3611 |
| 2020's | 45 (10.71) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 127 (27.67%) | 5.53% |
| Reviews | 50 (10.89%) | 6.00% |
| Case Studies | 22 (4.79%) | 4.05% |
| Observational | 2 (0.44%) | 0.25% |
| Other | 258 (56.21%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | Ki | 2.0300 | 1 | 1 |